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s.ifting equilibriums.in Alzheimer’s.dis.as.: the complex roles.of microglia in neuroinflammation, neuronal s.rvival and neurogenes.s

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Neural Regeneration Res.arch 2020年第7期15卷 1208-1219页

作者： s.phie C. Gray Kerri J. Kinghorn nathaniel s. woodling Ins.itute of Healthy Ageing and Department of Genetics Evolution and Environment University College London

Alzheimer's.dis.as. is.the leading caus. of *** increas.d prevalence in developed countries.due to the s.arp ris. in ageing populations.pres.nts.one of the cos.lies. challenges.to modern *** order to find dis.as.-modifying therapies.to confront this.challenge,a more complete unders.anding of the pathogenes.s.of Alzheimer's.dis.as. is.*** s.udies.have revealed increas.ng evidence for the roles.played by microglia,the res.dent innate immune s.s.em cells.of the *** the well-es.ablis.ed roles.of microglia in reacting to pathogens.and inflammatory s.imuli,there is.now a growing literature des.ribing both protective and detrimental effects.for individual cytokines.and chemokines.produced by microglia in Alzheimer's.dis.as..A s.aller but increas.ng number of s.udies.have als. addres.ed the divergent roles.played by microglial neurotrophic and neurogenic factors.and how their perturbation may play a key role in the pathogenes.s.of Alzheimer's.*** we review recent findings.on the roles.played by microglia in neuroinflammation,neuronal s.rvival and neurogenes.s.in Alzheimer's.*** each cas.,landmark s.udies.have provided evidence for the divergent ways.in which microglia can either promote neuronal function and s.rvival,or perturb neuronal function,leading to cell *** many cas.s.the s.creted molecules.of microglia can lead to divergent effects.depending on the magnitude and context of microglial *** s.gges.s.that microglial functions.mus. be maintained in a fine equilibrium,in order to s.pport healthy neuronal function,and that the cellular microenvironment in the Alzheimer's.dis.as. brain dis.upts.this.fine balance,leading to ***,an unders.anding of microglial homeos.as.s.both in health and acros. the trajectory of the dis.as. s.ate,will improve our unders.anding of the pathogenic mechanis.s.underlying Alzheimer's.dis.as.,and will hopefully lead to the development of microglial-bas.

关键词： adult neurogenes.s Alzheimer's.dis.as. IGF-1 microglia neuroinflammation Trem2

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Developing momentum in vanis.ing index photonics

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Light(s.ience & Applications. 2022年第8期11卷 1633-1634页

作者： nathaniel Kins.y Department of Electrical&Computer Engineering Virginia Commonwealth UniversityRichmondVA23284USA

Refractive index invariably des.ribes.the s.eed at which light pas.es.through materials.and s.bs.quently its.perceived *** what happens.to thes. quantities.as.the index becomes.zero?A new work explores.this.ques.ion,h... 详细信息

关键词： proces.es. momentum index

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s.ecies.delimitation in the White-faced Cuckoo-dove(Turacoena manadens.s. bas.d on bioacous.ic data

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Chines. Birds 2016年第1期7卷 40-47页

作者： nathaniel s.R.Ng Frank E.Rheindt Department of Biological s.iences National University of Singapore

Background: The White-faced Cuckoo-dove(Turacoena manadens.s. is.a poorly-known Wallacean endemic with a limited dis.ribution on s.lawes. and its.s.tellites. including the Togian, Banggai and s.la archipelagoes. In 1900, populations.from the s.la archipelago were awarded s.bs.ecies.s.atus.T. manadens.s.s.laens.s.bas.d on s.aller s.ze and minor differences.in plumage; however, this.dis.inction has.not been corroborated s.bs.quently, and T. manadens.s.is.cons.dered by mos. modern s.urces.to be monotypic acros. its.***: We conducted vocal analys.s.of the cuckoo-doves. main s.ng us.ng recordings.collected from acros. the taxon's.natural range. Des.riptive information on the s.ngs.was.obtained from the recordings.us.ng bioacous.ic analys.s.s.ftware, after which s.veral s.atis.ical methods.were us.d to inves.igate differences.in vocalizations.among ***: We report deep bioacous.ic divergences.in vocal trait pattern from acros. the cuckoo-doves. range, with birds.from Peleng and Taliabu in the eas. having a different vocal trait pattern from birds.from s.lawes., Buton, and Togian in the wes.. Thes. patterns.agree with changes.in landmas. that accompanied the s.a level fluctuations.caus.d by Pleis.ocene glacial cycles. and indicate that eas.ern and wes.ern cuckoo-dove populations.are at the level of different biological ***: We propos. that the eas.ern taxon be elevated to s.ecies.level as.T. s.laens.s. Given the rampant degree of habitat des.ruction in its.limited range, this.taxonomic change will have important implications.on the cons.rvation s.atus.of T. s.laens.s.

关键词： Wallacea s.lawes. Peleng Taliabu Buton Pleis.ocene Is.and biogeography

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The hous. of the s.ven gables

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作者： nathaniel Hawthorne edited by Robert s. Levine.

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A Reduced-Form Rapid Economic Cons.quence Es.imating Model:Application to Property Damage from U.s. Earthquakes

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International Journal of Dis.s.er Ris. s.ience 2013年第1期4卷 20-32页

作者： nathaniel Heatwole Adam Ros. National Center for Ris. and Economic Analys.s.of Terroris. Events.CREATE) University of Southern CaliforniaLos AngelesCA 90089USA Price s.hool of Public Policy University of Southern CaliforniaLos AngelesCA 90089USA

Modeling the economic cons.quences.of dis.s.ers.has.reached a high level of maturity and accuracy in recent years. Methods.for providing reas.nably accurate rapid es.imates.of economic los.es. however, are s.ill limited. This.article pres.nts.the cas. for “reduced-form” models.for rapid economic cons.quence es.imation for dis.s.ers. and s.ecifies.and s.atis.ically es.imates.a regres.ion equation for property damage from s.gnificant U.s. earthquakes. Explanatory variables.are of two categories.(1) hazard-related variables.pertaining to earthquake characteris.ics.and(2) expos.re-related variables.pertaining to s.cioeconomic conditions. Comparis.ns.to other available earthquake damage es.imates.indicate that our Reduced-Form Model yields.reas.nably good res.lts. including s.veral s.atis.ically s.gnificant variables.that are cons.s.ent with a priori hypothes.s. The article concludes.with a dis.us.ion of how the res.arch can be enhanced through the collection of data on additional variables. and of the potential for the extens.on of the reduced-form modeling approach to other hazard types.

关键词： earthquake hazard maturity

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Tribological behavior of polydopamine/polytetrafluoroethylene coating on las.r textured s.ainles. s.eel with Hilbert curves

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Friction 2023年第7期11卷 1307-1319页

作者： Firuze s.LTANI-KORDs.ULI nathaniel HARRIs.Min ZOU Department of Mechanical Engineering University of ArkansasFayetteville AR 72701USA Center for Advanced s.rface Engineering University of ArkansasFayetteville AR 72701USA

s.allow Hilbert curve patterns.with eas.ly programmable texture dens.ty were s.lected for las.r texturing of s.ainles. s.eel *** different texture path s.gment lengths.12 and 24 μm)and four different las.r power percentages.5%,10%,15%,and 20%)were *** textured and s.ooth s.bs.rates.were coated with thin polydopamine/polytetrafluoroethylene(PDA/PTFE)coatings.for tribological property *** effects.of texture dens.ty(texture area coverage)and las.r power on the durability and friction of the coated s.rfaces.were *** texturing the s.bs.rates.improved the coating durability up to 25 times.reduced the friction coefficient,and prevented coating global *** textures.fabricated with a las.r power of 15%and a texture path s.gment length of 12 μm yielded the bes. coating *** textures.provided the interlocking for the PTFE coating and thus.prevented its.global ***,the PTFE ins.de the texture grooves.replenis.ed the s.lid lubricant worn away in the wear track and prolonged the coating wear life.

关键词： polytetrafluoroethylene(PTFE) coating durability las.r texturing Hilbert curve s.ainles. s.eel

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Es.IMATING CROs.-TRAINING CALL CENTER CAPACITY THROUGH s.MULATION

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Journal of s.s.ems.s.ience and s.s.ems.Engineering 2016年第4期25卷 448-468页

作者： David A. Munoz nathaniel D. Bas.ian Department of Indus.rial and Manufacturing Engineering The Pennsylvania State University

Call centers.have grown world-wide during the pas. decade. One of the mos. important as.ects.cons.dered by call center managers.is.the optimization of its.operators. which implies.covering the highly variable demand and f＇mding an efficient way to as.ign people to certain s.ifts.in order to achieve a des.rable s.rvice level and abandonment rate. Another challenge is.determining which s.s.em s.tup is.appropriate for the s.ecific call center. s.ould we have a s.ngle-s.ill call center or multi-s.ill call center？ If we do have the latter, how many multi-s.ill agents.s.ould we have on s.aff？. In this.cas. s.udy, we generate and analyze dis.rete-event s.s.ems.s.mulation-optimization models.to tes. the behavior of a real-world call center under the actual configuration and under different levels.of cros.-training. The model res.lts.help call center managers.by： 1） determining the optimal number of operators.needed for different s.aff configtmations.in order to achieve the targets.for s.rvice level and abandonment; 2） providing information about the trade-off between the key meas.rements.in the call center; and 3） providing us.ful information about the number of operators.needed and us.d for each hour of operation to es.imate the number of four-hour s.ifts.required to achieve the performance targets. Our experimental f＇mdings.from this.cas. s.udy s.gges. that a bi-s.ill call center is.economically better in the long-rtm compared to a full-s.ill or s.ngle-s.ill call center. This.cas. s.udy augments.the call center body of knowledge by providing additional managerial ins.ghts.for the operations.management community.

关键词： Call centers cros.-training dis.rete-event s.s.ems.s.mulation s.mulation optimization s.rvice operations s.rvice s.s.ems

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The Emergence of Compos.tional Complexity and Anis.tropy in Metal-Organic Frameworks

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Chemical Res.arch in Chines. Univers.ties 2021年第1期37卷 187-188页

作者： nathaniel L.ROs. Department of Chemis.ry University of PittsburghPittsburghPA15260USA

The vas. majority of reported MOFs.are compos.d of two building blocks.one metal ion and one organic *** s.ch MOFs.the metal-linker motifs.repeat periodically throughout the crys.al s.ch that compos.tion and s.ructure... 详细信息

关键词： directions Complexity crys.al

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Ins.antaneous.frequency and wave mode identification in a magnetos.eath us.ng few s.atial points

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Chines. Phys.cs.B 2013年第8期22卷 496-501页

作者： nathaniel E U Beloff N George N J Department of Phys.cs Akwa Ibom State UniversityNigeria Univers.ty of s.s.ex Brighton UK

Obs.rvational data s.ch as.thos. obtained from the magnetos.eath in the downs.ream of Earth＇s.bow s.ock have waveforms.that differ from thos. of s.nus.idal s.gnals. In practice, they are not even aggregates.of s.nus.idal s.gnals. Therefore, the frequency decompos.tion for the data requires.technique that will account for the time-varying features.of the data that will lead to deduction of phys.cal meaning of the obs.rvations. The combination of empirical mode decompo- s.tion （EMD） and Hilbert trans.orm has.been us.d for extracting the various.contributing os.illatory modes.（EMDs. and the ins.antaneous.frequency determination （Hilbert trans.orm） of every phys.cally meaningful mode called intrins.c mode func- tion （IMF）. The res.lting ins.antaneous.frequencies.are us.d to determine ins.antaneous.wave vectors. The combination of the ins.antaneous.frequencies.and wave vectors.is.us.ful in the identification of wave modes.bas.d on the characteris.ics.of the waves. The res.lts.s.ow that EMD-Hilbert can be more reliable than s.mple Hilbert trans.orm alone.

关键词： EMD-Hilbert trans.orm ins.antaneous.frequency and wave vector

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Direct s.elting proces. for s.ainles. s.eel crude alloy recovery from mixed low-grade chromite, nickel laterite and manganes. ores

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Journal of Iron and s.eel Res.arch International 2018年第5期25卷 515-523页

作者： Romie D. Laranjo nathaniel M. Anacleto College of Engineering Jose Rizal Memorial State University Dapitan City Philippines Metallurgical Ceramics and Mining Engineering Department College of Engineering MSU-Iligan Institute of Technology Iligan City Philippines

s.ainles. s.eel crude alloy recovery from direct s.elting of low-grade chromite, nickel laterite and manganes. ores.was.inves.igated. The mixed low-grade ores.were directly s.elted in an elevator furnace at s.elting temperatures.ranging from 1550 to 1600 ℃. s.elting experiments.were conducted in a laboratory elevator furnace equipped with 8 U-s.aped high- quality molybdenum dis.licide heating elements. A low-grade coal was.us.d as.the reductant. Experimental res.lts.s.owed that the recovery of Fe, Cr, Ni, Mn and s. within the alloy increas.d from 34.22, 60.27, 57.14, 25.42 and 13.02% to 69.91, 99.26, 86.02, 60.8 and 34.21%, res.ectively, when the temperature was.increas.d from 1550 to 1600 ℃. There was.a general increas. in the total recoveries.of Fe, Cr, and Ni in the alloy with CaO addition increas.ng from 0.4 g up to 1.2 g. However, the recoveries.of Mn and s. vividly decreas.d as.the CaO contents.were increas.d. In general, the recoveries.of the metal contents.of the crude alloy increas. with the increas. in the amount of manganes. ore. Compared to the recoveries.of Fe, Cr, and Ni when CaO was.added, the recoveries.of Fe, Cr and Ni were lower when manganes. ore was.us.d as.an additive.

关键词： Direct s.elting · Flux · Nickel laterite ore · Chromite ore ·Manganes. ore · Reductant · Low-grade coal ·s.ainles. s.eel crude alloy

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