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AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南

临床与病理杂志 2016年第10期36卷 1467-1476页

作者： Zhongheng Zhang nathan j.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis jordi Rello Patrick M.Honore Win Sen Kuan juliet june Ray jiancang Zhou You Shang Yuetian Yu Christian jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) Department of Emergency Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 Department of Critical Care Medicine Jinhua Hospital of Zhejiang UniversityJinhua Zhejiang 321000 Department of Anesthesiology Mayo ClinicRochesterMNUSA Keenan Research Center for Biomedical Science of St.Michael's Hospital Departments of Anesthesia and PhysiologyInterdepartmental Division of Critical Care MedicineUniversity of TorontoTorontoONCanada Departments of Anesthesiology Critical CareEmergency Medicine and Pain TherapyZiekenhuis Oost-Limburgy GenkBelgium 2nd Department of Internal Medicine Attikcon University HospitalMedical SchoolNational and Kapodistrian University of AthensAthensGreece CIBERES Vall d'Hebron Institut of ResearchUniversitat Autonoma de BarcelonaSpain Universitair Ziekenhuis Brussely Vrije Universiteit Brussel Brussels BrusselsBelgium Emergency Medicine Department National University HospitalNational University Health SystemSingapore and the Department of SurgeryYong Loo Lin School of MedicineNational University of SingaporeSingapore DeWitt Daughtry Family Department of Surgery Jackson Memorial HospitalUniversity of Miami Leonard M.Miller School of MedicineMiamiFLUSA Department of Critical Care Medicine Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016 Department of Critical Care Medicine Union HospitalTongji Medical CollegueHuazhong University of Science and TechnologyWuhan 430022 Department of Critical Care Medicine Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001 University Hospital Dusseldorf Heinrich-Heine-University DusseldorfMedical FacultyDivision of CardiologyPulmonology and Vascular MedicineDusseldorfGermany Neurosciences Critical Care Unit Addenbrooke's HospitalCambridgeUK Department of Intensive Care Hopital ErasmeUniversite Libre de Bruxelles(ULB)BrusselsBelgium Dipartimento di Fisiopatologia Medico-Chirurgica e dei Trapianti Fondazione IRCCS Ca'Granda-Ospedale

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊... 详细信息

脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。

关键词：脓毒症早期识别诊断

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“薛定谔的细菌”诞生

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环球科学 2018年第12期 21-21页

作者：乔纳森·奥卡拉汉(撰文) 刘博尧(翻译) 不详

量子世界有着种种奇异的特性。理论上来说.量子力学要求一个粒子可以同时在两个地方出现。这种看似矛盾的现象叫做叠加态。两个粒子可以“纠缠”在一起,通过某种未知的机制跨过任意远的距离共享信息。或许量子力学中最著名的实验就是埃... 详细信息

量子世界有着种种奇异的特性。理论上来说.量子力学要求一个粒子可以同时在两个地方出现。这种看似矛盾的现象叫做叠加态。两个粒子可以“纠缠”在一起,通过某种未知的机制跨过任意远的距离共享信息。或许量子力学中最著名的实验就是埃尔温·薛定谔(Erwin Schrodinger)在1935年提出的思想实验——薛定谔的猫。

关键词：薛定谔细菌量子力学思想实验共享信息粒子奇异

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局部硅酮凝胶和压力衣疗法对儿童烧伤瘢痕防治的疗效:一项随机对照试验

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中华烧伤杂志 2021年第4期37卷 362-362页

作者：郭晓雨(编译) 雷芳(审校) 谢卫国(审校) Wiseman j Ware RS Simons M Children's Burns and Trauma Research Group Child Health Research Centre The University of Queensland Brisbane QLD Australia. Menzies Health Institute Queensland Griffith University Nathan QLD Australia. Department of Occupational Therapy Queensland Children's Hospital Brisbane QLD Australia. Pegg Leditschke Children's Burns Centre Queensland Children's Hospital Brisbane QLD Australia. Institute of Health and Biomedical Innovation School of Public Health and Social Work Queensland University of Technology Kelvin Grove QLD Australia. Centre for Functioning and Health Research Metro South Health Buranda QLD Australia. Department of Medical Imaging and Nuclear Medicine Queensland Children's Hospital Brisbane QLD Australia.

为了明确硅酮凝胶和压力衣单独应用及联合治疗对儿童烧伤瘢痕的疗效,研究者开展了一项多中心、随机对照试验。153例0~18岁烧伤儿童被随机分为单纯硅酮治疗组(51例)、单纯压力衣治疗组(49例)及硅酮凝胶和压力衣联合治疗组(53例)。随访至... 详细信息

为了明确硅酮凝胶和压力衣单独应用及联合治疗对儿童烧伤瘢痕的疗效,研究者开展了一项多中心、随机对照试验。153例0~18岁烧伤儿童被随机分为单纯硅酮治疗组(51例)、单纯压力衣治疗组(49例)及硅酮凝胶和压力衣联合治疗组(53例)。随访至烧伤后6个月,评估瘢痕厚度和瘙痒程度并行统计学分析。意向性治疗分析结果显示,单纯硅酮治疗组较硅酮凝胶和压力衣联合治疗组瘢痕厚度改善更明显(P=0.05),此外在瘢痕厚度及瘙痒强度方面未见其他的组间差异。

关键词：烧伤瘢痕硅酮凝胶治疗组压力衣瘢痕厚度瘙痒程度儿童烧伤随机对照试验

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Charting brain growth in tandem with brain templates at school age

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Science Bulletin 2020年第22期65卷 1924-1934,M0004页

作者： Hao-Ming Dong F.Xavier Castellanos Ning Yang Zhe Zhang Quan Zhou Ye He Lei Zhang Ting Xu Avram j.Holmes B.T.Thomas Yeo Feiyan Chen Bin Wang Christian Beckmann Tonya White Olaf Sporns jiang Qiu Tingyong Feng Antao Chen Xun Liu Xu Chen Xuchu Weng Michael P.Milham Xi-Nian Zuo Research Center for Lifespan Development of Brain and Mind Institute of PsychologyChinese Academy of Sciences(CAS)Beijing 100101China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Department of Child and Adolescent Psychiatry New York University School of MedicineNew YorkNY 10016USA nathan Kline Institute for Psychiatric Research OrangeburgNew YorkNY 10962USA Department of Psychology University of CASBeijing 100049China Department of Psychological and Brain Sciences Indiana UniversityBloomingtonIN 47405USA Child Mind Institute New YorkNY 10022USA Department of Psychology Yale UniversityNew HavenCT 06511USA Department of Electrical and Computer Engineering Clinical Imaging Research CentreN.1 Institute for Health and Memory Networks ProgramNational University of SingaporeSingapore 117574Singapore Department of Physics Zhejiang UniversityHangzhou 310058China Binzhou Medical University Yantai 264100China Donders Institute Radboud University Medical CentreNijmegen 6525 ENNetherlands Department of Child and Adolescent Psychiatry Erasmus UniversityRotterdam 3000 CBNetherlands Department of Radiology Erasmus University Medical CentreRotterdam 3000 CANetherlands School of Psychology Southwest UniversityChongqing 400715China Institute for Brain Research and Rehabilitation South China Normal UniversityGuangzhou 510631China Institute of Children Health Changzhou Children’s HospitalChangzhou 213003China Key Laboratory of Brain and Education School of Education ScienceNanning Normal UniversityNanning 530001China CAS Key Laboratory of Behavioral Science Institute of PsychologyBeijing 100101China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China

Brain growth charts and age-normed brain templates are essential resources for researchers to eventually contribute to the care of individuals with atypical developmental *** present work generates age-normed brain templates for children and adolescents at one-year intervals and the corresponding growth charts to investigate the influences of age and ethnicity using a common pediatric neuroimaging *** accelerated longitudinal cohorts with the identical experimental design were implemented in the United States and *** magnetic resonance imaging(MRI)of typically developing school-age children(TDC)was obtained up to three times at nominal intervals of1.25 *** protocol generated and compared population-and age-specific brain templates and growth charts,respectively.A total of 674 Chinese pediatric MRI scans were obtained from 457 Chinese TDC and 190 American pediatric MRI scans were obtained from 133 American ***-and age-specific brain templates were used to quantify warp cost,the differences between individual brains and brain *** growth charts for labeled brain network areas were *** analyses of cost functions supported the necessity of age-specific and ethnicitymatched brain templates,which was confirmed by growth chart *** analyses revealed volumetric growth differences between the two ethnicities primarily in lateral frontal and parietal areas,regions which are most variable across individuals in regard to their structure and ***-and ethnicity-specific brain templates facilitate establishing unbiased pediatric brain growth charts,indicating the necessity of the brain charts and brain templates generated in *** templates and growth charts as well as related codes have been made freely available to the public for open neuroscience(https://***/zuoxinian/CCS/tree/master/H3/Growth Charts).

关键词： Growth charts Neuroimaging Ethnicity Brain templates Development

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人源大麻素受体CB2的晶体结构

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科学新闻 2020年第2期 33-33页

作者：刘志杰 Xiaoting Li Tian Hua Kiran Vemuri jo-Hao Ho Yiran Wu Lijie Wu Petr Popov Othman Benchama Nikolai Zvonok K'ara Locke Lu Qu Gye Won Han Malliga R.Iyer Resat Cinar nathan j.Coffey jingjing Wang Meng Wu sevolod Katritch Suwen Zhao George Kunos Laura M.Bohn Alexandros Makriyannis Raymond C.Stevens 上海科技大学

文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃... 详细信息

文章简介大麻素受体CB2主要分布在人体的免疫系统,选择性调控大麻素受体CB2对炎症、纤维化及神经退行性疾病等具有较好的治疗潜力,同时可避免由大麻素受体CB1引起的精神活性。本研究报道了大麻素受体CB2与新型拮抗剂AM0257复合物2.8埃分辨率的晶体结构。经结构对比分析,发现同处于拮抗状态的CB2与CB1不但结构差别极大,拮抗状态的CB2-AM0257复合物结构

关键词：大麻素受体 CB2 晶体结构

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