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Food and Health 2024年第2期6卷 4-13页

作者： Cui-Cui Zeng martin G.Banwell Ping lan Wei-Min Chen Jing Chen Institute for Advanced and Applied Chemical Synthesis Jinan UniversityGuangzhou 510632China College of Pharmacy Jinan UniversityGuangzhou 510632China Guangdong Key Laboratory for Research and the Development of Natural Drugs The Marine Biomedical Research InstituteGuangdong Medical UniversityZhanjiang 524023China

Vaccarin,a flavonoid glycoside isolated from Vaccaria segetalis,is non-toxic to 3T3-L1 cells up to concentrations of 200μ***,we investigated the effects of this natural product on adipogenesis and lipolysis in 3T3-L1 *** results revealed that vaccarin significantly inhibited lipid accumulation by suppressing the adipogenesis-related transcription factors peroxisome proliferator-activated receptorγ(PPARγ)and the CCAAT/enhancer-binding proteinα(C/EBPα).Specifically,lipid accumulation decreased by up to 27.7±2.7%when 3T3-L1 adipocytes were treated with a 10μM concentration of *** studies showed that the compound inhibited adipogenesis through activation of the Hedgehog(Hh)signaling pathway and so restoring Smo and Gli1 expression at an early stage of *** mature 3T3-L1 cells,vaccarin significantly increased the secretion of glycerol into the surrounding medium and thus indicating that it accelerated the degradation of *** addition,vaccarin,was shown to enhance lipolysis through stimulation of the transcription levels of lipoprotein lipase,monoglycerides lipase,adipose triacylglyceride lipase,hormone-sensitive lipase and adipose differentiated-related *** told,vaccarin suppressed lipid accumulation and enhanced lipolysis during adipocyte differentiation by restoring Hh *** such,it is a phytochemical capable of halting adipocyte hyperplasia and,thereby,ameliorating the effects of obesity.

关键词： Adipogenesis Lipolysis Hedgehog signaling Vaccarin 3T3-L1 adipocytes

Total Syntheses of Favolasins A,E,G and K,Polyketides Isolated from Cultures of the Basidiomycetes Fungi Favolaschia *** 18686 and Favolaschia calocera BCC 36684

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Chinese Journal of Chemistry 2023年第12期41卷 1450-1464页

作者： Bingbing Sheng Ping lan Jolynn Kiong Zeinab G. Khalil Robert J. Capon martin G.Banwell Institute for Advanced and Applied Chemical Synthesis College of Pharmacy Jinan University Guangzhou Guangdong 510632 China Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM & New Drugs Research Jinan University Guangzhou Guangdong 510632 China Institute for Molecular Bioscience The University of Queensland St Lucia QLD 4072 Australia Guangdong Key Laboratory for Research and the Development of Natural Drugs The Marine Biomedical Research Institute Guangdong Medical University Zhanjiang Guangdong 524023 China

The structures assigned to all four members,1-4,of the recently reported favolasin class of natural product have been prepared for the first time by chemical ***-Miyaura cross-coupling chemistry was used to establish the associated biaryl *** key step used in preparing the 1,5-benzodioxepin ring system associated with compounds 3 and 4 was the acid-catalyzed 7-exo-tet cyclization of an appropriately substituted 2-(oxiran-2-ylmethoxy)phenol while a base-promoted 6-exo-tet cyclization of the same substrate was used to construct the 2,3-dihydrobenzo[b][1,4]dioxine core of target *** spectral data derived from the four synthetically-produced favolasins matched those reported for the corresponding natural *** biological screening of compounds 1-3 as well as a suite of fourteen precursors reveal that they display no notable anti-bacterial,anti-fungal or anti-tumor activities but congener K(4)is active,in the mM range,against Plasmodium falciparum.

关键词： Total syntheses Favolasins Suzuki-Miyaura cross-coupling Acetalization Anti-malarial

Electrochemical Behavior of Dissolved Fe_2O_3 in Molten CaCl_2-KF

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Journal of Iron and Steel Research(International) 2008年第6期15卷 48-51页

作者： WANG Shu-lan Geir martin Haarberg Eirin Kvalheim Department of Chemistry Northeastern University Shenyang 110004 Liaoning China Department of Materials Science and Engineering NTNU Trondheim 7429 Norway

The electrochemical behavior of dissolved Fe2O2 in 82.5CaCl2-17.5KF （mole percent, %） was studied using cy clic voltammetry, chronoamperometry, and galvanostatic electrolysis at 827 ℃, and the deposits were characterized by XRD and SEM. Pure iron was deposited on a rotating cylinder （210 r/min） with a cell voltage less than -- 1.0 V. Deposition rate was controlled by diffusion on a molybdenum electrode. The diffusion coefficient of iron species Fe（ Ⅲ ） in the melt at 827 ℃ was found to be 9.7×10^-5 cm^2/s.

关键词： iron electrolysis electrochemistry molten salt

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28例转移性肝癌腹腔镜肝切除术

中华肝胆外科杂志 2009年第12期15卷 895-897页

作者：吴志明 Nick O'Rourke lan Shaw Les nathanson lan martin George Fielding 绍兴县中心医院中国医科大学绍兴医院浙江省312030 Brisbane 4109 Department of surgery Royal Brisbane Hospital

目的总结转移性肝癌的腹腔镜肝切除术经验。方法对1999—2006年度布里斯班医院所实施的转移性肝癌腹腔镜肝切除术病人进行回顾性研究。结果经病理证实的28例转移性肝癌病人进行了腹腔镜肝切除，13例进行左肝外侧叶切除，9例进行了右半... 详细信息

目的总结转移性肝癌的腹腔镜肝切除术经验。方法对1999—2006年度布里斯班医院所实施的转移性肝癌腹腔镜肝切除术病人进行回顾性研究。结果经病理证实的28例转移性肝癌病人进行了腹腔镜肝切除，13例进行左肝外侧叶切除，9例进行了右半肝切除。其余6例行肝段或不规则切除。追踪随访12例由直结肠转移的转移性肝癌病人2年存活率和无瘤生存率分别为75％和67％。结论在严格选择过的恶性肿瘤病人中行腹腔镜肝切除术是安全可行的。对病人要有适当的分期．术者需具丰富的开腹肝切除术经验和腹腔镜操作技能。

关键词：腹腔镜肝切除肝转移

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结直肠癌肝转移的腹腔镜肝切除术

结直肠癌肝转移的腹腔镜肝切除术

2007年浙江省微创外科学术会议

作者：吴志明 Nick O'Rourke lan Shaw Les nathanson lan martin George Fielding Department of surgery Shaoxing No.4 HospitalShaoxing Royal Bdsbane Hospital Brisbane4109 Australia.

目的:讨结直肠癌肝转移的腹腔镜肝切除术的经验.方法:对1997～2004年度布里斯班医院所进行的所有肝切除术病人进行回顾性研究.结果:有84例病人进行了腹腔镜肝切除,其中 33例(39%)为恶性肿瘤.33例中有28例为转移性,其中22例为结直肠癌转... 详细信息

目的:讨结直肠癌肝转移的腹腔镜肝切除术的经验.方法:对1997～2004年度布里斯班医院所进行的所有肝切除术病人进行回顾性研究.结果:有84例病人进行了腹腔镜肝切除,其中 33例(39%)为恶性肿瘤.33例中有28例为转移性,其中22例为结直肠癌转移.13例病人进行左肝外侧叶切除,9例病人进行了右半肝切除,其余6例行肝段或下不规则切除.67%失去随访,追踪随访12例病人2年生存率为75%.结论:在高度选择过的恶性肿瘤病人中行腹腔镜肝切除术是可行的.但要求术者有丰富的开腹肝切除术经验和腹腔镜操作技能.

关键词：腹腔镜肝切除肝转移

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结直肠癌肝转移的腹腔镜肝切除术

结直肠癌肝转移的腹腔镜肝切除术

Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue

2007年浙江省外科学学术会议

作者：吴志明 Nick O'Rourke lan Shaw Les nathanson lan martin George Fielding 绍兴第四医院轻纺城医疗中心外科

目的:探讨结直肠癌肝转移的腹腔镜肝切除术的经验。方法:对1997～2004年度布里斯班医院所进行的所有肝切除术病人进行回顾性研究。结果:有84例病人进行了腹腔镜肝切除,其中33例(39%)为恶性肿瘤。33例中有28例为转移性,其中22例为结直肠...

目的:探讨结直肠癌肝转移的腹腔镜肝切除术的经验。方法:对1997～2004年度布里斯班医院所进行的所有肝切除术病人进行回顾性研究。结果:有84例病人进行了腹腔镜肝切除,其中33例(39%)为恶性肿瘤。33例中有28例为转移性,其中22例为结直肠癌转移。13例病人进行左肝外侧叶切除,9例病人进行了右半肝切除,其

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Genes & Diseases 2023年第1期10卷 267-283页

作者： Lakshmi Prabhu Matthew martin lan Chen Ozlem Demir Jiamin Jin Xiumei Huang Aishat Motolani Mengyao Sun Guanglong Jiang Harikrishna Nakshatri Melissa L.Fishel Steven Sun Ahmad Safa Rommie E.Amaro Mark R.Kelley Yunlong Liu Zhong-Yin Zhang Tao Lu Department of Pharmacology and Toxicology Indiana University School of MedicineIndianapolisIN 46202USA Chemical Genomics Core Facility Indiana University School of MedicineIndiana University School of MedicineIndianapolisIN 46202USA Department of Biochemistry and Molecular Biology Indiana University School of MedicineIndiana University School of MedicineIndianapolisIN46202USA Department of Chemistry and Biochemistry University of CaliforniaSan DiegoCA 92093USA Department of Radiation Oncology Indiana University School of MedicineIndianapolisIN 46202USA Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202USA Department of Medicine Indiana University School of MedicineIndianapolisIN 46202USA Department of Pediatrics Herman B Wells Center for Pediatric ResearchIndianapolisiN 46202USA Indiana University Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN46202USA

Market drugs,suchas Foodand Drug Administration(FDA)or European Medicines Agency(EMA)-approved drugs for specific indications provide opportunities for repurposing for newer *** potentially saves resources invested in clinical trials that verify drug safety and tolerance in humans prior to alternative indication *** arginine methyltransferase 5(PRMT5)overexpression has been linked to promoting the tumor phenotype in several cancers,including pancreatic ductal adenocarcinoma(PDAC),colorectal cancer(CRC),and breast cancer(BC),making PRMT5 an important target for cancer ***,we showed that PRMT5-mediated methylation of the nuclear factor(NF)-kB,partially contributes to its constitutive activation observed in *** this study,we utilized an AlphaLiSA-based high-throughput screening method adapted in our lab,and identified one FDA-approved drug,Candesartan cilexetil(Can,used in hypertension treatment)and one EMA-approved drug,Cloperastine hydrochloride(Clo,used in cough treatment)that had significant PRMT5-inhibitory activity,and their anti-tumor properties were validated using cancer phenotypic assays in ***,PRMT5 selective inhibition of methyltransferase activity was confirmed by reduction of both NF-kB methylation and its subsequent activation upon drug *** in silico prediction,we identified critical residues on PRMT5 targeted by these drugs that may interfere with its enzymatic ***,Clo and Can treatment have exhibited marked reduction in tumor growth in ***,we provide basis for pursuing repurposing Clo and Can as anti-PRMT5 cancer *** study offers potential safe and fast repurposing of previously unknown PRMT5 inhibitors into clinical practice.

关键词： Cancer Research NF-kB Pharmacology PRMT5 PRMT5 inhibitors

Grazing effects on herbage nutritive values depend on precipitation and growing season in Inner Mongolian grassland

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Journal of Plant Ecology 2016年第6期9卷 712-723页

作者： Haiyan Ren Guodong Han Zhichun lan Hongwei Wan Philipp Schönbach martin Gierus Friedhelm Taube Department of Grassland Science College of Ecology and Environmental ScienceInner Mongolia Agricultural UniversitySaihan DistrictZhaowuda Road 306Hohhot 010019China College of Agro-grassland Science College of Prataculture ScienceNanjing Agricultural UniversityXuanwu DistrictWeigang Road 1Nanjing 210000China Institute of Crop Science and Plant Breeding-Grass and Forage Science/Organic Agriculture Christian-Albrechts-UniversityHermann-Rodewald-Str.924118 KielGermany Center for Watershed Ecology Institute of Life Science and Ministry of Education Key Laboratory of Poyang Lake Environment and Resource UtilizationNanchang UniversityHonggutan New DistrictXuefu Road 999Nanchang 330031China

Aims Grasslands are widely used for production of livestock,which depend on the nutritive value of herbage ***,there are still large uncertainties as to how grazing,precipitation and growing season interactively affect herbage nutritive *** Here,based on a grazing experiment with seven grazing intensities in an Inner Mongolian grassland since the year 2005,we analysed nutritive value of four dominant grass species from June to September in both a relatively wetter year(2008)and a drier year(2010).Herbage with high nutritive value is characterized by high concentration of crude protein,high concentration of cellulase digestible organic matter and low concentration of neutral detergent *** Findings We found that(i)grazing significantly increased the nutritive value of Leymus chinensis,Agropyron michnoi and Cleistogenes squarrosa but had minor effects on the nutritive value of Stipa grandis.(ii)For all species,nutritive values were greater in the wetter year than in the drier year and were greatest in the early growing season(June)and lowest at the end of the growing season(September).Inter-annual and inter-seasonal variations in nutritive value were much greater for *** and *** than for *** and ***,suggesting higher water use efficiency for the latter two species.(iii)Grazing significantly decreased the drought resistance of three species,but not of ***.(iv)Grazing significantly increased inter-month variation in nutritive value for *** and *** but had relatively minor or no effects on that of *** and ***,grazing effects on species nutritive values showed strong inter-annual and seasonal patterns,and species-specific responses might be related to species traits(*** use efficiency,digestibility).Our results have important implications for ecosystem management of arid and semiarid grasslands under intense grazing and global climatic change.

关键词： grazing avoidance strategy drought resistance water limitation regrowth maturation

High-energy-density plasma in femtosecond-laser-irradiated nanowire-array targets for nuclear reactions

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Matter and Radiation at Extremes 2022年第6期7卷 29-40页

作者： Defeng Kong Guoqiang Zhang Yinren Shou Shirui Xu Zhusong Mei Zhengxuan Cao Zhuo Pan Pengjie Wang Guijun Qi Yao Lou Zhiguo Ma Haoyang lan Wenzhao Wang Yunhui Li Peter Rubovic martin Veselsky Aldo Bonasera Jiarui Zhao Yixing Geng Yanying Zhao Changbo Fu Wen Luo Yugang Ma Xueqing Yan Wenjun Ma State Key Laboratory of Nuclear Physics and Technology and Key Laboratory of HEDP of the Ministry of EducationCAPTSchool of PhysicsPeking UniversityBeijing 100871China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Key Laboratory of Nuclear Physics and Ion-Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Nuclear Science and Technology University of South ChinaHengyang 421001China INPAC and School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghai 200240China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518055China Institute of Experimental and Applied Physics Czech Technical University in PragueHusova 240/511000 Prague 1Czech Republic ELI Beamlines Center Institute of Physics of the Czech Academy of Sciences25241 DolníBrezanyCzechia Cyclotron Institute Texas A&M UniversityCollege StationTexas 77843USA Laboratori Nazionali del Sud INFNvia Santa Sofia62Catania 95123Italy Beijing Laser Acceleration Innovation Center HuairouBeijing 101400China Collaborative Innovation Center of Extreme Optics Shanxi UniversityTaiyuanShanxi 030006China

In this work,the high-energy-density plasmas(HEDP)evolved from joule-class-femtosecond-laser-irradiated nanowire-array(NWA)targets were numerically and experimentally *** results of particle-in-cell simulations indicate that ions accelerated in the sheath field around the surfaces of the nanowires are eventually confined in a plasma,contributing most to the high energy *** protons emitted from the front surfaces of the NWA targets provide rich information about the interactions that *** give the electron and ion energy densities for broad target parameter *** ion energy densities from NWA targets were found to be an order of magnitude higher than those from planar targets,and the volume of the HEDP was several-fold *** optimal target parameters,8%of the laser energy can be converted to confined protons,and this results in ion energy densities at the GJ/cm^(3) *** the experiments,the measured energy of the emitted protons reached 4 MeV,and the changes in energy with the NWA’s parameters were found to fit the simulation results *** measurements of neutrons from 2H(d,n)3He fusion with a yield of(24±18)×10^(6)/J from deuterated polyethylene NWA targets also confirmed these results.

关键词： irradiated confined eventually