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Justicia insularis Improves the in vitro Survival and Development of Ovine Preantral Follicles Enclosed in Ovarian Tissue

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Journal of Pharmacy and Pharmacology 2017年第9期5卷 668-680页

作者： Gildas Tetaping Mbemya Denise Damasceno Guerreiro nathalie jiatsa donfacl~ Luciana Mascena Silv~ Luis Alberto Vieira Geovania Francisca Canafistula de Sousa Benner Geraldo Alves Aryele Pinto Izaguirry Francielli Weber Santos Phelix Bruno Telefo Otilia Deusdenia Loiola Pessoa Johan Smitz Jose Ricardo de Figueiredo Ana Paula Ribeiro Rodrigues Faculty of Veterinary (FA VET) State University of Ceara Fortaleza 60714903 Brazil Laboratory of Reproduction Biotechnology (Biotech) State of University of Pampa Uruguaiana 97500970 Brazil Laboratory of Biochemistry of Medicinal Plants Food and Nutritional Sciences Faculty of Science University of DschangDschang 3451381 Cameroon Laboratory of Phytochemical Analysis of Medicinal Plants (LAFIPLAN) Federal University of Cear6 Fortaleza 60020181 Brazil Follicle Biology Laboratory Center for Reproductive Medicine Brussels 1090 Belgium

Objectives： Evaluating the addition effect of./. insularis extract and FSH on the survival, activation and ROS production after in vitro culture of ovine preantral follicles enclosed in ovarian tissue. Methods： In the first experiment, ovarian fragments were fixed （non-cultured control） or in vitro cultured in α-MEM＋（cultured control）, α-MEM＋ supplemented with FSH 50 ng/mL, or in α-MEM＋supplemented with J. insularis （JUS0.3; 1.25 or 5 mg/mL） for 1 or 7 days, at 39℃, 5% CO2. In the second experiment, fragments were fixed or cultured in α-MEM＋ supplemented with anethole 300 μg/mL ＋ FSH 50 ng/mL or in α-MEM＋ supplemented with anethole 300μg/mL ＋ 0.3 mg/mL JUS. Key findings： JUS0.3 was the only treatment that maintained the percentage of morphologically normal follicles similar to non-cultured control even after 7 days of culture. After 7 days of culture, a higher （p 〈 0.05） percentage of developing follicles was observed in JUS5 treatment compared with the other treatments except JUS 1.25. In the second experiment, FSH maintained the percentage of normal follicles and promoted activation of primordial follicles. A reduction （p 〈 0.05） of stromal cell density was observed in MEM＋＋ANE supplemented with JUS or FSH. Conclusions： J. insularis in a concentration-dependent manner maintained the levels of ROS and improved in vitro follicular survival and activation of ovine primordial follicles.

关键词： Medicinal plant antioxidant in vitro folliculogenesis preantral follicles.

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Froth flotation of scheelite – A review

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International Journal of Mining Science and Technology 2018年第3期28卷 373-384页

作者： nathalie Kupka Martin Rudolph Helmholtz Zentrum Dresden Rossendorf (HZDR) Helmholtz Institute Freiberg for Resource Technology (HIF)

Froth flotation of scheelite has regained new focus since the 2010s and research regarding floatability and reagents has made great progress over the years. The main objective was and remains the selective flotation of scheelite from other calcium-bearing minerals, in particular calcite, fluorite and apatite. Due to similar properties, most attempts have limited success or only specific application(linked to a type of ore or a location). This article aims at reviewing all general physical-chemical information on froth flotation of scheelite, including electrokinetic properties, influence of p H and already existing reagents as well as ones still under examination. It appears that chelating or mixed collectors and modified versions of sodium silicate and quebracho hold great promise for scheelite flotation, while the use of said depressants and/or promoters seems inevitable.

关键词： Scheelite Froth flotation Calcium-bearing minerals Selectivity challenges Promising reagents

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Millimeter wave band ultra wideband transmitter MMIC

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Journal of Semiconductors 2015年第9期36卷 125-130页

作者：金凌 nathalie Rolland SVA Communication Technology Co. Ltd Institut d'Electronique de Microélectronique et de NanotechnologieUSTLVilleneuve d'Ascq CedexFrance

This paper presents a new millimeter-wave （MMW） ultra wideband （UWB） transmitter MMIC which has been developed in an OMMIC 0.1 μm GaAs PHEMT foundry process （ft= 100 GHz） for 22-29 GHz vehicular radar systems. The transmitter is composed of an MMW negative resistance oscillator （NRO）, a power amplifier （PA）, and two UWB pulse generators （PGs）. In order to convert the UWB pulse signal to MMW frequency and reduce the total power consumption, the MMW NRO is driven by one of the UWB pulse generators and the power amplifier is triggered by another UWB pulse generator. The main advantages of this transmitter are： new design, simple architecture, high-precision distance measurements, infinite ON/OFF switch ratio, and low power consumption. The total power consumption of the transmitter MMIC is 218 mW with a peak output power of 5.5 dBm at 27 GHz.

关键词： millimeter-wave ultra wideband transmitter negative resistance oscillator MMIC GaAs pHEMT

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Egg quality, fatty acid composition and immunoglobulin Y content in eggs from laying hens fed full fat camelina or flax seed

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Journal of Animal Science and Biotechnology 2016年第3期7卷 374-381页

作者： Gita Cherian nathalie Quezada Department of Animal and Rangeland Sciences Oregon State University

Background： The current study was conducted to evaluate egg quality and egg yolk fatty acids and immunoglobulin（Ig Y） content from laying hens fed full fat camelina or flax ***： A total of 75, 48-week-old Lohman brown hens were randomly allocated to 3 treatments, with 5replicates containing 5 laying hens each replicate. The hens were fed corn-soybean basal diet（Control）, or Control diet with 10 % of full fat camelina（Camelina） or flax seed（Flax） for a period of 16 wk. Hen production performance egg quality, egg yolk lipids, fatty acids and Ig Y were determined every 28 d during the experimental ***： Egg production was higher in hens fed Camelina and Flax than in Control hens（P 〈 0.05）. Egg weight and albumen weight was lowest in eggs from hens fed Camelina（P 〈 0.05）. Shell weight relative to egg weight（shell weight %）, and shell thickness was lowest in eggs from hens fed Flax（P 〈 0.05）. No difference was noted in Haugh unit, yolk：albumen ratio, and yolk weight. Significant increase in α-linolenic（18：3 n-3）, docosapentaenoic（22：5 n-3）and docoshexaenoic（22：6 n-3） acids were observed in egg yolk from hens fed Camelina and Flax. Total n-3 fatty acids constituted 1.19 % in Control eggs compared to 3.12 and 3.09 % in Camelina and Flax eggs, respectively（P 〈 0.05）. Eggs from hens fed Camelina and Flax had the higher Ig Y concentration than those hens fed Control diet when expressed on a mg/g of yolk basis（P 〈 0.05）. Although the egg weight was significantly lower in Camelina-fed hens, the total egg content of Ig Y was highest in eggs from hens fed Camelina（P 〈 0.05）.Conclusions： The egg n-3 fatty acid and Ig Y enhancing effect of dietary camelina seed warrants further attention into the potential of using camelina as a functional feed ingredient in poultry feeding.

关键词： Camelina seed Egg quality Flax seed Immunoglobulin Y n-3 fatty acids

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Predictive-reactive Strategy for Flowshop Rescheduling Problem:Minimizing the Total Weighted Waiting Times and Instability

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Journal of Systems Science and Systems Engineering 2021年第3期30卷 253-275页

作者： Ayoub Tighazoui Christophe Sauvey nathalie Sauer Universitéde Lorraine LGIPMF-57000MetzFrance

Due to the fourth revolution experiencing,referred to as Industry 4.0,many production firms are devoted to integrating new technological tools to their manufacturing *** of them,is rescheduling the tasks on the machines responding to ***,for static scheduling,the efficiency criteria measure the performance of scheduling systems,in dynamic environments,the stability criteria are also used to assess the impact of jobs *** this paper,a new performance measure is investigated for a flowshop rescheduling *** one considers simultaneously the total weighted waiting time as the efficiency criterion,and the total weighted completion time deviation as the stability *** fusion could be a very helpful and significant measure for real life industrial *** disruption types are considered:jobs arrival and jobs ***,a Mixed Integer Linear Programming(MILP)model is developed,as well as an iterative predictive-reactive strategy for dealing with the online *** last,two heuristic methods are proposed and discussed,in terms of solution quality and computing time.

关键词： Rescheduling flowshop predictive-reactive strategy weighted waiting time stability weighted completion time deviation

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High-temperature investigation of mould slag crystallization by single and double hot thermocouple techniques

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Journal of Iron and Steel Research International 2019年第4期26卷 345-354页

作者： nathalie Kolbl Irmtraud Marschall Harald Harmuth Department Mineral Resources Engineering Chair of CeramicsMontanuniversitaet LeobenLeoben 8700StyriaAustria

Methods for the characterization of mould slag crystallization with special emphasis on the single/double hot thermocouple technique(SHTT/DHTT)are *** the continuous casting process of steels,horizontal heat transfer is mainly influenced by the crystallization behaviour of the mould flux ***,both precipitation of crystals out of a liquid phase and devitrification of the glassy film in contact with the mould are of main ***,various investigation methods are implemented to characterize different slag properties related to crystallization:a viscometer for determining the break temperature,differential thermal analysis(DTA),confocal scanning laser microscopy,and the water-cooled copper finger *** near-service conditions,DHTT reveals the most detailed information,including not only the crystallization or devitrification temperature but also the morphology as well as the crystallization *** to improvements in the device and the representation of the results,a comparison of different samples is ***,the application field of SHTT/DHTT is restricted to slag systems with low contents of evaporating ***,the time required for data analysis is significantly longer than that required for other methods,***,the application of DHTT is mainly advisable for mould slag research and development,whereas DTA can also be used for incoming inspections.

关键词： Single hot thermocouple technique Double hot thermocouple technique Mould slag Near-service condition In situ investigation Crystallization

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Computational fluid dynamics simulation of Hyperloop pod predicting laminar–turbulent transition

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Railway Engineering Science 2020年第1期28卷 97-111页

作者： nathalie Nick Yohei Sato Department of Mechanical and Process Engineering Swiss Federal Institute of TechnologyETH ZurichLEO B 9.1Leonhardstrasse 278092 ZurichSwitzerland Nuclear Energy and Safety Research Division Paul Scherrer InstituteForschungsstrasse 1115232 Villigen PSISwitzerland

Three-dimensional compressible flow simulationswere conducted to develop a Hyperloop pod. Thenovelty is the usage of Gamma transition model, in whichthe transition from laminar to turbulent flow can be ***, a mesh dependency study was undertaken,showing second-order convergence with respect to themesh refinement. Second, an aerodynamic analysis for twodesigns, short and optimized, was conducted with thetraveling speed 125 m/s at the system pressure 0.15 *** concept of the short model was to delay the transitionto decrease the frictional drag;meanwhile that of theoptimized design was to minimize the pressure drag bydecreasing the frontal area and introduce the transitionmore toward the front of the pod. The computed resultsshow that the transition of the short model occurred moreon the rear side due to the pod shape, which resulted in 8%smaller frictional drag coefficient than that for the optimizedmodel. The pressure drag for the optimized designwas 24% smaller than that for the short design, half ofwhich is due to the decrease in the frontal area, and theother half is due to the smoothed rear-end shape. The totaldrag for the optimized model was 14% smaller than that forthe short model. Finally, the influence of the systempressure was investigated. As the system pressure and theReynolds number increase, the frictional drag coefficientincreases, and the transition point moves toward the front,which are the typical phenomena observed in the transitionregime.

关键词： Computational fluid dynamics(CFD) Drag Subsonic compressible flow Hyperloop Laminar-turbulent transition

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On the road to new treatments for multiple sclerosis: targeting dendritic cell migration into the central nervous system

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Neural Regeneration Research 2019年第12期14卷 2088-2090页

作者： Megha Meena nathalie Cools Laboratory of Experimental Hematology Vaccine & Infectious Disease Institute (VAXINFECTIO) Faculty of Medicine and Health Sciences University of Antwerp

Distinct migratory pathways and trafficking of dendritic cells to the central nervous system (CNS): The immune system is a host defense mechanism protecting against invaders, such as bacteria and viruses, while maintaining tolerance to self. Nonetheless, a few sites throughout the body are believed to be immunologically inert, such as the testes, the eye and the brain. Indeed, experiments in the mid-20th century gave rise to the concept of the brain as a site of immune privilege. Originally, the immune privilege of the brain was thought to be absolute, attributed by a physical blood-brain barrier (BBB) protecting the CNS from the entry of pathogens and circulating immune cells. These views have changed and currently, the CNS is seen as an immune-specialized site regulated by immunological components into and within the CNS.

关键词： new treatments multiple sclerosis nervous system

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Evidence of a Light-Sensing Role for Folate in Arabidopsis Cryptochrome Blue-Light Receptors

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Molecular Plant 2008年第1期1卷 68-74页

作者： nathalie Hoang Jean-Pierre Bouly Margaret Ahmad Universite Paris Vl Casier 156 4 Place Jussieu 75005 Paris France Penn State University 25 Yearsley Mill Road Media PA 19063 USA

Arabidopsis cryptochromes cry1 and cry2 are blue-light signalling molecules with significant structural similarity to photolyases-a class of blue-light-sensing DNA repair enzymes. Like photolyases, purified plant cryptochromes have been shown to bind both flavin and pterin chromophores. The flavin functions as a light sensor and undergoes reduction in response to blue light that initiates the signalling cascade. However, the role of the pterin in plant cryptochromes has until now been unknown. Here, we show that the action spectrum for light-dependent degradation of cry2 has a significant peak of activity at 380 nm, consistent with absorption by a pterin cofactor. We further show that cry1 protein expressed in living insect ceils responds with greater sensitivity to 380 nm light than to 450 nm, consistent with a light-harvesting antenna pigment that transfers excitation energy to the oxidized flavin of cry1. The pterin biosynthesis inhibitor DHAP selectively reduces cryptochrome responsivity at 380 nm but not 450 nm blue light in these cell cultures, indicating that the antenna pigment is a folate cofactor similar to that of photolyases.

关键词： a Light-Sensing Role for Folate Arabidopsis Cryptochrome Blue-Light Receptors

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The exercise-cognition relationship:A virtuous circle

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Journal of Sport and Health Science 2019年第4期8卷 339-347页

作者： Michel Audiffren nathalie André Research Institute on Cognition and Learning (UMR CNRS 7295) University of PoitiersSport Sciences Faculty

Exercise and health psychology have generated 2 sets of empirical studies guided by separate theory-driven *** first axis focuses on the causal relationship between chronic exercise and cognition and,more particularly,high-level cognitive functions such as executive functions(EFs).The second axis examines factors influencing the adherence process to physical activity(PA).Research conducted during the past decade shows that these 2 topics are closely linked,with EFs and effortful control playing a pivotal role in the bidirectional relationship linking PA and mental/brain *** present article supports the idea that an individual engaged in the regular practice of effortful PA initiates a virtuous circle linking PA and effortful control in a bidirectional *** the one hand,chronic exercise leads to an improvement of EFs and effortful *** the other hand,gains in EFs and effortful control effectiveness lead to a reciprocal facilitation of the maintenance of PA over *** limitations and perspectives to this effort hypothesis are proposed in the last part of the article.

关键词： Adherence Effort Executive functions Physical activity Salience network

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