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DNA methylation profiling reveals new potential subtype-specific gene markers for early-stage renal cell carcinoma in Caucasian population

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Quantitative Biology 2022年第1期10卷 79-93页

作者： Alvaro Filbert Liko Edward Ciputra nathaniel Alvin Sanjaya Priskila Cherisca Then aka David Agustriawan Department of Biomedicine School of Life SciencesIndonesia International Institute for Life SciencesJakarta 13210Indonesia Department of Bioinformatics School of Life SciencesIndonesia International Institute for Life SciencesJakarta 13210Indonesia

Background:Renal cell carcinoma(RCC)is among the top adult cancers worldwide,with a challenging management due to lack of early diagnosis,therapy resistance,and diverse molecular *** DNA methylation has been associated with RCC development due to transcription *** discovered potential DNA methylation-based biomarkers for stage I RCC in Caucasian population from The Cancer Genome Atlas(TCGA)***:Patients’clinical,methylation beta-value,and mRNA expression data were *** methylation and expression analysis were conducted to obtain differentially methylated CpG-gene *** correlated CpG-gene pairs between their expression and methylation levels were selected using Pearson’s correlation test and then screened for any recorded somatic *** biomarker capacities were analyzed’using the Kaplan-Meier and receiver operating characteristic analysis,followed by protein network and functional enrichment ***:We obtained differentially methylated CpGs in clear cell(KIRC)and papillary RCC(KIRP)but not chromophobe RCC(KICH).Six inversely correlated CpG-gene pairs with no reported cancer-associated mutations were *** values were found in ATXN1 and RFTN1 for KIRC,along with GRAMD1B and TM4SF19 for KIRP,while diagnostic values were found in VIM and RFTN1 for KIRC,along with TNFAIP6 and TM4SF19 for *** subtypes showed enrichment of immune and metabolism-related ***:We discovered novel potential DNA methylation-based prognostic and diagnostic markers for early-stage RCC in Caucasian *** by wet laboratory analysis and adjustments for confounding variables might be needed,considering our study limitation to specific race.

关键词： biomarker chromophobe renal cell carcinoma clear cell renal cell carcinoma DNA methylation papillary renal cell carcinoma TCGA

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Environmental engineering of transition metal dichalcogenide optoelectronics

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Frontiers of physics 2018年第4期13卷 21-52页

作者： Trevor LaMountain Erik J. Lenferink Yen-Jung Chen Teodor K. Stanev nathaniel P. Stern Department of Physics and Astronomy Northwestern University Evanston Illinois 60208 USA

The explosion of interest in two-dimensional van der Waals materials has been in many ways driven by their layered geometry. This feature makes possible numerous avenues for assembling and ma- nipulating the optical and electronic properties of these materials. In the specific case of monolayer transition metal dichalcogenide semiconductors, the direct band gap combined with the flexibility for manipulation of layers has made this class of materials promising for optoelectronics. Here, we review the properties of these layered materials and the various means of engineering these properties for optoeleetronics. We summarize approaches for control that modify their structural and chemical en- vironment, and we give particular detail on the integration of these materials into engineered optical fields to control their optical characteristics. This combination of controllability from their layered surface structure and photonic environment provide an expansive landscape for novel optoelectronic phenomena.

关键词： transition metal dichalcogenides optoelectronics van der Waals materials heterostructures excitons

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The N-formyl peptide receptors: contemporary roles in neuronal function and dysfunction

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Neural Regeneration Research 2020年第7期15卷 1191-1198页

作者： Peter J.G. Cussell Margarita Gomez Escalada nathaniel G.N. Milton Andrew W.J. Paterson Centre for Biomedical Science Research School of Clinical and Applied Sciences Leeds Beckett University

N-formyl peptide receptors(FPRs)were first identified upon phagocytic leukocytes,but more than four decades of research has unearthed a plethora of non-myeloid roles for this receptor *** are expressed within neuronal tissues and markedly in the central nervous system,where FPR interactions with endogenous ligands have been implicated in the pathophysiology of several neurodegenerative diseases including Alzheimer's disease and Parkinson's disease,as well as neurological cancers such as *** the homeostatic function of FPRs in the nervous system is currently undefined,a variety of novel physiological roles for this receptor family in the neuronal context have been posited in both human and animal *** developments in recent years have implicated FPRs in the process of neurogenesis and neuronal differentiation which,upon greater characterisation,could represent a novel pharmacological target for neuronal regeneration therapies that may be used in the treatment of brain/spinal cord injury,stroke and *** review aims to summarize the recent progress made to determine the physiological role of FPRs in a neuronal setting,and to put forward a case for FPRs as a novel pharmacological target for conditions of the nervous system,and for their potential to open the door to novel neuronal regeneration therapies.

关键词： Alzheimer's disease formyl peptide receptor neural regeneration neuroblastoma neurodegeneration neuroinflammation neuronal differentiation stroke

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Risk factors for penile fracture compared with a surgical control cohort in the United States: the role of substance abuse

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Asian Journal of Andrology 2021年第3期23卷 236-239页

作者： nathaniel Christian-Miller Andrew T Lenis Katherine E Fero Josef Madrigral Sriram V Eleswarapu Karim Chamie Peyman Benharash Cardiovascular Outcomes Research Laboratories(CORELAB) Department of SurgeryDavid Geffen School of Medicine at UCLALos AngelesCA 90095USA Department of Urology David Geffen School of Medicine at UCLALos AngelesCA 90095USA

Penile fracture(PF)is a surgical *** its rarity,we queried a national cohort over an 11-year period to study the temporal and demographic variations in presentation,evaluation,and management of patients with PF compared with a cohort of control *** National Inpatient Sample was queried between the years 2005 and 2016 for patients with a diagnosis of *** patients were selected as a control cohort,given the non-discriminatory nature of this *** and demographic data of the patients were compared with that of *** symptoms,rates of surgical repair,and rates of associated surgical procedures were evaluated in the PF *** the study period,5802 patients were hospitalized for *** annual incidence of PF remained unchanged at 1.0-1.8 cases per 100000 hospitalizations over the study *** with the control cohort,PF patients were more likely to be younger(38.7 years vs 41.2 years,P≤0.001),have lower rates of comorbidities except erectile dysfunction(1.4%vs 0.1%,P≤0.001),and were more likely of Black race(25.4%vs 6.2%,P≤0.001).Notably,PF patients had significantly higher rates of substance abuse(26.4%vs 18.1%,P≤0.001),despite no difference in the diagnosed psychiatric *** rarely presented with hematuria(3.5%);however,urethral evaluation was performed in 23.1%,most commonly with cystoscopy(19.2%).PF occurs more commonly in a younger,healthier male population,and among ***,rates of substance abuse appear to be higher in the PF cohort compared with those of controls.

关键词： epidemiology penile fracture penis urethra urethral injury

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Reliability of a simple fluoroscopic image to assess leg length discrepancy during direct anterior approach total hip arthroplasty

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World Journal of Orthopedics 2021年第11期12卷 850-858页

作者： Sandi Caus Hailee Reist Christopher Bernard Michael Blankstein nathaniel J Nelms The Robert Larner College of Medicine University of VermontBurlingtonVT 05405United States Department of Orthopaedics and Rehabilitation Unviversity of VermontBurlingtonVT 05405United States

BACKGROUND Direct anterior approach(DAA)total hip arthroplasty(THA)in a supine position provides a unique opportunity to assess leg length discrepancy(LLD)intraoperatively with *** fluoroscopic techniques are useful but are generally complicated or *** the use of multiple techniques for leg length assessment,LLD continues to be a major post-operative source of patient dissatisfaction further emphasizing the importance of near-anatomic *** utility of an alternative direct measurement of LLD on an intra-operative fluoroscopic pelvic image during DAA THA has not been *** To determine the reliability of a novel simple intra-operative measurement of LLD using a parallel line technique on a single fluoroscopic digital image of the *** One hundred and seventy-one patients who underwent DAA THA were included for ***-operative fluoroscopic and post-operative anterior-posterior radiographs were imported to TraumaCad and calibrated for LLD *** was measured on each image using the right-left hip differences in lesser trochanter to pelvic reference line *** reference points included the teardrops and *** LLD was compared to the gold-standard measurement of LLD measured on a post-operative *** Mean absolute difference in teardrop referenced LLD between fluoroscopic and post-operative radiographs was 2.17 mm and based on the ischia mean absolute difference was 2.63 *** regression of fluoroscopic and post-operative radiograph LLD based on teardrop and ischia LLD found r2 values of 0.57 and 0.84,*** absolute difference between fluoroscopic and postoperative x-ray LLD was within 5 mm in 95%of cases regardless of pelvic *** This study demonstrates that a single fluoroscopic view obtained during DAA THA for leg length assessment is clinically useful.

关键词： Leg-length discrepancy Total hip arthroplasty Intra-operative fluoroscopy Direct anterior approach Limb asymmetry

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The house of the seven gables

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作者： nathaniel Hawthorne edited by Robert S. Levine.

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Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation

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Bone Research 2015年第3期3卷 173-181页

作者： Edward Maharam Miguel Yaport nathaniel L Villanueva Takintope Akinyibi Damien Laudier Zhiyong He Daniel J Leong Hui B Sun Leni and Peter W.May Department of Orthopedics Icahn School of Medicine at Mount Sinai Departments of Orthopedic Surgery Albert Einstein College of Medicine Radiation Oncology Albert Einstein College of Medicine

Mesenchymal stem cell （MSC）-based treatments have shown promise for improving tendon healing and repair. MSCs have the potential to differentiate into multiple lineages in response to select chemical and physical stimuli, including into tenocytes. Cell elongation and cytoskeletal tension have been shown to be instrumental to the process of MSC differentiation. Previous studies have shown that inhibition of stress fiber formation leads MSCs to default toward an adipogenic lineage, which suggests that stress fibers are required for MSCs to sense the environmental factors that can induce differentiation into tenocytes. As the Rho/ROCK signal transduction pathway plays a critical role in both stress fiber formation and in cell sensation, we examined whether the activation of this pathway was required when inducing MSC tendon differentiation using rope-like silk scaffolds. To accomplish this, we employed a loss-of-function approach by knocking out ROCK, actin and myosin （two other components of the pathway） using the specific inhibitors Y-27632, Latrunculin A and blebbistatin, respectively. We demonstrated that independently disrupting the cytoskeleton and the Rho/ ROCK pathway abolished the expression of tendon differentiation markers and led to a loss of spindle morphology. Together, these studies suggest that the tension that is generated by MSC elongation is essential for MSC teno-differentiation and that the Rho/ROCK pathway is a critical mediator of tendon differentiation on rope-like silk scaffolds.

关键词： MSCs Figure Rho/Rock signal transduction pathway is required for MSC tenogenic differentiation

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Fathers' Day

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英语学习 1997年第6期 42-47页

作者：林琳 nathaniel Benchley

Father's Day reveals George Adams's inner conflict aboutvisiting his son's English class on a special day set asidefor ***'s discomfort in the school setting is fi-nally offset by his son's composition about the pride... 详细信息

关键词：外语教学 Day Fathers

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Application of Optimization Principle in Landmark University Project Selection under Multi-Period Capital Rationing Using Linear and Integer Programming

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Open Journal of Optimization 2019年第3期8卷 73-82页

作者： nathaniel Kayode Oladejo Department of Physical Sciences Mathematics Programme Landmark University Nigeria

The current structure of Landmark University (LU) was induced by raising a generation of solution providers through a qualitative and life-applicable training system that focuses on values and creative knowledge by making it more responsive and relevant to the modern-day demands of demonstration, industrialization and development. The challenge facing Landmark University is the question of which of its numerous projects they should invest to give maximum output with minimum input. In this paper, we maximize the Net Present Value (NPV) and maintain the net discount cash overflow of each project per period as contained and extracted as the secondary data of cash inflows of the Landmark University (LU) monthly financial statement and annual reports from 2012 to 2017 of which the documents have been regrouped as small and large scale projects as many enterprises make more use of the trial-and-error method and as such firms have been finding it difficult in allocating scarce resources in a manner that will ensure profit maximization and/or cost minimization with a simple and accurate decision making by the company through an optimization principle in selecting LU project under multi-period capital rationing using linear programming (LP) and integer programming (IP). The annual net cash flow which is the difference between the cash inflows and cash outflows during each period for the project was estimated and recorded. The discount factors were estimated at cost of capital of 10% for each cash flow per period with the corresponding NPV at 10% which revealed that the optimal decision achieves maximum returns of $110 × 102 and this assisted the project manager to select a large number of the variable projects that can maximize the profit which is far better than relying on an ad-hoc judgmental approach to project investment that could have cost 160 × 102 for the same project. Sensitivity analysis on the project parameters are also carried out to test the extent to which pro

关键词： Optimization Linear Integer Programming Sensitivity Investment Maximize Net Present Value

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The Blithedale romance

The Blithedale romance

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作者： nathaniel Hawthorne edited by Richard H. Millington.

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