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分子细胞生物学报:英文版 2016年第1期8卷 2-16页

作者： Yanping Zhu Ta-Wei Liu Zarina Madden Scott A.Yuzwa Kelsey Murray Samy Cecioni natasha Zachara David J.Vocadlo Department of Chemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Molecular Biology and Biochemistry Simon Fraser UniversityBurnabyBritish Columbia V5A 1S6Canada Department of Biological Chemistry Johns Hopkins University Medical SchoolBaltimoreMD 21205USA

O-glycosylation of the nuclear pore complex(NPC)by O-linked N-acetylglucosamine(O-GlcNAc)is conserved within *** nucleoporins(Nups)comprising the NPC are constitutively O-GlcNAcylated,but the functional role of this modification remains *** loss ofO-GlcNAc,induced by either inhibition ofO-GlcNAc transferase(OGT)or deletion of the gene encoding OGT,leads to decreased cellular levels of a number of natively O-GlcNAcylated *** of O-GlcNAc enables increased ubiquitination of these Nups and their increased proteasomal *** decreased half-life of these deglycosylated Nups manifests in their gradual loss from the NPC and a downstream malfunction of the nuclear pore selective permeability barrier in both dividing and post-mitotic *** findings define a critical role of O-GlcNAc modification of the NPC in maintaining its composition and the function of the selectivity *** results implicate NPC glycosylation as a regulator of NPC function and reveal the role of conserved glycosylation of the NPC among metazoans.

关键词： post-translational modiﬁcation O-GlcNAcylation nuclear pore complex protein stability ubiquitination nucleoporin glycosylation

The Effects of Pre-Surgical Education on Patient Expectations in Total Knee Arthroplasties

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Open Journal of Preventive Medicine 2015年第12期5卷 449-455页

作者： Steven Furney natasha Montez Department of Health and Human Performance Texas State University San Marcos USA Invictus Health Solutions New Braunfels USA

As patients prepare for total-knee arthroplasty surgery, they have many expectations related to their long-term recovery and function. This research examined whether the use of a pre-surgical patient education class with an additional long-term expectation module addressing recovery during the first 12 months after surgery was more effective in modifying participant’s pre-surgical expectations than participants receiving the standard pre-surgical education class alone. Prior to the class each participant completed one disease-specific instrument, a general-health survey, and a total-knee replacement expectation survey. After the class, each participant once again completed the total-knee replacement survey. Included in the study were 42 participants who were enrolled in a pre-surgical education course that was randomized. The participants in the control group received the standard pre-surgical education addressing pre-surgical topics. The participants in the intervention group received the standard pre-surgical education plus an additional module that specifically addressed long-term recovery and function up to 12 months post surgery. The primary outcome of the data revealed that participants’ who received the standard pre-surgical education with the additional module and who had an educational level higher than highschool, had expectations that were able to be modified to coincide with the surgeons’ expectations.

关键词： Osteoarthritis Total-Knee Arthroplasty Pre-Surgical Education Patient Expectations

Suitable energy platform significantly improves charge separation of g-C3N4 for CO2 reduction and pollutant oxidation under visible-light

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Progress in Natural Science:Materials International 2019年第2期29卷 138-144页

作者： Amir Zada Nauman Ali Fazle Subhan natasha Anwar Muhammad Ishaq Ali Shah Muhammad Ateeq Zahid Hussain Khair Zaman Momin Khan Department of Chemistry Abdul Wali Khan University Key Laboratory of Functional Inorganic Materials Chemistry (Heilongjiang University) Ministry of Education School of Chemistry and Materials Science International Joint Research Center for Catalytic Technology Institute of Chemical Sciences University of Peshawar

The photocatalytic activities of g-C3N4can be significantly improved by increasing life time of the photogenerated charges. Here, in this work we introduced TiO2as proper energy platform to accept the photogenerated electrons from g-C3N4during photocatalysis. The nanophotocatalysts formed from the combination of a suitable amount of TiO2nanoparticles and g-C3N4nanosheets showed 8.75 and 4.22% enhancement in photocatalytic activities for CO2reduction and 2-chlorophenol(2-CP) degradation under visible light illumination as compared to bare g-C3N4. Based on the surface photovoltage spectra, photoluminescence spectra and examination of formed hydroxyl radicals, it was confirmed that these enhanced photoactivities were attributed to the much-improved charge separation via the electron transfer from g-C3N4to TiO2. From trapping experiments,it was found that hydroxyl radicals were the major species involved in the photocatalytic degradation of *** study is helpful to synthesize efficient photocatalysts to cope with energy and environmental issues.

关键词： Nanophotocatalyst Charge separation CO2 reduction Pollutant degradation

Automated Deep Learning Empowered Breast Cancer Diagnosis UsingBiomedical Mammogram Images

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Computers, Materials & Continua 2022年第6期71卷 4221-4235页

作者： JoséEscorcia-Gutierrez Romany F.Mansour Kelvin Belen Javier Jiménez-Cabas Meglys Pérez natasha Madera Kevin Velasquez Electronics and Telecommunications Engineering Program Universidad Autónoma del CaribeBarranquilla08001Colombia Department of Mathematics Faculty of ScienceNew Valley UniversityEl-Kharga72511Egypt Mechatronics Engineering Program Universidad Autónoma del CaribeBarranquilla08001Colombia Department of Computational Science and Electronic Universidad de la CostaCUCBarranquilla08001Colombia

Biomedical image processing is a hot research topic which helps to majorly assist the disease diagnostic *** the same time,breast cancer becomes the deadliest disease among women and can be detected by the use of different imaging *** mammograms can be used for the earlier identification and diagnostic of breast cancer to minimize the death *** the proper identification of breast cancer has mainly relied on the mammography findings and results to increased false *** resolving the issues of false positives of breast cancer diagnosis,this paper presents an automated deep learning based breast cancer diagnosis(ADL-BCD)model using digital *** goal of the ADL-BCD technique is to properly detect the existence of breast lesions using digital *** proposed model involves Gaussian filter based pre-processing and Tsallis entropy based image *** addition,Deep Convolutional Neural Network based Residual Network(ResNet 34)is applied for feature extraction ***,a hyper parameter tuning process using chimp optimization algorithm(COA)is applied to tune the parameters involved in ResNet 34 *** wavelet neural network(WNN)is used for the classification of digital mammograms for the detection of breast *** ADL-BCD method is evaluated using a benchmark dataset and the results are analyzed under several performance *** simulation outcome indicated that the ADL-BCD model outperforms the state of art methods in terms of different measures.

关键词： Breast cancer digital mammograms deep learning wavelet neural network Resnet 34 disease diagnosis

Assessment scales for delirium: A review

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World Journal of Psychiatry 2012年第4期2卷 58-70页

作者： Sandeep Grover natasha Kate Department of Psychiatry Postgraduate Institute of Medical Education and Research Chandigarh 160012 India

Over the years many scales have been designed for screening, diagnosis and assessing the severity of delirium. In this paper we review the various instruments available to screen the patients for delirium, instruments available to diagnose delirium, assess the severity, cognitive functions, motoric subtypes, etiology and associated distress. Among the various screening instruments, NEECHAM confusion scale and delirium observation scale appear to be most suitable screening instrument for patients' in general medical and surgical wards, depending on the type of rater(physician or nurse). In general, the instruments which are used for diagnosis [i.e., confusion assessment method(CAM), CAM for intensive care unit(CAM-ICU), Delirium Rating Scale-revised version(DRS-R-98), memorial selirium assessment scale, etc. ] are based on various Diagnostic and Statistical Manual criteria and have good to excellent reliability and fair to good validity. Among the various diagnostic instruments, CAM is considered to be most useful instrument because of its accuracy, brevity, and ease of use by clinicians and lay interviewers. In contrast, DRS-R-98 appears to be a comprehensive instrument useful for diagnosis, severity rating and is sensitive to change and hence can be used for monitoring patients over a period. In the ICU setting, evidence suggests that CAM-ICU and Nursing Delirium Screening Scale had comparable sensitivities, but CAM-ICU has higher specificity. With regard to assessment of delirium in pediatric age group, certain instruments like Pediatric Anesthesia Emergence Delirium scale and pediatric CAM-ICU has been designed and have been found to be useful.

关键词： Delirium Screening Diagnosis Cognition

Nephrotic Sydrome Can Be a Marker for Prostatic Carcinoma

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Modern Research in Inflammation 2017年第4期6卷 29-36页

作者： natasha Takova Alexander Otsetov Department of Urology Centre Hospitalier Saint Dié des Vosges Saint-Dié des Vosges France Department of Pathology Institute for Medical Biosciences Ume&#229 University Ume&#229 Sweden

Paraneoplastic syndromes (PS) represent a large spectrum of symptoms, associated with malignant diseases. PS can be diagnosed in asymptomatic patients with occult carcinoma, clinically active cancer, and during clinical remission, suggesting a recurrence of the neoplasm. The underlying mechanisms of PS are not completely understood but several authors have suggested that the increased production of biologically active immune factors and cytokines from the neoplastic cells may underlie the etiology of PS. Although rare, the renal involvement of patients with prostatic carcinoma has been reported. The most common paraneoplastic-associated glomerulopathy in prostatic cancer is the membranoproliferative glomerulonephritis with nephrotic syndrome (NS). In this review, we aimed to discuss the incidence of nephrotic syndrome secondary to prostatic carcinoma, its challenging diagnosis, clinical manifestation, and treatment.

关键词： Paraneoplastic Syndromes Prostatic Carcinoma Malignancy-Associated Glomerulonephritis Nephrotic Syndrome (Bio)Marker

Identification and Preliminary Characterization of a New Chemical Affecting Glucosyltransferase Activities Involved in Plant Cell Wall Biosynthesis

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Molecular Plant 2008年第6期1卷 977-989页

作者： Olga Zabotina Erik Maim Georgia Drakakaki Vincent Bulone natasha Raikhel Institute for Integrative Genome Biology Center for Plant Cell Biology and Department of Botany and Plant Sciences University of California Riverside CA92521 USA School of Biotechnology Royal Institute of Technology (KTH) AlbaNova University Center Stockholm SE-106 91 Sweden Present address: Department of Biochemistry Biophysics and Molecular Biology Iowa State University Ames IA 50014 USA

Chemical genetics as a part of chemical genomics is a powerful and fast developing approach to dissect biological processes that may be difficult to characterize using conventional genetics because of gene redundancy or lethality and, in the case of polysaccharide biosynthesis, plant flexibility. Polysaccharide synthetic enzymes are located in two main compartments--the Golgi apparatus and plasma membrane-and can be studied in vitro using membrane fractions. Here, we first developed a high-throughput assay that allowed the screening of a library of chemicals with a potential effect on glycosyltransferase activities. Out of the 4800 chemicals screened for their effect on Golgi glucosyltransferases, 66 compounds from the primary screen had an effect on carbohydrate biosynthesis. Ten of these compounds were confirmed to inhibit glucose incorporation after a second screen. One compound exhibiting a strong inhibition effect （ID 6240780 named chemical A） was selected and further studied. It reversibly inhibits the transfer of glucose from UDP-glucose by Golgi membranes, but activates the plasma membrane-bound callose synthase. The inhibition effect is dependent on the chemical structure of the compound, which does not affect endomembrane morphology of the plant cells, but causes changes in cell wall composition. Chemical A represents a novel drug with a great potential for the study of the mechanisms of Golgi and plasma membrane-bound glucosyltransferases.

关键词： cell walls callose synthase chemical screening and identification glycosyltransferase Golgi plasma membrane

Blueprint for Excellence in Advanced Non-Small Cell Lung Cancer

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Blueprint for Excellence in Advanced Non-Small Cell Lung Can...

Biochemical and molecular changes in peach fruit exposed to cold stress conditions

第三届中国肿瘤内科大会

作者： natasha Leighl Medical Oncologist Princess Margaret Hospital

＜正＞Lung cancer remains a leading cause of mortality worldwide,with a global incidence of 1.3 million cases annually,and 1.1 million ***-line chemotherapy in advanced NSCLC with platinum doublets has long remained the standard,with median survival times of 8 to 10 months in good performance status patients. More recently,we have seen advances in outcome of selected subgroups of advanced NSCLC,notably those with non-squamous histology.

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Molecular Horticulture 2023年第1期3卷 64-80页

作者： Giulia Franzoni natasha Damiana Spadafora Tiziana Maria Sirangelo Antonio Ferrante Hilary J.Rogers Department of Agricultural and Environmental Sciences University of MilanVia Celoria 220133 MilanItaly Department of Chemical Pharmaceutical and Agricultural SciencesUniversity of Ferrara44121 FerraraItaly ENEA-Italian National Agency for New Technologies Energy and Sustainable Economic Development-Division Biotechnologies and Agroindustry00123 RomeItaly School of Biosciences Cardiff UniversitySir Martin Evans BuildingMuseum AvenueCardiff CF103AXUK

Storage or transportation temperature is very important for preserving the quality of ***,low temperature in sensitive fruit such as peach can induce loss of *** exposed to a specific range of temperatures and for a longer period can show chilling injury(CI)*** susceptibility to CI at low temperature varies among cultivars and genetic *** with agronomic management,appropriate postharvest management can limit quality *** importance of correct temperature management during postharvest handling has been widely ***,due to long-distance markets and complex logistics that require multiple actors,the management of storage/transportation conditions is crucial for the quality of products reaching the *** fruit exposed to low temperatures activate a suite of physiological,metabolomic,and molecular changes that attempt to counteract the negative effects of chilling *** this review an overview of the factors involved,and plant responses is presented and critically *** disorders associated with CI generally only appear after the storage/transportation,hence early detection methods are needed to monitor quality and detect internal changes which will lead to CI *** detection tools are assessed:they need to be easy to use,and preferably non-destructive to avoid loss of products.

关键词： Chilling injury Postharvest Cold stress Gene expression Molecular tools Prunus persica L

Hygiene hypothesis in inflammatory bowel disease: A criticalreview of the literature

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World Journal of Gastroenterology 2008年第2期14卷 165-173页

作者： natasha A Koloski Laurel Bret Graham Radford-Smith Department of Gastroenterology Royal Brisbane & Women'sHospital Herston Queensland 4072Australia Department of Gastroenterology Royal Brisbane & Women’sHospitalHerston Queensland 4072Australia

The hygiene hypothesis is thought to be a significant contributor to the growing incidence of inflammatory bowel disease (IBD) around the world, although the evidence for specific factors that underlie the hygiene hypothesis in IBD is unclear. We aimed to systematically review the literature to determine which hygiene-related factors are associated with the development of IBD. Publications identified from a broad based MEDLINE and Current Contents search between 1966 and 2007 on key terms relevant to the 'hygiene hypothesis' and IBD including H pylori exposure, helminths, cold chain hypothesis, measles infection and vaccination, antibiotic use, breastfeeding, family size, sibship, urban upbringing, day care attendance and domestic hygiene were reviewed. The literature suggests that the hygiene hypothesis and its association with decreased microbial exposure in childhood probably plays an important role in the development of IBD, although the strength of the supporting data for each of the factors varies considerably. The most promising factors that may potentially be associated with development of IBD include H pylori exposure, helminths, breastfeeding and sibship. However, the vast majority of studies in this area are plagued by serious methodological shortcomings, particularly the reliance on retrospective recall of information making it difficult to truly ascertain the importance of a 'hygiene hypothesis' in IBD. The 'hygiene hypothesis' in IBD is an important area of research that may give clues to the aetiology of this disease. Directions for future research are recommended.

关键词： Inflammatory bowel disease Hygiene hypothesis Microbial exposure Cold chain hypothesis H pylori Helminths Measles Antibiotic Breastfeeding Child care