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国外畜牧学（猪与禽） 2000年第5期20卷 8-11页

作者：覃矜魏华田 Lee Johnston nathalie Trottie 美国明尼苏达大学美国密执安州立大学

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临空眺望

现代装饰（家居） 2011年第5期 38-44页

作者： Winy Maas Jacob van Rijs nathalie de Vries 肖俊 MVRDV建筑设计事务所

项目地址英国萨福克郡项目面积210m^2Balancing Barn是一座悬臂式的度假住宅,坐落在英国郊外一个依山傍水、风景秀丽的地方。整个建筑的设计和施工充分反映了房屋的地势条件以及周围的自然环境。传统的建筑外形以及反光的金属立面参考... 详细信息

项目地址英国萨福克郡项目面积210m^2Balancing Barn是一座悬臂式的度假住宅,坐落在英国郊外一个依山傍水、风景秀丽的地方。整个建筑的设计和施工充分反映了房屋的地势条件以及周围的自然环境。传统的建筑外形以及反光的金属立面参考了当地的建筑语汇。可以说,该设计旨在探索在乡村环境中植入现代建筑的可行性。此外,它又是一座兼具宁静气质与令人兴奋的外形的度假小屋。

关键词：建筑外形项目地址乡村环境项目面积建筑语汇萨福克悬臂式古典风格室内装饰造访者

Progress towards using community context with clinical data in primary care

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Family Medicine and Community Health 2019年第1期7卷 15-19页

作者： Heather Angier Elizabeth A Jacobs nathalie Huguet Sonja Likumahuwa-Ackman Stephanie Robert Jennifer E DeVoe Oregon Health&Science University PortlandOregonUSA University of Texas at Austin Dell Medical SchoolAustinTexasUSA University of Wisconsin-Madison MadisonWisconsinUSA

Community-level factors have significant impacts on *** is renewed enthusiasm for integrating these data with electronic health record(EHR)data for use in primary care to improve health equity in the ***,it is valuable to reflect on what has been published to ***,we comment on:(1)recommendations about combining community-level factors in EHRs for use in primary care;(2)examples of how these data have been combined and used;and(3)the impact of using combined data on healthcare,patient health and health *** found publications discussing the potential of combined data to inform clinical care,target interventions,track population health and spark community partnerships with the goal of reducing health disparities and improving health *** there is great enthusiasm and potential for using these data to inform primary care,there is little evidence of improved healthcare,patient health or health equity.

关键词： clinical integrating equity

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改善母猪生产率的营养学方法(续完)

国外畜牧学（猪与禽） 2000年第6期20卷 21-25页

作者：覃矜魏华田 Lee Johnston nathalie Trottie 美国明尼苏达大学美国密执安州立大学

Vangl2 regulation in a mammalian model for planar polarity

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Vangl2 regulation in a mammalian model for planar polarity

Biochemical and Oxidative Stress Parameters of Broilers Fed Meal and Protein Isolate of <i>Mucuna pruriens</i>Seeds

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Arnaud Giese La Lasvaux Claire Mazzocco Elodie Richard Matthew W.Kelley nathalie Sans John Brigande Mireille Montcouquiol INSERM U862 Neurocentre MagendiePlanar Polarity and Plasticity groupBordeauxFrance University of Bordeaux France

Vangl2 is one of the central proteins controlling the establishment of Planar Cell Polarity in different tissues and ***,results in both flies and mammals suggest that that the localization of Vangl2 protein to specific intracellular microdomains is crucial for normal ***,the molecular mechanisms that control Vangl2 trafficking within a cell are largely ***,we identify a new binding partner for Vangl2,G-protein signaling-GAIP -interacting protein 1(GIPC1).We show that the central PDZ domain of GIPC1 directly associates with the last 12 amino acids of Vangl2,and that GIPC1,along with the motor protein MyosinⅥ(MyoⅥ),co-localizes with Vangl2 in endosomal *** show that a GIPC1/MyoⅥcomplex regulates the levels of Vangl2 at the plasma membrane. Consistent with this result,high resolution imaging by STED microscopy reveals a depletion of Vangl2 in the proximal membrane of hair cells,a location with a large accumulation of ***,downregulation of GIPC1 in hair cells by shRNA in vitro or in utero leads to hair cell maturation defects,including defects in hair bundle orientation and *** results demonstrate a role for GIPC1 in the regulation of Vangl2 protein within developing hair cells. Moreover,morphological analysis of the effects of depletion of GIPC1 indicates a broader role for this molecule in the development of both stereociliary bundles and planar cell polarization.

关键词： planar polarity inner ear traffic cochlea Van Gogh-like 2

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Open Journal of Animal Sciences 2021年第2期11卷 354-368页

作者： Mweugang Ngouopo nathalie Miegoue Emile Youssoufa Tchoubou Yacouba Manga Pelyang Maurice Madjou Solange Njintang Yanou Nicolas Nukenine Elias Nchiwan Fonteh Anyangwe Florence Pamo Tedonkeng Etienne Department of Biological Sciences Faculty of Sciences University of Ngaoundere Ngaoundere Cameroon Department of Zootechnic Animal Nutrition and Production Research Unit Faculty of Agronomy and Agricultural Sciences Universi-ty of Dschang Dschang Cameroon

Mucuna pruriens (velvet bean) represents an interesting source of protein poorly studied. The effect of dietary inclusion of meal and protein isolate of Mucuna seeds on biochemical and oxidative stress parameter of broilers (135-one-day Cobb500 chickens) was investigated. Three isonitrogenous diets were formulated from soya bean meal (Control group: RTS), Mucuna meal (coded RFM) and Mucuna protein isolate (coded RIM). Each of the dietary treatments was triplicated with 15 birds per replicate in a completely randomized design. The birds were offered feed and water ad libitum. The results revealed significant (p 0.05) effect of N source on the organ total proteins with treatment RFM and RIM exhibiting lower but comparable levels in the Liver (2.01 and 1.98 g/dL), Heart (1.95 and 1.89 g/dL) and Kidney (1.92 and 1.91 g/dL). Triglycerides contents were significantly (p

体外替代整合测试策略ITS开发及Bottom Up/Top-Down测试策略比较

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体外替代整合测试策略ITS开发及Bottom Up/Top-Down测试策略比较

The HINT ProjectmExploring the Use of New Technologies in Heritage Interpretation

中国毒理学会第七次全国毒理学大会暨第八届湖北科技论坛

作者： Alice CAI nathalie Alepee Jose Cotovio 欧莱雅(中国)研发和创新中心欧莱雅法国研发和创新中心

针对皮肤腐蚀性和皮肤刺激性测试,世界经济合作与发展组织(OECD)最新采纳了一个整合测试评估策略,为如何运用模块化手段将已有的和新获得的信息整合在一起对物质进行分类和标识提供了指导(OECD GD203)。基于SkinEthicTM重组人类表皮模型... 详细信息

针对皮肤腐蚀性和皮肤刺激性测试,世界经济合作与发展组织(OECD)最新采纳了一个整合测试评估策略,为如何运用模块化手段将已有的和新获得的信息整合在一起对物质进行分类和标识提供了指导(OECD GD203)。基于SkinEthicTM重组人类表皮模型(RHE)已于先前被接受纳入皮肤刺激性(OECD TG 439)和皮肤腐蚀性(OECD TG 431)的法规评估方法指南,本项研究的目的旨在评估如何进一步在所推荐的OECD整合测试评估策略中实际应用SkinEthicRHE模型测试方法。来自于86个被测物质的数据被整合于一个倒置(BoSom Up)和由上而下(Top—Down)的测试策略中,从而来评定其分别对于EU CLP和UN GHS系统分类的预测能力。对于EU CLP系统,该策略显示:在刺激性无分类物质(non—classified)和分类物质(classified)的区分中其准确性达84.8%,在腐蚀性和非腐蚀性物质的区分中其准确性高达94.4%,而对于4个亚分类(sub—categories)区分的准确性达68.5%。对于UN GHS系统,该策略显示:在刺激性无分类物质(non—classified)和分类物质(classified)的区分中其准确性达89.5%,在腐蚀性和非腐蚀性物质的区分中其准确性高达93.4%,而对于4个GHS亚分类(sub-categories,除分类3温和刺激性以外)区分的准确性达74.2%。由此可得出结论,SkinEthicRHE模型的皮肤刺激性和皮肤腐蚀性数据应用于这样一个Bottom Up和Top-Down的整合测试策略中,可以准确并安全地实现按照EU CLP和UN GHS系统标准来进行物质的分类,并且不受所选用的测试策略顺序的局限。

关键词：体外替代整合测试策略重组人类表皮模型皮肤刺激性皮肤腐蚀性

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Journal of Earth Science and Engineering 2014年第3期4卷 156-174页

作者： Robina R. Barton David Cooper Anne Guyomard Sophie. C. Justice Peter Samsom Elizabeth Picket Cathrien. L. Posthumus nathalie Cayla Geopark Shetland Shetland Amenity Trust Garthspool Lerwick ZEl ONY UK . Geopark Chablais Syndicatlntercommunald Amenagement du Chablais Thonon-Les-Bains 74200 France North Pennines AONB Partnership The Old Co-op Building Stanhope DL13 2UY UK Geopark de Hondsrug Bronnegerstraat 129531 TG Borger The Netherlands ED YTEM (Laboratory of Environment Dynamics and Territories) UMR CNRS-University of Savoy Technolac 73 376 Le Bourgetdu Lac Cedex France

The HINT project is a four-country collective of Global heritage interpretation. HINT is a two-year project part funded Geoparks researching the uses and benefits of new technologies in by the European Leader Programme. The partners are Geopark Shetland （Scotland）, Chablais Geopark （France）, North Pennines Area of Outstanding Natural Beauty （England） and Geopark de Hondsrug （The Netherlands）. Each partner has developed a pilot project to investigate the practicalities of interpreting and communicating heritage, especially geological heritage, using a particular technology. An overview of each of the four pilot projects is given. The overall aim of the pilot projects is to develop best practice in using new technologies for heritage interpretation and to share information and ideas within the project partnership and with geoparks and heritage organizations around the world. This paper, developed by the HINT partners, aims to give an insight into the practical process of developing interpretive tools using new technologies. Some common problems are highlighted and some ways in which these can be addressed are shown.

关键词： Technology interpretation education tourism heritage.

Rab7 in vivo cyclization promoted by a split mini-intein SspDnaB

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Rab7 in vivo cyclization promoted by a split mini-intein Ssp...

Water limitation and rootstock genotype interact to alter grape berry metabolism through transcriptome reprogramming

The 4th ISGO International Conference on Structural Genomics

作者： Olena Pylypenko nathalie Bleimling Tammy Woo Pavel Prosselkov Nicholas E.Dixon Roger S.Goody Alexey Rak Max Planck Institute of Molecular Physiology Department of Physical Biochemistry Otto-Hahn-Str 11Dortmund44227 Germany Max Planck Institute of Molecular Physiology Department of Physical Biochemistry Otto-Hahn-Str 11Dortmund44227 Germany Max Planck Institute of Molecular Physiology Department of Physical Biochemistry Otto-Hahn-Str 11Dortmund44227 Germany Research School of Chemistry Building 35 Australian National UniversityScience RoadActon ACT 2601 Canberra Australia Research School of Chemistry Building 35 Australian National UniversityScience RoadActon ACT 2601 Canberra Australia Max Planck Institute of Molecular Physiology Department of Physical Biochemistry Otto-Hahn-Str 11Dortmund 44227 Germany Max Planck Institute of Molecular Physiology Department of Physical Biochemistry Otto-Hahn-Str 11Dortmund 44227 Germany

＜正＞Rab7 protein is a small GTPase of the Ras superfamily whose activity is restricted to modulating membrane fusion events between late endsomes and lysosomes. Like other GTPases of the Ras superfamily, Rab7 cycle ...

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Horticulture Research 2015年第1期2卷 242-254页

作者： Mariam Berdeja Philippe Nicolas Christian Kappel Zhan Wu Dai Ghislaine Hilbert Anthony Peccoux Magali Lafontaine nathalie Ollat Eric Gomès Serge Delrot Ecophysiologie et Génomique Fonctionnelle de la Vigne University BordeauxISVVUMR 1287Villenave d′Ornon F-33140France Department of General and Organic Viticulture Hochschule Geisenheim UniversityGeisenheimGermany Boyce Thompson Institute for Plant Research IthacaNY 14850USA Institut für Biochemie und Biologie Universität PotsdamKarl-Liebknecht-Str.24–25Potsdam 14476Germany

Grapevine is a perennial crop often cultivated by grafting a scion cultivar on a suitable *** influence scions,particularly with regard to water uptake and ***,one of the possibilities to adapt viticulture to the extended drought stress periods is to select rootstocks conferring increased tolerance to ***,the molecular mechanisms associated with the ability of rootstock/scion combination to influence grape berry metabolism under drought stress are still poorly *** transcriptomic changes induced by drought stress in grape berries(*** noir)from vines grafted on either 110R(drought-tolerant)or 125AA(drought-sensitive)rootstock were *** experiments were conducted in the vineyard for two years and two grape berry developmental stages(50%and 100%veraison).The genome-wide microarray approach showed that water stress strongly impacts gene expression in the berries,through ontology categories that cover cell wall metabolism,primary and secondary metabolism,signaling,stress,and hormones,and that some of these effects strongly depend on the rootstock ***,under drought stress,berries from vines grafted on 110R displayed a different transcriptional response compared to 125AA-concerning genes related to jasmonate(JA),phenylpropanoid metabolism,and pathogenesis-related *** data also suggest a link between JA and secondary metabolism in water-stressed ***,genes related to secondary metabolism and JA are more induced and/or less repressed by drought stress in the berries grafted on the drought-sensitive rootstock *** rootstock-dependent gene expression changes are relevant for berry composition and sensory properties.

关键词： metabolism drought programming