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Analysis of mid-spatial frequency wavefront distortions from a liquid-cooled flash-lamp pumped Nd:phosphate laser amplifier

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High Power Laser Science and Engineering 2024年第1期12卷 24-29页

作者： Pierre-Marie Dalbies Sandy Cavaro Edouard Bordenave nathalie Blanchot Julien G.Moreau Jérôme Neauport CEA CESTA Le BarpFrance

Mid-spatial frequency wavefront deformation can be deleterious for the operation of high-energy laser systems. When fluid cooled high-repetition-rate amplifiers are used, the coolant flow is likely to induce such detrimental mid-spatial frequency wavefront deformations. Here, we describe the design and performance of a 90 mm × 90 mm aperture, liquid-cooled Nd:phosphate split-slab laser amplifier pumped by flash-lamps. The performance of the system is evaluated in terms of wavefront aberration and gain at repetition rates down to 1 shot per minute. The results show that this single cooled split-slab system exhibits low wavefront distortions in the medium to large period range, compatible with a focus on target, and despite the use of liquid coolant traversed by both pump and amplified wavelengths. This makes it a potential candidate for applications in large high-energy laser facilities.

关键词： flash-lamp pumping high-power laser laser cooling neodymium glass wavefront error

Z-Score in Fetal Echocardiography–Is there Still Room for New Studies?

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Congenital Heart Disease 2024年第3期19卷 305-314页

作者： Marcio Fragoso Vieira nathalie Jeanne Bravo-Valenzuela Edward Araujo Júnior Department of Obstetrics Paulista School of MedicineFederal University of São Paulo(EPM-UNIFESP)São Paulo-SP04023-062Brazil Department of Obstetrics Federal University of Ceará(UFC)Sobral-CE60020-181Brazil Department of Pediatrics Pediatric CardiologySchool of MedicineFederal University of Rio de Janeiro(UFRJ)Rio de Janeiro-RJ21941-853Brazil

Congenital heart disease(CHD)is the most common type of birth defect,representing a signiﬁcant cause of peri-natal morbidity and *** diagnosis of such anomalies is crucial for improving *** pro-tocols recommend a qualitative assessment of cardiac structures using two-dimensional ultrasound(2DUS)and color Doppler *** cases of suspected abnormalities,quantitative assessments through cardiac structure measurements and reference curves can aid in accurate *** to centiles widely employed in obste-trics,Z-scores provide more precise quantiﬁcation of various cardiac structures,particularly at the extremes of the *** the development of reference curves and Z-scores has progressed over the past two decades,a lack of standardization in measurements and statistical methodology for their determination is *** reference curves requires adherence to speciﬁc recommendations to improve their *** purpose of this study is to provide a narrative review of the major studies that have generated reference values for cardiac struc-tures using 2DUS and Z-scores,to evaluate their methodology,and to provide a summary of the results.

关键词： Z-scores reference ranges fetal echocardiography

Human Papillomavirus Within Psoriasis Plaques in a Patient With Psoriasis:A Case Report

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International Journal of Dermatology and Venereology 2024年第1期7卷 55-57页

作者： Karen P.Lema-Matehu nathalie P.Lascano-Gallegos Santiago A.Palacios-Álvarez School of Medicine Eugenio Espejo UTE UniversityQuito 170147Ecuador Department of Dermatology Centro de la PielQuito 170508Ecuador

Introduction:Psoriasis may be triggered by several factors,and its pathophysiology is related to inflammatory cellular *** herein describe a patient with psoriasis who developed warts on multiple psoriasis plaques and was successfully treated with systemic subcutaneous *** presentation:A 67-year-old man who had been diagnosed with psoriasis 14 years previously developed an outbreak of small erythematous desquamative plaques distributed symmetrically on his arms and *** spiny whitish papules had developed over his previously established psoriasis *** appearance of the papules was consistent with viral *** patient was treated with systemic methotrexate injected subcutaneously and oral folic acid,both dosed *** treatment produced good ***:A remarkable feature of this case is that psoriasis was the first diagnosis and that human papillomavirus(HPV)appeared over widespread erythematous squamous *** pathophysiology of psoriasis is related to inflammatory cellular *** authors have reported that HPV proteins may stimulate keratinocyte *** have reported that HPV infection mostly stimulates systemic interleukin 17 production;consequently,HPV infection could provide a better environment for interleukin 17 secretion and facilitate new onset of *** report indicated that methotrexate was discontinued in a patient who presented with both pathologies,although we had very good ***:Psoriasis and HPV may be pathophysiologically *** may stimulate keratinocyte proliferation and systemic interleukin 17 production,resulting in a better environment for *** methotrexate injected subcutaneously resulted in a good outcome in our patient.

关键词： human papillomavirus methotrexate psoriasis case report

Evaluation of the Reproduction Parameters of “Lohmann Brown” Strain Chickens Fed with Cajanus cajan Leaf Meal in the Republic of Congo

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Open Journal of Animal Sciences 2024年第3期14卷 234-248页

作者： Richard Missoko Mabeki Alexis Jonas Ognika Dora Chérita Ekou nathalie Myreille Ockoyi Parisse Akouango Laboratory of Animal Production and Biodiversity National School of Agronomy and Forestry Marien Ngouabi University Brazzaville Republic of the Congo Department of Animal Production and Health Marien Ngouabi University Brazzaville Republic of the Congo

The objective of this study was to evaluate the reproductive parameters of “Lohmann Brown” strain chickens fed on Cajanus cajan leaves and to assess the viability of the chicks after hatching. 40 hens of the “Lohmann Brown” strain fed on Cajanus cajan leaf flour laid 219 eggs divided into four batches depending on the rate of incorporation of Cajanus cajan leaf flour in the rations (0%, 5%, 10% and 15%) were trained and introduced into the incubator. Results: the incubator indicates a hatching temperature of 38˚C to 37.2˚C and relative humidity of 60% to 70%. Hatching performance shows that: The 15% batch recorded the highest fertility rate 86.95% compared to 26.88% of the control batch. The CC 15% batch recorded the highest hatching rate 36.87. The lowest rate (17.18%) was recorded in the control batch (CC 0%). The highest embryonic mortality rate was recorded in the CC 15% batch. The lowest rate in the CC 10% batch. Concerning unfertilized eggs, the highest rate is 72.20% (CC 0%), and the lowest are (12.03%;57.42% and 66.66%) recorded in CC batches. 15%, CC 5% and CC 10% respectively. For the shell mortality rate, the highest is 18.58% recorded in the CC 15% batch. The lowest shell mortality rate is 2.07%, obtained in the control batch (CC 0%);the dust mortality rate was 0% for all chicks. The study seems to indicate that the incorporation of Cajanus cajan leaf meal up to 15% into the reproduction type ration in hens does not cause any harmful effects on the reproduction performance of laying hens.

关键词： Egg Incubation Hatching Fertility Mortality Viability

On the impact of grinding conditions in the flotation of semi-soluble salt-type mineral-containing ores driven by surface or particle geometry effects?

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International Journal of Mining Science and Technology 2023年第7期33卷 855-872页

作者： Lucas Pereira nathalie Kupka Duong Huu hoang Bruno Michaux Sondos Saquran Doreen Ebert Martin Rudolph Helmholtz-Zentrum Dresden-Rossendorf Helmholtz Institute Freiberg for Resource TechnologyFreiberg 09599Germany Maelgwyn Mineral Services Ltd Cardiff CF244PAUnited Kingdom

Grinding and flotation processes are often studied independently, despite the well-established grinding influence on flotation performance, which affects not only particle size and thus liberation but also shape and leads to complex changes in pulp chemistry affecting the particle surface properties relevant for selective bubble attachment. Yet, no study jointly investigated these possible causes and many are limited to single mineral flotation. We relate grinding conditions to changes in pulp chemistry and particle surface properties and assess their impact on upgrading. We studied three non-sulfide ores with different feed grades and valuables: scheelite, apatite, and fluorite. These were dry-, wet-, and wet conditionedground before flotation in a laboratory mechanical cell. Results were evaluated with bulk-and particle-specific methodologies. The selectivity of the process is higher after dry grinding for the fluorite and apatite ores and irrelevant for the scheelite ore. Variations in flotation kinetics of individual particles associated to their size and shape are not sufficient to explain these results. The higher concentration of Ca2+and Mg2+observed in the pulp after wet grinding, altering particle surface properties, better explains the phenomenon. Additionally, we demonstrate how particle shape impacts are system specific and related to both entrainment and true flotation.

关键词： Grinding-flotation interactions Semi-soluble salt-type minerals Geometallurgy Particle-based separation modelling Surface interactions

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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Military Medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu Marina A.Gritsenko Young-Mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

Intraocular complications of IFN-α and ribavirin therapy in patients with chronic viral hepatitis C

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World Journal of Gastroenterology 2007年第22期13卷 3137-3140页

作者： Damien Sène Valérie Touitou Bahram Bodaghi David Saadoun Gabriel Perlemuter nathalie Cassoux Jean-Charles Piette Phuc Le hoang Patrice Cacoub Department of Internal Medicine Hpital Pitié-Salpêtrière Paris France Department of Ophtalmology Hpital Pitié-Salpêtrière Paris France Department of Hepatogastroenterology Hpital Antoine Béclère Clamart. France

We report a panel of severe inflammatory and vascular intraocular disorders occurring during interferon-alpha （IFN-α） treatment in eight hepatitis C virus （HCV）- infected patients. These events include three cases of Vogt-Koyanagi-Harada like （VKH） disease （an association of panuveitis, retinal detachment, ear and meningeal detachment and skin and hair changes）, two cases of central retinal vein occlusion, one case of central retinal artery occlusion, one case of severe hypertensive retinopathy and one case of bilateral ischemic optic neuropathy with severe visual impairment. Rare as they are, such severe ophthalmological complications require a close follow-up of HCV-infected patients under IFN-α breabnent with ophthalmological monitoring if any ocular manifestation occurs.

关键词： Hepatitis C virus Interferon-alpha Intra-ocular complications Central retinal vein occlusion Central retinal artery occlusion Acute anterior ischemicoptic neuritis Vogt-Koyanagi-Harada like disease

Froth flotation of scheelite – A review

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International Journal of Mining Science and Technology 2018年第3期28卷 373-384页

作者： nathalie Kupka Martin Rudolph Helmholtz Zentrum Dresden Rossendorf (HZDR) Helmholtz Institute Freiberg for Resource Technology (HIF)

Froth flotation of scheelite has regained new focus since the 2010s and research regarding floatability and reagents has made great progress over the years. The main objective was and remains the selective flotation of scheelite from other calcium-bearing minerals, in particular calcite, fluorite and apatite. Due to similar properties, most attempts have limited success or only specific application(linked to a type of ore or a location). This article aims at reviewing all general physical-chemical information on froth flotation of scheelite, including electrokinetic properties, influence of p H and already existing reagents as well as ones still under examination. It appears that chelating or mixed collectors and modified versions of sodium silicate and quebracho hold great promise for scheelite flotation, while the use of said depressants and/or promoters seems inevitable.

关键词： Scheelite Froth flotation Calcium-bearing minerals Selectivity challenges Promising reagents

Risk Factors Associated with Unsuccessful Vaginal Birth after One Cesarean (VBAC-1) in Puerto Rico

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Open Journal of Obstetrics and Gynecology 2024年第6期14卷 888-902页

作者： Irazú Guinan Marjorie Suárez Fabiola Angulo Luis Mayol Paula Suárez Lisandris Dominicci nathalie Chang Saribel Torres Antonio Rodríguez Raymond L. Tremblay Maricarmen Colón-Díaz Department of Physiology and Pathology San Juan Bautista School of Medicine Caguas USA

Background: Cesarean section (CS) has increased steadily over the last decade, with an estimated one-third of women delivering by cesarean section worldwide. Objective: Our study aimed to investigate the demographic and associated factors influencing vaginal birth after one cesarean (VBAC-1) success focusing on variables like pre-pregnancy BMI, diabetes, hypertension, education, and smoking. Study Design and Methods: In this retrospective study, we analyzed 285 cases (81 unsuccessful VBAC-1, 204 successful VBAC-1) from San Juan City Hospital (Puerto Rico) between January 1, 2019, and December 31, 2020. We used odds ratios and model selection comparison to assess the impact of variables on successful VBAC-1, using a significance threshold of 95% CI. Model selection assessed binomial model combinations using a generalized linear approach to identify key risk factors. Results: Unsuccessful VBAC-1 (a repeat cesarean), was associated with diabetes (OR: 0.376, p = 0.086), hypertension (OR: 0.23, p = 0.006), and university-educated women (OR: 1.372, p = 0.711). High school-educated women had an OR of 3.966 (p = 0.105), while overweight women were 0.481 times more likely to have unsuccessful VBAC-1 (p = 0.041). Significant associations were not found with obesity (OR: 0.574, p = 0.122), underweight/normal (OR: 1.01, p = 0.810), or smoking (OR: 1.227, p = 0.990). Conclusion: Results revealed women with higher education levels, hypertension, or diabetes are less likely to have a successful VBAC-1. Understanding the complex interactions affecting these outcomes is aimed at establishing guidelines for healthcare professionals to conduct systematic risk/benefit assessments. This study lays a foundation for evidence-based practices and policies, offering initial insights into VBAC-1 success factors in Puerto Rico.

关键词： Diabetes Hypertension Obesity Trial of Labor Vaginal Birth after Cesarean