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A Novel Computerized Cognitive Test for the Detection of Mild Cognitive Impairment and Its Association with Neurodegeneration in Alzheimer’s Disease Prone Brain Regions

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Advances in Alzheimer's Disease 2023年第3期12卷 38-54页

作者： Rosie E. Curiel Cid D. Diane Zheng Marcela Kitaigorodsky Malek Adjouadi Elizabeth A. Crocco Mike Georgiou Christian Gonzalez-Jimenez Alexandra Ortega Mohammed Goryawala natalya nagornaya Pradip Pattany Efrosyni Sfakianaki Ubbo Visser David A. Loewenstein Center for Cognitive Neuroscience and Aging and Department of Psychiatry and Behavioral Sciences Miller School of Medicine University of Miami Miami Florida USA Center for Advanced Technology and Education Department of Electrical and Computer Engineering College of Engineering and Computing Florida International University Miami Florida USA Department of Radiology and Nuclear Medicine Miller School of Medicine University of Miami Miami Florida USA Department of Computer Science University of Miami Miami Florida USA

During the prodromal stage of Alzheimer’s disease (AD), neurodegenerative changes can be identified by measuring volumetric loss in AD-prone brain regions on MRI. Cognitive assessments that are sensitive enough to measure the early brain-behavior manifestations of AD and that correlate with biomarkers of neurodegeneration are needed to identify and monitor individuals at risk for dementia. Weak sensitivity to early cognitive change has been a major limitation of traditional cognitive assessments. In this study, we focused on expanding our previous work by determining whether a digitized cognitive stress test, the Loewenstein-Acevedo Scales for Semantic Interference and Learning, Brief Computerized Version (LASSI-BC) could differentiate between Cognitively Unimpaired (CU) and amnestic Mild Cognitive Impairment (aMCI) groups. A second focus was to correlate LASSI-BC performance to volumetric reductions in AD-prone brain regions. Data was gathered from 111 older adults who were comprehensively evaluated and administered the LASSI-BC. Eighty-seven of these participants (51 CU;36 aMCI) underwent MR imaging. The volumes of 12 AD-prone brain regions were related to LASSI-BC and other memory tests correcting for False Discovery Rate (FDR). Results indicated that, even after adjusting for initial learning ability, the failure to recover from proactive semantic interference (frPSI) on the LASSI-BC differentiated between CU and aMCI groups. An optimal combination of frPSI and initial learning strength on the LASSI-BC yielded an area under the ROC curve of 0.876 (76.1% sensitivity, 82.7% specificity). Further, frPSI on the LASSI-BC was associated with volumetric reductions in the hippocampus, amygdala, inferior temporal lobes, precuneus, and posterior cingulate.

关键词： Mild Cognitive Impairment Proactive Semantic Interference MRI Volume Cortical Thickness LASSI-L

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Pathogenetic treatment of candidal vulvovaginitis

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中国现代医学杂志 2013年第2期23卷 21-24页

作者： nagornaya VF Baylo NV Odessa National Medical University

The paper presents the possibility of the combined use of antimycotic sertaconazole nitrate and probiotics Fermalac to optimize the treatment of vulvovaginal candidiasis during and outside of *** of Fermalac allows to control the effectiveness and duration of antimycotic *** therapy provides elimination of the pathogen in 100% of non-pregnant and 40% of pregnant patients.

关键词：医学临床诊断疾病

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Incorporating shape constraints in generalized additive modelling of the height-diameter relationship for Norway spruce

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Forest Ecosystems 2016年第2期3卷 112-125页

作者： natalya Pya Matthias Schmidt Department of Mathematics School of Science and TechnologyNazarbayev University The Northwest German Forest Research Station Department of Forest Growth

Background： Measurements of tree heights and diameters are essential in forest assessment and modelling. Tree heights are used for estimating timber volume, site index and other important variables related to forest growth and yield, succession and carbon budget models. However, the diameter at breast height （dbh） can be more accurately obtained and at lower cost, than total tree height. Hence, generalized height-diameter （h-d） models that predict tree height from dbh, age and other covariates are needed. For a more flexible but biologically plausible estimation of covariate effects we use shape constrained generalized additive models as an extension of existing h-d model approaches. We use causal site parameters such as index of aridity to enhance the generality and causality of the models and to enable predictions under projected changeable climatic conditions. Methods： We develop unconstrained generalized additive models （GAM） and shape constrained generalized additive models （SCAM） for investigating the possible effects of tree-specific parameters such as tree age, relative diameter at breast height, and site-specific parameters such as index of aridity and sum of daily mean temperature during vegetation period, on the h-d relationship of forests in Lower Saxony, Germany. Results： Some of the derived effects, e.g. effects of age, index of aridity and sum of daily mean temperature have significantly non-linear pattern. The need for using SCAM results from the fact that some of the model effects show partially implausible patterns especially at the boundaries of data ranges. The derived model predicts monotonically increasing levels of tree height with increasing age and temperature sum and decreasing aridity and social rank of a tree within a stand, The definition of constraints leads only to marginal or minor decline in the model statistics like AIC An observed structured spatial trend in tree height is modelled via 2-dimensional surface fitting. Conclusions： We

关键词： Height-diameter curve Norway spruce Shape constrained additive models Impact of climate change,Varying coefficient models

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Influence of friction on buckling of a drill string in the circular channel of a bore hole

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Petroleum Science 2016年第4期13卷 698-711页

作者： Valery Gulyayev natalya Shlyun Department of Mathematics National Transport UniversityKiev Ukraine

Enhancement of technology and techniques for drilling deep directed oil and gas bore hole is one of the most important problems of the current petroleum *** infrequently, the drilling of these bore holes is attended by occurrence of extraordinary situations associated with technical accidents. Among these is the Eulerian loss of stability of a drill string in the channel of a curvilinear bore hole. Methods of computer simulation should play a dominant role in prediction of these states. In this paper, a new statement of the problem of critical buckling of the drill strings in 3D curvilinear bore holes is proposed. It is based on combined use of the theory of curvilinear elastic rods, Eulerian theory of stability, theory of channel surfaces, and methods of classical mechanics of systems with nonlinear constraints. It is noted that the stated problem is singularly perturbed and its solutions have the shapes of localized harmonic wavelets. The calculation results showed that the friction effects lead to essential redistribution of internal axial forces, as well as changing the eigenmode shapes and sites of their localization. These features make the buckling phenomena less predictable and raise the role of computer simulation of these effects.

关键词： Directed bore hole Drill string Critical states Singular perturbation Friction forces Harmonic wavelet

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Positron Spectroscopy of Free Volume in Poly(vinylidene fluoride) after Helium Ions Irradiation

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Chinese Journal of Polymer Science 2019年第5期37卷 527-534页

作者： Jin-Zhe Lyu Roman Laptev natalya Dubrova Division for Experimental Physics School of Nuclear Science & EngineeringNational Research Tomsk Polytechnic University

Free volume is an extremely important intrinsic defect in polymers. Structurally, free volume is the randomly distributed holes in the polymer molecular chain segments. In proton exchange membrane fuel cells, free volume is also the space needed for the directional conduction of protons. Irradiation by α particles to grafting sulfonated poly(vinylidene fluoride)(PVDF) is one of the methods to produce proton exchange membrane with good proton channel rate. Positron annihilation lifetime spectroscopy was used to study the free volume size at different absorbed dose levels from 0.13 MGy to 0.65 MGy. Measurement method of positron annihilation lifetime spectroscopy for PVDF based on ^(44) Ti positron source was developed. For low dose irradiation at 0.26 MGy, a decrease in free volume and practically unchanged crystallinity were observed. Further increase of absorbed dose range from 0.26 MGy to 0.39 MGy led to an increasing crystallinity with the same free volume level. For the absorbed dose from 0.39 MGy to 0.65 MGy, crystallinity was decreased but free volume remained almost constant.

关键词： Positron annihilation Free volume XRD Poly(vinylidene fluoride) Helium ions Connection Degradation

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Surgical techniques for the management of male infertility

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Asian Journal of Andrology 2012年第1期14卷 94-102,177页

作者： natalya A Lopushnyan Thomas J Walsh Department of Urology University of Washington Seattle WA 98195 USA

Evaluation and surgical treatment of male infertility has evolved and expanded, now leading to more precise diagnoses and tailored treatments with diminished morbidity and greater success. Surgeries for male infertility are divided into four major categories：（i） diagnostic surgery; （ii） surgery to improve sperm production; （iii） surgery to improve sperm delivery; and （iv） surgery to retrieve sperm for use with in vitrofertilization and intracytoplasmic sperm injection （IVF-ICSI）. While today we are more successful than ever in treating male infertility, pregnancy is still not always achieved likely due to factors that remain poorly understood. Clinicians treating infertility should advocate for couple-based therapy, and require that both partners have a thorough evaluation and an informed discussion before undergoing specific surgical therapies.

关键词： male infertility testis varicocele

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Estimating geographic concentrations of quaternary industries in Europe using Artificial Light-At-Night (ALAN) data

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International Journal of Digital Earth 2017年第9期10卷 861-870,871-878页

作者： natalya A.Rybnikova Boris A.Portnov Department of Natural Resources and Environmental Management University of HaifaHaifaIsrael

Mapping geographic concentrations of quaternary industries(QIs)may help to assess regional performance and formulate informed development ***,fine resolution data on QIs concentrations are sparsely ***,for the year 2010,only 45%of all NUTS3 regions(*** of the third and most detailed level of the Nomenclature of Units for Territorial Statistics of the EU)provide relevant *** this study,we investigate a possibility that artificial light-at-night(ALAN),captured by satellite sensors,can help to identify geographic concentrations of *** this study,we use year-2010 NUTS3 Eurostat data,and combine them with data on ALAN intensities,obtained from the *** Meteorological Satellite Program(US-DMSP)for the years 2000 and *** both ordinary least squares(OLS)and spatial dependency(SD)models,ALAN emerged as a statistically significant predictor(t=8.392–14.608;P<.01),helping to explain,along with other predictors,up to 75%of QIs regional *** obtained models and regional data presently available enabled estimates of QIs concentrations for European NUTS3 regions with missing data.

关键词： Quaternary industries(QIs) artificial light-at-night(ALAN) NUTS3 regions Europe

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Russian school of the theory and geometry of gearing： Its origin and golden period （1935-1975）

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Frontiers of Mechanical Engineering 2016年第1期11卷 44-59页

作者： Dmitry BABICHEV Sergey LAGUTIN natalya BARMINA Department of Applied Mechanics Tyumen State Oil and Gas University Tyumen 625000 Russia Electrostal Plant of Heavy Machine Engineering Electrostal City144012 Russia Institute of Mechanics Kalashnikov Izhevsk State Technical Universitylzhevsk 426069 Russia

During the second half of the twentieth century, Soviet scientists were among the world leaders in the theory and geometry of gearing or the theoretical fundamentals of designing gears and gear-cutting tools. The authors of the current paper review works related to the development of the theory of gearing （TG） written in Russian from the mid-1930s to the present. Overall, the review covers more than 400 publications of nearly 200 authors （among more than 1000 studied works）. This review involves some works on gear strength and accuracy to attract more experts. This paper presents a short list of works from the seventeenth century to the nineteenth century and discusses the basic concepts of the TG. This paper also includes a review of more than 160 papers in Russian for the period of 1935-1975, which is the ＂golden age＂ of the TG. The main features and achievements during this period are also considered. The distinctive feature of this review is the use of diagrams that visually present TG experts and the dates and themes of their published works. The diagrams also show the following aspects： 1） The most popular and important themes in a specific period, 2） the most important publications on the themes of interest to readers, and 3） the direction of the works and scope of interests of every researcher.

关键词： theory of gearing (TG) gear geometry,generating surface gear synthesis gear analysis

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Fine structure and phase composition of Fe–14Mn–1.2C steel:influence of a modified mixture based on refractory metals

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International Journal of Minerals,Metallurgy and Materials 2017年第5期24卷 523-529页

作者： Anna Zykova natalya Popova Mark Kalashnikov Irina Kurzina Tomsk Polytechnic University Tomsk State University of Architecture and Building Chemical Department Tomsk State University

The effect of TiO;,ZrO;and Na;AlF;ultrafine powders on the fine structure and the phase composition of Fe–14Mn–1.2C steel was *** introduction of the ultrafine powders into the melt influenced the grain size,the quantity,and the character of distribution of nonmetallic inclusions in the railroad *** microstructure of castings was improved significantly because of the refinement of the grain structure and an increase of the grain-boundary *** the modifying mixture was introduced into the melt,either the microtwins of one or two intersecting systems or the precipitations of ε-martensite of different types,or simultaneously the microtwins and wafers of ε-martensite,were present in each grain.

关键词： manganese steel fine structure phase composition refractory metals

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Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency

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World Journal of Gastroenterology 2019年第20期25卷 2430-2441页

作者： Peter Layer Nataliya Kashirskaya natalya Gubergrits Department of Internal Medicine Israelitic HospitalHamburg 22297Germany Department of Genetic Epidemiology (Cystic Fibrosis group) Federal State Budgetary Institution “Research Centre for Medical Genetics”Moscow 115522Russia Department of Internal Medicine Donetsk National Medical UniversityLyman 83001Ukraine

The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy (PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency (PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters (such as height, body weight and body mass index), or gastrointestinal symptoms (such as abdominal pain, stool consistency and flatulence). PERT improved PEI-related malabsorption and weight maintenance in patients with cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post-surgical states. In patients with chronic pancreatitis, PERT improved PEI-related symptoms and quality of life measures. Several small retrospective studies have also suggested that PERT may have a positive impact on survival, but long-term studies assessing this effect were not identified. PERT is effective for treating malnutrition and supporting weight maintenance, and it is associated with improved quality of life and possibly with enhanced survival in patients with PEI. However, there is evidence that not all patients with PEI receive adequate PERT. Future work should aim to assess the long-term effects of PERT on the survival of patients with PEI.

关键词： Pancreatic exocrine insufficiency Pancreatic enzyme replacement therapy Survival Quality of life Malabsorption Cystic fibrosis Chronic pancreatitis Pancreatic cancer Post-surgical states

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