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Prevalence,genotypes and factors associated with HCV infection among prisoners in Northeastern Brazil

World Journal of Gastroenterology 2011年第25期17卷 3027-3034页

作者： Bruno Fernandes de oliveira Santos nathalie oliveira de santana Alex Vianey Callado Franca department of Medicine Federal University of SergipeAracajuSergipe 49060-100Brazil

AIM:To determine hepatitis C virus (HCV) seroprevalence and its genotypes,and to identify the factors associated with HCV ***:This cross-sectional study,conducted in two prisons (one male and one female) in the State of Sergipe,Brazil,comprised 422 *** of the prisoners underwent a rapid test for the detection of HCV *** with a positive result were tested for antiHCV by enzyme linked immunosorbent assay and for HCV RNA by qualitative polymerase chain reaction (PCR).The virus genotype was defined in every serum sample that presented positive for *** order to determine the factors independently associated with positive serology for HCV,multivariate logistic regression was ***:HCV seroprevalence was 3.1%.Of the 13 subjects with positive anti-HCV,11 had viremia confirmed by *** these,90.9% had genotype 1.A total of 43 (10.2%) were injecting drug users,and HCV seroprevalence in this subgroup was 20.6%.The variable most strongly associated with positive serology for HCV was use of injecting drugs [odds ratio (OR),23.3;95% confidence interval (CI),6.0-90.8].Age over 30 years (OR,5.5;95%CI,1.1-29.2),history of syphilis (OR,9.8;95%CI,1.7-55.2) and history of household contact with HCV positive individual (OR,14.1;95%CI,2.3-85.4) were also independently associated with HCV ***:Most of the HCV transmissions result from parenteral ***,there is evidence to suggest a role for sex and household contact with an infected subject in virus transmission.

关键词：丙型肝炎病毒病毒感染基因型巴西 logistic回归发生率东北部血清阳性率

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