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Hot spots of DNA double-strand breaks and genomic contacts of human rDNA units are involved in epigenetic regulation

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Journal of Molecular Cell Biology 2015年第4期7卷 366-382页

作者： Nickolai A.Tchurikov Daria M.Fedoseeva Dmitri v.Sosin Anastasia v.Snezhkina nataliya v.melnikov. Anna v.Kudryavtseva Yuri v.Kravatsky Olga v.Kretova Department of Epigenetic Mechanisms of Gene Expression Regulation Engelhardt Institute of Molecular BiologyMoscow 119334Russia Group of Postgenomic Studies Engelhardt Institute of Molecular BiologyMoscow 119334Russia Laboratory of DNA-Protein Interactions Engelhardt Institute of Molecular BiologyMoscow 119334Russia

DNA double-strand breaks(DSBs)are involved in many cellular mechanisms,including replication,transcription,and genome *** recent observation that hot spots of DSBs in human chromosomes delimit DNA domains that possess coordinately expressed genes suggests a strong relationship between the organization of transcription patterns and hot spots of *** this study,we performed mapping of hot spots of DSBs in a human 43-kb ribosomal DNA(rDNA)repeated *** observed that rDNA units corresponded to the most fragile sites in human chromosomes and that these units possessed at least nine specific regions containing clusters of extremely frequently occurring DSBs,which were located exclusively in non-coding intergenic spacer(IGS)*** hot spots of DSBs corresponded to only a specific subset of DNase-hypersensitive sites,and coincided with CTCF,PARP1,and HNRNPA2B1 binding sites,and H3K4me3 *** rDNA-4C data indicate that the regions of IGS containing the hot spots of DSBs often form contacts with specific regions in different chromosomes,including the pericentromeric regions,as well as regions that are characterized by H3K27ac and H3K4me3 marks,CTCF binding sites,ChIA-PET and RIP signals,and high levels of *** data suggest a strong link between chromosome breakage and several different mechanisms of epigenetic regulation of gene expression.

关键词： double-strand breaks fragile sites rDNA IGS PARP1 HNRNPA2B1 4C

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Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency

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World Journal of Gastroenterology 2019年第20期25卷 2430-2441页

作者： Peter Layer nataliya Kashirskaya Natalya Gubergrits Department of Internal Medicine Israelitic HospitalHamburg 22297Germany Department of Genetic Epidemiology (Cystic Fibrosis group) Federal State Budgetary Institution “Research Centre for Medical Genetics”Moscow 115522Russia Department of Internal Medicine Donetsk National Medical UniversityLyman 83001Ukraine

The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy (PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency (PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters (such as height, body weight and body mass index), or gastrointestinal symptoms (such as abdominal pain, stool consistency and flatulence). PERT improved PEI-related malabsorption and weight maintenance in patients with cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post-surgical states. In patients with chronic pancreatitis, PERT improved PEI-related symptoms and quality of life measures. Several small retrospective studies have also suggested that PERT may have a positive impact on survival, but long-term studies assessing this effect were not identified. PERT is effective for treating malnutrition and supporting weight maintenance, and it is associated with improved quality of life and possibly with enhanced survival in patients with PEI. However, there is evidence that not all patients with PEI receive adequate PERT. Future work should aim to assess the long-term effects of PERT on the survival of patients with PEI.

关键词： Pancreatic exocrine insufficiency Pancreatic enzyme replacement therapy Survival Quality of life Malabsorption Cystic fibrosis Chronic pancreatitis Pancreatic cancer Post-surgical states

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Mechanisms of connective tissue formation and blocks of mitogen activated protein kinase

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Frontiers of Chemical Science and Engineering 2012年第2期6卷 232-237页

作者： lrina A SHURYGINA Michael G SHURYGIN nataliya I AYUSHINOvA Galina B GRANINA Nikolay v ZELENIN Scientific Center of Reconstructive and Restorative Surgery SB RAMS lrkutsk 664003Russia

Ninety male Wistar rats were selected under the ＂Guide for the Care and Use of Laboratory Animals＂ for skin-muscle wound models. Three groups of animals were examined respectively for inoculation of inhibitor of p38 MAPK （mitogen activated protein kinase） SB 203580 and JNK inhibitor SP 600125, and a control. Light microscopy, immunohistochemistry, and tensometry revealed that the inhibition of p38 or JNK cascades have modified the formation of the connective tissue scar. The degree of connective tissue growth in the area of surgical wound had been significantly reduced by the end of observation （30 d） as the SB 203580 was applied （% volume of collagen 43.60 （41.05 - 60.15） vs. 73.54 （66.87 - 78.01） in control, p = 0.002）. Conversely, when we have applied the JNK blocker, the density of collagen in scar tissue increased （78.14 （72.77 - 81.14）, p = 0.022 vs. control）. SB203580 inhibits the expression of p38, c-Jun and c-Fos. When we have used the JNK blocker, the expression of c-Fos and c-Jun decreased, but the expression of p38 increased. This determines the high functional activity of fibroblasts after using SP 600125. Obtained results show the importance of studying regulators of cell differentiation as potential drugs, which significantly affect the outcome of the pathological processes.

关键词： connective tissue mitogen activated protein kinase (MAPK) p38 JNK

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Enhancing Solar Energy Production Forecasting Using Advanced Machine Learning and Deep Learning Techniques: A Comprehensive Study on the Impact of Meteorological Data

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Computers, Materials & Continua 2024年第11期81卷 3147-3163页

作者： nataliya Shakhovska Mykola Medykovskyi Oleksandr Gurbych Mykhailo Mamchur Mykhailo Melnyk Instutute of Computer Science and Information Technologies Lviv Polytechnic National UniversityLviv79013Ukraine Department of Applied Mathematics University of Agriculture in KrakowKrakow31-120Poland Blackthorn AI Ltd.LondonEC1V 2NXUK

The increasing adoption of solar photovoltaic systems necessitates accurate forecasting of solar energy production to enhance grid stability,reliability,and economic *** study explores advanced machine learning(ML)and deep learning(DL)techniques for predicting solar energy generation,emphasizing the significant impact of meteorological data.A comprehensive dataset,encompassing detailed weather conditions and solar energy metrics,was collected and preprocessed to improve model *** models were developed and trained with different preprocessing ***,three datasets were prepared.A novel hour-based prediction wrapper was introduced,utilizing external sunrise and sunset data to restrict predictions to daylight hours,thereby enhancing model performance.A cascaded stacking model incorporating association rules,weak predictors,and a modified stacking aggregation procedure was proposed,demonstrating enhanced generalization and reduced prediction *** indicated that models trained on raw data generally performed better than those on stripped *** Long Short-Term Memory(LSTM)with Inception layers’model was the most effective,achieving significant performance improvements through feature selection,data preprocessing,and innovative modeling *** study underscores the potential to combine detailed meteorological data with advanced ML and DL methods to improve the accuracy of solar energy forecasting,thereby optimizing energy management and planning.

关键词： Solar energy prediction machine learning deep learning

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Pulsed laser reshaping and fragmentation of upconversion nanoparticles-from hexagonal prisms to ID nanorods through“Medusa”-like structures

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Nano Research 2021年第4期14卷 1141-1148页

作者： Laszlo Sajti Denis N.Karimov vasilina v.Rocheva nataliya A.Arkharova Kirill v.Khaydukov Oleg I.Lebedev Alexey E.voloshin Alla N.Generalova Boris N.Chichkov Evgeny v.Khaydukov AIT Austrian Institute of Technology GmbH Wiener Neustadt2700Austria Federal Scientific Research Centre“Crystallography and Photonics”Russian Academy of Sciences Moscow119333Russia Laboratoire CRISMAT UMR6508CNRS-ENSIACENUniversite CaenCaen14050France Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow 117997Russia Institutfiir Quantenoptik Leibniz Universitat HannoverHannover30167Germany Center of Biomedical Engineering Institute of Molecular Medicine Sechenov First Moscow State Medical UniversityMoscow119991Russia

One dimensional(1D)nanostructures attract considerable attention,enabling a broad application owing to their unique ***,the precise mechanism of 1D morphology attainment remains a matter of *** this study,ultrafast picosecond(ps)laser-induced treatment on upconversion nanoparticles(UCNPs)is offered as a tool for 1 D-nanostructures ***,reshaping through recrystallization process and bioadaptation of initially hydrophobic(β-Na_(1.5)Y_(1.5_)F_(6):Yb^(3+),Tm^(3+)/β-Na_(1.5)Y_(1.5_)F_(6))core/shell nanoparticles by means of one-step laser treatment in water are demonstrated.“True”1D nanostructures through"Medusa^-like structures can be obtained,maintaining anti-Stokes luminescence functionalities.A matter of the one-dimensional UCNPs based on direction of energy migration processes is *** proposed laser treatment approach is suitable for fast UCNP surface modification and nano-to-nano transformation,that open unique opportunities to expand UCNP applications in industry and biomedicine.

关键词： upconversion nanoparticles fluoride crystals upconversion nanorods one-dimensional(1D)structures laser-induced reshaping

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PNN-SvM Approach of Ti-Based Powder’s Properties Evaluation for Biomedical Implants Production

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Computers, Materials & Continua 2022年第6期71卷 5933-5947页

作者： Ivan Izonin Roman Tkachenko Michal Gregus Zoia Duriagina nataliya Shakhovska Lviv Polytechnic National University Lviv79013Ukraine Comenius University in Bratislava Bratislava82005Slovak Republic The John Paul II Catholic University of Lublin Lublin20-708Poland

The advent of additive technologies has provided a significant breakthrough in the production of medical *** has reduced costs,increased productivity and accuracy of the implant manufacturing ***,there are problems associated with assessing defects in the microstructure,mechanical and technological properties of alloys,both during their production by powder metallurgy and in the process of 3D *** traditional research methods of alloys properties demand considerable human,material,and time *** the same time,artificial intelligence tools create opportunities for intelligent evaluation of the conformity for the microstructure,phase composition,and properties of titanium powder’s *** provides new possibilities for the efficient production of biocompatible implants for various functional ***,the accuracy of the methods and models used should be as high as *** this paper we designed a hybrid PNN-SvM(Probabilistic Neural Network-Support vector Machine)high-precision approach for the intelligent evaluation of alloy properties for additive manufacturing of biomedical *** have proposed a new approach for extending the dimensionality of input data space by the outputs of the summation layer of the modified PNN *** classification based on the expanded dataset is performed using *** conducted experimental modeling of the proposed approach using a data set on the properties of titanium alloys Ti-6Al-4v and *** have demonstrated a significant increase in the accuracy of the PNN-SvM scheme compared to the single classifiers that form it and other machine learning methods.

关键词： PNN SvM hybrid systems classification accuracy medical implants additive manufacturing 3D printing titanium alloys

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Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov Aleksey v.Maksimkin nataliya A.Sipyagina Tarek Dayyoub Alena N.Malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.Nematulloev Dmitry v.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National University of Science and Technology"MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHMWPE) films, which provided special conditions for the crystallization of dissolved UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHMWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

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Structure Transformations in the Polycrystalline (Ti,Nb)<sub>3</sub>Al Alloy under Shock-Wave Loading

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Journal of Modern Physics 2011年第10期2卷 1141-1145页

作者： nataliya v. Kazantseva Evgenii v. Shorokhov 不详

Structure transformations in the two-phase (Ti, Nb)3Al alloy, induced by shock-wave loading, were studied. The samples were subjected to an impact of a steel plate. The maximum pressure on the samples’ surfaces was 100 GPa, while the maximum temperature was 573 K. The β0→α2 phase transformation occurred during strong deformations. High temperature rectilinear dislocations (such types of dislocations usually could arise at 1073 K) with the c-component, which occasionally formed slip bands, were located at the α2-phase grains after the shock. The deformation α2-phase twins were not observed.

关键词： Ti3Al Phase Transformation Shock Waves

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Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice

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World Journal of Diabetes 2020年第12期11卷 596-610页

作者： vadim v Klimontov Anton I Korbut Iuliia S Taskaeva nataliya P Bgatova Maksim v Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein Laboratory of Endocrinology Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Laboratory of Ultrastructural Research Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Laboratory of Clinical Immunogenetics Research Institute of Clinical and Experimental Lymphology–Branch of the Institute of Cytology and GeneticsSiberian Branch of Russian Academy of Sciences(RICEL–Branch of IC&G SB RAS)Novosibirsk 630060Russia Center for Genetic Resources of Laboratory Animals Institute of Cytology and GeneticsSiberian Branch of Russian Academy of SciencesNovosibirsk 630090Russia Department of Cardiometabolic Diseases Research Boehringer Ingelheim Pharma GmbHBiberach 88397Germany

BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney ***,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully *** of podocytes and nephrin expression in glomeruli in db/db diabetic *** We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 ***-matched male db/+mice were included as non-diabetic *** of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were *** evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,*** nephrin and transforming growth factor beta(TGF-β)were assessed by *** Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were *** expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated *** was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were *** decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of *** These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney *** anti-albuminuric effect of EMPA could be attributed to mitigation o

关键词： Diabetes Chronic kidney disease Albuminuria Podocyte Sodium-glucose transporter 2 inhibitors Empagliflozin

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voice Control for an Industrial Robot as a Combination of various Robotic Assembly Process Models

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Journal of Computer and Communications 2017年第11期5卷 1-15页

作者： Svitlana Maksymova Rami Matarneh vyacheslav v. Lyashenko nataliya v. Belova Department of Computer-Integrated Technologies Automation and Mechatronics Kharkiv National University of Radio Electronics Kharkiv Ukraine Department of Computer Science Prince Sattam Bin Abdulaziz University Al-Kharj Saudi Arabia Department of Informatics Kharkiv National University of Radio Electronics Kharkiv Ukraine

Models for the design of assembly processes are considered. various models for the voice control of an industrial robot are considered: a logical model, semantic networks, a frame model and Petri nets. It is shown that this set of models allows describing the process of designing the technological process for an industrial robot. The logical model of the technological process allows you to define logical relationships. A model based on semantic networks describes the relationship between assembly units in a detail. This allows you to determine the order and method of registration, as well as the mutual orientation of assembly units in the product. The frame model provides the ability to streamline the execution of the build process. A model based on Petri nets allows one to describe the type and sequence of technological transitions. Based on the proposed models, a method of voice control for an industrial robot is developed. The basic principles of voice control for an industrial robot are considered.

关键词： Robot voice Control Frame Model Petri Nets Logic Model Semantic Nets Robotic Assembly Processes

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