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World Journal of Radiology 2024年第7期16卷 256-264页

作者： Takashi Ono Hiraku Sato Yuya Miyasaka Yasuhito Hagiwara natsuko Yano Hiroko Akamatsu Mayumi Harada Mayumi Ichikawa Department of Radiation Oncology Faculty of MedicineYamagata UniversityYamagata 990-9585Japan Department of Heavy Particle Medical Science Yamagata University Graduate School of Medical ScienceYamagata 990-9585Japan

BACKGROUND Carbon ion radiotherapy(CIRT)is currently used to treat prostate *** bleeding is a major cause of toxicity even with ***,to date,a correlation between the dose and volume parameters of the 12 fractions of CIRT for prostate cancer and rectal bleeding has not been ***,the clinical risk factors for rectal bleeding were absent after 12 fractions of *** To identify the risk factors for rectal bleeding in 12 fractions of CIRT for prostate *** Among 259 patients who received 51.6 Gy[relative biological effectiveness(RBE)],in 12 fractions of CIRT,15 had grade 1(5.8%)and nine had grade 2 rectal bleeding(3.5%).The dose-volume parameters included the volume(cc)of the rectum irradiated with at least x Gy(RBE)(Vx)and the minimum dose in the most irradiated x cc normal rectal volume(Dx).RESULTS The mean values of D6cc,D2cc,V10 Gy(RBE),V20 Gy(RBE),V30 Gy(RBE),and V40 Gy(RBE)were significantly higher in the patients with rectal bleeding than in those *** cutoff values were D6cc=34.34 Gy(RBE),D2cc=46.46 Gy(RBE),V10 Gy(RBE)=9.85 cc,V20 Gy(RBE)=7.00 cc,V30 Gy(RBE)=6.91 cc,and V40 Gy(RBE)=4.26 *** D2cc,V10 Gy(RBE),and V20 Gy(RBE)cutoff values were significant predictors of grade 2 rectal *** The above dose-volume parameters may serve as guidelines for preventing rectal bleeding after 12 fractions of CIRT for prostate cancer.

关键词： Carbon ion radiotherapy Prostate cancer Rectal bleeding Dose volume parameters Prevention

Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaingmongkol Anuradha Budhu Hien Dang Siritida Rabibhadana Benjarath Pupacdi So Mee Kwon Marshonna Forgues Yotsawat Pomyen Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Maggie Cam Ping He Stephen M.Hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen Snorri S.Thorgeirsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling Holly S.Stevenson Daniel Edelman Paul S.Meltzer Christopher A.Loffredo natsuko hama Tatsuhiro Shibata Robert H.Wiltrout Curtis C.Harris Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinogenesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinogenesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicology Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess Chulabhorn College of Medical Science BangkokThailand Chulabhorn Hospital BangkokThailand Rajavej Hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Pathology Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Genetics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Georgetown University Medical Center WashingtonDCUSA Division of Cancer Genomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Program Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholangiocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiological and biological *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical Research Support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center Research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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Enzyme-instructed self-assembly of peptides containing phosphoserine to form supramolecular hydrogels as potential soft biomaterials

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Frontiers of Chemical Science and Engineering 2017年第4期11卷 509-515页

作者： Jie Zhou Xuewen Du Jiaqing Wang natsuko Yamagata Bing Xu Department of Chemistry Brandeis University 415 South St. Waltham MA 02453 USA.

Enzyme-instructed self-assembly （EISA） offers a facile approach to explore the supramolecular assemblies of small molecules in cellular milieu for a variety of biomedical applications. One of the commonly used enzymes is phosphatase, but the study of the substrates of phosphatases mainly focuses on the phos- photyrosine containing peptides. In this work, we examine the EISA of phosphoserine containing small peptides for the first time by designing and synthesizing a series of precursors containing only phosphoserine or both phos- phoserine and phosphotyrosine. Conjugating a phospho- serine to the C-terminal of a well-established self- assembling peptide backbone, （naphthalene-2-1y）-acetyl- diphenylalanine （NapFF）, affords a novel hydrogelation precursor for EISA. The incorporation ofphosphotyrosine, another substrate of phosphatase, into the resulting precursor, provides one more enzymatic trigger on a single molecule, and meanwhile increases the precursors＇ propensity to aggregate after being fully dephosphorylated. Exchanging the positions of phosphorylated serine and tyrosine in the peptide backbone provides insights on how the specific molecular structures influence self-assembling behaviors of small peptides and the subsequent cellular responses. Moreover, the utilization of D-amino acids largely enhances the biostability of the peptides, thus providing a unique soft material for potential biomedical applications.

关键词： enzyme-instructed self-assembly phosphoser-ine phosphatase supramolecular hydrogel

Particle size distribution of brominated flame retardants in house dust from Japan

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Emerging Contaminants 2016年第2期2卷 109-117页

作者： natsuko Kajiwara Hidetaka Takigami Center for Material Cycles and Waste Management Research National Institute for Environmental Studies16-2 OnogawaTsukubaIbaraki 305-8506Japan

The present study was conducted to examine the concentrations,profiles,and mass distributions of polybrominated diphenyl ethers(PBDEs),hexabromocyclododecanes(HBCDs),and polybrominated dibenzo-p-dioxins/furans(PBDD/Fs)based on the particle sizes of house dust samples from five homes in *** removal of impurities from house dust from vacuum cleaner bags,selected indoor dust samples were size fractionated(>2 mm,1-2 mm,0.5-1 mm,250-500 mm,106-250 mm,53-106 mm,and250 mm in size and fluffy dust were *** conclusion is that particulate dust<250 mm in size without fluffy dust should be used to analyze dust for brominated flame retardants.

关键词： Brominated flame retardant PBDEs HBCDs House dust Particle size

Porphyromonas gingivalis,a periodontal pathogen,impairs post-infarcted myocardium by inhibiting autophagosome–lysosome fusion

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International Journal of Oral Science 2023年第4期15卷 626-639页

作者： Yuka Shiheido-Watanabe Yasuhiro Maejima Shun Nakagama Qintao Fan natsuko Tamura Tetsuo Sasano Department of Cardiovascular Medicine Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan

While several previous studies have indicated the link between periodontal disease (PD) and myocardial infarction (MI), theunderlying mechanisms remain unclear. Autophagy, a cellular quality control process that is activated in several diseases, includingheart failure, can be suppressed by Porphyromonas gingivalis (P.g.). However, it is uncertain whether autophagy impairment byperiodontal pathogens stimulates the development of cardiac dysfunction after MI. Thus, this study aimed to investigate therelationship between PD and the development of MI while focusing on the role of autophagy. Neonatal rat cardiomyocytes(NRCMs) and MI model mice were inoculated with wild-type P.g. or gingipain-deficient P.g. to assess the effect of autophagyinhibition by P.g. Wild-type P.g.-inoculated NRCMs had lower cell viability than those inoculated with gingipain-deficient P.g. Thisstudy also revealed that gingipains can cleave vesicle-associated membrane protein 8 (VAMP8), a protein involved in lysosomalsensitive factor attachment protein receptors (SNAREs), at the 47th lysine residue, thereby inhibiting autophagy. Wild-type P.g.-inoculated MI model mice were more susceptible to cardiac rupture, with lower survival rates and autophagy activity thangingipain-deficient P.g.-inoculated MI model mice. After inoculating genetically modified MI model mice (VAMP8-K47A) with wildtype P.g., they exhibited significantly increased autophagy activation compared with the MI model mice inoculated with wild-typeP.g., which suppressed cardiac rupture and enhanced overall survival rates. These findings suggest that gingipains, which arevirulence factors of P.g., impair the infarcted myocardium by cleaving VAMP8 and disrupting autophagy. This study confirms thestrong association between PD and MI and provides new insights into the potential role of autophagy in this relationship.

关键词： inhibiting myocardium periodontal

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Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 874-882页

作者： Tomoko KATONO Takayuki KAWATO natsuko TANABE Naoto SUZUKI Kazuhiro YAMANAKA Hitoshi OKA Masafumi MOTOHASHI Masao MAENO Kanda Surugadai Chiyoda-kuTokyo 101-8310Japan Department of Oral Health Sciences Nihon UniversitySchool of DentistryTokyo 101-8310Japan Japan Department of Biochemistry Nihon University School of Dentistry.Tokyo 101-8310Japan

Tobacco smoking is an important risk factor for the development of severe ***,we showed that nicotine affected mineralized nodule formation,and that nicotine andlipopolysaccharide stimulated the formation of osteoclast-like cells by increasing production of macrophagecolony-stimulating factor （M-CSF） and prostaglandin E2（PGE2） by human osteoblastic Saos-2 *** thepresent study,we examined the effects of nicotine on the expression of matrix metalloproteinases （MMPs）,tissue inhibitors of matrix metalloproteinases （TIMPs）,the plasminogen activation system including thecomponent of tissue-type plasminogen activator （tPA）,urokinase-type PA （uPA）,and PA inhibitor type 1（PAI-1）,α7 nicotine receptor,and *** also examined the effect of the nicotine antagonist D-tubocurarineon nicotine-induced expression of *** expression was examined using real-time polymerase chainreaction （PCR） to estimate mRNA *** addition,expression of the MMP,TIMP,uPA,tPA,and PAI-1proteins was determined by Western blotting *** treatment caused expression of MMP-1,2,3,and 13,but not MMP-14,to increase significantly after 5 or 10 d of culture;MMP-14 expression did notchange through day *** of MMP-1 expression by nicotine treatment was eliminated bysimultaneous treatment with *** the presence of nicotine,expression of uPA,PAI-1,orTIMP-1,2,3,or 4 did not change over 14 d of culture,whereas expression of tPA increased significantly byday *** also increased expression of the α7 nicotine receptor and c-fos *** results suggestthat nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1,2,3,and 13,thereby tipping the balance between bone matrix formation and resorption toward the latter process.

关键词： nicotine matrix metalloproteinase tissue inhibitor of matrix metalloproteinase plasminogen activation system

Lipopolysaccharide Enhances the Production of Nicotine-Induced Prostaglandin E2 by an Increase in Cyclooxygenase-2 Expression in Osteoblasts

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Acta Biochimica et Biophysica Sinica 2007年第3期39卷 163-172页

作者： Maiko SHOJI natsuko TANABE Narihiro MITSUI Naoto SUZUKI Osamu TAKEICHI Tomoko KATONO Akira MOROZUMI Masao MAENO Department of Oral Health Sciences Nihon University School of DentistryTokyo 101-8310Japan Division of Functional Morphology Dental Research Center.Nihon University School ofDentistryTokyo 101-8310Japan Nihon University Grndudte School of Dentistry Tokyo 101-8310Japan Division of Functional Morphology Dental Research Center.Nihon University School of DentistryTokyo 101-8310Japan Department of Endodontics Nihon University School of DentisityTokyo 101-8310Japan Division of Advanced Dental Treatment Dental Research CenterNihon University School of DentistryTokyo 101-8310Japan Nihon University Graduate School of Dentistry Tokyo 101-8310Japan

Previous studies have indicated that lipopolysaccharide（LPS）from Gram-negative bacteria inplaque induces the release of prostaglandin E2（PGE2）,which promotes alveolar bone resorption in periodontitis,and that tobacco smoking might be an important risk factor for the development and severity of *** determined the effect of nicotine and LPS on alkaline phosphatase（ALPase）activity,PGE2production,and the expression of cyclooxygenase（COX-1,COX-2）,PGE2receptors Ep1-4,and macrophage colonystimulating factor（M-CSF）in human osteoblastic Saos-2 *** cells were cultured with 10-3M nicotinein the presence of 0,1,or 10μg/ml LPS,or with LPS *** activity decreased in cells cultured withnicotine or LPS alone,and decreased further in those cultured with both nicotine and LPS,whereas PGE2production significantly increased in the former and increased further in the *** itself,nicotine did notaffect expression of COX-1,COX-2,any of the PGE2receptors,or M-CSF,but when both nicotine and LPSwere present,expression of COX-2,Ep3,Ep4,and M-CSF increased *** addition of10-4M indomethacin eliminated the effects of nicotine and LPS on ALPase activity,PGE2production,and M-CSF *** of protein kinase A was high in cells cultured with nicotine and *** suggest that LPS enhances the production of nicotine-induced PGE2by an increase in COX-2 expres-sion in osteoblasts,that nicotine-LPS-induced PGE2interacts with the osteoblast Ep4 receptor primarily inautocrine or paracrine mode,and that the nicotine-LPS-induced PGE2then decreases ALPase activity andincreases M-CSF expression.

关键词： nicotine lipopolysaccharide prostaglandin E2 cyclooxygenase-2 Ep4 receptor

Study of the Conditions Surrounding Fatigue That Are Common to Medical Professionals Working in Emergency and Critical Care Centers in Japan

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Health 2020年第1期12卷 27-37页

作者： natsuko Makino Department of Nursing School of Health Sciences Sapporo Medical University Sapporo Japan

This study aimed to clarify the conditions surrounding fatigue that are common to medical professionals working in emergency and critical care centers in Japan. Semi-structured interviews were conducted with eight professionals ranging from doctors, nurses and pharmacists to clinical engineering technologists and radiation technologists. Their narratives were analyzed using the qualitative descriptive approach to determine fatigue common to all professionals and the reasons behind it. The five categories that emerged as the reasons for fatigue common to the subjects were [playing one’s role in treatment and procedures for emergency and critical patients], [accommodating the patient’s background and coming to terms with the outcome], [difficulties in liaising with other professionals], [feeling pressure as a responsible professional in emergency care] and [loss of sense of time caused by variable working hours]. The results revealed that fatigue common to all of the subjects was related to dealing with patients, coordinating with other professionals, having professional responsibilities and the working environment. This study suggests that arrangements to improve the working environment, ensure adequate staffing, and provide mental health support for the well-being of medical professionals working in emergency and critical care centers are necessary.

关键词： Fatigue Medical Professionals Emergency and Critical Care Centers

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Open Journal of Nursing 2020年第11期10卷 1038-1047页

作者： natsuko Kojima Kyoko Asazawa Division of Nursing Faculty of Nursing Tokyo Healthcare University Tokyo Japan

Background: The aim of this study was to investigate Japanese students and employed adults’ characteristic features, and sexual situation, and to find the correlated factors of lesbian, gay, bisexual, transgender (LGBT) recognition in order to obtain suggestions for improved relationships with sexual minorities in a diversifying society. Methods: This quantitative cross-sectional descriptive correlational study occurred during 2018 to 2019 when 2210 questionnaires were distributed to a purposive sample of eligible participants. A total of 1534 completed questionnaires (69.4%) were returned, of which 1439 (65.1%) were suitable for analyses. The survey included respondents’ 1) characteristics, 2) sexual situation, and 3) LGBT recognition scale. Data were analyzed with descriptive statistics, factor analysis, reliability analysis, and structural equation modeling. SPSS ver. 26.0 (SPSS, Chicago, IL, USA) was used for data analysis at a 5% significance level. Results: The LGBT recognition score was significantly affected by suffering from gender identity (standardized partial regression coefficient: β = 0.17, p −0.19, p Conclusions: Suffering from gender identity, learning about LGBT experience, experience of disclosure from LGBT person, sexual problem with intimate relationship, and diversity penetration had a positive effect, whereas age had negative effects on the LGBT recognition score.

关键词： Sexual and Gender Minorities Cross-Sectional Studies Covariance Structure Analysis