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A comparison of survival and pathologic features of non-alcoholic steatohepatitis and hepatitis C virus patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2012年第31期18卷 4145-4149页

作者： Roberto Hernandez-Alejandro Kris P Croome Martin Drage Nathalie Sela Jeremy Parfitt natasha chandok Paul Marotta Cheryl Dale William Wall Douglas Quan Multi-Organ Transplant Program Department of SurgeryLondon Health Sciences CentreOntario N6A 5A5Canada Department of Pathology London Health Sciences CentreOntario N6A 5A5Canada

AIM:To compare the clinical outcome and pathologic features of non-alcoholic steatohepatitis(NASH) patients with hepatocellular carcinoma(HCC) and hepatitic C virus(HCV) patients with HCC(another group in which HCC is commonly seen) undergoing liver ***:Patients transplanted for HCV and NASH at our institution from January 2000 to April 2011 were *** explanted liver histology and pre-transplant liver biopsies were examined by two specialist liver *** demographics,disease free survival,explant liver characteristics and HCC features(tumour number,cumulative tumour size,vascular invasion and differentiation) were compared between HCV and NASH liver transplant ***:A total of 102 patients with NASH and 283 patients with HCV were *** incidence of HCC in NASH transplant recipients was 16.7%(17/102).The incidence of HCC in HCV transplant recipients was 22.6%(64/283).Patients with NASH-HCC were statistically older than HCV-HCC patients(P < 0.001).A significantly higher proportion of HCV-HCC patients had vascular invasion(23.4% vs 6.4%,P = 0.002) and poorly differentiated HCC(4.7% vs 0%,P < 0.001) compared to the NASH-HCC group.A trend of poorer recurrence free survival at 5 years was seen in HCV-HCC patients compared to NASH-HCC who underwent a Liver transplantation(P = 0.11).CONCLUSION:Patients transplanted for NASH-HCC appear to have less aggressive tumour features compared to those with HCV-HCC,which likely in part accounts for their improved recurrence free survival.

关键词：丙型肝炎病毒肝细胞肝癌酒精性患者病理特点脂肪 NASH 组织学检查

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