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Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases

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Latent membrane protein 1 of Epstein-Barr virus regulates p5...

以制度型开放促进服务业改革深化的思路和建议

2008年中国病理生理学会第十一届肿瘤和第十二届免疫专业委员会学术会议

作者： Lili Li Lili Guo Zijian Li Xue Chen Xiangjian Luo Xiaoqian Ma Lanbo Xiao Ya Cao Cancer research Institute,Xiangya School of Medicine,Central South University,110 Xiangya Road,Changsha,Hunan,PR China Cancer research Institute,Xiangya School of Medicine,Central South University,110 Xiangya Road,Changsha,Hunan,P.R.China,

The Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP 1),an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC).Phosphorylation of p53 protein is likely to play the key role in regulating its activity,p53 protein accumulates but mutation of p53 gene is not common in *** molecular mechanisms of p53 augmentation have not been completely ***,the role of MAP kinases in the phosphorylation of p53 modulated by LMP1 was determined,p53 could be activated and phosphorylated clearly at Serl5, Ser20,Ser392 and Thr81 modulated by ***,LMPl-induced phosphorylation of p53 at Serl5 was directly by ERKs;at Ser20 and Thr81 by JNK,at Ser 15 and Ser392 by p38 *** phosphorylation of p53 was associated with its transcriptional activity and stability modulated by *** results strongly suggest that MAP kinases have a direct role in LMPl-induced phosphorylation of p53 at multiple sites,which provide a novel view for us to tmderstand the mechanism of the activation of p53 in the carcinogenesis of nasopharyngeal carcinoma.

关键词： Epstein-Barr virus Latent membrane protein 1 p53 MAP Kinases phosphorylation

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中国经济报告 2020年第5期 35-57页

作者：国务院发展研究中心市场经济研究所课题组刘涛刘馨王微王青李汉卿王立坤王念漆云兰不详

当前,服务业已成为我国国民经济的第一大产业,对于经济高质量发展意义重大,亟需加快破除制约服务业提质增效发展的体制机制障碍。国际服务贸易规则面临重构,全球服务业开放重点正从传统的边境措施向边境内措施拓展,对各国加快完善法律... 详细信息

当前,服务业已成为我国国民经济的第一大产业,对于经济高质量发展意义重大,亟需加快破除制约服务业提质增效发展的体制机制障碍。国际服务贸易规则面临重构,全球服务业开放重点正从传统的边境措施向边境内措施拓展,对各国加快完善法律法规和制度体系提出了更高要求。为此,要坚持对外开放的基本国策和发展理念,以制度型开放为引领,着力建立与国际先进规则相衔接的服务业法律法规、管理体制、运行机制、政策体系,在持续推动服务业向更大范围、更宽领域、更深层次开放中,加快形成科学规范、运行有效、成熟定型的服务业发展制度框架,打造具有国际竞争力的制度优势。

关键词：制度型开放高质量发展服务业改革开放

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政策措施落实情况跟踪审计实务研究

审计研究 2017年第3期 12-18页

作者：上海市审计学会课题组林忠华上海市审计学会课题组

政策措施落实情况跟踪审计,是国务院交办的重要任务,是审计机关的法定职责。上海市审计机关持续开展政策措施落实情况跟踪审计,取得了一些成效,但尚未形成比较成熟的操作模式,实际工作中面临着审计范围较窄、深度有限、组织管理不够健... 详细信息

政策措施落实情况跟踪审计,是国务院交办的重要任务,是审计机关的法定职责。上海市审计机关持续开展政策措施落实情况跟踪审计,取得了一些成效,但尚未形成比较成熟的操作模式,实际工作中面临着审计范围较窄、深度有限、组织管理不够健全、知识储备和人员素质不足等困难。本文总结上海市审计机关开展政策措施落实情况跟踪审计实践中遇到的主要问题,结合上海市"十三五"规划确定的发展目标,深入研究下一阶段开展政策措施落实情况跟踪审计的重点内容和方式方法,提出围绕深化中国(上海)自由贸易试验区改革、加快建设具有全球影响力的科技创新中心、推进供给侧结构性改革等重要工作任务,聚焦政策措施落实情况跟踪审计重点内容,为审计工作实践提供参考借鉴。

关键词：政策落实跟踪审计国家审计

A LINEAR THEORY FOR DISTURBANCE OF COHERENT STRUCTURE AND MECHANISM OF SAND WAVES IN OPEN-CHANNEL FLOW

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International Journal of Sediment research 2001年第2期16卷 234-243页

作者： Yuchuan BAI1, Andreas MALCHEREK2 and Changbo JIANG 1 Institute for Sedimentation on River and Coast Engineering, Tianjin University, Tianjin 300072, China. E-Mail: Ychbai@*** 2 Federal Waterways Engineering and research Institute Institute for Sedimentation on River and Coast Engineering Tianjin University Tianjin 300072 China.E-Mail: Ychbai@*** Federal Waterways Engineering and research Institute Coastal Department D-22559 Hamburg Germany.

The formation of sand wave is such a process in which the roughness and discontinuity of the original bed surface cause the disturbance of the bottom laminar flow in an open channel, and the development of the disturbance in turn leads to instability of the flow and the appearance of the coherent structure. The evolution and development of the coherent structure further promote the undulations of bed surface and sand waves rise finally. The sand wave is explained as a result of action that the bed sediment particles are disturbed by the coherent structure. This study shows that the sand wave formation is the result of disturbance action of neutral coherent structure, and the sand wave shape obtained in computations is identical to the practical one.

关键词： Coherent structure Sand wave Open channel flows

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构建霍尔果斯特殊经济开发区初探

新疆职业大学学报 2011年第4期19卷 30-32,64页

作者：祝辉中共新疆维吾尔自治区委员会党校政治学教研部新疆乌鲁木齐830002

构建霍尔果斯特殊经济开发区的设想是在新疆向西开放上升为国家战略的新历史背景下,在党中央、国务院着眼于进一步加大沿边开放力度,充分利用亚欧大陆桥交通枢纽的独特区位优势,努力把新疆打造成我国对外开放的重要门户和基地的基础上... 详细信息

构建霍尔果斯特殊经济开发区的设想是在新疆向西开放上升为国家战略的新历史背景下,在党中央、国务院着眼于进一步加大沿边开放力度,充分利用亚欧大陆桥交通枢纽的独特区位优势,努力把新疆打造成我国对外开放的重要门户和基地的基础上提出的一项重大战略举措。通过分析构建霍尔果斯经济开发区的重要意义和比较优势,进而提出了构建霍尔果斯特殊经济开发区的若干设想。

关键词：霍尔果斯经济开发区比较优势

EUTROPHICATION AND RED TIDES AS CONSEQUENCES OF ECONOMIC DEVELOPMENT

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International Journal of Sediment research 2001年第4期16卷 508-518页

作者： Zhao-Yin WANG1, Yongsheng WU2, and Guangqian WANG3 1 Prof., Dept. of Hydraulic Engineering, Tsinghua University & International research and Training Center on Erosion and Sedimentation, Beijing 100084, China, Email: zywang@*** or zywang@sun Prof. Dept. of Hydraulic Engineering Tsinghua University & International Research and Training Center on Erosion and Sedimentation Beijing 100084 China Dr. Dept. of Hydraulic Engineering Tsinghua University Beijing 100084 China Prof. Dept. of Hydraulic Engineering Tsinghua University Beijing 100084 China

This paper reports the phenomena of eutrophication and red tides correlated with human activities, especially economic development. The fertilizer production in China has been accelerated since the 1970s and has approximately doubled the rate of nitrogen input into the terrestrial N cycle. While the rate of the total population growth of China maintains relatively stable the rate of population growth in cities and towns in the 1980s and 1990s was 10 times higher than ever before. As a result, the urban sewage discharge increased by 400%, which carries 1 million tons of nitrogen into the environmental waters per year. The mining of P minerals and application of P-containing fertilizers greatly enhanced the input of P into the waters. Harmful algal blooms are consequence of the eutrophication. The high frequency of algal bloom is related to the quick economic development since the 1970s and the eutrophication of environmental waters. Analysis indicates that the number of the red tide events in the China Seas roughly follows the curve of the growth rate of GDP with a time lag of about 5-6 years. The time lag is explained as the period of the cycle of accumulation, denitrification and release of the nutrients with transportation and resuspension of the sediment.

关键词： Eutrophication Red tide. Economic development Nutrients Sediment

国家重大政策措施落实情况跟踪审计管理创新研究

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审计研究 2017年第3期 19-22,29页

作者：浙江省审计学会课题组陈英姿王祥张斌浙江省审计学会课题组

国家重大政策措施落实情况跟踪审计是国务院赋予审计机关的新职能,在国家审计发展中的地位日渐重要。本课题组以浙江省政策措施落实情况跟踪审计为例,坚持以问题为导向,在深入总结浙江省政策措施落实情况跟踪审计实践经验的基础上,深刻... 详细信息

国家重大政策措施落实情况跟踪审计是国务院赋予审计机关的新职能,在国家审计发展中的地位日渐重要。本课题组以浙江省政策措施落实情况跟踪审计为例,坚持以问题为导向,在深入总结浙江省政策措施落实情况跟踪审计实践经验的基础上,深刻剖析了政策措施落实情况跟踪审计审计计划不够全面、审计重点有待明确、审计成果转化利用率低、审计人员专业知识不足等问题,并从政策措施落实情况跟踪审计管理创新的原则与目标调整、政策措施落实情况跟踪审计管理重点两方面探讨了政策措施落实情况跟踪审计管理创新的途径,对适合政策措施落实情况跟踪审计进一步科学发展的审计管理方式进行了探索,以期为审计实践提供指导。

关键词：政策措施落实情况跟踪审计审计管理创新

EXPERIMENTAL STUDY ON WAVE ENERGY DISSIPATION AND COHESIVE SEDIMENT TRANSPORT IN SILT COAST

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International Journal of Sediment research 2001年第2期16卷 224-233页

作者： Shixiong HU1 and Onyx WAI2 1 International research and Training Center on Erosion and Sedimentation, P.O.Box 366, Beijing 100044, China. 2 Department of Civil and Structure Engineering, Hong Kong Polytechnic University, Hong Kong, China. International research and Training Center on Erosion and Sedimentation P.O.Box 366 Beijing 100044 China Department of Civil and Structure Engineering Hong Kong Polytechnic University Hong Kong China.

The interaction between the wave and fluid mud layer plays an important role in the development of silt coast. Sediment is essentially transported in the form of rheological flow of mud layer under the wave action, and on the other hand, the fluid mud layer damps the wave considerably. This paper studies the laws of wave energy dissipation and mud bed deformation, and the movement of mud layer through laboratory experiments. The results show that the wave energy dissipation follows an exponential law along the propagation distance. The bulk density of the mud layer affects the rate of the wave energy dissipation greatly. The wave damping coefficient （Ki） is a function of the mud density affected greatly by the relative wave height （H/h）. Analysis also indicates that the mud density affect the rate of mud transport and the moving velocity (Vmax) of the surface mud is inversely proportional to the mud density. Both the relative wave height （H/h） and wave-damping coefficient （Ki） are proportional to the Vmax. Analysis also shows that the mud transport rate （Tr） is proportional to the wave damping rate (1-H0/H15), the relative wave height （H/h）, and inversely proportional to the volume concentration （Cv） and dimensionless coefficient of H/gT2.

关键词： Wave energy dissipation Cohesive sediment transport Mud erosion

Rainfall-induced landslide stability analysis in response to transient pore pressure——A case study of natural terrain landslide in Hong Kong

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Science China(Technological Sciences) 2003年第z1期46卷 52-68页

作者： LAN Hengxing, ZHOU Chenghu C. F. LeeWANG Sijing & WU Faquan State Key Laboratory of Natural Resources and Environmental System, Institute of Geographical Sci-ences and Natural Resources research, Chinese Academy of Sciences, Beijing 100101, China Department of Civil Engineering, Hong Kong University, Hong Kong, China 3. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China Chinese Acad Sci State Key Lab Nat Resources & Environm Syst Inst Geog Sci & Nat Resources Res Beijing 100101 Peoples R China Univ Hong Kong Dept Civil Engn Hong Kong Hong Kong Peoples R China Chinese Acad Sci Inst Geol & Geophys Beijing 100029 Peoples R China

Transient pore pressure in response to short intense rainfall process plays an important role in shallow landslide occurrence. Using GIS technology, we carry out the rainfall-induced landslide stability analysis in response to transient pore pressure by means of transient and unsaturated rainfall infiltration modeling. A case study is performed on the shallow landslide stability analysis in Hong Kong. Detailed analysis and discussion reached some useful conclusions on the tempo-spatial behavior and characteristics of slope stability response and pore pressure response to typical rainfall process. Comparison analysis is performed on some important issues including landslide stability response in different types of slopes with different hydraulic properties, antecedent rainfall and landslide stability, and the nature of pore pressure response time. These studies might give us an important insight into landslide tringgering mechanism and the hydrological process in response to rainfall, and provide systematic information and evidences for effective risk assessment and warning system establishment.

关键词： rainfall-induced landslide, transient pore pressure, landslide stability in response to rainfall, GIS.