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Inhibitory effect of topiramate on Lewis lung carcinoma metastasis and its relation with AQP1 water channel

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Acta Pharmacologica Sinica 2004年第1期 56-62页

作者： Bing MA, Yang XIANG, Tao LI, He-ming YU, Xue-jun LIDepartment of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083 national Research Institute for family planning, Beijing 100081, China

AIM: To study the effect of topiramate on tumor metastasis and its relation with aquaporin 1 (AQP1) water channel. METHODS: Lewis lung carcinoma metastatic model was used to determine the effect of topiramate on tumor growth and metastasis. Colorimetric estimation was used to investigate the action of topiramate on carbonic anhydrase (CA) activity. Western blotting and immunohistochemical analysis were used to study the influence of topiramate on AQP1 water channel expression in lungs or tumor tissues of mice bearing Lewis lung carcinoma.

关键词： topiramate aquaporins tumor metastasis carbonic anhydrase

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How to Stay Flu-Free

ChinAfrica 2013年第5期5卷 61-61页

作者： WHO and national health and family planning commission of China

Influenza A H7 viruses are a group of influenza viruses that normally circulate among birds. The influenza A （H7N9） virus is one subgroup of the larger group of H7 viruses. Although some H7 viruses （H7N2, H7N3 and H7N7） have occasionally been found to infect humans, no human infections of H7N9 viruses had been reported until recent events in China.

关键词： Jiangsu Province family planning

Launch of “Maternal and Child health in China” Campaign

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China Population Today 2014年第6期31卷 46-46页

作者： Department of Maternal and Child health of national health and family planning commission Department of Maternal and Child health of national health and family planning commission

On the morning of June 28,2014,under the joint guidance of national health and family planning commission(NHFPC)and All-China Women's Federation,the launching ceremony of "Maternal and Child health in China"campaign was held in *** was jointly organized by Maternal and Child health Center of Chinese Center for Disease Control and Prevention,China Women Activity Center and

关键词：儿童健康中国计划生育疾病预防妇幼保健活动中心签字仪式委员会

Forum on New Urbanization and Social Integration of Migrant Population 2014 & Symposium on Migrant Population Data Development and Sharing Held in Beijing

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China Population Today 2014年第5期31卷 41-41页

作者： Department of family planning and Service and Management for Migrant Population,national health and family planning commission Department of family planning and Service and Management for Migrant Population National Health and Family Planning Commission

On July 5,2014,the Forum on New Urbanization and Social Integration of Migrant Population2014&Symposium on Migrant Population Data Development and Sharing was held,jointly by Department of family planning and Service and Management for Migrant Population of national health and family planning commission(NHFPC)and Social Transformation and Social Governance Collaborative Innovation Center of Renmin University of China,at School of Chinese Classics at Renmin University of China.

关键词：流动人口城市化论坛社会经济委员会副主任农村工作 Pei

Effects of acetazolamide and anordiol on osmotic water permeability in AQP1-cRNA injected Xenopus oocyte

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Acta Pharmacologica Sinica 2004年第1期 92-99页

作者： Bing MA, Yang XIANG, Sheng-mei MU, Tao LI, He-ming YU, Xue-jun LIDepartment of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083 national Research Institute for family planning, Beijing 100081, China

AIM: To study the effects of acetazolamide and anordiol on osmotic water permeability in aquaporin 1 (AQP1)-cRNA injected Xenopus oocyte and their mechanisms. METHODS: AQP1 gene constructed in pBluescript was transcripted into cRNA in vitro and then the cRNA was injected in Xenopus oocytes. The effects of acetazolamide and anordiol on the water transport function of AQP1 were observed by assaying the osmotic swelling of oocytes. In addition, their effects on protein expression of AQP1 were quantitatively investigated by Western blotting method. RESULTS: After incubation for 15 min or 72 h, acetazolamide, a carbonic anhydrase inhibitor, equally reduced the water permeability of AQP1-cRNA injected oocyte in a dose-dependent manner. After incubation for 72 h, anordiol, an antiestrogen with partial estrogenic activity, reduced the osmotic water permeability dose dependently as well; however, no discernable action was observed after incubation with anordiol for 15 min. The Western blotting

关键词： aquaporins acetazolamide anordiol permeability Xenopus

THE SOCIAL ECONOMIC FACTORS INFLUENCING HANDICAP AND DEATH RATE FOR ONE-CHILD IN 1990S,CHINA

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THE SOCIAL ECONOMIC FACTORS INFLUENCING HANDICAP AND DEATH R...

Survey of knowledge and attitude about AIDS among six areas

第二次北京生育调节国际学术研讨会

作者： Zhang Living Liu Yunrong Dept.of Social Science Research in Reproductive health national Research Institute for family planning Beijing 100081 China.

＜正＞According to the definition of reproduction health stated by WHO,one aspect of implications is that reproduction is carried to a successful outcome, i.e.,infants survive and grow up *** response to the changed global situation and broader concept of"reproductive health",the higher requirement for the child health care should be given in the society,as well as in the femily planning

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生殖医学杂志 2005年第B10期14卷 60-67页

作者：郭欣程怡民李颖黄娜武俊青汝小美 Peking Union Medical College 100730 national Research Institute for family planning 100081 Shanghai Research Institute for family planning 200032 national family planning commission 100088

Objective:To explore the circumstances,influencing factors,and the extent of discrimina-tion and prejudice towards ***:This is a cross-sectional *** county from each of the six provinces was se-lected.800 respondents were then chosen from each province through cluster sampling.A closed-ended questionnaire was used to study the demographic characteristics,AIDS knowledge,and re-lated attitudes towards ***:In this survey,3,095 respondents(64.5%)feared AIDS;66.5% of respondentsthought AIDS patients or HIV infectors should be treated separately;40.1% of respondentsthought that AIDS patients or HIV carriers should have been confined in freedom;and 1,497 re-spondents(31.2%)said that they were not willing to donate to AIDS *** andprejudice towards AIDS among the six regions were different partially(P<0.01).Conclusion:Discrimination and prejudice commonly ***,characteristics of theregistered residence,educational level,and knowledge about AIDS are the main factors related todiscrimination and *** respondents had prejudice against AIDS,because they werelacking correct knowledge about the transmission ways of *** the six regions,discrim-ination and prejudice were lowest in a region in Henan province and highest in Jiangsu province.

关键词： AIDS Discrimination Prejudice Transmission ways

Acetazolamide inhibits aquaporin-1 protein expression and angiogenesis

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Acta Pharmacologica Sinica 2004年第6期25卷 110-114页

作者： Yang XIANG2, Bing MA, Tao LI, Jun-wei GAO, He-ming YU3, Xue-jun LI4 Departmentof Pharmacology, School of Basic Medical Sciences, Peking University, Beijing 100083 2Life Science Institute, Nanjing University, Nanjing 210093 3national Research Institute for family planning, Beijing 100081,China Life Science Institute Nanjing University Nanjing 210093 Department of Pharmacology School of Basic Medical Sciences Peking University 北京 100083 national Research Institute for family planning 北京 100081

AIM: To study effects of acetazolamide on aquaporin-1 (AQP1) protein expression and angiogenesis. METHODS: Establishing Lewis-lung-carcinoma model, the localization of AQP1 in tumor tissues was investigated by immuno- histochemical methods; The biological activity of acetazolamide was detected by endothelial cells proliferation test (MTT) assay and chorioallantoic membrane (CAM) vascular inhibition test. RESULTS: Immunohistochemical localization of AQP1in mice tumor was labeled in capillaries, post capillary venules endothelial cells. After being treated with acetazolamide, the number of capillaries and post capillary venules was significantly decreased in tumor tissue. Acetazolamide showed significant inhibitory effect on angiogenesis in CAMand endothelial cell proliferation. CONCLUSION: Acetazolamide might be identified and developed as one of potential lead compounds for a new therapeutic intervention in inhibiting cancer angiogenesis.

关键词： neoplasms acetazolamide angiogenesis inhibitors CHIP28

Extracellular protein profiles of fluids secreting from the caput and cauda epididymides and spermaducts in adult rats:identification and characterization of fertility-associated antigen

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Extracellular protein profiles of fluids secreting from the ...