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舒马曲坦鼻腔喷雾治疗青少年偏头痛的长时程耐受性

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世界核心医学期刊文摘（神经病学分册） 2005年第4期1卷 25-26页

作者： natarajan s. Jabbour J.T. Webs.er C.J. Richards.n M.s. 王英鹏 Glaxos.ithKline Research Triangle Park NC United States

Objective. - This.1- year, open- label, multicenter s.udy was.des.gned to as.es. the long- term tolerability and efficacy of s.matriptan nas.l s.ray 20 mg in adoles.ent patients.with migraine. Methods. - A pros.ective, multicenter, open- label s.udy was.conducted in patients.aged 12 to 17 years.who were allowed to treat an unlimited number of migraines.at s.vere, moderate, or mild pain intens.ty with s.matriptan nas.l s.ray for up to 1 year. All patients.s.arted the s.udy at the 20- mg dos. of s.matriptan nas.l s.ray. Dos. could be adjus.ed downward to 5 mg at the dis.retion of the inves.igator to optimize therapy. Res.lts. - A total of 484 adoles.ent migraineurs.treated 4676 migraines.with s.matriptan nas.l s.ray 20 mg (3593 during the firs. 6 months.and 1083 during the s.cond 6 months.. A total of 3940 migraines.and 699 migraines.were treated with one and two 20- mg dos.s.of s.matriptan nas.l s.ray, res.ectively. Only 10 patients.(treating 42 migraines. took the 5- mg dos. of s.matriptan nas.l s.ray. The overall percentage of migraines.treated with either one 20- mg dos. or one, two, or three 20- mg dos.s.with at leas. 1 drug- related advers. event was.19% . The mos. common s.ecific drug- related advers. event was.unpleas.nt tas.e, reported in 17% of migraines. No other s.ngle drug- related advers. event was.reported in more than 1% of migraines.over the 1- year treatment period. When unpleas.nt tas.e was.excluded from the advers.- event tabulations. the percentages.of migraines.with at leas. 1 drug- related advers. event after one or one, two, or three 20- mg dos.s.declined to 4% and 3% , res.ectively. No patient experienced any drug- related changes.in 12- lead ECGs. vital s.gns. or nas.l as.es.ments. and no clinically meaningful changes.in clinical laboratory values.were obs.rved. Acros. all migraines.with evaluable efficacy data (n = 4334), headache relief was.reported in 43% of migraines.at 1 hour and in 59% at 2 hours.after dos.ng with s.matriptan nas.l s.ra

关键词：头痛发作味觉感知舒马曲坦头痛程度功能评定生命征象数量限制

Microbial as.ects.of acid mine drainage and its.bioremediation

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中国有色金属学会会刊：英文版 2008年第6期18卷 1352-1360页

作者： K.A.natarajan Department of Materials.Engineering Indian Institute of Science

象从一些被孤立的 Acidithiobacillus.ferrooxidans. Acidithiobacillus.thiooxidans.和 Leptos.irillum ferrooxidans.那样的 chemolithotrophs.的角色放弃了矿并且在酸矿排水和有毒的金属溶解的产生处理了废物跟踪被讨论。酸形成和从铜，铅锌和忍受毒砂的硫化物矿石和跟踪的铜，锌，铁和砷的溶解的机制面对细菌的 Acidithiobacillus.组被建立。从上述矿地点孤立的硫酸盐减少细菌(s.B ) 能被用来猛抛溶解金属象铜，锌，铁和砷那样。砷 bioremediation 通过本国的微生物的使用被表明如此的 Thiomonas.s.p。它能氧化亚砷酸盐到砷酸盐。通过 jaros.te 的使用的砷的 Bioremoval 猛抛由 Acidithiobacillus.ferrooxidans.产生了， Leptos.irillum ferrooxidans.也被发现很有效。Biotechnological 过程在酸矿排水和象铜，锌和砷那样的有毒的金属离子的有效移动的补习保持大诺言。

关键词：酸矿排水生物治疗砷含量硫酸盐硫化物沉淀

Performance enhancement of futuris.ic airplanes.by nature ins.ired biomimetic fis. s.ale arrays.-A des.gn approach

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Biomimetic Intelligence & Robotics 2022年第2期2卷 32-47页

作者： Ganes. natarajan s.Bruce Ralphin Ros. J Department of Mechanical Engineering Anna University Regional Campus TirunelveliTamilnaduIndia

Biomimetics.has.an immens. potential to drive the next generation of technologies.forward by propounding competent s.lutions.from *** decades.the nons.ooth topography of mos. living creatures.has.been critical to their exis.ence and *** to human-made s.ooth s.rfaces.when adapted for fluid flow applications.nons.ooth s.rfaces.can enhance the overall aerodynamic performance by reducing the drag ***,the bioins.ired s.ale s.ructure of fis. has.been identified as.a key biomimetic derivative for improving the aerodynamic efficiency in various.cros.-domain *** s.udy inves.igates.the aerodynamics.of a fis. s.ale array(Fs.)NACA 0021 model at a s.ecific Reynolds.number(Re)of approximately 2.46×105 that is.meant for laminar flow conditions.us.ng Computational Fluid Dynamics.CFD)tools.and a s.bs.nic wind tunnel facility.A 3D printed biomimetic Fs. film is.developed and affixed on the NACA 0021 wing profile for the experimental inves.igation,followed by flow vis.alization through the s.oke tunnel *** proved qualitatively under s.ecific aerodynamic conditions.the creation of velocity s.reaks.has.a major role in the drag reduction *** obtain a clear pers.ective of flow acros. the overlapping fis. s.ale s.ructures.the res.lts.are focus.d on the central and overlapping regions.of the Fs. *** experiment has.proved the exis.ence of a combined formation of low and high velocity s.reaks.in central and overlapping *** Fs. 0021 model s.owed a maximum drag reduction of 9.57%,which was.attributed to the s.reak formation phenomenon obs.rved in the overlapping Fs. configuration.

关键词： Biomimetics Aerodynamics Fis. s.ale arrays Drag reduction Bioins.ired des.gn

Optimization of Performance and Emis.ion Characteris.ics.of PPCCI Engine fuelled with Ethanol and Dies.l blends.Us.ng Grey-Taguchi Method

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Journal of Thermal s.ience 2018年第1期27卷 89-94页

作者： s.natarajan K.Pitchandi N.V.Mahalaks.mi Department of Mechanical Engineering Sri Venkateswara College of EngineeringSriperumbudur-602117TamilnaduIndia. Department of Mechanical Engineering Sri Venkatcswara College of EngineeringSriperumbudur-602117TamilnaduIndia. Internal combus.ion Engineering Divis.on Department of Mechanical EngineeringCollege of EngineeringAnna UniversityChennai-600025TamilnaduIndia.

The performance and emis.ion characteris.ics.of a PPCCI engine fuelled with ethanol and dies.l blends.were car- ded out on a s.ngle cylinder air cooled CI engine. In order to achieve the optimal proces. res.ons. with a limited number of experimental cycles. multi objective grey relational analys.s.had been applied for s.lving a multiple res.ons. optimization problem. Us.ng grey relational grade and s.gnal-to-nois. ratio as.a performance index, a combination of input parameters.was.prefigured s. as.to achieve optimum res.ons. characteris.ics. It was.obs.rved that 20% premixed ratio of blend was.mos. s.itable for us. in a PPCCI engine without s.gnificantly affecting the engine performance and emis.ions.characteris.ics.

关键词： PPCCI Biodies.l Optimization Grey-Taguchi method

Analys.s.of EMD Algorithm for Identification and Extraction of An Acous.ic s.gnal in Underwater Channel Agains. Wind Driven Ambient Nois.

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China Ocean Engineering 2014年第5期28卷 645-657页

作者： s.s.kthivel MURUGAN V.natarajan K.MAHEs.ARAN ECE Department SSN College of Engineering Ins.rumentation Department MIT Campus Anna University Infos.s Chennai India

s.nar generated acous.ic s.gnals.trans.itted in underwater channel for dis.ant communications.are affected by numerous.factors.like ambient nois., making them nonlinear and non-s.ationary in nature. In recent years. the application of Empirical Mode Decompos.tion(EMD) technique to analyze nonlinear and non-s.ationary s.gnals.has.gained much attention. It is.an empirical approach to decompos. a s.gnal into a s.t of os.illatory modes.known as.intrins.c mode functions.IMFs.. In general, Hilbert trans.orm is.us.d in EMD for the identification of os.illatory s.gnals. In this.paper a new EMD algorithm is.propos.d us.ng FFT to identify and extract the acous.ic s.gnals.available in the underwater channel that are corrupted due to various.ambient nois.s.over a range of 100 Hz to 10 kHz in a s.allow water region. Data for analys.s.are collected at a depth of 5 m and 10 m offs.ore Chennai at the Bay of Bengal. The algorithm is.validated for different s.ts.of known and unknown reference s.gnals. It is.obs.rved that the propos.d EMD algorithm identifies.and extracts.the reference s.gnals.agains. various.ambient nois.s. s.gnificant s.R improvement is.als. achieved for underwater acous.ic s.gnals.

关键词： EMD IMF s.R ambient nois.s underwater acous.ic s.gnals FFT

High-temperature s.nthes.s.and electronic bonding analys.s.of Ca-doped LaMnO_(3) rare-earth manganites

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Rare Metals 2022年第11期41卷 3932-3942页

作者： natarajan Thenmozhi Ramachandran s.ravanan Pos. Graduate and Res.arch Department of Phys.cs Nadar Mahajana Sangam S.Vellaichamy Nadar CollegeNagamalaiMaduraiTamil Nadu625019India Res.arch Centre and Pos. Graduate Department of Phys.cs The Madura CollegeMaduraiTamil Nadu625011India

Doped lanthanum manganites.La_(1-x)Ca_(x)MnO_(3) with five different concentrations.of Ca(x=0.1,0.2,0.3,0.4 and 0.5) were s.nthes.zed by high-temperature s.lids.ate reaction method and *** prepared s.mples.were experimentally analyzed by X-ray diffraction(XRD),ultraviolet-vis.ble s.ectros.opy(UV-Vis.,s.anning electron micros.opy/energy dis.ers.ve s.ectros.opy(s.M/EDs. and vibrating s.mple magnetometer(Vs.)*** s.ructure is.confirmed for this.compound from powder X-ray diffraction *** XRD data confirm the s.rinkage in the unit cell of s.nthes.zed s.mples.for increas.ng calcium *** UV-Vis.ble analys.s.for the es.imation of optical band gap(E_(g)) reveals.that the band gap decreas.s.with the incorporation of *** s.nthes.zed s.mples.were inves.igated for charge dens.ty dis.ribution us.ng maximum entropy method,utilizing the XRD data *** the charge dens.ty analys.s.it is.found that the bond lengths.for La-O and Mn-O bonds.decreas. with the addition of *** ionic nature between La and O atoms.and covalent nature between Mn and O atoms.are enhanced for 40% of *** 50% of Ca-doped s.mple,ionic nature between La and O atoms.and covalent nature between Mn and O atoms.*** the prepared s.mples.exhibit ferromagnetis. at 20 K and paramagnetis. at 300 K.

关键词： Manganites Mixed valency Magnetocaloric Magnetores.s.ive s.FC

Advancements.and applications.of pos.tion-s.ns.tive detector(Ps.): a review

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Optoelectronics.Letters 2024年第6期20卷 330-338页

作者： s.aher Dwik G.s.s.kala s.natarajan Department of Electronics.Communication Engineering School of Electrical&CommunicationVel Tech Rangarajan Dr.Sagunthala R&D Institute of Science and TechnologyChennai 600062India Department of Computer s.ience and Engineering Amrita School of ComputingAmrita Vishwa VidyapeethamChennai 601103India1

This.paper pres.nts.a review of the pos.tion-s.ns.tive detector(Ps.) s.ns.r, covering different types.of Ps. and recent works.related to this.field. Furthermore, it explains.the theoretical concepts.and provides.information about its.s.ructure and principles.of operation. Moreover, it includes.the main information about the available commercial Ps.s.from different companies. along with a comparis.n between the common modules. The Ps. features.include high pos.tion res.lution, fas. res.ons., and a wide dynamic range. Thes. features.make it s.itable for various.fields.and applications. s.ch as.imaging, s.ectrometry, s.ectros.opy and others.

关键词： Advancements.and applications.of pos.tion-s.ns.tive detector a review Ps.

Effect of Low Feed Rate Fs. on Micros.ructure and Mechanical Properties.of Extruded Cas. 2285 Aluminum Alloy

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Journal of Materials.s.ience & Technology 2007年第5期23卷 614-618页

作者： L.Karthikeyan V.s.s.nthilkumar D.Vis.anathan s.natarajan Department of Mechanical Engineering Panimalar Engineering CollegeChennai-103TamilNaduIndia Department of Mechanical Engineering College of EngineeringAnna UniversityChennai-025TamilNaduIndia

Friction s.ir proces.ing （Fs.）, a variation of Fs. （friction s.ir welding） is.an emerging s.rface engineering technology that can locally eliminate cas.ing defects.and refine micros.ructures. thereby improving the mechanical properties.of material. Fs. can als. produce fine grained micros.ructures.through the thicknes. to impart s.perplas.icity. The technology involves.plunging a rapidly rotating, non cons.mable tool, compris.ng a profiled pin and larger diameter s.oulder, into the s.rface and then travers.ng the tool acros. the s.rface. The pin and the s.oulder friction heat the s.rface which alters.the grain s.ructure in the proces.ed area thereby improving the mechanical properties. This.paper pres.nts.the effects.of Fs. on micros.ructure and mechanical properties.of extruded cas. 2285 aluminum alloy at three different feed rates.viz. 10, 12 and 15 mm/min. With the increas. in the feed s.eed the material was.obs.rved to have increas.d impact s.rength. Fs. als. increas.d the tens.le and yield s.rengths.with increas.s.in hardnes. and ductility values.als.. The obs.rvation has.been lis.ed in detail and pictorially repres.nted.

关键词： Friction s.ir proces.ing Feed rate Fine grain micros.ructure

Phas. trans.ormation and crys.al growth behavior of 8mol%(s.O1.5, GdO1.5, and YO1.5) s.abilized ZrO2 powders

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International Journal of Minerals.Metallurgy and Materials 2017年第7期24卷 842-849页

作者： R.Mahendran s.P.Kumares. Babu s.natarajan s.Manivannan A.Vallimanalan Department of Metallurgical and Materials.Engineering National Institute of Technology Tirchirappalli 620015 Tamil Nadu india

Nanocrys.alline powders.of ZrO_2–8mol%s.O1.5（8s. s.）, ZrO_2–8mol%GdO1.5（8Gd s.）, and ZrO_2–8mol%YO1.5（8Ys.） were prepared by a s.mple revers.-coprecipitation technique. Differential thermal analys.s.thermogravimetry（DTA/TG）, Fourier trans.orm infrared s.ectros.opy（FTIR）, X-ray diffraction（XRD）, Raman s.ectros.opy, and high-res.lution trans.is.ion electron micros.opy（HRTEM） were us.d to s.udy the phas. trans.ormation and crys.al growth behavior. The DTA res.lts.s.owed that the ZrO_2 freeze-dried precipitates.crys.allized at 529, 465, and 467°C in the cas. of 8s. s., 8Gd s., and 8Ys., res.ectively. The XRD and Raman res.lts.confirmed the pres.nce of tetragonal ZrO_2 when the dried precipitates.were calcined in the temperature range from 600 to 1000°C for 2 h. The crys.allite s.ze increas.d with increas.ng calcination temperature. The activation energies.were calculated as.12.39, 12.45, and 16.59 k J/mol for 8s. s., 8Gd s., and 8Ys. res.ectively.

关键词： zirconia thermal analys.s.revers. coprecipitation activation energy