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Artificial light at night decreases the pupillary light response of dark-adapted toads to bright light

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Integrative Zoology 2023年第5期18卷 867-875页

作者： Jean SECONDI Madeleine f.SCRIBA nathalie MONDY Thierry LENGAGNE Univ Lyon UniversitéClaude Bernard Lyon 1CNRSENTPEVilleurbanneFrance facultédes Sciences Universitéd’AngersAngersFrance

Artificial light at night(ALAN)is expanding *** physiological effects have been reported in animals,but we still know little about the consequences for the visual *** pupil contributes to control incoming light onto the *** increases in light intensity evokes the pupil light reflex(PLR).Intrinsically photosensitive retinal ganglion cells(ipRGC)affect PLR and melatonin expression,which largely regulate circadian rhythms and PLR *** receive inputs from various photoreptors with different peak sensitivities implying that PLR could be altered by a broad range of light *** predicted ALAN to enhance *** to our prediction,dark-adapted cane toads Rhinella marina,exposed to ALAN(5 lx)for 12 days,exhibited a lower PLR than controls and individuals exposed to 0.04 lx,even after 1 h in bright *** cannot conclude whether ALAN induced a larger pupil size in dark-adapted toads or a slower initial ***,the response was triggered by a light source with an emission peak(590 nm)well above the sensitivity peak of melanopsin,the main photoreceptor involved in ***,ALAN alters the capacity of toads to regulate the incoming light in the eye at night,which may reduce the performance of visually guided behaviors,and increase mortality by predators or road kills at *** first study emphasizes the need to focus on the effect of ALAN on the vision of nocturnal organisms to better understand how this sensory system is altered and anticipate the consequences for organisms.

关键词： amphibian anuran light pollution pupillary light reflex vision

froth flotation of scheelite – A review

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International Journal of Mining Science and Technology 2018年第3期28卷 373-384页

作者： nathalie Kupka Martin Rudolph Helmholtz Zentrum Dresden Rossendorf (HZDR) Helmholtz Institute Freiberg for Resource Technology (HIF)

froth flotation of scheelite has regained new focus since the 2010s and research regarding floatability and reagents has made great progress over the years. The main objective was and remains the selective flotation of scheelite from other calcium-bearing minerals, in particular calcite, fluorite and apatite. Due to similar properties, most attempts have limited success or only specific application(linked to a type of ore or a location). This article aims at reviewing all general physical-chemical information on froth flotation of scheelite, including electrokinetic properties, influence of p H and already existing reagents as well as ones still under examination. It appears that chelating or mixed collectors and modified versions of sodium silicate and quebracho hold great promise for scheelite flotation, while the use of said depressants and/or promoters seems inevitable.

关键词： Scheelite froth flotation Calcium-bearing minerals Selectivity challenges Promising reagents

Millimeter wave band ultra wideband transmitter MMIC

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Journal of Semiconductors 2015年第9期36卷 125-130页

作者：金凌 nathalie Rolland SVA Communication Technology Co. Ltd Institut d'Electronique de Microélectronique et de NanotechnologieUSTLVilleneuve d'Ascq CedexFrance

This paper presents a new millimeter-wave （MMW） ultra wideband （UWB） transmitter MMIC which has been developed in an OMMIC 0.1 μm GaAs PHEMT foundry process （ft= 100 GHz） for 22-29 GHz vehicular radar systems. The transmitter is composed of an MMW negative resistance oscillator （NRO）, a power amplifier （PA）, and two UWB pulse generators （PGs）. In order to convert the UWB pulse signal to MMW frequency and reduce the total power consumption, the MMW NRO is driven by one of the UWB pulse generators and the power amplifier is triggered by another UWB pulse generator. The main advantages of this transmitter are： new design, simple architecture, high-precision distance measurements, infinite ON/Off switch ratio, and low power consumption. The total power consumption of the transmitter MMIC is 218 mW with a peak output power of 5.5 dBm at 27 GHz.

关键词： millimeter-wave ultra wideband transmitter negative resistance oscillator MMIC GaAs pHEMT

Egg quality, fatty acid composition and immunoglobulin Y content in eggs from laying hens fed full fat camelina or flax seed

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Journal of Animal Science and Biotechnology 2016年第3期7卷 374-381页

作者： Gita Cherian nathalie Quezada Department of Animal and Rangeland Sciences Oregon State University

Background： The current study was conducted to evaluate egg quality and egg yolk fatty acids and immunoglobulin（Ig Y） content from laying hens fed full fat camelina or flax ***： A total of 75, 48-week-old Lohman brown hens were randomly allocated to 3 treatments, with 5replicates containing 5 laying hens each replicate. The hens were fed corn-soybean basal diet（Control）, or Control diet with 10 % of full fat camelina（Camelina） or flax seed（flax） for a period of 16 wk. Hen production performance egg quality, egg yolk lipids, fatty acids and Ig Y were determined every 28 d during the experimental ***： Egg production was higher in hens fed Camelina and flax than in Control hens（P 〈 0.05）. Egg weight and albumen weight was lowest in eggs from hens fed Camelina（P 〈 0.05）. Shell weight relative to egg weight（shell weight %）, and shell thickness was lowest in eggs from hens fed flax（P 〈 0.05）. No difference was noted in Haugh unit, yolk：albumen ratio, and yolk weight. Significant increase in α-linolenic（18：3 n-3）, docosapentaenoic（22：5 n-3）and docoshexaenoic（22：6 n-3） acids were observed in egg yolk from hens fed Camelina and flax. Total n-3 fatty acids constituted 1.19 % in Control eggs compared to 3.12 and 3.09 % in Camelina and flax eggs, respectively（P 〈 0.05）. Eggs from hens fed Camelina and flax had the higher Ig Y concentration than those hens fed Control diet when expressed on a mg/g of yolk basis（P 〈 0.05）. Although the egg weight was significantly lower in Camelina-fed hens, the total egg content of Ig Y was highest in eggs from hens fed Camelina（P 〈 0.05）.Conclusions： The egg n-3 fatty acid and Ig Y enhancing effect of dietary camelina seed warrants further attention into the potential of using camelina as a functional feed ingredient in poultry feeding.

关键词： Camelina seed Egg quality flax seed Immunoglobulin Y n-3 fatty acids

Non-alcoholic fatty liver disease and the impact of genetic,epigenetic and environmental factors in the offspring

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World Journal of Gastroenterology 2022年第25期28卷 2890-2899页

作者： Natalia Balassiano Wajsbrot nathalie Carvalho Leite Gil f Salles Cristiane A Villela-Nogueira Division of Hepatology Clementino Fraga Filho University HospitalFederal University of Rio de JaneiroRio de Janeiro 20941-913Brazil Department of Internal Medicine Medical SchoolFederal University of Rio de JaneiroRio de Janeiro 22750-240Brazil

Non-alcoholic fatty liver disease(NAfLD)is the most common chronic liver disease worldwide and is strongly associated with metabolic *** recently,a significant impact of parental NAfLD in the offspring was demonstrated and has been widely ***,pathogenetic pathways implicated in the inheritance by the offspring and relatives are still under ***,multiple mechanisms are involved as well as in NAfLD pathogenesis *** the multifactorial involved mechanisms,genetic,epigenetic and environmental backgrounds are strongly related to NAfLD development in the ***,based on recent evidence from the available literature concerning genetic,epigenetic and environmental disease modifiers,this review aimed to discuss the relationship between parental NAfLD and its impact on the offspring.

关键词： Steatosis Genetic Epigenetic Environmental Offspring Non-alcoholic fatty liver disease

Predictive-reactive Strategy for flowshop Rescheduling Problem:Minimizing the Total Weighted Waiting Times and Instability

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Journal of Systems Science and Systems Engineering 2021年第3期30卷 253-275页

作者： Ayoub Tighazoui Christophe Sauvey nathalie Sauer Universitéde Lorraine LGIPMF-57000MetzFrance

Due to the fourth revolution experiencing,referred to as Industry 4.0,many production firms are devoted to integrating new technological tools to their manufacturing *** of them,is rescheduling the tasks on the machines responding to ***,for static scheduling,the efficiency criteria measure the performance of scheduling systems,in dynamic environments,the stability criteria are also used to assess the impact of jobs *** this paper,a new performance measure is investigated for a flowshop rescheduling *** one considers simultaneously the total weighted waiting time as the efficiency criterion,and the total weighted completion time deviation as the stability *** fusion could be a very helpful and significant measure for real life industrial *** disruption types are considered:jobs arrival and jobs ***,a Mixed Integer Linear Programming(MILP)model is developed,as well as an iterative predictive-reactive strategy for dealing with the online *** last,two heuristic methods are proposed and discussed,in terms of solution quality and computing time.

关键词： Rescheduling flowshop predictive-reactive strategy weighted waiting time stability weighted completion time deviation

High-temperature investigation of mould slag crystallization by single and double hot thermocouple techniques

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Journal of Iron and Steel Research International 2019年第4期26卷 345-354页

作者： nathalie Kolbl Irmtraud Marschall Harald Harmuth Department Mineral Resources Engineering Chair of CeramicsMontanuniversitaet LeobenLeoben 8700StyriaAustria

Methods for the characterization of mould slag crystallization with special emphasis on the single/double hot thermocouple technique(SHTT/DHTT)are *** the continuous casting process of steels,horizontal heat transfer is mainly influenced by the crystallization behaviour of the mould flux ***,both precipitation of crystals out of a liquid phase and devitrification of the glassy film in contact with the mould are of main ***,various investigation methods are implemented to characterize different slag properties related to crystallization:a viscometer for determining the break temperature,differential thermal analysis(DTA),confocal scanning laser microscopy,and the water-cooled copper finger *** near-service conditions,DHTT reveals the most detailed information,including not only the crystallization or devitrification temperature but also the morphology as well as the crystallization *** to improvements in the device and the representation of the results,a comparison of different samples is ***,the application field of SHTT/DHTT is restricted to slag systems with low contents of evaporating ***,the time required for data analysis is significantly longer than that required for other methods,***,the application of DHTT is mainly advisable for mould slag research and development,whereas DTA can also be used for incoming inspections.

关键词： Single hot thermocouple technique Double hot thermocouple technique Mould slag Near-service condition In situ investigation Crystallization

Computational fluid dynamics simulation of Hyperloop pod predicting laminar–turbulent transition

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Railway Engineering Science 2020年第1期28卷 97-111页

作者： nathalie Nick Yohei Sato Department of Mechanical and Process Engineering Swiss Federal Institute of TechnologyETH ZurichLEO B 9.1Leonhardstrasse 278092 ZurichSwitzerland Nuclear Energy and Safety Research Division Paul Scherrer InstituteForschungsstrasse 1115232 Villigen PSISwitzerland

Three-dimensional compressible flow simulationswere conducted to develop a Hyperloop pod. Thenovelty is the usage of Gamma transition model, in whichthe transition from laminar to turbulent flow can be ***, a mesh dependency study was undertaken,showing second-order convergence with respect to themesh refinement. Second, an aerodynamic analysis for twodesigns, short and optimized, was conducted with thetraveling speed 125 m/s at the system pressure 0.15 *** concept of the short model was to delay the transitionto decrease the frictional drag;meanwhile that of theoptimized design was to minimize the pressure drag bydecreasing the frontal area and introduce the transitionmore toward the front of the pod. The computed resultsshow that the transition of the short model occurred moreon the rear side due to the pod shape, which resulted in 8%smaller frictional drag coefficient than that for the optimizedmodel. The pressure drag for the optimized designwas 24% smaller than that for the short design, half ofwhich is due to the decrease in the frontal area, and theother half is due to the smoothed rear-end shape. The totaldrag for the optimized model was 14% smaller than that forthe short model. finally, the influence of the systempressure was investigated. As the system pressure and theReynolds number increase, the frictional drag coefficientincreases, and the transition point moves toward the front,which are the typical phenomena observed in the transitionregime.

关键词： Computational fluid dynamics(CfD) Drag Subsonic compressible flow Hyperloop Laminar-turbulent transition

On the road to new treatments for multiple sclerosis: targeting dendritic cell migration into the central nervous system

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Neural Regeneration Research 2019年第12期14卷 2088-2090页

作者： Megha Meena nathalie Cools Laboratory of Experimental Hematology Vaccine & Infectious Disease Institute (VAXINFECTIO) Faculty of Medicine and Health Sciences University of Antwerp

Distinct migratory pathways and trafficking of dendritic cells to the central nervous system (CNS): The immune system is a host defense mechanism protecting against invaders, such as bacteria and viruses, while maintaining tolerance to self. Nonetheless, a few sites throughout the body are believed to be immunologically inert, such as the testes, the eye and the brain. Indeed, experiments in the mid-20th century gave rise to the concept of the brain as a site of immune privilege. Originally, the immune privilege of the brain was thought to be absolute, attributed by a physical blood-brain barrier (BBB) protecting the CNS from the entry of pathogens and circulating immune cells. These views have changed and currently, the CNS is seen as an immune-specialized site regulated by immunological components into and within the CNS.

关键词： new treatments multiple sclerosis nervous system