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Liver transplantation is beneficial regardless of cirrhosis stage or acute-on-chronic liver failure grade:A single-center experience

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World Journal of Gastroenterology 2022年第40期28卷 5881-5892页

作者： Eduardo Cervantes-Alvarez Mario Vilatoba nathaly limon-de la rosa Osvely Mendez-Guerrero David Kershenobich Aldo Torre Nalu Navarro-Alvarez PECEM Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico City 14080Mexico department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico department of Trasplant Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico City 14080Mexico department of Molecular Biology Universidad Panamericana School of MedicineMexico City 03920Mexico department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States

BACKGROUND Liver transplantation for the most critically ill remains controversial;however,it is currently the only curative treatment *** To assess immediate posttransplant outcomes and compare the short(1 year)and long-term(6 years)posttransplant survival among cirrhotic patients stratified by disease *** We included cirrhotic patients undergoing liver transplantation between 2015 and 2019 and categorized them into compensated cirrhosis(CC),decompensated cirrhosis(DC),and acute-on-chronic liver failure(ACLF).ACLF was further divided into severity *** primary outcomes of interest were total days of intensive care unit(ICU)and hospital stay,development of complications and posttransplant survival at 1 and 6 *** 235 patients underwent liver transplantation(CC=11,DC=129 and ACLF=95).Patients with ACLF had a significantly longer hospital stay[8.0(6.0-13.0)vs CC,6.0(3.0-7.0),and DC 7.0(4.5-10.0);P=0.01]and developed more infection-related complications[47(49.5%),vs CC,1(9.1%)and DC,38(29.5%);Plant survival at 1-and 6-years was similar among groups(P=0.60 and P=0.90,respectively).ACLF patients stratified according to ACLF grade[ACLF-1 n=40(42.1%),ACLF-2 n=33(34.7%)and ACLF-3 n=22(23.2%)],had similar ICU and hospital stay length(P=0.68,P=0.54),as well as comparable frequencies of overall and infectious posttransplant complications(P=0.58,P=0.80).There was no survival difference between ACLF grades at 1 year and 6 years(P=0.40 and P=0.15).CONCLUSION Patients may benefit from liver transplantation regardless of the cirrhosis *** patients have a longer hospital stay and frequency of infectious complications;however,excellent,and comparable 1 and 6-year survival rates support their enlisting and transplantation including those with ACLF-3.

关键词： Liver transplantation Acute-on-chronic liver failure Prognosis Survival analysis Critical care

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Histopathological impact of SARS-CoV-2 on the liver:Cellular damage and long-term complications

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World Journal of Gastroenterology 2024年第22期30卷 2866-2880页

作者： Alfonso Rodriguez-Espada Moises Salgado-de la Mora Briana Mariette Rodriguez-Paniagua nathaly limonde la rosa Monica Itzel Martinez-Gutierrez Santiago Pastrana-Brandes Nalu Navarro-Alvarez department of Molecular Biology Universidad Panamericana School of MedicineCampus MéxicoMexico 03920Mexico department of Internal Medicine Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico department of Surgery University of Colorado Anschutz Medical CampusDenverCO 80045United States PECEM Facultad de MedicinaUniversidad Nacional Autónoma de MéxicoMexico 04360Mexico department of Gastroenterology Instituto Nacional de Ciencias Médicas y Nutrición Salvador ZubiránMexico 14080Mexico

Coronavirus disease 2019(COVID-19),caused by the highly pathogenic severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),primarily impacts the respiratory tract and can lead to severe outcomes such as acute respiratory distress syndrome,multiple organ failure,and *** extensive studies on the pathogenicity of SARS-CoV-2,its impact on the hepatobiliary system remains *** liver injury is commonly indicated by reduced albumin and elevated bilirubin and transaminase levels,the exact source of this damage is not fully *** mechanisms for injury include direct cytotoxicity,collateral damage from inflammation,drug-induced liver injury,and ischemia/***,evidence often relies on blood tests with liver enzyme *** this comprehensive review,we focused solely on the different histopathological manifestations of liver injury in COVID-19 patients,drawing from liver biopsies,complete autopsies,and in vitro liver *** present evidence of the direct impact of SARS-CoV-2 on the liver,substantiated by in vitro observations of viral entry mechanisms and the actual presence of viral particles in liver samples resulting in a variety of cellular changes,including mitochondrial swelling,endoplasmic reticulum dilatation,and hepatocyte *** ly,we describe the diverse liver pathology observed during COVID-19 infection,encompassing necrosis,steatosis,cholestasis,and lobular *** also discuss the emergence of long-term complications,notably COVID-19-related secondary sclerosing *** the histopathological liver changes occurring during COVID-19 infection is pivotal for improving patient recovery and guiding decision-making.

关键词： Liver SARS-CoV-2 COVID-19 Angiotensin-converting enzyme 2 Histopathology Liver biopsies Liver autopsy In vitro

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Searching for alternatives to brain regeneration

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Neural Regeneration Research 2021年第11期16卷 2198-2200页

作者： Chiara la rosa Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly department of Veterinary Sciences University of TurinGrugliascoItaly

Brain regeneration from an evolutionary perspective:Brain regeneration(the full restoration of tissue after loss from injury or disease)is the most sought after goal for researchers working in developmental *** also appears to be the most challenging to achieve when considering the mammalian *** remarkable regenerative capacities can be present in the central nervous systems of many non-mammalian vertebrates(e.g.,fish,amphibians),these kinds of processes appear to be dramatically reduced in mammals(Bonfanti,2011).

关键词： regeneration sought injury

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Fatty acids in microalgae and cyanobacteria in a changing world:Contrasting temperate and cold environments

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BIOCELL 2022年第3期46卷 607-621页

作者： MARCELO P.HERNANDO IRENE R.SCHLOSS FLORENCIA de la rosa MARLEEN de TROCH Comisión Nacional de Energía Atómica(CNEA) Centro Atómico ConstituyentesDepartamento de RadiobiologíaSan MartínBuenos AiresArgentina Red de Investigación de Estresores Marinos-costeros en América latina y el Caribe(REMARCO) Mar del Plata7602Argentina Instituto Antártico Argentino(IAA) San MartínBuenos AiresArgentina Centro Austral de Investigaciones Científicas(CADIC-CONICET) Ushuaia9410Argentina Universidad Nacional de Tierra del Fuego Ushuaia9410Argentina Instituto de Ciencias Básicas y Experimentales(ICBE) Universidad de MorónMorónBuenos AiresArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos AiresArgentina Ghent University Faculty of SciencesBiology DepartmentMarine BiologyGhent9000Belgium

Under the present changing climate conditions and the observed temperature increase,it is of high importance to understand its effects on aquatic microbial life,and organisms’adaptations at the biochemical *** adjust to temperature or salinity stress and avoid cell damage,organisms alter their degree of fatty acids(FAs)***,temperature is expected to have strong effects on both the quantity and quality of FAs in aquatic *** we review some recent findings about FAs sensitivity to climate change in contrasting ***,heat waves may induce changes in the relative abundance of polyunsaturated FAs(PUFA).However,the impact of the exposure to warming waters is different in temperate and polar *** cold marine waters,high concentration of omega-3(ω3)FAs such as eicosapentaenoic acid(EPA)is promoted due to the activation of the desaturase *** this way,cells have enough energy to produce or activate antioxidant protection mechanisms and avoid oxidative stress due to heat ***,under high irradiance and heat wave conditions in temperate environments,photosystems’protection is achieved by decreasing EPA concentration due to desaturase *** FAs are transferred in aquatic food ***,any alteration in the production of essential FAs by phytoplankton(the main source ofω3)due to climate warming can be transferred to higher trophic levels,with cascading effects for the entire aquatic ecosystem.

关键词： Antarctic Temperate Essential FAs Increased temperature Microalgae Cyanobacteria

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Vascular endothelial growth factor：an essential neurotrophic factor for motoneurons？

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Neural Regeneration Research 2018年第7期13卷 1181-1182页

作者： Paula M.Calvo Angel M.Pastor rosa R.de la Cruz departamento de Fisiologia Facultad de Biologia Universidad de Sevilla Sevilla Spain

Vascular endothelial growth factor（VEGF）,an angiogenic factor with neuroprotective effects：The VEGF was initially characterized by its vasculogenic and angiogenic activities and its capacity to promote vascular permeability（Yancopoulos et al.,2000）.VEGF is also known as VEGF-A and is the prototype member of a related group of five trophic factors,VEGF-B,VEGF-C,VEGF-D and placental growth factor（Pl GF;lange et al.,2016）.

关键词： VEGFR Vascular endothelial growth factor:an essential neurotrophic factor for motoneurons

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Role of vascular endothelial growth factor as a critical neurotrophic factor for the survival and physiology of motoneurons

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Neural Regeneration Research 2023年第8期18卷 1691-1696页

作者： Paula M.Calvo Rosendo G.Hernández rosa R.de la Cruz Angel M.Pastor departamento de Fisiología Facultad de BiologíaUniversidad de SevillaSevillaSpain

Vascular endothelial growth factor(VEGF)was discovered by its angiogenic ***,during evolution,it appeared earlier as a neurotrophic factor required for the development of the nervous system in invertebrates lacking a circulatory *** aimed at reviewing recent evidence indicating that VEGF has neuroprotective effects in neurons exposed to a variety of *** particular interest is the link established between VEGF and motoneurons,especially after the design of the VEGFδ/δmutant *** mice are characterized by low levels of VEGF and develop muscle weakness and motoneuron degeneration resembling amyotrophic lateral *** administration of VEGF through several routes to animal models of amyotrophic lateral sclerosis delays motor impairment and motoneuron degeneration and increases life *** are new recent advances in the role of VEGF in the physiology of *** experimental aims use the extraocular(abducens)motoneurons lesioned by axotomy as a model for studying VEGF *** abducens motoneurons exhibit severe alterations in their discharge activity and a loss of synaptic *** exogenous administration of VEGF to axotomized abducens motoneurons,either from the transected nerve or intraventricularly,fully restores the synaptic and discharge properties of abducens motoneurons,despite being *** addition,when an anti-VEGF neutralizing antibody is delivered from the muscle to intact,uninjured abducens motoneurons,these cells display alterations in their discharge pattern and a loss of synaptic boutons that resemble the state of *** these data indicate that VEGF is an essential neurotrophic factor for motoneurons.

关键词： abducens nucleus amyotrophic lateral sclerosis cell death extracellular single-unit recordings eye movements neurodegeneration oculomotor trophic factors

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Do large brains of long-living mammals prefer non-newly generated,immature neurons？

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Neural Regeneration Research 2018年第4期13卷 633-634页

作者： Ottavia Palazzo Chiara la rosa Matteo Piumatti Luca Bonfanti Neuroscience Institute Cavalieri Ottolenghi(NICO) OrbassanoItaly institute of zoology-neurogenetics universitat regensburgGermany department of veterinary sciences university of turinGrugliasco(TO)Italy universitélibre de bruxelles(ulb) institute for interdisciplinary research in human biology(iribhm)BrusselsBelgium

Brain plasticity is heterogeneous in mammals：Brain regeneration and repair are the dream of every neurobiologist as well as every common citizen in the world who knows that most neurological diseases,dementia and other age-related problems affecting the central nervous system（CNS）do represent a heavy health and social *** re-generative processes are not＂ a natural property of the mammalian CNS, rather, due to evolutionary constraints they seem substantially reduced （if compared to those occurring in non-mammalian vertebrates） and hardly inducible by therapeutic approaches （reviewed in Martino et al., 2011）.

关键词： PSA Figure DCX Do large brains of long-living mammals prefer non-newly generated,immature neurons

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Effect of BaF2 addition on luminescence properties of Er3+/Yb3+ co-doped phosphate glasses

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Journal of Rare Earths 2018年第1期36卷 58-63页

作者： K.Linganna R.Narro-García P.Manasa H.desirena E.de la rosa C.K.Jayasankar department of Physics Sri Venkateswara University Advanced Optical Lens Research Center Korea Photonics Technology Institute (KOPTI) Centro de Física Aplicada y Tecnología Avanzada UNAM Centro de Investigaciones en Optica

Er3+/Yb3+co-doped phosphate glasses（P2O5-Al2O3-BaO-BaF2-K2O-Er2O3-Yb2O3） with varying BaF2content,were prepared by a conventional melt quenching technique and their spectroscopic properties were examined through the Raman, absorption, emission and decay measurements. Raman spectra(350-1400 cm-1) of the Er3+/Yb3+co-doped phosphate glasses with varying BaF2content, were recorded upon laser excitation at 785 nm. Near infrared luminescence spectra were measured in the1400-1600 nm region under 970 nm diode laser excitation and characteristic band was observed at1533 nm corresponding to4Ⅰ13/2→4Ⅰ15/2transition of Er3+ion. The decay curves for the4Ⅰ13/2level of Er3+ion, were measured and the lifetime is found to decrease from 7.94 to 7.70 ms when BaF2content increases from 0 to 8 mol% and then increases up to 7.83 ms with further increase in BaF2content（12 mol%）. The emission *** and figure of merit for the4Ⅰ13/2→4Ⅰ15/2transition of Er3+ion were evaluated and compared to the other host matrices. The upconversion luminescence was measured and intense red emission was observed for all the studied samples.

关键词： Er3+/Yb3+co-doped phosphate glasses Raman spectra Absorption and emission cross-sections Lifetime Rare earths

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Effects of Tillage and Crop Residue Management on Maize Yields and Net Returns in the Central Mexican Highlands Under Drought Conditions

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Pedosphere 2014年第4期24卷 476-486页

作者： R.ROMERO-PEREZGROVAS N.VERHULST D.de la rosa V.HERNáNdeZ M.MAERTENS J.deCKERS B.GOVAERTS International Maize and Wheat Improvement Center(CIMMYT) P.O.Box 6-641Mexico D.F.06600(Mexico) department of Earth and Environmental Sciences University of LeuvenCelestijnenlaan 200 ELeuven 3001(Belgium) Mathematics Research Center(CIMAT) Jalisco S/NValencianaGuanajuatoMexico CP 36240(Mexico)

In the subtropical highlands of Central Mexico, where the main crop is maize （Zea mays）, the conventional practice （CP） involves tillage, monoculture and residue removal, leading to soil degradation and unsustainable use of natural resources and agricultural inputs. Conservation agriculture （CA） has been proposed as a viable alternative in the region, based on reduction in tillage, retention of adequate levels of crop residues and soil surface cover and use of crop rotation. This study began in 2009 when the highlands of Central Mexico suffered from a prolonged drought during vegetative maize growth in July-August, providing an opportunity for the on-farm comparison of CA with CP under severe drought conditions which 21 climate change models projected to become more frequent. Under dry conditions, CA resulted in higher yields and net returns per hectare as early as the first and second years after adoption by farmers. As an average of 27 plots under farmers＇ management in 2009, the maize yields were 26% higher under CA （6.3 t ha-1） than under CP （5.0 t ha-l）. 2010 was close to a normal year in terms of rainfall so yields were higher than in 2009 for both practices; in addition, the yield difference between the practices was reduced to 19% （6.8 t ha-1 for CA vs. 5.7 t ha-1 for CP）. When all the 2009 and 2010 observations were analyzed in a modified stability analysis, CA had an overall positive effect of 3 838 Mexican Pesos ha-1 （320 $US ha-1） on net return and 1.3 t ha-1 on yield. After only one to two years of adoption by farmers on their fields, CA had higher yields and net returns under dry conditions that were even drier than those predicted by the analyzed 21 climate change models under a climate change scenario, emission scenario A2.

关键词： climate change conservation agriculture conventional practice emission scenario modified stability analysis

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A Review on Genetically Modified Plants designed to Phytoremediate Polluted Soils： Biochemical Responses and International Regulation

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Pedosphere 2018年第5期28卷 697-712页

作者： Edgar VAZQUEZ-NUNEZ Julian M. PENA-CASTRO Fabian FERNANdeZ-LUQUENO Eduardo CEJUDO Maria G. de la rosa-ALVAREZ Maria C. GARCIA-CASTANED departamento de Ingenierias Quimica Electronica y Biomedica Division de Ciencias e Ingenierlas Universidad de Guanajuato (UG) Campus Leon Loma del Bosque 103 Leon Gto. 37150 (Mexico) laboratorio de Biotecnologla Vegetal Instituto de Biotecnologia Universidad del Papaloapan Tuxtepec Oaxaca 68333 (Mexico) programa en Sustentabilidad de los Recursos Naturales y Eneryla Cinvestav Saltillo Industria Metalurgica 1062 Parque Industrial Saltillo-Ramos-Arizpe Ramos Arizpe Coahuila 25900 (Mexico) CONACYT Unidad de Ciencias del Agua (UCIA) Centro de Investigacion Cientifica de Yucatan A.C. Cancdn Quintana Roo 77500 (Mexico) Center for the Environmental Implications of Nanotechnology University of California at Los Angeles- University of Texas at El Paso 500 W University Ave El Paso 79968 (USA) CONACYT Universidad de Guanajuato Loma del Bosque 103 Leon Guanajuato 37150 (Mexico)

In recent years,there has been an increasing interest in finding sustainable strategies for the efficient removal of contaminants from *** objective of this review is to examine the biochemical principles of specific genetic modifications in plants,their applications in the field for specific contaminants as phytotechnologies,and their international *** addition,the review presents some biological aspects of rhizosphere-related phenomena,the interactions of organic and inorganic pollutants with plants,and the performance of the phytotechnologies across the *** the last few decades,at least eight genera of genetically modified plants(GMPs)have been tested and used for soil remediation with outstanding ***,Nicotiana,and Oryza are the plant genera most widely *** plant genes such as metal transporters,chelators,metallothioneins,phytochelatins,and oxygenases have been transferred to plants to improve the elimination of contaminants in *** discuss some important aspects of gene manipulation and its application for removal of diverse contaminants.A key challenge faced by phytotechnologies is the final disposal of the generated biomass,from a safety *** argue that the commercial success of phytotechnologies depends on the generation of valuable biomass on contaminated land and its use for bioenergy *** use of such technologies would promote a broader understanding of the importance of plants,especially GMPs,in the environment and their contribution to environmental sustainability.

关键词： bioenergy contaminants gene manipulation phytotechnology plant-microbe interaction regulatory policy soil pollu-tion soil remediation

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