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香港旺角户外广告与城市商业空间的关系探析

山西建筑 2014年第27期40卷 18-21页

作者：吴矜黄为琳李小娇华南理工大学广州学院广东广州510400 华阳国际设计集团广东深圳518000 深圳市新城市规划建筑设计有限公司广东深圳518000

以外伸式广告牌为主要研究对象,从地域文化的延续传承、城市空间构造、建筑立面景观构成等角度,对香港旺角的弥敦道及西洋菜南街进行了调查,分析了户外广告牌对香港传统商业街区的影响,并提出了相关改进建议与策略。

关键词：外伸式广告牌地域特色城市空间

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人源大麻素受体CB2的晶体结构

科学新闻 2020年第2期 33-33页

作者：刘志杰 Xiaoting Li Tian Hua Kiran Vemuri Jo-Hao Ho Yiran wu Lijie wu Petr Popov Othman Benchama Nikolai Zvonok K'ara Locke Lu Qu Gye Won Han Malliga R.Iyer Resat Cinar nathan J.Coffey Jingjing Wang Meng wu sevolod Katritch Suwen Zhao George Kunos Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 上海科技大学

文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃... 详细信息

文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃分辨率的晶体结构。经结构对比分析,发现同处于拮抗状态的CB2与CB1不但结构差别极大,拮抗状态的CB2-AM0257复合物结构

关键词：大麻素受体 CB2 晶体结构

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中老年椎体骨赘和腰椎间盘退变的相关性

实用医学杂志 2016年第7期32卷 1133-1136页

作者：刘湘季伟李伦超韦文武朱青安王吉兴南方医科大学南方医院脊柱骨科广州市510515 解放军总医院第一附属医院北京市100048

目的:分析中老年椎体骨赘与腰椎间盘退变的相关性及探讨骨赘形成的可能机制。方法:回顾性分析120例中老年腰腿痛患者,利用X线及MRI分别观察骨赘和腰椎间盘退变,根据nathan方法将骨赘分为4度,定义Ⅱ度及以上为存在骨赘,再根据Pfirrmann... 详细信息

目的:分析中老年椎体骨赘与腰椎间盘退变的相关性及探讨骨赘形成的可能机制。方法:回顾性分析120例中老年腰腿痛患者,利用X线及MRI分别观察骨赘和腰椎间盘退变,根据nathan方法将骨赘分为4度,定义Ⅱ度及以上为存在骨赘,再根据Pfirrmann方法将腰椎间盘退变分为5级,对所测参数进行统计学分析。结果:骨赘与年龄在各腰椎节段均呈正相关,相关系数r差异具有统计学意义(P<0.05);下腰椎L3/4、L4/5的骨赘比例(76.7%、70.8%)比上腰椎L1/2、L2/3(31.7%、46.7%)高,骨赘形成和腰椎间盘退变在各腰椎节段均呈正相关,相关系数r具有统计学差异(P<0.01)。结论:随着腰椎间盘退变加重,椎体骨赘形成越明显,腰椎间盘退变导致椎体应力过高是骨赘形成重要原因。

关键词：腰椎骨赘腰椎间盘退变相关性

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The DIRECT consortium and the REST-meta-MDD project:towards neuroimaging biomarkers of major depressive disorder

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Psychoradiology 2022年第1期2卷 32-42页

作者： Xiao Chen Bin Lu Hui-Xian Li Xue-Ying Li Yu-Wei Wang Francisco Xavier Castellanos Li-Ping Cao Ning-Xuan Chen Wei Chen Yu-Qi Cheng Shi-Xian Cui Zhao-Yu Deng Yi-Ru Fang Qi-Yong Gong Wen-Bin Guo Zheng-Jia-Yi Hu Li Kuang Bao-Juan Li Le Li Tao Li Tao Lian Yi-Fan Liao Yan-Song Liu Zhe-Ning Liu Jian-Ping Lu Qing-Hua Luo Hua-Qing Meng Dai-Hui Peng Jiang Qiu Yue-Di Shen Tian-Mei Si Yan-Qing Tang Chuan-Yue Wang Fei Wang Hua-Ning Wang Kai Wang Xiang Wang Ying Wang Zi-Han Wang Xiao-Ping wu Chun-Ming Xie Guang-Rong Xie Peng Xie Xiu-Feng Xu Hong Yang Jian Yang Shu-Qiao Yao Yong-Qiang Yu Yong-Gui Yuan Ke-Rang Zhang Wei Zhang Zhi-Jun Zhang Jun-Juan Zhu Xi-Nian Zuo Jing-Ping Zhao Yu-Feng Zang the DIRECT consortium Chao-Gan Yan CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China International Big-Data Center for Depression Research Chinese Academy of SciencesBeijing 100101China Magnetic Resonance Imaging Research Center Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Graduate University of Chinese Academy of SciencesBeijing 101408China Department of Child and Adolescent Psychiatry NYU Grossman School of MedicineNew YorkNY 10016USA nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA 9Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510370China Capital Normal University Beijing 100089China Department of Psychiatry Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310020ZhejiangChina Department of Psychiatry First Affiliated Hospital of Kunming Medical UniversityKunmingYunnan 650032China Shanghai Mental Health Center Shanghai Jiao Tong University School of MedicineShanghai 200030China Huaxi MR Research Center(HMRRC) Department of RadiologyWest China Hospital of Sichuan UniversityChengduSichuan 610044China Research Unit of Psychoradiology Chinese Academy of Medical SciencesChengduSichuan 610052China Department of Psychiatry and National Clinical Research Center for Mental DisordersThe Second Xiangya Hospital of Central South UniversityChangsha 410011HunanChina Department of Psychiatry The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400042China Xijing Hospital of Air Force Military Medical University Xi’anShaanxi 710032China Center for Cognitive Science of Language Beijing Language and Culture UniversityBeijing 100083China Affiliated Mental Health Center&Hangzhou Seventh People’s Hospital Zhejiang University School of

Despite a growing neuroimaging literature on the pathophysiology of major depressive disorder(MDD),repro-ducible findings are lacking,probably reflecting mostly small sample sizes and heterogeneity in analytic *** address these issues,the Depression Imaging REsearch ConsorTium(DIRECT)was *** REST-meta-MDD project,pooling 2428 functional brain images processed with a standardized pipeline across all participating sites,has been the first effort from *** this review,we present an overview of the moti-vations,rationale,and principal findings of the studies so far from the REST-meta-MDD *** from the first round of analyses of the pooled repository have included alterations in functional connectivity within the default mode network,in whole-brain topological properties,in dynamic features,and in functional *** well-powered exploratory observations have also provided the basis for future longitudinal hypothesis-driven *** these fruitful explorations,DIRECT has proceeded to its second stage of data sharing that seeks to examine ethnicity in brain alterations in MDD by extending the exclusive Chinese original sample to other ethnic groups through international collaborations.A state-of-the-art,surface-based preprocessing pipeline has also been introduced to improve *** images from patients with bipolar disorder and schizophrenia will be included to identify shared and unique abnormalities across diag-nosis *** addition,large-scale longitudinal studies targeting brain network alterations following antidepressant treatment,aggregation of diffusion tensor images,and the development of functional magnetic resonance imaging-guided neuromodulation approaches are *** these endeavours,we hope to accelerate the translation of functional neuroimaging findings to clinical use,such as evaluating longitudinal effects of antidepressant medications and developing individualized

关键词： major depressive disorder DIRECT R-fMRI database neuroimaging