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House of gold

House of gold

作者： natasha Solomons.

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人工智能会“偷走”潜艇的隐身能力吗?

科技纵览 2022年第9期 38-43页

作者： natasha Bajema 不详

潜艇的价值主要在于其隐蔽性。有一种名为为“相互确保摧毁”的威慢战略,其关键在于尽量确保潜艇在核战争的第一次导弹打击中幸存下来,从而在第二次打击时发射导弹回击。因此,任何可能有效地让海洋变透明、令潜航的潜艇轻而易举被发现... 详细信息

潜艇的价值主要在于其隐蔽性。有一种名为为“相互确保摧毁”的威慢战略,其关键在于尽量确保潜艇在核战争的第一次导弹打击中幸存下来,从而在第二次打击时发射导弹回击。因此,任何可能有效地让海洋变透明、令潜航的潜艇轻而易举被发现的新技术都会破坏世界和平。

关键词：隐身能力人工智能第二次打击核战争潜艇隐蔽性

Postvaccination breakthrough SARS-CoV-2 infections among adults in Malaysia and attitudes towards future vaccination

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Asian Pacific Journal of Tropical Medicine 2023年第7期16卷 296-304页

作者： Praneetha Kumar Nair Kai Ern Koh Christine Yvonne Bede Lee Ai Ren natasha Mevuni Dinethma Mahanama Thin Mon Kyaw Htoo Htoo Kyaw Soe Soe Moe Kazi Majidur Rahaman Mila Nu Nu Htay Faculty of Medicine Manipal University College MalaysiaMalaysia Department of Community Medicine Faculty of MedicineManipal University College MalaysiaMalaysia Department of Medicine Faculty of MedicineManipal University College MalaysiaMalaysia

Objective:To determine the frequency and severity of the breakthrough infections and the associated factors in ***:This cross-sectional study was conducted among the adult general population in Malaysia who completed at least one dose of *** validated online questionnaires were used for data collection between December 2022 to February *** participants were recruited by a convenient sampling *** data were analysed by descriptive statistics,and logistic regression by using SPSS(Version 27).Qualitative data from open-ended questions were analysed as thematic analysis by using RQDA ***:A total of 524 participants'data were analyzed and 77.5%of them completed three doses of COVID-19 *** infections after vaccination were reported in 57.3%of the *** group of 18 and 30 years(aOR 2.32,95%CI 1.01-5.32)and other ethnicities(aOR 2.00,95%CI 1.02-3.93)significantly associated with the occurrence of breakthrough infections.A total of 35.5%of the participants were not willing to take another booster dose in the future because of their attitudes towards fear of long-term side effects,lack of trust to the vaccine,less susceptibility to severe infection,belief in natural immunity,and ***:Future public health policies and interventions should be focused on disseminating the information about safety of booster doses of vaccine,management and re-assurance of side effects,and targeted vaccination to the working(younger age group)and ethnic minorities.

关键词： COVID-19 SARS CoV-2 Breakthrough infection Vaccine Malaysia

Diagnostic utility of flexible fiberoptic nasopharyngolaryngoscopy recorded onto a smartphone: A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2018年第2期4卷 135-139页

作者： Jason A. Brant Kevin Leahy natasha Mirza Hospitals of the University of Pennsylvania Philadelphia PA USA

Objectives: To evaluate the diagnostic accuracy of flexible fiberoptic examinations of the larynx recorded onto smartphones. Methods: Prospective, blinded study of inpatients requiring laryngoscopy. A live exam was per-formed, then a smartphone was attached to the endoscope using a novel coupling device and the same examination was recorded. The live and recorded exams were evaluated by two lar-yngologists, each blinded to the findings of the other. Results: Eighteen subjects were evaluated. Evaluation of airway patency was identical (Kappa = 1.0 [1, 1]). Evaluation of vocal cord motion was identical for 14 subjects: 9 normal, 3 paretic, 2 paralytic (Kappa = 0.69 [0.38, 1]). Conclusion: There is high correlation between laryngeal diagnoses using live flexible fiberoptic laryngoscopy and recordings using a coupling device to transfer the recordings on to smart-phones. Critical findings such as airway patency and vocal fold motion showed the highest cor-relation.

关键词： Telemedicine Laryngoscopy Smartphone

An Approach to Quantify Endomembrane Dynamics in Pollen Utilizing Bioactive Chemicals

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Molecular Plant 2013年第4期6卷 1202-1213页

作者： Nolan Ung Michelle Q. Brown Glenn R. Hicks natasha V. Raikhel Center for Plant Cell Biology and Department of Botany and Plant Sciences University of California Riverside Riverside CA 92521 USA

Tip growth of pollen tubes and root hairs occurs via rapid polar growth. These rapidly elongating cells require tip-focused endomembrane trafficking for the deposition and recycling of proteins, membranes, and cell wall materials. Most of the image-based data published to date are subjective and non-quantified. Quantitative and com- parative descriptors of these highly dynamic processes have been a major challenge, but are highly desirable for genetic and chemical genomics approaches to dissect this biological network. To address this problem, we screened for small molecules that perturbed the localization of a marker for the Golgi Ras-like monomeric G-protein RAB2：GFP expressed in transgenic tobacco pollen. Semi-automated high-throughput imaging and image analysis resulted in the identifica- tion of novel compounds that altered pollen tube development and endomembrane trafficking. Six compounds that caused mislocalization and varying degrees of altered movement of RAB2：GFP-labeled endomembrane bodies were used to generate a training set of image data from which to quantify vesicle dynamics. The area, velocity, straightness, and intensity of each body were quantified using semi-automated image analysis tools revealing quantitative differences in the phenotype caused by each compound. A score was then given to each compound enabling quantitative comparisons between compounds. Our results demonstrate that image analysis can be used to quantitatively evaluate dynamic sub- cellular endomembrane phenotypes induced by bioactive chemicals, mutations, or other perturbing agents as part of a strategy to quantitatively dissect the endomembrane network.

关键词： endomembranes vesicle trafficking quantification pollen chemical biology.

Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance

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World Journal of Gastroenterology 2018年第28期24卷 3055-3070页

作者： Whitney Duff natasha Haskey Gillian Potter Jane Alcorn Paulette Hunter Sharyle Fowler College of Kinesiology University of Saskatchewan Irving K Barber School of Arts and Science University of British Columbia-Okanagan Department of Psychology University of Saskatchewan College of Pharmacy and Nutrition University of Saskatchewan St Thomas More College University of Saskatchewan Department of Medicine University of Saskatchewan

We performed a scoping review on sought-after complementary therapies for patients with inflammatory bowel disease(IBD), specifically diet, physical activity and exercise(PA/E), and psychotherapy. We aim to update patients with IBD on therapies for self-care and provide physicians with guidance on how to direct their patients for the management of IBD. A search of MEDLINE, EMBASE, and PUBMED was completed in Sept 2016. Studies on diet, PA/E, or psychotherapy in patients with IBD were included. Medical Subject Heading terms and Boolean operators were used. The search was limited to full-text English articles describing an adult population. This review included 67 studies: Diet(n = 19); PA/E(n = 19); and psychotherapy(n = 29). We have made the following recommendations:(1) Diet: Consumption of diets rich in vegetables, fruit and soluble fiber may be beneficial in IBD. A trial of a low FODMAP diet can be considered in those patients with functional gastrointestinal symptoms. Restrictive diets are lacking in evidence and should be avoided;(2) PA/E: Regular lowmoderate intensity activity, including cardiovascular and resistance exercise, has been shown to improve quality of life(QOL) and may improve inflammation; and(3) psychotherapy: Therapies such as cognitive-behavioural interventions, mindfulness, hypnosis, and stress management have been shown to improve QOL, but evidence is limited on their impact on anxiety, depression, and disease activity. Overall, these complementary therapies are promising and should be used to treat patients with IBD from a more holistic perspective.

关键词： Scoping review Inflammatory bowel disease Diet Exercise Psychotherapy

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人工智能最糟糕的真实应用场景

科技纵览 2022年第1期 6-8页

作者： natasha Bajema 不详

人工智能(Al)的最糟糕应用场景在好莱坞电影大片中屡见不鲜:机器学会了类似人类的智能,具备了感知能力,免不了变成邪恶的霸主,并企图摧毁人类。这种叙事技巧利用了我们对技术的先天恐惧,反映出时常伴随新技术产生的深刻变化。

关键词：人工智能应用场景叙事技巧好莱坞电影感知能力深刻变化

Taurine protects against retinal and optic nerve damage induced by endothelin-1 in rats via antioxidant effects

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Neural Regeneration Research 2018年第11期13卷 2014-2021页

作者： natasha Najwa Nor Arfuzir Renu Agarwal Igor Iezhitsa Puneet Agarwal Sabrilhakim Sidek Nafeeza Mohd Ismail Center for Neuroscience Research Faculty of MedicineUniversiti Teknologi MARA Sungai Buloh Campus Volgograd State Medical University Research Institute of Pharmacology Faculty of Medicine International Medical UniversityIMU Clinical School

Endothelin-1（ET-1）, a potent vasoconstrictor, is involved in retinal vascular dysregulation and oxidative stress in glaucomatous eyes. Taurine（TAU）, a naturally occurring free amino acid, is known for its neuroprotective and antioxidant properties. Hence, we evaluated its neuroprotective properties against ET-1 induced retinal and optic nerve damage. ET-1 was administered intravitreally to Sprague-Dawley rats and TAU was injected as pre-, co-or post-treatment. Animals were euthanized seven days post TAU injection. Retinae and optic nerve were examined for morphology, and were also processed for caspase-3 immunostaining. Retinal redox status was estimated by measuring retinal superoxide dismutase, catalase, glutathione, and malondialdehyde levels using enzyme-linked immuosorbent assay. Histopathological examination showed significantly improved retinal and optic nerve morphology in TAU-treated groups. Morphometric examination showed that TAU pre-treatment provided marked protection against ET-1 induced damage to retina and optic nerve. In accordance with the morphological observations, immunostaining for caspase showed a significantly lesser number of apoptotic retinal cells in the TAU pre-treatment group. The retinal oxidative stress was reduced in all TAU-treated groups, and particularly in the pre-treatment group. The findings suggest that treatment with TAU, particularly pre-treatment, prevents apoptosis of retinal cells induced by ET-1 and hence prevents the changes in the morphology of retina and optic nerve. The protective effect of TAU against ET-1 induced retinal and optic nerve damage is associated with reduced retinal oxidative stress.

关键词： endothelin-1 retina optic nerve taurine oxidative stress

Prostate tumor neuroendocrine differentiation via EMT: The road less traveled

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Asian Journal of Urology 2019年第1期6卷 82-90页

作者： Haley Dicken Patrick J.Hensley natasha Kyprianou Department of Urology University of Kentucky College of MedicineLexingtonKYUSA Department of Molecular and Cellular Biochemistry University of Kentucky College of MedicineLexingtonKYUSA Department of Toxicology&Cancer Biology University of Kentucky College of MedicineLexingtonKYUSA

The long-standing challenge in the treatment of prostate cancer is to overcome therapeutic resistance during progression to lethal *** transforming-growth factor-b(TGF-b)signaling accelerates prostate tumor progression in a transgenic mouse model via effects on epithelial-mesenchymal transition(EMT),and neuroendocrine differentiation driving tumor progression to castration-resistant prostate cancer(CRPC).Neuroendocrine prostate cancer(NEPC)is highly aggressive exhibiting reactivation of developmental programs associated with EMT induction and stem cell-like *** androgen receptor(AR)is a critical driver of tumor progression as well as therapeutic response in patients with metastatic *** signaling interactions between the TGF-β mechanistic network and AR axis impact the EMT phenotypic conversions,and perturbation of epithelial homeostasis via EMT renders a critical venue for epithelial derived tumors to become invasive,acquire the neuroendocrine phenotype,and rapidly *** of microtubule targeting taxane chemotherapy and androgen/AR targeting therapies have survival benefits in CRPC patients,but therapeutic resistance invariability develops,leading to *** evidence from our group recently demonstrated that chemotherapy(cabazitaxel,second line taxane chemotherapy),or TGF-β receptor signaling targeted therapy,caused reversion of EMT to mesenchymal-epithelial transition and tumor re-differentiation,in in vitro and in vivo prostate cancer *** this review,we discuss the functional contribution of EMT dynamic changes to the development of the neuroendocrine phenotypedthe newly characterized pathological feature of prostate tumors in the context of the tumor microenvironment-navigated cell lineage changes and the role of this neuroendocrine phenotype in metastatic progression and therapeutic resistance.

关键词： Neuroendocrine differentiation Cell polarity Prostate cancer Androgen deprivation therapy Epithelialmesenchymal transition