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Mandibular Fibrosarcoma and Bile Duct Adenoma in a Pet Rabbit (<i>Oryctolagus cuniculi</i>): A Case Report

Open Journal of Pathology 2014年第2期4卷 32-40页

作者： Inge Thas Gerry M. Dorrestein nathalie ariel cohen-solal DAP Thas Gent Belgium Imagerie Medical Veterinaire Brussels Belgium Pathology Laboratory NOIVBD Veldhoven The Netherlands

This report describes the clinical manifestations and pathological findings in a 4-year-old neutered male dwarf rabbit diagnosed with a mandibular fibrosarcoma. The rabbit was evaluated for a unilateral mandibular swelling and an acute onset of oral blood loss. Physical examination confirmed a marked facial asymmetry with a swollen painful left mandible. Radiographic projections of the skull revealed a left mandibular mass extending into the oral cavity. Tissue biopsies demonstrated severe bone destruction and a presumptive pathological diagnosis of a mandibular osteosarcoma were made. A helical CT (computed tomography) study of the skull confirmed the severe mandibular bone destruction and the oral extension of the mass. The patient was treated palliative with oral meloxicam and subcutaneous penicillin injections. Six months later, the rabbit died in a natural way. Postmortem examination led to final diagnosis of severe left facial malformation due to mandibular fibrosarcoma. A bile duct adenoma was found in the liver. To the author’s knowledge, this is the first description of a spontaneous mandibular fibrosarcoma in a pet rabbit.

关键词： Bile Duct Adenoma Facial Swelling Fibrosarcoma Mandible Rabbit

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Unraveling pathological mechanisms in neurological disorders:the impact of cell-based and organoid models

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Neural Regeneration Research 2022年第10期17卷 2131-2140页

作者： Jake Langlie Rahul Mittal ariel Finberg nathalie B.Bencie Jeenu Mittal Hossein Omidian Yadollah Omidi Adrien A.Eshraghi Department of Otolaryngology Hearing Research and Communication Disorders LaboratoryUniversity of Miami Miller School of MedicineMiamiFLUSA College of Pharmacy Nova Southeastern UniversityFort LauderdaleFLUSA Department of Neurological Surgery University of Miami Miller School of MedicineMiamiFLUSA Department of Biomedical Engineering University of MiamiCoral GablesFLUSA Department of Pediatrics University of Miami Miller School of MedicineMiamiFLUSA

Cell-based models are a promising tool in deciphering the molecular mechanisms underlying the pathogenesis of neurological disorders as well as aiding in the discovery and development of future drug *** greatest challenge is creating cell-based models that encapsulate the vast phenotypic presentations as well as the underlying genotypic etiology of these *** this article,we discuss the recent advancements in cell-based models for understanding the pathophysiology of neurological *** reviewed studies discussing the progression of cell-based models to the advancement of three-dimensional models and organoids that provide a more accurate model of the pathophysiology of neurological disorders in *** better we understand how to create more precise models of the neurological system,the sooner we will be able to create patient-specific models and large libraries of these neurological *** three-dimensional models can be used to discover the linking factors to connect the varying phenotypes,such models will also help to understand the early pathophysiology of these neurological disorders and how they are affected by their *** three-dimensional cell models will allow us to create more specific treatments and uncover potentially preventative measures in neurological disorders such as autism spectrum disorder,Parkinson’s disease,Alzheimer’s disease,and amyotrophic lateral sclerosis.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis autism spectrum disorder cell-based model central nervous system induced pluripotent stem cells mesenchymal stem cells organoid model organ-on-a-chip Parkinson’s disease three-dimensional model

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