检索结果-南通市图书馆

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一座梯田式的曲线书山——天津滨海图书馆

设计家 2017年第3期 98-102页

作者： Winy Maas Jacob van Rijs nathalie de Vries Wenchian Shi María López Calleja Chi Li ángel Sánchez Navarro Daehee Suk Guang Ruey Tan Xichen Sun Michael Zhang Kyosuk Lee Mariya Gyaurova Jaime Dominguez Bálgoma Antonio Luca Coco Costanza Cuccato Matteo Artico Tomaso Maschietti Ossip van Duivenbode MVRDV建筑设计事务所

项目地点:天津滨海新区项目面积:33,700平方米完成时间:2017项目功能:图书馆合作建筑师:中国天津市城市规划设计研究院建筑分院室内设计:天津市建筑设计院灯光照明:华谊建源照明设计所有项目资料由MVRDV事务所提供MVRDV与天津城市规划... 详细信息

项目地点:天津滨海新区项目面积:33,700平方米完成时间:2017项目功能:图书馆合作建筑师:中国天津市城市规划设计研究院建筑分院室内设计:天津市建筑设计院灯光照明:华谊建源照明设计所有项目资料由MVRDV事务所提供MVRDV与天津城市规划设计研究院合作建成天津滨海图书馆,于10月正式开放:这个全新的33,700m2文化中心以中庭的发光球形报告厅为焦点,四周环绕着梯田般层叠的书架,书架贯穿中央天井与球体相呼应。波浪式的书架是建筑中的主要空间元素,既界定了空间。

关键词：天津滨海图书馆天津市建筑设计院城市规划设计研究院建筑师建筑体量项目面积

法国城市绿色基础设施的认知与实施三个案例研究(巴黎、马赛、斯特拉斯堡)

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风景园林 2013年第6期20卷 88-95页

作者：罗兰·科米尔艾蒂安·格雷斯伦姗德林·格拉特伦娜塔莉·布兰孙帅巴黎狄德罗大学 CNRS实验室 CNRSLADYSS、巴黎狄德罗大学北方工业大学建筑工程学院

由11支团队、50名社会科学和生态学领域的研究人员共同推进的法国国家方案"城市绿色框架(Trame Verte Urbaine)",已经建立了一套城市绿色基础设施的评估体系,并为法国各地实施地方层面的绿色基础设施政策制定了参考。城市绿地主要具有... 详细信息

由11支团队、50名社会科学和生态学领域的研究人员共同推进的法国国家方案"城市绿色框架(Trame Verte Urbaine)",已经建立了一套城市绿色基础设施的评估体系,并为法国各地实施地方层面的绿色基础设施政策制定了参考。城市绿地主要具有提供持续生态系统服务的功能,为规划者和各地方政府进行相关工作提供了一定参考,例如,绿道可以被视为新城市文明指引下的一项兼具美学和生态价值的基础设施。本文研究了法国3座具有不同城市文化和环境背景的城市,具体包括巴黎(法国北部),马赛(法国南部)和斯特拉斯堡(法国东部)。

关键词：绿色基础设施公共政策感知生物多样性自然

Head Neck:检测细针穿刺样品中的HPV16可用于诊断HPV阳性

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现代生物医学进展 2017年第8期17卷 I0004-I0004页

作者： Lars Sivars MD David Landin MD Linnea Haeggblom MSci Nikolaos Tertipis PhD nathalie Gr uuml n PhD Cinzia Bersani PhD Linda Marklund MD, PhD Mehran Ghaderi PhD Anders N auml sman MD, PhD Torbj ouml rn Ramqvist PhD Cecilia Nordfors PhD Eva Munck ndash Wikland MD, PhD Edneia Tani MD, PhD Tina Dalianis MD, PhD Department of Oncology - Pathology Karolinska Institutet Stockholm Sweden Department of Oto-Rhino-Laryngology Head and Neck Surgery CLINTEC Karolinska Institutet Stockholm Sweden Department of Clinical Pathology Karolinska University Hospital Stockholm Sweden Department of Medical Biochemistry and Microbiology Microbiology - Immunology Uppsala University Uppsala Sweden

口咽鳞状细胞癌HPV16是指人乳头瘤病毒16型。HPV有多种类型，其中低危型HPV感染，主要引起生殖器疣（俗称菜花）。而高危型HPV感染则引起生殖器癌和子宫颈癌上皮细胞病变，此病毒为生殖器癌和子宫颈癌前细胞病毒的开端。

关键词： HPV16 人乳头瘤病毒16型鳞状细胞癌阳性诊断样品穿刺检测

EGFR Expression Is Unreliable to Decide for Cetuximab Treatment in Patients with Metastatic Colorectal Cancer: Results from “ERBITUX-OUEST”

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Open Journal of Internal Medicine 2016年第2期6卷 56-67页

作者： Jean-Philippe Metges Erick Gamelin Alain Volant Olivier Capitain Jean-François Ramée Jean-Luc Raoul Jean-Yves Douillard Pierre-Luc Etienne Isabelle Cumin Olivier Dupuis Roger Faroux Marie-Aude Coulon Philippe Deguiral Karine Bideau Nacr Eddine Achour Alain Gourlaouen Corinne Alleaume Annie Wdowik Laurent Miglianico Yann Touchefeu Vincent Klein Alain Penchet Ludovic Rosenfeld Daniel Martin Claire Stampfli Jean-Jacques Auger Alain Bargain Murielle Broyer-Petit Jérome Chettrit Louis-Rémi De Ybarlucea Serge Eloit Pierre Marie Girardot nathalie Heresbach Christian Laboisse Eric Lavoine Gilles Lemasson Claire Magois Sophie Michalak Norbert Padilla Joseph Politis Frédéric Staroz Bruno Turlin Arnaud Uguen Viorel Vasiliu Véronique Verriele Fanny Marhuenda Delphine Déniel Lagadec Christian Riché Françoise Grudé Observatoire dédié au Cancer des régions Bretagne et Pays de la Loire France Centre Hospitalier Régional Universitaire (CHRU) Brest France Institut de Cancérologie de l’Ouest (ICO) Paul Papin Angers France Centre Catherine de Sienne Nantes France CRLCC Eugène Marquis Rennes France ICO René Gauducheau Nantes France Centre CARIO-HCPA Plérin France Centre Hospitalier Bretagne Sud (CHBS) Lorient France Clinique Victor Hugo Le Mans France Centre Hospitalier Départemental (CHD) La Roche-sur-Yon France CH Le Mans France Clinique Mutualiste de l’Estuaire Saint-Nazaire France CHIC Quimper France Clinique Pasteur Lanroze Brest France CH MORLAIX France CH Saint-Brieuc France CHBA Vannes France CHP Saint-Grégoire France CHU Nantes France Hopital Privé Océane Vannes France Clinique Saint-Michel et Sainte-Anne Quimper France Pole Santé Sarthe et Loire La Flèche France Polyclinique du Maine Laval France Polyclinique Sud Quimper France CH Laval France Polyclinique Cesson Sévigné France Laboratoire d’anatomie et de cytologie pathologiques Cholet France Cabinet d’anatomie et de cytologie pathologiques Saint-Malo France Laboratoire d’anatomie et de cytologie pathologiques Lorient France Institut d’histopathologie Nantes France Laboratoire de Pathologie Médicale Laval France ARMOR Pathologie Plérin France Laboratoire d’anatomie et de cytologie pathologiques Rennes France Laboratoire d’anatomie et de cytologie pathologiques Angers France Laboratoire Analyses Biologie Glasgow Brest France CHU Angers France Centre d’anatomie et de cytologie pathologiques Le Mans France Cabinet d’anatomie et de cytologie pathologiques Vannes France Laboratoire d’anatomie et de cytologie pathologiques Quimper France CHU Rennes France

Purpose: Although controversial, assessment of epidermal growth factor receptor (EGFR) expression is required for the approved indications of Cetuximab in metastatic colorectal cancer (mCRC). With the objective of improving patient selection, “ERBITUX-OUEST” study aimed at analyzing EGFR status in a large cohort of mCRC patients who received cetuximab without preliminary EGFR screening, and assessing the correlation between EGFR status and response to treatment retrospectively. Patients and methods: 332 patients treated with Irinotecan Cetuximab based regimen after progression on irinotecan or oxaliplatin therapy were included. EGFR status was assessed using three available immunohistochemistry (IHC) tests and in situ hybridization in case of negativity. Clinical outcomes of EGFR-positive and EGFR-non-detected (or considered as negative with at least one test) patients were compared. Results: Of the 332 samples centrally screened, 194 were classified as full-positive (i.e., EGFR-positive for all three tests), 86 as full-negative, and 52 as discordant. One third of the 131 negative samples with FDA approved test should be reclassified as positive with at least one of the two others tests. Regarding results from FDA approved test only, neither objective response rate (ORR), progression-free survival (PFS) nor overall survival (OS) differed significantly between EGFR-negative and EGFR-positive patients (P = 0.788, 0.326 and 0.888, respectively). Similarly, comparison of full-negative to other groups did not show any significant difference in terms of ORR (P = 0.507), PFS (P = 0.222) or OS (P = 0.686). Conclusion: These data strongly argue against mCRC patients selection for Cetuximab treatment based on EGFR expression as measured by currently available IHC technics.

关键词： Metastatic Colorectal Cancer Cetuximab EGFR Expression

经I-gel^TM喉罩气管插管与LMA Fastrach^TM喉罩气管插管的比较：一项随机对照临床试验

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麻醉与镇痛 2013年第1期9卷 24-28页

作者： Antoine Elie Halwagi nathalie Massicotte Alexandre Lallo Main Gauthier Daniel Boudreault Monique Ruel Frangois Girard 罗洁沈一维(译) 闵苏(校) Department of Anesthesiology Centre Hospitalier de l'Universite de Montreal Hopital Notre-Dame Montreal Quebec Canada

背景I-gel喉罩是一种不带充气套囊的声门上通气道，其设计允许气管导管无障碍通过，且既往研究已表明其能与声门进行良好对位。在本前瞻性随机临床试验中，我们比较了经i-gel喉罩和LMA Fastrach喉罩辅助进行气管插管盲插的成功率。方法... 详细信息

背景I-gel喉罩是一种不带充气套囊的声门上通气道，其设计允许气管导管无障碍通过，且既往研究已表明其能与声门进行良好对位。在本前瞻性随机临床试验中，我们比较了经i-gel喉罩和LMA Fastrach喉罩辅助进行气管插管盲插的成功率。方法将160例需行全身麻醉和气道管理的患者随机分为2组，每组分别进行经i-gd喉罩或LMAFastrach喉罩辅助的气管插管。全麻诱导后，每组患者置入相应喉罩并确认有效肺通气，随后进行气管导管盲插。观测气管插管次数并计算首次插管成功率和最终插管成功率。结果每组各入选80例患者。i-gel喉罩辅助插管组首次插管成功率为69％，而LMA Fastrach喉罩辅助插管组为74％（差异的95％可信区间CI为-9％-19％，P=0．60）。l-gel喉罩组的最终插管成功率低于LMAFastrach喉罩组（分别为73％和91％，差异的95％CI为7％。31％，P〈0．0001）。结论经i-gd喉罩或LMA Fastrach喉罩辅助气管导管盲插首次成功率相近，但首次插管失败后，i-gel喉罩并不提高后续插管成功率，且其最终插管成功率低于LMAFastrach喉罩。

关键词：随机对照临床试验气管插管 LMA 喉罩前瞻性随机临床试验插管成功率气管导管气道管理

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前臂桡侧皮瓣是阴茎再造术的标准术式吗？

中国美容整形外科杂志 2012年第5期23卷 I0004-I0009页

作者： Stan Monstrey Piet Hoebeke Gennaro Selvaggi Peter Ceulemans Koen Van Landuyt Phillip Blondeel Moustapha Hamdi nathalie Roche Steven Weyers Griet De Cuypere 姚尧陶凯魏峰高景恒张晨比利时根特根特大学医院整形外科泌尿外科妇科精神疾病与性别问题科沈阳军区总医院整形外科《中国美容整形外科杂志》编辑部大连大学附属新华医院整形外科

背景与目的阴茎再造的目标明确，已有多种皮瓣用于阴茎再造，但没有一种皮瓣是最为理想的再造方法。尽管如此，前臂桡侧皮瓣目前是应用最多、并被广泛认可的标准术式。方法本文回顾分析了287例前臂桡侧皮瓣阴茎再造的结果，是迄今为止... 详细信息

背景与目的阴茎再造的目标明确，已有多种皮瓣用于阴茎再造，但没有一种皮瓣是最为理想的再造方法。尽管如此，前臂桡侧皮瓣目前是应用最多、并被广泛认可的标准术式。方法本文回顾分析了287例前臂桡侧皮瓣阴茎再造的结果，是迄今为止患者数最多的报道。手术均由同一医疗小组完成。许多研究数据都已发表在之前的文章中，本综述的主要目的是评价这个“标准术式”可以在多大程度上达到手术预期的目的。结果评价指标包括所需手术次数、并发症、外形美观度、触觉、性敏感度、排尿难易度、供皮区并发症、阴囊外形以及性生活质量等。结论由于缺乏前瞻性随机对照研究，尚不能证明前臂桡侧皮瓣是阴茎再造的最佳方法。但是，这项大样本研究证明，前臂桡侧皮瓣阴茎再造术是一种可靠的再造方法，可以形成外观接近正常的阴茎和阴囊，术后患者可直立排尿，多数患者性生活满意。该手术多数分Ⅱ期完成。该技术的主要缺点包括早期尿道瘘发生率较高，前臂供皮区遗留瘢痕，以及可能并发慢性泌尿系统并发症。尽管缺乏足够的证据，但是笔者认为，如果想要获得更好的手术效果，必须加强整形再造外科医师与泌尿外科医师之间的多学科间紧密合作。

关键词：前臂桡侧皮瓣阴茎再造术标准术式泌尿系统并发症前瞻性随机对照研究泌尿外科医师手术次数性生活质量

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研究神经胶质细胞的新兴技术

神经损伤与功能重建 2020年第10期15卷 F0003-F0003页

作者： Hélène Hirbec Nicole Déglon Lynette C Foo Inbal Goshen Jaime Grutzendler Emilie Hangen Tirzah Kreisel nathalie Linck Julien Muffat Sara Regio Sybille Rion Carole Escartin 杜一星 Institute for Functional Genomics(IGF) University of MontpellierCNRSINSERMMontpellierFrance Laboratory of Neurotherapies and Neuromodulation Department of Clinical NeuroscienceLausanne University HospitalUniversity of LausanneLausanneSwitzerland Laboratory of Neurotherapies and Neuromodulation Neuroscience Research CenterLausanne University Hospital and University of LausanneLausanneSwitzerland Neuroimmunology and Neurodegeneration Section The Neuroscience and Rare Diseases Discovery and Translational AreaF.Hoffman-La RocheBaselSwitzerland Edmond and Lily Safra Center for Brain Sciences The Hebrew University of JerusalemJerusalemIsrael Department of Neurology Yale University School of MedicineNew HavenConnecticutUSA Department of Neuroscience Yale University School of MedicineNew HavenConnecticutUSA Commissariatà l'Energie Atomique et aux Energies Alternatives Département de la Recherche FondamentaleInstitut de Biologie François JacobMIRCenFontenay-aux-RosesFrance Centre National de la Recherche Scientifique Neurodegenerative Diseases LaboratoryUniversitéParis-SudUniversitéParis-SaclayUMR 9199Fontenay-aux-RosesFrance Program in Neurosciences and Mental Health The Hospital for Sick Childrenand Department of Molecular GeneticsThe University of TorontoTorontoCanada 不详

大脑的发育、生理功能和病理与神经元和不同类型的神经胶质细胞(如星形胶质细胞、小胶质细胞、少突胶质细胞和少突胶质细胞的前体细胞等)之间的相互作用密切相关。研究脑功能及其功能障碍,除了神经元之外,还需要对不同类型的神经胶质细... 详细信息

大脑的发育、生理功能和病理与神经元和不同类型的神经胶质细胞(如星形胶质细胞、小胶质细胞、少突胶质细胞和少突胶质细胞的前体细胞等)之间的相互作用密切相关。研究脑功能及其功能障碍,除了神经元之外,还需要对不同类型的神经胶质细胞进行研究。近年来,多项技术突破使“神经胶质科学家”能够解决新的具有挑战性的生物学问题。这些技术发展使得以中/高含量工作流研究特定细胞类型的作用成为可能,并在保存完好的环境中对其相互作用进行精细的分析。本综述阐明了几种可能揭示神经胶质细胞在特定脑功能或疾病中作用的尖端实验方法。这些实验方法包括高级细胞培养,诱导多能干细胞(iPSC)衍生的人神经胶质细胞,病毒载体,原位胶质细胞成像,光学遗传学和化学遗传学方法,以及高内涵分子分析。本文还阐述了某些技术的临床转化,通过特定的脑成像方法以监控患者的神经胶质细胞。本文亦讨论了每种技术的优点,缺陷和未来发展,并提供了选定的示例以说明现在如何可以解决特定的“胶质生物学”问题。

关键词：神经胶质细胞少突胶质细胞小胶质细胞星形胶质细胞脑功能细胞培养细胞类型脑成像

Observatory science with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz Peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu Ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous Pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana Piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-Peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De Pasquale nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino Poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès Paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji Peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour YunPeng Men Mariano Méndez Roberto P.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert Paul T.O'Brien Mauro Orlandini Julian P.Osborne Luigi Pacciani Stéphane Paltani Maurizio Paolillo Iossif E.Papadakis Biswajit Paul Alberto Pellizzoni Uria Peretz Miguel A.Pérez Torres Emanuele Perinati Chanda Prescod-Weinstein Pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e Planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSPAR SPA University of Alabama in Huntsville Department of Physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton Pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat Politecnica de Catalunya(UPC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-Planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle Physics(ECAP) Friedrich Alexander Universit?t Erlangen-Nurnberg Purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of Physics and Astronomy University of Southampton IRAP Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology Physics Department Middle East Technical University Department of Physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de Pesquisas Espaciais-INPE National Space Institute Technical University of Denmark(DTU Space) Department of Physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of Physics and A

In this White Paper we present the potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTP will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Science, the eXTP mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves