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Wearable multifunctional printed graphene sensors

npj Flexible Electronics 2019年第1期3卷 132-141页

作者： Altynay Kaidarova Mohammed Asadullah Khan Marco Marengo Liam Swanepoel Alexander Przybysz Cobus Muller Andreas Fahlman Ulrich Buttner nathan r.geraldi rory P.Wilson Carlos M.Duarte Jurgen Kosel Computer Electrical and Mathematical Sciences&Engineering(CEMSE)King Abdullah University of Science and Technology(KAUST)Thuwal 23955Saudi Arabia Mechanical Engineering 7600 Stellenbosch UniversityStellenboschSouth Africa Carrer d’Eduardo Primo Yúfera 146013 ValenciaSpain red Sea research Center(rSrC)and Computational Biosciences research Center King Abdullah University of Science and Technology(KAUST)Kingdom of Saudi ArabiaThuwal 23955Saudi Arabia Swansea Lab for Animal Movement BiosciencesSwansea UniversitySwansea SA28PP WalesUK

The outstanding properties of graphene have initiated myriads of research and development;yet, its economic impact is hamperedby the difficulties encountered in production and practical application. recently discovered laser-induced graphene is generated bya simple printing process on flexible and lightweight polyimide films. Exploiting the electrical features and mechanical pliability ofLIG on polyimide, we developed wearable resistive bending sensors that pave the way for many cost-effective measurementsystems. The versatile sensors we describe can be utilized in a wide range of configurations, including measurement of force,deflection, and curvature. The deflection induced by different forces and speeds is effectively sensed through a resistancemeasurement, exploiting the piezoresistance of the printed graphene electrodes. The LIG sensors possess an outstanding range forstrain measurements reaching >10% A double-sided electrode concept was developed by printing the same electrodes on bothsides of the film and employing difference measurements. This provided a large bidirectional bending response combined withtemperature compensation. Versatility in geometry and a simple fabrication process enable the detection of a wide range of flowspeeds, forces, and deflections. The sensor response can be easily tuned by geometrical parameters of the bending sensors and theLIG electrodes. As a wearable device, LIG bending sensors were used for tracking body movements. For underwater operation,PDMS-coated LIG bending sensors were integrated with ultra-low power aquatic tags and utilized in underwater animal speedmonitoring applications, and a recording of the surface current velocity on a coral reef in the red Sea.

关键词： underwater printing utilized

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Compliant lightweight non-invasive standalone“Marine Skin”tagging system

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npj Flexible Electronics 2018年第1期2卷 97-105页

作者： Joanna M.Nassar Sherjeel M.Khan Seneca J.Velling Andrea Diaz-Gaxiola Sohail F.Shaikh nathan r.geraldi Galo A.Torres Sevilla Carlos M.Duarte Muhammad M.Hussain mmh Labs Computer Electrical Mathematical Science and Engineering DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia Material&Nanoscience Program Faculty of ScienceUniversity of WaterlooWaterlooON N2L-3G1Canada red Sea research Center(rSrC) Biological and Environmental Sciences and Engineering(BESE)DivisionKing Abdullah University of Science and Technology(KAUST)Thuwal 23955-6900Saudi Arabia

Current marine research primarily depends on weighty and invasive sensory equipment and telemetric network to understand the marine environment,including the diverse fauna it contains,as a function of animal behavior and size,as well as equipment *** match animal morphology and activity within the surrounding marine environment,here we show a physically flexible and stretchable skin-like and waterproof autonomous multifunctional system,integrating Bluetooth,memory chip,and high performance physical *** sensory tag is mounted on a swimming crab(Portunus pelagicus)and is capable of continuous logging of depth,temperature,and salinity within the harsh ocean *** fully packaged,ultra-lightweight(r),and compliant“Marine Skin”system does not have any wired connection enabling safe and weightless cuttingedge approach to monitor and assess marine life and the ecosystem’s health to support conservation and management of marine ecosystems.

关键词： Marine system Skin

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Neurogenic potential of NG2 in neurotrauma:a systematic review

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Neural regeneration research 2024年第12期19卷 2673-2683页

作者： Yuri r.rigo radharani Benvenutti Luis V.Portela nathan r.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MEDLINE,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

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role of chromosome 1q copy number variation in hepatocellular carcinoma

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World Journal of Hepatology 2021年第6期13卷 662-672页

作者： nathan r Jacobs Pamela A Norton Department of Microbiology and Immunology Drexel University College of MedicinePhiladelphiaPA 19102United States

Chromosome 1q often has been observed to be amplified in hepatocellular *** review summarizes literature reports of multiple genes that have been proposed as possible 1q amplification *** largely fall within *** addition,publicly available copy number alteration data from The Cancer Genome Atlas project were used to identify additional candidate genes involved in *** most frequent location for gene amplification was 1q22,consistent with the results of the literature *** genes TPM3 and NUF2 were found to be candidates whose amplification and/or mrNA up-regulation was most highly associated with poorer hepatocellular carcinoma outcomes.

关键词： Liver cancer Chromosomal amplification Hepatocellular carcinoma The Cancer Genome Atlas

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nvestigating the role of exiting vehicles and turn indicator usage in gap acceptance at single-lane roundabouts

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Frontiers of Structural and Civil Engineering 2017年第1期11卷 8-16页

作者： nathan P. BELZ Civil and Environmental Engineering University of Alaska - Fairbanks Fairbanks AK 99775-5960 USA

roundabouts are becoming a preferred form of intersection control type due to their safety and capacity benefits. Yield control at roundabout entries inherently reduces fuel consumption and emissions when compared to other conventional intersection types. However, these benefits can be limited by poor driver behavior and judgment when entering the roundabout. This research addresses the nature of gap distributions and use of turn indicators by exiting vehicles at three single-lane roundabouts in Vermont, New York, and Alaska. Presented here is a comparison of vehicle headways measured at two different locations in each roundabout. rejected headways are analyzed in the context of priority abstaining events when entering drivers yield to vehicles exiting on the same leg of the roundabout suggesting that ＂true＂ critical gaps are being overestimated. results indicate that exiting vehicles, particularly those that do not use their turn indicators when departing from the major-stream of traffic have an influence on the entry decision of drivers on the same approach. This behavior is of particular concern for intersection efficiency （i.e., delay） and sustainability （i.e., excess fuel consumption and emissions）. results prompt the consideration of more consistent guidance on and enforcement of turn indicator use during roundabout negotiations.

关键词： roundabouts exiting vehicles turn indicator use headways

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Metamaterial-based graphene thermal emitter

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Nano research 2018年第7期11卷 3567-3573页

作者： Cheng Shi nathan H. Mahlmeister Isaac J. Luxmoore Geoffrey r. Nash College of Engineering Mathematics and PhysicaI Sciences University of Exeter Exeter EX4 4QF UK

A thermal emitter composed of a frequency-selective surface metamaterial layer and a hexagonal boron nitride-encapsulated graphene filament is demonstrated. The broadband thermal emission of the metamaterial （consisting of ring resonators） was tailored into two discrete bands, and the measured reflection and emission spectra agreed well with the simulation results. The high modulation frequencies that can be obtained in these devices, coupled with their operation in air, confirm their feasibility for use in applications such as gas sensing.

关键词： graphene hexagonal boron nitride thermal emitter infrared metamaterial

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Spectral square moments of a resonance sum for Maass forms

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Frontiers of Mathematics in China 2017年第5期12卷 1183-1200页

作者： nathan SALAZAr Yangbo YE Department of Mathematics The University of Iowa Iowa City Iowa 52242-1419 USA

Let f be a Maass cusp form for Г0（N） with Fourier coefficients 1 k2. λf（n） and Laplace eigenvalue 1/4 ＋k2 For real α≠0 and β 〉 0, consider the sum Sx（f; α,β） = ∑n λf（n）e（αnβ）φ（n/X）, where φ is a smooth function of compact support. We prove bounds for the second spectral moment of Sx （f;α, β）, with the eigenvalue tending towards infinity. When the eigenvalue is sufficiently large, we obtain an average bound for this sum in terms of X. This implies that if f has its eigenvalue beyond X1/2＋ε, the standard resonance main term for Sx（f; ±2√q 1/2）, q ∈Z＋, cannot appear in general. The method is adopted from proofs of subconvexity bounds for rankin-Selberg L-functions for GL（2） × GL（2）. It contains in particular a proof of an asymptotic expansion of a well-known oscillatory integral with an enlarged range of Kε≤ L≤ K1-ε. The same bounds can be proved in a similar way for holomorphie cusp forms.

关键词： Cusp form Maass form Fourier coefficient of cusp form Kuznetsovtrace formula resonance sum first derivative test weighted stationary phase

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Grain boundary effects in high-temperature liquid-metal dealloying: a multi-phase field study

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npj Computational Materials 2023年第1期9卷 1039-1049页

作者： nathan Bieberdorf Mark Asta Laurent Capolungo Department of Materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Materials Science and Technology Division Los Alamos National LaboratoryLos AlamosNM 87545USA

A multi-phase field model is employed to study the microstructural evolution of an alloy undergoing liquid dealloying,specifically considering the role of grain boundaries.A semi-implicit time-stepping algorithm using spectral methods is implemented,which enables simulating large 2D and 3D domains over long time scales while still maintaining a realistic interfacial *** reveal a mechanism of coupled grain–boundary migration to maintain equilibrium contact angles with the topologically complex solid–liquid interface,which locally accelerates diffusion-coupled growth of a liquid channel into the *** mechanism asymmetrically disrupts the ligament connectivity of the dealloyed structure in qualitative agreement with published experimental *** grain boundary migration-assisted corrosion channels form even for precursors with small amounts of the dissolving alloy species,below the parting *** activation of this grain boundary dealloying mechanism depends strongly on grain boundary mobility.

关键词： alloying grain alloy

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Interfacing peripheral nerve with macro-sieve electrodes following spinal cord injury

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Neural regeneration research 2017年第6期12卷 906-909页

作者： nathan K.Birenbaum Matthew r.Mac Ewan Wilson Z.ray Department of Biomedical Engineering Washington University in St.Louis Department of Neurosurgery Washington University School of Medicine

Macro-sieve electrodes were implanted in the sciatic nerve of five adult male Lewis rats following spinal cord injury to assess the ability of the macro-sieve electrode to interface regenerated peripheral nerve fibers post-spinal cord injury. Each spinal cord injury was performed via right lateral hemisection of the cord at the T_（9–10） site. Five months post-implantation, the ability of the macro-sieve electrode to interface the regenerated nerve was assessed by stimulating through the macro-sieve electrode and recording both electromyography signals and evoked muscle force from distal musculature. Electromyography measurements were recorded from the tibialis anterior and gastrocnemius muscles, while evoked muscle force measurements were recorded from the tibialis anterior, extensor digitorum longus, and gastrocnemius muscles. The macro-sieve electrode and regenerated sciatic nerve were then explanted for histological evaluation. Successful sciatic nerve regeneration across the macro-sieve electrode interface following spinal cord injury was seen in all five animals. recorded electromyography signals and muscle force recordings obtained through macro-sieve electrode stimulation confirm the ability of the macro-sieve electrode to successfully recruit distal musculature in this injury model. Taken together, these results demonstrate the macro-sieve electrode as a viable interface for peripheral nerve stimulation in the context of spinal cord injury.

关键词： sieve evoked stimulation distal viable regeneration implanted assessed regenerated implantation

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Appendectomy and Clostridium difficile colitis:relationships revealed by clinical observations and immunology

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World Journal of Gastroenterology 2013年第34期19卷 5607-5614页

作者： nathan L Sanders r randal Bollinger ryan Lee Steven Thomas William Parker Department of Surgery Duke University Medical Center

Advances in understanding the interaction between the human immune system and the microbiome have led to an improved understanding of the function of the vermiform appendix as a safe-house for beneficial bacteria in the *** advances have been made despite long standing clinical observations that the appendectomy is a safe and effective ***,more recent clinical data show that an appendectomy puts patients at increased risk for recurrent Clostridium difficile(***)-associated colitis,and probably other diseases associated with an altered *** the same time,appendectomy does not apparently put patients at risk for an initial onset of ***-associated *** clinical observations point toward the idea that the vermiform appendix might not effectively protect the microbiome in the face of broad spectrum antibiotics,the use of which precedes the initial onset of ***-associated ***,these observations point to the idea that historically important threats to the microbiome such as infectious gastrointestinal pathogens have been supplanted by other threats,particularly the use of broad spectrum antibiotics.

关键词： Appendectomy Clostridium difficile Colitis Diarrheal illness Vermiform appendix

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