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Neurogenic potential of NG2 in neurotrauma:a systematic review

Neural Regeneration Research 2024年第12期19卷 2673-2683页

作者： Yuri R.Rigo Radharani Benvenutti Luis V.Portela nathan R.Strogulski Departamento de Bioquímica Instituto de Ciências Básicas da SaúdeUniversidade Federal do Rio Grande do Sul(UFRGS)Porto AlegreBrazil School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health SciencesDublinIreland School of Biochemistry and Immunology Trinity Biomedical Sciences InstituteTrinity College DublinUniversity of DublinDublinIreland

Regenerative approaches towards neuronal loss following traumatic brain or spinal cord injury have long been considered a dogma in neuroscience and remain a cutting-edge area of *** is reflected in a large disparity between the number of studies investigating primary and secondary injury as therapeutic to rgets in spinal co rd and traumatic brain *** advances in biotechnology may have the potential to reshape the current state-of-the-art and bring focus to primary injury neurotrauma *** studies using neural-glial factor/antigen 2(NG2)cells indicate that they may differentiate into neurons even in the developed *** these cells show great potential to play a regenerative role,studies have been conducted to test various manipulations in neurotrauma models aimed at eliciting a neurogenic response from *** the present study,we systematically reviewed the experimental protocols and findings described in the scientific literature,which were peer-reviewed original research articles(1)describing preclinical experimental studies,(2)investigating NG2 cells,(3)associated with neurogenesis and neurotrauma,and(4)in vitro and/or in vivo,available in PubMed/MeDLINe,Web of Science or SCOPUS,from 1998 to ***,we have reviewed a total of 1504 papers,and summarized findings that ultimately suggest that NG2 cells possess an inducible neurogenic potential in animal models and in *** also discriminate findings of NG2 neurogenesis promoted by different pharmacological and genetic approaches over functional and biochemical outcomes of traumatic brain injury and spinal co rd injury models,and provide mounting evidence for the potential benefits of manipulated NG2 cell ex vivo transplantation in primary injury *** findings indicate the feasibility of NG2 cell neurogenesis strategies and add new players in the development of therapeutic alternatives for neurotrauma.

关键词： neural-glial antigen 2 neural-glial factor 2 neuron differentiation NG2 cell regeneration spinal cord injury(SCI) traumatic brain injury(TBI)

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胰岛素对昆虫病原线虫生长发育、生殖力及致病力的影响

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中国生物防治学报 2024年第4期40卷 856-865页

作者：钱秀娟孙丹臧建成 edwin e.lewis 甘肃农业大学植物保护学院/甘肃省农作物病虫害生物防治工程实验室西藏农牧学院植物科学学院美国爱达荷大学农业与生命科学学院昆虫学植物病理学及线虫学系

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经... 详细信息

昆虫病原线虫是一种极具潜力的生防因子，因其高效的杀虫特性而受到国际生防界的广泛关注，胰岛素作为一种蛋白质多肽，已被证实对昆虫、线虫等的生长发育、寿命均有重要调控作用。为了明确胰岛素对昆虫病原线虫的影响，本试验通过对经卡森斯氏线虫Steinernemakraussei0657L和短尾异小杆线虫Heterorhabditisbrevicaudis0641TY侵染的大蜡螟Galleriamellonella注射不同浓度胰岛素，观测昆虫病原线虫的生活史及其对大蜡螟的致病力，以明确胰岛素对昆虫病原线虫生长发育、生殖力、致病力的影响。结果表明：胰岛素干预时间和干预浓度均可对卡森斯氏线虫0657L在寄主昆虫体内的生长发育产生影响，侵染当天（t）干预和高浓度（1:500）干预，会明显缩短其发育历期；侵染当天无论是高浓度还是低浓度的胰岛素干预，均会明显缩短短尾异小杆线虫0641TY的发育历期，且相比较卡森斯氏线虫0657L，胰岛素促进短尾异小杆线虫0641TY发育历期的效果更明显。在卡森斯氏线虫0657L侵染大蜡螟10 d后，注射低浓度的胰岛素，可显著提高其生殖力；在短尾异小杆线虫0641TY侵染大蜡螟1d后，注射低浓度的胰岛素，可显著提高其生殖力。胰岛素对卡森斯氏线虫0657L致病力有影响，在24 h内高浓度胰岛素可显著缩短寄主昆虫的死亡时间，但是侵染36 h后，各处理间差异不显著；而对短尾异小杆线虫0641TY致病力无影响。综上所述，胰岛素对卡森斯氏线虫0657L和短尾异小杆线虫0641TY的发育和生殖力均有影响，且对卡森斯氏线虫致病力有影响。

关键词：胰岛素昆虫病原线虫生长发育生殖力致病力

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Systematic Radio Telescope Alignment Using Portable Fringe Projection Profilometry

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Nanomanufacturing and Metrology 2024年第1期7卷 75-85页

作者： Joel Berkson Justin Hyatt nathan Julicher Byeongjoon Jeong Isaac Pimienta Rachel Ball Wyatt ellis Jason Voris Diego Torres‑Barajas Daewook Kim James C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.TucsonAZ 85721USA Department of Astronomy at Steward Observatory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

In 2019,the event Horizon Telescope(eHT)released the first-ever image of a black hole event *** are now aiming for higher angular resolutions of distant targets,like black holes,to understand more about the fundamental laws of gravity that govern our *** achieve this higher resolution and increased sensitivity,larger radio telescopes are needed to operate at higher frequencies and in larger *** like the next-generation Very Large Array(ngVLA)and the Square-Kilometer Array(SKA)require building hundreds of telescopes with diameters greater than 10 ms over the next *** has a twofold *** telescope surfaces need to be more accurate to operate at higher frequencies,and the logistics involved in maintaining a radio telescope need to be simplified to support them properly in large *** of these problems can be solved with improved methods for surface metrology that are faster and more accurate with a higher *** leads to faster and more accurate panel alignment and,therefore,a more productive *** this paper,we present the use of binocular fringe projection profilometry as a solution to this problem and demonstrate it by aligning two panels on a 3-m radio telescope *** measurement takes only 10 min and directly delivers feedback on the tip,tilt,and piston of each panel to create the ideal reflector shape.

关键词： Metrology Fringe projection profilometry Off-axis alignment Radio astronomy Radio antenna

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efficacy of nonsolvent flower pollen extracts in healthy women with urinary incontinence:A randomized,double-blind,placebo-controlled,parallel study

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Current Urology 2024年第3期18卷 203-211页

作者： Marc Moulin erin D.lewis David C.Crowley Colleen e.May Malkanthi evans KGK Science Inc. LondonOntarioCanada Graminex L.L.C.SaginawMIUSA

Background Urinary incontinence(UI)is a debilitating and common condition that adversely affects quality of *** and surgical approaches for managing UI symptoms may result in undesirable risks and *** randomized,double-blind,placebo-controlled,parallel study investigated the efficacy of 2 nonsolvent flower pollen extracts on UI in healthy *** and methods One-hundred and fourteen women aged 40–75 years who scored≥5 on the International Consultation on Incontinence Questionnaire-Urinary Incontinence Short Form(ICIQ-SF)were randomized to receive either Graminex®RCT Fem™UI,Graminex®PollenBerry®,or placebo for 24 *** primary outcome was the change in the ICIQ-SF score between the trial and placebo groups after 24 weeks of *** secondary outcomes included changes in the frequency of nocturia(recorded in 3-day void diaries)and 24-hour leakage volume(assessed via pad weight)after 6,12,18,and 24 weeks of supplementation and changes in stress-induced urinary leakage volume(after completion of a provocative maneuver challenge)after 24 weeks of *** All the groups demonstrated improvement in ICIQ-SF scores at week 24(pe RCT Fem™UI group had the greatest improvement in ICIQ-SF scores(−4.07±3.4),followed by the PollenBerry®group(−3.34±2.87)and placebo group(−2.61±3.52).The RCT Fem™UI group had corresponding improvements in 24-hour leakage volume(−17.68±39.84 g)and frequency of nocturia(−0.52±1.26)(p≤0.05).PollenBerry®supplementation significantly improved stress-induced urinary leakage volume(−7.12±15.64 g)at week *** study products demonstrated safe hematological and chemical *** RCT Fem™UI supplementation resulted in significant and clinically meaningful reductions in UI severity,with corresponding improvements in daily urinary leakage volume and frequency of ***®significantly improved stress-induced urinary leakage volume,suggesting that it may be eff

关键词： Urinary incontinence Pollen extract Healthy women Dietary supplement ICIQ-SF Urinary leakage

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胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能研究进展

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昆虫学报 2024年 1-13页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin e.lewis 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室美国爱达荷大学农学院线虫学系

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫、线虫体内均存在胰岛素样肽信号通路和及胰岛素样生长因子通路,在调控其代谢、生长发育、繁殖、胁迫抗性和寿命,且均与脊椎动物的胰岛素样肽信号通路和及胰岛素样生长因子通路高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans等的胰岛素信号通路研究,作为一根探针,在生命科学研究中为人类胰岛素相关疾病研究提供试验模型,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫作为一种重要的生防因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,ePN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对昆虫病原线虫的影响,必须同时关注胰岛素对寄主昆虫的影响。为了能科学系统地展开胰岛素对昆虫病原线虫的影响并进行深入探讨,本文就胰岛素/胰岛素样生长因子对昆虫和线虫的生理功能展开综述,以期为研究胰岛素对昆虫病原线虫的影响及昆虫病原线虫的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

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existence of Solutions of a Convolution Integral equation

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Journal of Applied Mathematics and Physics 2024年第5期12卷 1835-1847页

作者： Henry Otoo Benjamin Dadzie Mensah lewis Brew Mathematical Sciences Department University of Mines and Technology Tarkwa Ghana Faculty of Science and Technology University of Silesia in Katowice Sosnowiec Poland

In this study, we prove the of existence of solutions of a convolution Volterra integral equation in the space of the Lebesgue integrable function on the set of positive real numbers and with the standard norm defined on it. An operator P was assigned to the convolution integral operator which was later expressed in terms of the superposition operator and the nonlinear operator. Given a ball Br belonging to the space L it was established that the operator P maps the ball into itself. The Hausdorff measure of noncompactness was then applied by first proving that given a set M∈ B r the set is bounded, closed, convex and nondecreasing. Finally, the Darbo fixed point theorem was applied on the measure obtained from the set e belonging to M. From this application, it was observed that the conditions for the Darbo fixed point theorem was satisfied. This indicated the presence of at least a fixed point for the integral equation which thereby implying the existence of solutions for the integral equation.

关键词： Volterra Integral equation Convolution Fixed Point existence Noncompactness

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Nat Methods:利用CRISPR-Cas9组合筛选发现癌症弱点

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现代生物医学进展 2017年第17期17卷 I0001-I0001页

作者： John Paul Shen, Ana Bojorquez-Gomez, Katherine Licon, Kristin Klepper, Daniel Pekin, Alex N Beckett, Kyle Salinas Sanchez, Jason F Kreisberg, Trey Ideker John Paul Shen, Trey Ideker, Prashant Mali John Paul Shen, Dongxin Zhao, Dan Du, Assen Roguev, Jason F Kreisberg, Nevan Krogan, Lei Qi, Trey Ideker, Prashant Mali Dongxin Zhao, Chih-Chung Kuo, Prashant Mali Roman Sasik, Amanda Birmingham, Aaron N Chang, Trey Ideker Jens Luebeck, Alex Thomas Alex Thomas, Chih-Chung Kuo, nathan e lewis Dan Du Assen Roguev, Nevan Krogan nathan e lewis Lei Qi Department of Medicine Division of Genetics University of California San Diego La Jolla California USA Moores UCSD Cancer Center La Jolla California USA The Cancer Cell Map Initiative (CCMI) La Jolla and San Francisco California USA Department of Bioengineering University of California San Diego La Jolla California USA Center for Computational Biology & Bioinformatics University of California San Diego La Jolla California USA Bioinformatics & Systems Biology Program University of California San Diego La Jolla California USA Novo Nordisk Center for Biosustainability at the University of California San Diego La Jolla California USA eli and edythe Broad Center of Regeneration Medicine and Stem Cell Research Department of Cell and Tissue Biology University of California San Francisco San Francisco California USA Department of Cellular and Molecular Pharmacology University of California San Francisco San Francisco California USA Department of Pediatrics University of California San Diego La Jolla California USA Department of Bioengineering Stanford University Stanford California USA.

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（synthetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在... 详细信息

导致癌症的基因突变也会削弱癌细胞，从而使得人们有机会开发选择性地杀死它们同时不影响正常细胞的药物。这一概念被称作”合成致死性（synthetic lethality）”，这是因为这些药物仅对发生突变的（或者说合成的）细胞是致命性的。在一项新的研究中。来自美国加州大学圣地亚哥分校、加州大学旧金山分校、斯坦福大学和癌细胞图谱项目（Cancer Cell Map Initiative）的研究人员开发出一种新的方法来寻找合成致死性的基因组合。

关键词：组合筛选癌症美国加州大学利用基因突变斯坦福大学癌细胞正常细胞

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昆虫和线虫胰岛素/胰岛素样生长因子的生理功能研究进展

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昆虫学报 2024年第7期67卷 1006-1018页

作者：钱秀娟刘长仲杨亚贤马丽娟陈红李茜童 edwin e.lewis 甘肃农业大学植物保护学院甘肃省农作物病虫害生物防治工程实验室兰州730070 Department of entomology Plant Pathology and NematologyCollege of Agricultural and Life SciencesUniversity of IdahoIdahoID 83844-229USA

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模... 详细信息

胰岛素是由胰岛素细胞分泌的一种分子量较小的蛋白质激素,通过细胞信号转导通路控制调节糖、脂肪和蛋白质代谢,进而对生命有机体产生影响。昆虫和线虫体内均存在胰岛素信号通路,调控其代谢、生长发育和寿命,且均与脊椎动物高度同源。模式生物黑腹果蝇Drosophila melanogaster和秀丽隐杆线虫Caenorhabditis elegans的胰岛素信号通路研究,作为一根探针,为人类胰岛素相关疾病研究提供试验模型,对生命科学的研究具有重要意义,因此有关线虫和昆虫的胰岛素研究较为深入。昆虫病原线虫(entomopathogenic nematode,ePN)作为一种重要的生物防治因子,其生命周期既包括在寄主昆虫内的寄生阶段,又包括在自然界当中的自由生活阶段。在寄生阶段,线虫体内携带的共生细菌主要通过对寄主昆虫的血液循环系统起作用,从而造成寄主昆虫的死亡,因此,ePN与寄主昆虫的血液系统有着密切的关系。综上,探讨胰岛素对ePN的影响,必须同时关注胰岛素对线虫和寄主昆虫的影响。为了能科学系统地展开胰岛素对ePN的影响并进行深入探讨,本文就昆虫和线虫胰岛素/胰岛素样生长因子的生理功能展开综述,以期为研究胰岛素对ePN影响及ePN的应用中胰岛素的干预应用提供思路及理论基础。

关键词：胰岛素昆虫线虫昆虫病原线虫共生细菌生理代谢

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Metal-Organic Frameworks Housing Active Molecules as Bioinspired Catalysts

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CCS Chemistry 2024年第6期6卷 1380-1402页

作者： Yin Zhang Peter e.VanNatta Junyu Ren Shengqian Ma Department of Chemistry University of North TexasDentonTexas 76201 Department of Chemical and Biomolecular engineering National University of SingaporeSingapore 117585

Optimization of activity,selectivity,and stability of catalysts for practical application is a long-soughtafter *** progress in the advancement of rational catalyst design routinely takes queues from ***,enzymes are renowned for their high efficiency and selectivity in diverse and significant reactions under mild *** the well-known merits of enzymes,they often remain unsuitable for industrial catalysis due to issues,including limited environment(solvent/temperature/pH)compatibility,considerable structural uncertainty,and highly specific reaction *** the context of bioinspired catalysis design,the development of synthetic heterogeneous catalyst analogs,which may not only mimic enzymes to reproduce or even surpass their performance but also bypass their intrinsic limitations,is thus,desirable and has been extensively studied in the context of porous *** metal-organic framework(MOF)is a superior candidate for porous materials towards this goal,thanks to facile and modular preparation,explicit crystalline composition/structure,tunable pore size/environment,and excellent *** introduction of active molecular species such as bioactive molecules(e.g.,proteins,enzymes,peptides,amino acids,porphyrins)and chemically active molecules(e.g.,frustrated lewis pairs)into metal-organic frameworks(MOFs)via pore encapsulation,chemical postmodification,or bottom-up construction has been shown to facilitate the cooperative enhancement of catalysis through the enforcement of proximity,enhancement of control/activity,and even inducement of unexpected *** this minireview,we sought to summarize the last 5 years of fruitful progress,exploiting MOFs housing active molecules for substantial catalysis applications,including asymmetric reactions,CO_(2)conversion(reduction,cycloaddition),biocatalytic H_(2)O_(2)/dye degradation,and so on,and discuss challenges and opportunities in the prospective exploration of these system

关键词： metal-organic framework bioinspired catalyst active molecular species

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Developmental environment contributes to rapid trait shifts among newly colonized subterranean habitats

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Zoological Research 2023年第4期44卷 808-820页

作者： nathan e.Swanson Andrew G.Gluesenkamp Alexandra e.Donny Suzanne e.McGaugh Department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSaint PaulMN 55108USA Department of ecology and evolutionary Biology University of California IrvineIrvineCA 92697-2525USA Center for Conservation and Research San Antonio ZooSan AntonioTexas 78212USA ecology Evolutionand BehaviorUniversity of MinnesotaSaint PaulMN 55108USA Department of Biology Stanford UniversityStanfordCA 94305USA

Recent colonization of extreme environments provides unique opportunities to study the early steps of adaptation and the potential for rapid convergent ***,phenotypic shifts during recent colonization may also be due to plasticity in response to changes in the rearing ***,we analyzed a suite of morphological and behavioral traits in paired surface,subterranean,and facultatively subterranean Mexican tetras(Astyanax mexicanus)from recent introductions in two separate watersheds outside of their native *** found a variety of phenotypic and behavioral shifts between subterranean and surface populations that are similar to those observed in relatively ancient populations in *** this rapid morphological divergence,we found that most of these trait differences were due to plasticity in response to rearing *** most trait assays in common-garden,lab-raised fish indicated that phenotypic shifts in wild fish were the result of plasticity,we also found evidence of genetic control in several traits present in subterranean ***,wall-following behavior,an important subterranean foraging behavior,was greater in lab-born subterranean fish than in lab-born surface fish,suggesting rapid divergence of this trait between subterranean and surface ***,this study sheds light on the early steps of subterranean evolution,identifies potential rapid behavioral evolution,and suggests that plasticity in traits involving exploratory behavior may facilitate subterranean colonization.

关键词： Plasticity Adaptation Subterranean Cavefish evolution Common garden

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