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Navigating the ethical terrain:Off-label and experimental treatments in medical case reports

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World Journal of Methodology 2025年第1期15卷 1-5页

作者： Madhan Jeyaraman naveen Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077India Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002India

This article explores the ethical considerations surrounding the reporting of offlabel and experimental treatments in medical case reports,with a focus on fields such as oncology,psychiatry,and *** emphasizes the balance between innovation and evidence-based medicine,highlighting the critical role of case reports in disseminating clinical experiences and advancing medical *** discussion delves into the ethical framework guiding case reporting,including principles of patient autonomy,informed consent,non-maleficence,beneficence,justice,and *** such as negative outcome reporting,commercial interests,and the balance between innovation and caution are *** for ethical vigilance,the development of comprehensive guidelines,and the role of regulatory bodies are proposed to ensure patient safety and uphold scientific *** article concludes by underscoring the importance of a collaborative effort among clinicians,researchers,ethicists,and regulatory bodies to foster the responsible advancement of medical science while adhering to the highest ethical standards.

关键词： Ethical considerations Patient autonomy Informed consent Non-maleficence Beneficence Transparency Evidence-based medicine

Beyond statistical significance:Embracing minimal clinically important difference for better patient care

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World Journal of Methodology 2025年第1期15卷 33-41页

作者： naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Sangeetha Balaji Sathish Muthu Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Research Methods Orthopaedic Research GroupCoimbatore 641045Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia Department of Biotechnology Faculty of EngineeringKarpagam Academy of Higher EducationCoimbatore 641021Tamil NaduIndia Department of Orthopaedics Government Medical CollegeKarur 639004Tamil NaduIndia

The minimal clinically important difference(MCID)represents a pivotal metric in bridging the gap between statistical significance and clinical relevance,addressing the direct impact of medical interventions from the patient's *** comprehensive review analyzes the evolution,applications,and challenges of MCID across medical specialties,emphasizing its necessity in ensuring that clinical outcomes not only demonstrate statistical significance but also offer genuine clinical utility that aligns with patient expectations and *** discuss the evolution of MCID since its inception in the 1980s,its current applications across various medical specialties,and the methodologies used in its calculation,highlighting both anchor-based and distribution-based ***,the paper delves into the challenges associated with the application of MCID,such as methodological variability and the interpretation difficulties that arise in clinical *** for the future include standardizing MCID calculation methods,enhancing patient involvement in setting MCID thresholds,and extending research to incorporate diverse global *** steps are critical to refining the role of MCID in patient-centered healthcare,addressing existing gaps in methodology and interpretation,and ensuring that medical interventions lead to significant,patient-perceived improvements.

关键词： Minimal clinically important difference Patient-centered care Clinical relevance Global health

Malpractice or masterful practice?Navigating vicarious liability in healthcare

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World Journal of Clinical Cases 2025年第2期13卷 10-13页

作者： Satvik N Pai naveen Jeyaraman Madhan Jeyaraman Swaminathan Ramasubramanian Department of Orthopaedics PES University Institute of Medical Sciences and ResearchBengaluru 560100KarnatakaIndia Department of Orthopaedics ACS Medical College and HospitalDr MGR Educational and Research InstituteChennai 600077Tamil NaduIndia Department of Orthopaedics Government Medical CollegeOmandurar Government EstateChennai 600002Tamil NaduIndia

In the intricate landscape of healthcare,vicarious liability looms large,shaping the responsibilities and actions of healthcare practitioners and administrators *** by a poignant scenario of a medication error,this article navigates the complexities of vicarious liability in *** explains the legal basis and ramifications of this theory,emphasizing its importance in fostering responsibility,protecting patient welfare,and easing access to *** paper explores the practical effects of vicarious responsibility on day-to-day operations,leadership practices,and decision-making processes via the eyes of senior consultants,junior doctors,and hospital *** comprehensive insights and real-world examples,it underscores the imperative of fostering a culture of accountability,communication,and quality care to navigate the intricate web of liabilities inherent in modern healthcare.

关键词： Vicarious liability Healthcare Responsibility Litigation Patient welfare

Linear and nonlinear propagation characteristics of multi-Gaussian laser beams

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Chinese Physics B 2020年第11期29卷 370-379页

作者： naveen Gupta Sandeep Kumar Lovely Professional University PhagwaraIndia

Theoretical investigation on the propagation characteristics of a new class of laser beams known as multi Gaussian(M.G)laser beams has been *** investigate the linear characteristics,propagation of the laser beam in vacuum has been ***,the nonlinear characteristics have been investigated in *** nonlinearity of the plasma has been modeled by relativistic mass nonlinearity of the plasma electrons in the field of laser *** is based on finding the semi analytical solution of the wave equation for the slowly varying envelope of the laser ***,the dynamical evolutions of the beam width and longitudinal phase of the laser beam have been investigated in detail.

关键词： self-focusing multi Gaussian self phase modulation self-channeling

Transportation mode detection using cumulative acoustic sensing and analysis

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Frontiers of Computer Science 2021年第1期15卷 237-239页

作者： Dinesh VIJ naveen AGGARWAL University Institute of Engineering and Technology Panjab UniversityChandigarh 160014India

1 Introduction Smartphone sensing has emerged as an active area of interest for researchers,as these are increasingly being used in smart transportation *** paper focuses on a smartphone based vehicle monitoring system,*** mode *** of the transportation mode of a commuter is usually carried out through a combination of motion sensors such as an accelerometer and position sensors such as GPS[1].

关键词： mode smart transportation

Effect of different geometrical non-uniformities on nonlinear vibration of porous functionally graded skew plates: A finite element study

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Defence Technology（防务技术） 2022年第6期18卷 918-936页

作者： H.S.naveen Kumar Subhaschandra Kattimani Department of Mechanical Engineering National Institute of Technology KarnatakaSurathkal575025India

This article presents the investigation of nonlinear vibration analysis of tapered porous functionally graded skew(TPFGS)plate considering the effects of geometrical non-uniformities to optimize the thickness in the structural *** TPFGS plate is analyzed considering linearly,bi-linearly,and exponentially varying *** plate’s effective material properties are tailor-made using a modified power-law distribution in which gradation varies along the thickness direction of the TPFGS *** the non-linear finite element formulation to develop the kinematic equation’s displacement model for the TPFGS plate is based on the first-order shear deformation theory(FSDT)in conjunction with von Karman’s *** nonlinear governing equations are established by Hamilton’s *** direct iterative method is adopted to solve the nonlinear mathematical relations to obtain the nonlinear *** influence of the porosity distributions and porosity parameter indices on the nonlinear frequency responses of the TPFGS plate for different skew angles and variable thicknesses are studied for various geometrical *** influence of taper ratio,variable thickness,skewness,porosity distributions,gradation,and boundary conditions on the plate’s nonlinear vibration is *** nonlinear frequency analysis reveals that the geometrical nonuniformities and porosities significantly influence the porous functionally graded plates with varying thickness than the uniform ***,exponentially and linearly variable thicknesses can be considered for the thickness optimizations of TPFGS plates in the structural design.

关键词： Functionally graded material Shear deformation theory Porosity distributions Variable thickness Geometrical skewness Nonlinear free vibration

Numerical modelling of reinforced concrete flexural members strengthened using textile reinforced mortars

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Frontiers of Structural and Civil Engineering 2023年第4期17卷 649-668页

作者： naveen Revanna Charles K.S.Moy Department of Civil Engineering Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China

Externally bonded(EB)and near-surface mounted(NSM)bonding are two widely adopted and researched strengthening methods for reinforced-concrete *** composite substrates are easy to reach and repair using appropriate surface treatments,whereas NSM techniques can be easily applied to the soffit and concrete member *** EB bonded fiber-reinforced polymer(FRP)technique has a significant drawback:combustibility,which calls for external protective agents,and textile reinforced mortar(TRM),a class of EB composites that is noncombustible and provides a similar functionality to any EB FRP-strengthened *** study employs a finite element analysis technique to investigate the failing failure of carbon textile reinforced mortar(CTRM)-strengthened reinforced concrete *** principal objective of this numerical study was to develop a finite element model and validate a set of experimental data in existing literature.A set of seven beams was modelled and calibrated to obtain concrete damage plasticity(CDP)*** predicted results,which were in the form of load versus deflection,load versus rebar strain,tensile damage,and compressive damage patterns,were in good agreement with the experimental ***,a parametric study was conducted to verify the applicability of the numerical model and study various influencing factors such as the concrete strength,internal reinforcement,textile roving spacing,and externally-applied load *** ultimate load and deflection of the predicted finite element results had a coefficient of variation(COV)of 6.02%and 5.7%,respectively.A strain-based numerical comparison with known methods was then conducted to investigate the debonding *** developed finite element model can be applied and tailored further to explore similar TRM-strengthened beams undergoing debonding,and the preventive measures can be sought to avoid premature debonding.

关键词： fiber reinforced polymer textile reinforced mortar finite element analysis concrete damage plasticity calibration and validation parametric study

Power system reconfiguration and loss minimization for a distribution systems using ＂Catfish PSO＂ algorithm

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Frontiers in Energy 2014年第4期8卷 434-442页

作者： K Sathish KUMAR S naveen School of Electrical Engineering VIT University Vellore 632014 India

One of the very important ways to save electrical energy in the distribution system is network reconfiguration for loss reduction. Distribution networks are built as interconnected mesh networks; however, they are arranged to be radial in operation. The distribution feeder reconfiguration is to find a radial operating structure that optimizes network performance while satisfying operating constraints. The change in network configuration is performed by opening sectionalizing （normally closed） and closing tie （normally opened） switches of the network. These switches are changed in such a way that the radial structure of networks is maintained, all of the loads are energized, power loss is reduced, power quality is enhanced, and system security is increased. Distribution feeder reconfiguration is a complex nonlinear combinator- ial problem since the status of the switches is non- differentiable. This paper proposes a new evolutionary algorithm （EA） for solving the distribution feeder reconfiguration （DFR） problem for a 33-bus and a 16- bus sample network, which effectively ensures the loss minimization.

关键词： distribution system reconfiguration (DFR),power loss reduction catfish particle swarm optimization(catfish PSO) radial structure

Comprehensive evaluation of key management hierarchies for outsourced data

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Cybersecurity 2019年第1期2卷 150-166页

作者： naveen Kumar Anish Mathuria Indian Institute of Information Technology VadodaraIndia Dhirubhai Ambani Institute of Information and Communication Technology GandhinagarIndia

Key management is an essential component of a cryptographic access control system with a large number of *** manages the secret keys assigned to the system entities in such a way that only authorized users can access a *** access control allows read access of a resource by the authorized users and disallows *** important objective of a key management is to reduce the secret key storage with each authorized *** this end,there exist two prominent types of key management hierarchy with single key storage per user used for read access control in data outsourcing scenario:user-based and *** this work,we analyze the two types of hierarchy with respect to static hierarchy characteristics and dynamic operations such as adding or revoking user *** analysis shows that the resource-based hierarchies can be a better candidate which is not given equal emphasis in the literature.A new heuristic for minimizing the key management hierarchy is introduced that makes it practical in use even for a large number of users and *** performance evaluation of dynamic operations such as adding or revoking a user’s read subscription is shown experimentally to support our analytical results.

关键词： Key management hierarchy Data outsourcing Access control