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Design of Biologically Active Macromolecular Ligands and Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova Andrei I.Fischer Natalia A.Nesterova Anatoliy v.Dobrodumov Anzhelika v.Garshinina Olga D.Shuvaeva nataly. v.zakharova Evgenii F.Panarin Institute of Macromolecular Compounds Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorodintsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamidobenzoic acid(MABA)with neutral comonomers(N-vinylpyrrolidone(vP),N-methyl-N-vinylacetamide(MvAA),N-methacryloyl glucosamine(MAG))and anionic comononer sodium styrene sulfonate(NaSS)were synthesized by radical *** interactions between the prepared copolymers and Tb^(3+)ions in aqueous solutions were studied;the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamide units(vP,MvAA)is three times more intense than that observed for the complexes between Tb^(3+)and MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled by the values of binding constants between Tb^(3+)and MABA and the content of MABA units in a *** studied copolymers and their complexes with Tb^(3+)have low cytotoxicity and a pronounced antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanide complexes Antiviral activity Cytotoxicity

Evaluation of Carbon and Electron Flow in Lactobacillus brevis as a Potential Host for Heterologous 1-Butanol Biosynthesis

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Advances in Microbiology 2013年第5期3卷 450-461页

作者： Oksana v.Berezina German Jurgens Natalia v.zakharova Rustem S.Shakulov Sergey v.Yarotsky Tom B.Granstrom State Research Institute of Genetics and Selection of Industrial Microorganisms MoscowRussian Federation Department of Biotechnology and Chemical Technology School of Chemical TechnologyAalto UniversityEspooFinland

Heterofermentative lactic acid bacterium Lactobacillus brevis may be considered as a promising host for heterologous butanol synthesis because of tolerance to butanol and ability to ferment pentose and hexose sugars from wood hydrolysates that are cheap and renewable carbohydrate source. Carbon and electron flow was evaluated in two L. brevis strains in order to assess metabolic potential of these bacteria for heterologous butanol synthesis. Conditions required for generation of acetyl-CoA and NADH which are necessary for butanol biosynthesis have been determined. Key enzymes controlling direction of metabolic fluxes in L. brevis in various redox conditions were defined. In anaerobic glucose fermentation, the carbon flow through acetyl-CoA is regulated by aldehyde dehydrogenase ALDH possessing low affinity to NADH and activity (KmNADH= 200 μM, vmax= 0.03 U/mg of total cell protein). Aerobically, the NADH-oxidase NOX (KmNADH= 25 μM, vmax = 1.7 U/mg) efficiently competes with ALDH for NADH that results in formation of acetate instead of acetyl-CoA. In general, external electron acceptors (oxygen, fructose) and pentoses decrease NADH availability for native ethanol and recombinant butanol enzymes and therefore reduce carbon flux through acetyl-CoA. Pyruvate metabolism was studied in order to reveal redirection possibilities of competitive carbon fluxes towards butanol synthesis. The study provides a basis for the rational development of L. brevis strains producing butanol from wood hydrolysate.

关键词： Lactobacillus brevis Metabolism Carbon and Electron Flow Heterologous Butanol Synthesis SO2-Ethanol-Water Hydrolysate

Functional and Pathological Influence of Hypothermia on Spike Activity of Cortical Neurons

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Journal of Behavioral and Brain Science 2021年第5期11卷 107-130页

作者： Yulia S. Mednikova Nadezhda M. zakharova Natalia v. Pasikova Institute of Higher Nervous Activity and Neurophysiology of RAS Moscow Russia ICB RAS Federal Research Center “Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences Pushchino Russia

In sensorimotor cortical slices of guinea pig using local iontophoretic application of glutamate to the soma and dendrites it was found that a decrease of temperature of incubating fluid from 34 to 21°C - 22°C changes the somatic responses to the local injection of glutamate to the dendritic loci, while the responses to iontophoretic application of glutamate to the soma remain unchanged. Hypothermic changes in reactivity to dendritic stimulation start below 30°C and coincide with changes in the spontaneous activity of neurons, both in the direction of increasing and decreasing the frequency of firing in different nerve cells. On hypothermic decrease of spontaneous activity, the latencies of evoked dendritic responses on the soma became more longer, while on hypothermic increase of firing level, somatic spike responses to iontophoretic application of glutamate to dendritic loci appeared with shorter latencies. Hypothermic changes in the physiological parameters of neurons were accompanied by a drop in spike amplitude at the same temperature and with its further decrease. At the same time, there was a decrease of spike reaction to iontophoretic application of acetylcholine below 30°. It is proposed that the reason for hypothermic changes of neuronal activity is decreasing rate of M-cholinergic process at 27°C - 29°C which leads to opening K+ channels of neuronal membranes and hence to attenuation of conductive function of dendrites and to imbalance of K+ ion homeostasis. Peculiarities of hypothermic regulation of neuronal spike activity depend on individual functional properties of cortical neurons.

关键词： Cortical Slices Spike Activity Acetylcholine Glutamate Hypothermia Dendro-Somatic Propagation

MOLECULAR ORGANIZATION OF POLY（N-ETHYL-4-vINYLPYRIDINIUM）-DODECYL SULFATE COMPLEXES:EFFECT OF POLYMERIZATION DEGREE,TEMPERATURE AND CONCENTRATION.

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MOLECULAR ORGANIZATION OF POLY（N-ETHYL-4-VINYLPYRIDINIUM）-...

Physiological Response of Halophyte (<i>Suaeda altissima</i>(L.) Pall.) and Glycophyte (<i>Spinacia oleracea</i>L.) to Salinity

40th IUPAC Congress

作者： M.v. Otdelnova E.M. Ivleva J.A. zakharova Department of Chemistry Moscow State UniversityMoscow 119992Russia Department of Chemistry Moscow State UniversityMoscow 119992Russia Department of Chemistry Moscow State UniversityMoscow 119992Russia

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American Journal of Plant Sciences 2013年第2期4卷 427-435页

作者： nataly.R. Meychik Yuliya I. Nikolaeva Igor P. Yermakov Plant Physiology Department Faculty of Biology M. V. Lomonosov Mosow State University Moscow Russia Plant Physiology Department Faculty of Biology M. V. Lomonosov Mosow State University Moscow Russia.

We have done a comparative study of ion status, growth and biochemical parameters in shoots and roots of seablite (Suaeda altissima (L.) Pall.) and spinach (Spinacia oleracea L.) grown with different salinity levels in the medium (0.5 - 750 mМ). A distinctive feature of the halophyte was a high Na+ content in tissues at its low concentration in the medium (0.5 mM). In these conditions, Na+ accumulation in seablite roots was four-fold higher than in spinach roots, and Na+ content in seablite leaves was almost 20-fold higher than in spinach. Together with an increase in sodium concentration in the medium, K+ content decreased six-fold in seablite leaves, while in spinach it did not decrease so drastically. We can suppose that in the halophyte, some processes occur only in the presence of sodium, and these functions of sodium cannot be fully fulfilled by potassium. Analysis of protein and total nitrogen content in tissues shows that at high salinity, the ability to synthesize non-protein nitrogen-containing compounds increases in the halophyte and decreases in the glycophyte. Data on proline content dynamics show that its increase in tissues of spinach (salinity levels 150 and 250 mМ) and seablite (salinity levels 0.5 and 750 mМ) is an indicator of plant injury. In seablite and spinach, proline is not a major osmoregulator. Its concentration both in roots and leaves was no more than 2.5 μmol/g fresh weight. The data presented in this work concern the accumulation and distribution of Na+, Cl?, K+ and ions, as well as growth and biochemical parameters. Our data show that the development of adaptation reactions in the whole plants in the conditions of high salinity is determined by morphofunctional systems and their interaction.

关键词： Suaeda altissima (L.) Pall. Spinacia oleracea L. Salinity Ions Praline Nitrogen Protein

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v_2O_5薄膜的电学性质及其应用

材料导报 2000年第10期14卷 36-38,10页

作者：童茂松戴国瑞高鼎三 Galina zakharova Olga Pozdniakova 吉林大学电子工程系集成光电子国家重点联合实验室长春130023 俄罗斯科学院乌拉尔分院固态化学研究所

综述了v_2O_5薄膜材料的结构、电学性质及其在电学中的应用。

关键词：电致变色敏感特性氧化钒薄膜结构电学性质

Mn^(2+)掺杂对v_2O_5纳米材料结构与电化学性能的影响

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无机材料学报 2013年第11期28卷 1200-1206页

作者：李兆龙孙华君徐杰张晓艳黄胜男朱泉峣陈文 Galina S.zakharova 武汉理工大学材料复合新技术国家重点实验室武汉430070 俄罗斯科学院乌拉尔分院固态化学研究所

以v2O5粉末、H2O2和Mn(CH3COO)2·4H2O为原料,采用水热法制备了纳米结构的锂离子电池阴极材料Mnx v2O5。运用X射线衍射(XRD)、X射线光电子能谱分析(XPS)和扫描电镜(SEM)测试对制备的材料进行结构和形貌表征,并利用充放电测试和交流阻抗... 详细信息

以v2O5粉末、H2O2和Mn(CH3COO)2·4H2O为原料,采用水热法制备了纳米结构的锂离子电池阴极材料Mnx v2O5。运用X射线衍射(XRD)、X射线光电子能谱分析(XPS)和扫描电镜(SEM)测试对制备的材料进行结构和形貌表征,并利用充放电测试和交流阻抗测试研究了样品的电化学性能。结果表明:随着锰掺杂量的增加,v2O5的正交晶型层状结构未发生改变,其层间距逐渐扩大,形貌由纳米短棒状向纳米带簇状变化。电化学测试表明:Mn2+掺杂提高了v2O5的电化学性能,其首次充放电效率由70.8%提高到90%以上;Mn0.01v2O5经过90次充放电循环后,其容量仍为192.2 mAh/g。Mn2+掺杂对v2O5电极材料的离子电导率有影响,Mn0.02v2O5离子电导率由未掺杂时的6.27×10-4S/cm提高到1.58×10-3S/cm。

关键词： Mnxv2O5 电极材料离子掺杂电化学性能

Hereditary Immunity and the Origin of Atherosclerosis

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Open Journal of Immunology 2014年第1期4卷 14-21页

作者： Sergey N. Rumyantsev vil K. Gerasimov Jergy Grzezczuk Roman A. Aron nataly.F. Avrova Irina v. Belyakova Ludmila v. Bobrakova Kirill F. Dubrov Ludmila v. Perkus vladimir F. Pospelov Nina M. Rogacheva Nikolay P. Shabalov Department of Evolutionary Immunology Andent Inc. Jersey City USA

This paper tries to present new confirmation for the opinion about the infectious origin of atherosclerosis from the viewpoint of the current knowledge of hereditary immunity. The performed integrative investigation included the reinterpretation of known clinical and epidemiological observations, supported by immunological, molecular ecological, genetic, and genomic discoveries. The revealed body of firstly achieved information is compatible with the concept that infectious agents contribute the clue step to the development of atherosclerosis over its initial stage performed during the triggering of the arterial endothelial wall by the molecular agent of proposed infectious origin.

关键词： Epidemic Spread Heterozygosity Homozygosity Immune Mosaicism Integrative Approach Plaque Formation

溶胶-凝胶法制备复合钒钼酸铵干凝胶薄膜及其湿敏特性研究

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功能材料 2001年第2期32卷 175-177页

作者：童茂松戴国瑞张玉书吴运大何秀丽高鼎三 vICTOR volkov GALINA zakharova 吉林大学电子工程系集成光电子国家重点联合实验室吉林长春130023 俄罗斯科学院乌拉尔分院固态化学研究所

通过溶胶－凝胶法制备了复合钒钼酸铵Ｈ２－ｘ（ＮＨ４）ｘＶ１０Ｍｏ２Ｏ３１＋δ＋·ｎＨ２０（ｘ＝０，１，２）干凝胶薄膜，对其进行ＴＸＲＤ和ＸＰＳ分析，同时研究了其温敏性能。

关键词：溶胶-凝胶法复合钒钼酸铵干凝胶薄膜湿敏特性制备