检索结果-南通市图书馆

作者： natasha Abdulrauf Mzee 华中师范大学

学位级别：硕士

本文采用案例研究法探析坦桑尼亚政党在赋权女性走上领导岗位时所面临的挑战,旨在提出更好的干预政策和策略,以提升本国女性领导人的综合能力。数据来源既有一手数据,也有引用的二手数据。一手原始数据的收集使用了问卷调查和深度访谈... 详细信息

本文采用案例研究法探析坦桑尼亚政党在赋权女性走上领导岗位时所面临的挑战,旨在提出更好的干预政策和策略,以提升本国女性领导人的综合能力。数据来源既有一手数据,也有引用的二手数据。一手原始数据的收集使用了问卷调查和深度访谈等方法。问卷调查对象为公民联合阵线、民主与发展党、坦桑尼亚革命党等三大政党成员。受访者共193人;二手数据来源多样,有图书馆、网络、政府机构以及关注妇女事务的民间社会组织和非政府组织。以女性对其自身愿景使命、成就挑战和未来计划的认知作为反思对象,本研究清晰地分析了当前政治中的男权结构。这从基层组织开始就阻碍了女性的参政与升迁机会。即使能够走到事业顶峰,女性仍然面临挑战,很难操作行使权力并表现自己的能力。本研究利用女性主义的概念、理论和方法论来回答研究问题。研究结果表明,成长经历决定了女性是否会形成走上领导岗位的愿望抱负,但当前的女孩们自幼就生活在一个两性严重不平等的社会。当她们步入政坛,女性领导者的偏好则会受其愿望抱负指引,渴望看到一个所有人生而平等的世界。但研究发现,一些女性走上领导岗位后会被“男性”同化,习得与男性相似的行为风格。同时,女政治家及渴望踏入政坛的女性还面临着家庭、资源、政党、选举期间的性别暴力、不安全的大环境以及缺乏媒体正面报道等诸多挑战。尤其是后者,即缺乏媒体的正面报道,会造成选民无法了解女性所取得的成绩。研究结果还表明,社会对女性能力和领导力持有性别偏见。本文结尾部分提出了几项政策建议,有助于减轻女性面临的问题挑战,从而提高领导岗位的女性占比。

关键词：坦桑尼亚政党领导岗位女性赋权性别平等

Unusual switchable peroxidase-mimicking nanozyme for the determination of proteolytic biomarker

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Nano Research 2019年第3期12卷 509-516页

作者： Claire McVey natasha Logan Nguyen T. K. Thanh Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological Sciences Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK Biophysics Group Department of Physics and Astronomy University College London London WC1E 6BT UK UCL Healthcare Biomagnetic and Nanomaterials Laboratories 21 Albemarle Street London W1S 4BS UK Material and Advanced Technologies for Healthcare Queens University Belfast 18-30 Malone Road Belfast BT9 5BN UK

Detection of enzyme biomarkers originating from either bio-fluids or contaminating microorganisms is of utmost importance in clinical diagnostics and food safety. Herein, we present a simple, low-cost and easy-to-use sensing approach based on the switchable peroxidase-mimicking activity of plasmonic gold nanoparticles (AuNPs) that can catalyse for the oxidation of 3,3’,5’5-tetramethylbenzidine (TMB) for the determination of protease enzyme. The AuNP surface is modified with casein, showing dual functionalities. The first function of the coating molecule is to suppress the intrinsic peroxidase-mimicking activity of AuNPs by up to 77.1%, due to surface shielding effects. Secondly, casein also functions as recognition sites for the enzyme biomarker. In the presence of protease, the enzyme binds to and catalyses the degradation of the coating layer on the AuNP surface, resulting in the recovery of peroxidase-mimicking activity. This is shown visually in the development of a blue colored product (oxidised TMB) or spectroscopically as an increase in absorbance at 370 and 650 nm. This mechanism allows for the detection of protease at 44 ng·mL^-1 in 90 min. The nanosensor circumvents issues associated with current methods of detection in terms of ease of use, compatibility with point-of-care testing, low-cost production and short analysis time. The sensing approach has also been applied for the detection of protease spiked in ultra-heat treated (UHT) milk and synthetic human urine samples at a limit of detection of 490 and 176 ng·mL^-1, respectively, showing great potential in clinical diagnostics, food safety and quality control.

关键词： gold nano particles peroxidase-mimicking nanozyme enzyme detection biomarkers

Loggerhead Sea Turtles Hand-Reared in Captivity: Isotopic Insights into Their Inherent Dietary Variation

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Evidence for a role of mitogen-activated protein kinases in the treatment of experimental acute pancreatitis

Open Journal of Ecology（生态学期刊） 2024年第5期 435页

作者： Brenda natasha Mejía-Guarnizo Carlos Julio Polo-Silva Guiomar Aminta Jauregui-Romero Antonio Delgado-Huertas

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World Journal of Gastroenterology 2014年第44期20卷 16535-16543页

作者： natasha Irrera Alessandra Bitto Monica Interdonato Francesco Squadrito Domenica Altavilla Department of Clinical and Experimental Medicine University of Messina Department of Paediatric Gynaecological Microbiological and Biomedical Sciences University of Messina

Acute pancreatitis(AP) is an inflammatory disease characterized by acute inflammation and necrosis of the pancreatic parenchyma. AP is often associated with organ failure, sepsis, and high mortality. The pathogenesis of AP is still not well understood. In recent years several papers have highlighted the cellular and molecular events of acute pancreatitis. Pancreatitis is initiated by activation of digestive enzymes within the acinar cells that are involved in autodigestion of the gland, followed by a massive infiltration of neutrophils and macrophages and release of inflammatory mediators, responsible for the local and systemic inflammatory response. The hallmark of AP is parenchymal cell necrosis that represents the cause of the high morbidity and mortality, so that new potential therapeutic approaches are indispensable for the treatment of patients at high risk of complications. However, not all factors that determine the onset and course of the disease have been explained. Aim of this article is to review the role of mitogen-activated protein kinases in pathogenesis of acute pancreatitis.

关键词： Experimental acute pancreatitis Mitogen-activated protein kinases Mitogen-activated protein kinases inhibitors Cytokines Cholecystokinin Cerulein

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House of gold

House of gold

Emerging role of dual biologic therapy for the treatment of inflammatory bowel disease

作者： natasha Solomons.

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World Journal of Clinical Cases 2023年第12期11卷 2621-2630页

作者： Matthew D McCormack natasha A Wahedna David Aldulaimi Peter Hawker Department of Gastroenterology South Warwickshire NHS Foundation TrustWarwick HospitalWarwick CV345BWUnited Kingdom

Biologic agents have now been used in the management of inflammatory bowel disease(IBD)for many years where experience,expertise and confidence in their use has developed over *** the United Kingdom,there are well established guidelines and recommendations for both single agent biologic treatments,and with combination therapy of a biologic agent with a small molecule agent in maintenance *** recent times,there has been increasing interest and experience using dual biologic therapy(DBT)in IBD,primarily in difficult to treat and refractory cases with high disease ***,published data on use,experience and safety profiles is limited and large-scale studies remain low in number in this developing *** therefore aim to present a summary and review of the available published data in this area to help us better understand the emerging role of DBT in IBD.

关键词： Dual biologic therapy Inflammatory bowel disease Crohn’s disease Ulcerative colitis Combination therapy Biologic safety

Sources,production and commercial applications of fungal chitosan:A review

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Journal of Bioresources and Bioproducts 2022年第2期7卷 3-16页

作者： Tanzina Huq Avik Khan David Brown natasha Dhayagude Zhibin He Yonghao Ni Department of Chemical Engineering&Limerick Pulp and Paper Centre University of New BrunswickFrederictonNew Brunswick E3B 5A3Canada Chinova Bioworks Inc. 85 Hubbard RdFrederictonNBE3B 6B3Canada

Chitosan is a type of biopolymer that can be obtained from animal/marine sources,and it can also be extracted or produced from agriculture waste products like mushroom or different fungal sources after the chitin *** on the size of mushroom farm,the amount of waste ranges between 5%and 20%of the production *** cell wall of the filamentous fungi,a good source of chitin,offers an easy way to extract *** physicochemical character-istics such as molecular weight and degree of deacetylation of fungal chitosan can be controlled compared to chitosan obtained from crustacean *** sourced chitosan can be used in food,pharmaceutical or biomedical applications for different applications,for example,as an antimicrobial agent,coating material,water purification or *** review mainly fo-cused on the extraction of chitin from mushroom or different fungal sources and also showed some applications of commercial chitosan products.

关键词： Fungal chitosan Source Production Commercial application

An Approach to Quantify Endomembrane Dynamics in Pollen Utilizing Bioactive Chemicals

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Molecular Plant 2013年第4期6卷 1202-1213页

作者： Nolan Ung Michelle Q. Brown Glenn R. Hicks natasha V. Raikhel Center for Plant Cell Biology and Department of Botany and Plant Sciences University of California Riverside Riverside CA 92521 USA

Tip growth of pollen tubes and root hairs occurs via rapid polar growth. These rapidly elongating cells require tip-focused endomembrane trafficking for the deposition and recycling of proteins, membranes, and cell wall materials. Most of the image-based data published to date are subjective and non-quantified. Quantitative and com- parative descriptors of these highly dynamic processes have been a major challenge, but are highly desirable for genetic and chemical genomics approaches to dissect this biological network. To address this problem, we screened for small molecules that perturbed the localization of a marker for the Golgi Ras-like monomeric G-protein RAB2：GFP expressed in transgenic tobacco pollen. Semi-automated high-throughput imaging and image analysis resulted in the identifica- tion of novel compounds that altered pollen tube development and endomembrane trafficking. Six compounds that caused mislocalization and varying degrees of altered movement of RAB2：GFP-labeled endomembrane bodies were used to generate a training set of image data from which to quantify vesicle dynamics. The area, velocity, straightness, and intensity of each body were quantified using semi-automated image analysis tools revealing quantitative differences in the phenotype caused by each compound. A score was then given to each compound enabling quantitative comparisons between compounds. Our results demonstrate that image analysis can be used to quantitatively evaluate dynamic sub- cellular endomembrane phenotypes induced by bioactive chemicals, mutations, or other perturbing agents as part of a strategy to quantitatively dissect the endomembrane network.

关键词： endomembranes vesicle trafficking quantification pollen chemical biology.

Non-pharmacological therapies for inflammatory bowel disease: Recommendations for self-care and physician guidance

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World Journal of Gastroenterology 2018年第28期24卷 3055-3070页

作者： Whitney Duff natasha Haskey Gillian Potter Jane Alcorn Paulette Hunter Sharyle Fowler College of Kinesiology University of Saskatchewan Irving K Barber School of Arts and Science University of British Columbia-Okanagan Department of Psychology University of Saskatchewan College of Pharmacy and Nutrition University of Saskatchewan St Thomas More College University of Saskatchewan Department of Medicine University of Saskatchewan

We performed a scoping review on sought-after complementary therapies for patients with inflammatory bowel disease(IBD), specifically diet, physical activity and exercise(PA/E), and psychotherapy. We aim to update patients with IBD on therapies for self-care and provide physicians with guidance on how to direct their patients for the management of IBD. A search of MEDLINE, EMBASE, and PUBMED was completed in Sept 2016. Studies on diet, PA/E, or psychotherapy in patients with IBD were included. Medical Subject Heading terms and Boolean operators were used. The search was limited to full-text English articles describing an adult population. This review included 67 studies: Diet(n = 19); PA/E(n = 19); and psychotherapy(n = 29). We have made the following recommendations:(1) Diet: Consumption of diets rich in vegetables, fruit and soluble fiber may be beneficial in IBD. A trial of a low FODMAP diet can be considered in those patients with functional gastrointestinal symptoms. Restrictive diets are lacking in evidence and should be avoided;(2) PA/E: Regular lowmoderate intensity activity, including cardiovascular and resistance exercise, has been shown to improve quality of life(QOL) and may improve inflammation; and(3) psychotherapy: Therapies such as cognitive-behavioural interventions, mindfulness, hypnosis, and stress management have been shown to improve QOL, but evidence is limited on their impact on anxiety, depression, and disease activity. Overall, these complementary therapies are promising and should be used to treat patients with IBD from a more holistic perspective.

关键词： Scoping review Inflammatory bowel disease Diet Exercise Psychotherapy

Measuring^(222)Rn in aquatic environment via Pulsed Ionization Chamber Radon Detector

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海洋学报:英文版 2023年第8期42卷 185-189,I0001-I0006页

作者： Lijun Song Wen Liu Shibin Zhao Chunqian Li Jinjia Guo natasha Dimova Bochao Xu Frontiers Science Center for Deep Ocean Multispheres and Earth System/Key Laboratory of Marine Chemistry Theory and Technology of Ministry of Education Ocean University of ChinaQingdao 266100China Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China College of Chemistry and Chemical Engineering Ocean University of ChinaQingdao 266100China College of Information Science and Engineering Ocean University of ChinaQingdao 266100China R&D Center for Marine Instruments and Apparatuses Qingdao Marine Science and Technology CenterQingdao 266200China Department of Geological Sciences College of Arts and SciencesUniversity of AlabamaTuscaloosa 35487USA

Radon(Rn)is a naturally occurring radioactive inert gas in nature,and^(222)Rn has been routinely used as a powerful tracer in various aquatic environmental research on timescales of hours to days,such as submarine groundwater *** we developed a new approach to measure^(222)Rn in discrete water samples with a wide range of^(222)Rn concentrations using a Pulsed Ionization Chamber(PIC)Radon *** sensitivity of the new PIC system is evaluated at 6.06 counts per minute for 1 Bq/L when a 500 mL water sample volume is used.A robust logarithmic correlation between sample volumes,ranging from 250 mL to 5000 mL,and system sensitivity obtained in this study strongly suggests that this approach is suitable for measuring radon concentration levels in various natural *** to the currently available methods for measuring radon in grab samples,the PIC system is cheaper,easier to operate and does not require extra accessories(e.g.,drying tubes etc.)to maintain stable measurements throughout the counting procedure.

关键词： ^(222)Rn radon measurement Pulsed Ionization Chamber Radon Detector radon in discrete water samples submarine groundwater discharge