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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie M.K.Verge nataliya tokarska Justin M.Naniong Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Multiple sclerosis(MS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to *** efficient and effective repair programs following demyelination is a major goal and challenge in *** MS therapies focus largely on modulating the immune aspects of the disease contributing to *** this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few MS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage

Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system

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Neural Regeneration Research 2022年第5期17卷 1042-1050页

作者： Lydia Ayanwuyi nataliya tokarska Nikki A.McLean Jayne M.Johnston Valerie M.K.Verge Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Our lab has shown that brief electrical nerve stimulation(ES)has a dramatic impact on remyelination of lysophosphatidyl choline(LPC)-induced focally demyelinated rat peripheral nerves,while also inducing an axon-protective phenotype and shifting macrophages from a predominantly pro-inflammatory toward a pro-repair *** this same potential exists in the central nervous system is not ***,for proof of principle studies,the peripheral nerve demyelination and ES model was adapted to the central nervous system,whereby a unilateral focal LPC-induced demyelination of the dorsal column at the lumbar enlargement where the sciatic nerve afferents enter was created,so that subsequent ipsilateral sciatic nerve ES results in increased neural activity in the demyelinated *** reveal a robust focal demyelination at 7 days post-LPC *** of 1-hour ES at 7 days post-LPC polarizes macrophages/microglia toward a pro-repair phenotype when examined at 14 days post-LPC;results in smaller LPC-associated regions of inflammation compared to non-stimulated controls;results in significantly more cells of the oligodendroglial lineage in the demyelinated region;elevates myelin basic protein levels;and shifts the paranodal protein Caspr along demyelinated axons to a more restricted distribution,consistent with reformation of the paranodes of the nodes of *** also significantly enhanced levels of phosphorylated neurofilaments detected in the zones of demyelination,which has been shown to confer axon *** these findings support that strategies that increase neural activity,such as brief electrical stimulation,can be beneficial for promoting intrinsic repair following focal demyelinating insults in demyelinating diseases such as multiple *** animal procedures performed were approved by the University of Saskatchewan's Animal Research Ethics Board(protocol#20090087;last approval date:November 5,2020).

关键词： axon protection demyelination immune response lysophosphatidyl choline macrophage microglia multiple sclerosis myelin nervous system repair neural activity polarization

Age and geochemical evolution of granite magmatism in Olkhon region from Caledonian syncollisional ore-free granite to the rare metal granite and pegmatite of Middle Paleozoic intraplate setting

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China Geology 2024年第1期7卷 63-79页

作者： Viktor Antipin Valentina Makrygina Larisa Kushch nataliya Sheptyakova Vinogradov Institute of Geochemistry SB RAS664033 IrkutskRussia

The detailed description of two granite complexes in the Olkhon subterrane is *** Early Paleozoic Sharanur complex was formed by granitization of gneisses of the Olkhon *** includes migmatites,granite-gneisses,granites and pegmatites of normal alkalinity;they belong to the type of syncollisional *** Middle Paleozoic Aya granite complex includes mother Aya massif of amazonite-bearing granites and several types of rare-metal *** have elevated alkalinity,low of Ba,Sr,and high LILE and HFSE elements *** Aya pegmatites lie in northwest cracks of stretching and associated with the rise of the territory under the influence of the North Asian *** cracks and pegmatites mark the beginning of a new intraplate geodynamic *** geochemical types are distinguished among the pegmatites of this *** are amazonite pegmatites of Li-F type with Ta mineralization and complex type pegmatite with Be-Rb-Nb-Ta and Li-F mineralization(the Ilixin vein).The Tashkiney pegmatite vein is similar to Ilixin,but lies in the gneisses of the Olkhon *** shows high concentrations of Be,Nb,Ta,as well as W,Sn,but lacks Li and F,due to a greater depth and higher temperature of the melt crystallization of this pegmatite.

关键词： Pegmatite Geochemistry Submantle plume Magmatism Caledonian collision Middle Paleozoic intraplate setting Be-Rb-Nb-Ta-Li-F mineralization Olkhon region Russia

Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov Aleksey V.Maksimkin nataliya A.Sipyagina Tarek Dayyoub Alena N.Malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.Nematulloev Dmitry V.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National University of Science and Technology"MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHMWPE) films, which provided special conditions for the crystallization of dissolved UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHMWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms

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Animal Models and Experimental Medicine 2024年第5期 591-605页

作者： Mohammad Yasin Zamanian Niloofar Taheri Montather F.Ramadan Yasser Fakri Mustafa Safa Alkhayyat Klunko nataliya Sergeevna Hashem O.Alsaab Ahmed Hjazi Farnoosh Molavi Vasei Siamak Daneshvar Department of Physiology School of Medicine Hamadan University of Medical Sciences Department of Pharmacology and Toxicology School of Pharmacy Hamadan University of Medical Sciences School of Medicine Shahroud University of Medical Sciences College of Dentistry Al-Ayen University Department of Pharmaceutical Chemistry College of Pharmacy University of Mosul College of Pharmacy The Islamic University Department of Training of Scientific and Scientific-Pedagogical Personnel Russian New University Department of Pharmaceutics and Pharmaceutical Technology Taif University Department of Medical Laboratory College of Applied Medical Sciences Prince Sattam bin Abdulaziz University Department of Clinical Biochemistry School of Medicine Rafsanjan University of Medical Sciences Department of Surgery School of Medicine Hamadan University of Medical Sciences

Flavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer(CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription *** results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase-2 and wingless-related integration site(Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin-dependent kinase 2 and cyclin-dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2(CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y-box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal-regulated kinase 1/2, and disrupting the repair process of DNA double-strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit α(PIK3CA)-mutant CRC, resulting in a reduction in phosphatidylinositol-3 kinase(PI3K) expressio

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Optimization of the Active Composition of the Wind Farm Using Genetic Algorithms

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Computers, Materials & Continua 2021年第12期69卷 3065-3078页

作者： nataliya Shakhovska Mykola Medykovskyy Roman Melnyk nataliya Kryvinska Department of Artificial Intelligence Lviv Polytechnic National UniversityLviv79013Ukraine Department of Automared Systems Control Lviv Polytechnic National UniversityLviv79013Ukraine Faculty of Management Comenius UniversityBratislava81499Slovakia

The article presents the results of research on the possibilities of using genetic algorithms for solving the multicriteria optimization problem of determining the active components of a wind *** is carried out on two parameters:efficiency factor of wind farm use(integrated parameter calculated on the basis of 6 parameters of each of the wind farm),average power deviation level(average difference between the load power and energy generation capabilities of the active wind farm).That was done an analysis of publications on the use of genetic algorithms to solve multicriteria optimization *** simulations were performed,which allowed us to analyze the obtained statistical data and determine the main optimization *** was carried out a comparative analysis of the obtained results with other methods,such as the dynamic programming method;the dynamic programming method with the general increase of the set loading;the modified dynamic programming method,neural *** is established that the average power deviation for the genetic algorithm and for the modified dynamic programming method is located at the same level,33.7 and 28.8 kW,*** average value of the efficiency coefficient of wind turbine used for the genetic algorithm is 2.4%less than for the modified dynamic programming ***,the time of finding the solution by the genetic algorithm is 3.6 times less than for the modified dynamic programming *** obtained results provide an opportunity to implement an effective decision support system in energy flow management.

关键词： Wind farm genetic algorithm active composition of the wind farm optimization

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冰岛东部最美小镇白日梦想家们的隐世仙境

环球人文地理 2024年第13期 144-153页

作者：邓文倩 Vladimir marieagns nataliya Fotokon Sen Isabel Baldovi Marc Jedamus Kristina Ryan Unsplash 摄图网

冰岛东部峡湾，有一个小镇被群山、瀑布环绕，远离城市喧嚣，宛如被时间遗忘的世外桃源。在电影《白日梦想家》中，男主角沃尔特为了找到杂志新刊的底片，踏上了一段奇幻冒险旅程。他在影片里看似穿越了格陵兰岛、冰岛、尼泊尔、喜马拉...

冰岛东部峡湾，有一个小镇被群山、瀑布环绕，远离城市喧嚣，宛如被时间遗忘的世外桃源。在电影《白日梦想家》中，男主角沃尔特为了找到杂志新刊的底片，踏上了一段奇幻冒险旅程。他在影片里看似穿越了格陵兰岛、冰岛、尼泊尔、喜马拉雅山脉……但实际上整部电影的取景地全都在冰岛。影片最令人印象深刻的部分，大概是沃尔特用公仔和小孩子交换滑板后，在一条盘山公路上急速滑行。公路的尽头就是被LonelyPlanet评为“冰岛东部最美小镇”的塞济斯菲厄泽。

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最狭长山脉造就最狭长国度散落在智利与秘鲁的异度空间之谜

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环球人文地理 2024年第5期 38-49页

作者：丸子 Mark.C 胡子捷森郭卓然徐霄宇惺辰 MitchellFrye Nicole videobuzzing nataliya atosan Leckerstudio

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪...

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪勒拉。其中最引人关注的是中安第斯，这里仿佛是被神明选中的圣地，狭长的智利拥有世界上最孤独的岛屿；神秘的秘鲁掌握着印加帝国古老的文明。

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Contribution of pancreatic enzyme replacement therapy to survival and quality of life in patients with pancreatic exocrine insufficiency

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World Journal of Gastroenterology 2019年第20期25卷 2430-2441页

作者： Peter Layer nataliya Kashirskaya Natalya Gubergrits Department of Internal Medicine Israelitic HospitalHamburg 22297Germany Department of Genetic Epidemiology (Cystic Fibrosis group) Federal State Budgetary Institution “Research Centre for Medical Genetics”Moscow 115522Russia Department of Internal Medicine Donetsk National Medical UniversityLyman 83001Ukraine

The objective of this study was to analyze the current evidence for the use of pancreatic enzyme replacement therapy (PERT) in affecting survival and quality of life in patients with pancreatic exocrine insufficiency (PEI). Systematic searches of the literature were performed using the PubMed database. Articles were selected for inclusion if they reported findings from trials assessing the effects of PERT on quality of life, survival, malabsorption, growth parameters (such as height, body weight and body mass index), or gastrointestinal symptoms (such as abdominal pain, stool consistency and flatulence). PERT improved PEI-related malabsorption and weight maintenance in patients with cystic fibrosis, chronic pancreatitis, pancreatic cancer, and post-surgical states. In patients with chronic pancreatitis, PERT improved PEI-related symptoms and quality of life measures. Several small retrospective studies have also suggested that PERT may have a positive impact on survival, but long-term studies assessing this effect were not identified. PERT is effective for treating malnutrition and supporting weight maintenance, and it is associated with improved quality of life and possibly with enhanced survival in patients with PEI. However, there is evidence that not all patients with PEI receive adequate PERT. Future work should aim to assess the long-term effects of PERT on the survival of patients with PEI.

关键词： Pancreatic exocrine insufficiency Pancreatic enzyme replacement therapy Survival Quality of life Malabsorption Cystic fibrosis Chronic pancreatitis Pancreatic cancer Post-surgical states

An Ensemble Methods for Medical Insurance Costs Prediction Task

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Computers, Materials & Continua 2022年第2期70卷 3969-3984页

作者： nataliya Shakhovska Nataliia Melnykova Valentyna Chopiyak Michal Gregus ml Department of Artificial Intelligence Lviv Polytechnic National UniversityLviv79013Ukraine Department of Clinical Immunology and Allergology Danylo Halytsky Lviv National Medical UniversityLviv79010Ukraine Faculty of Management Comenius UniversityBratislava81499Slovakia

The paper reports three new ensembles of supervised learning predictors for managing medical insurance *** open dataset is used for data analysis methods *** usage of artificial intelligence in the management of financial risks will facilitate economic wear time and money and protect patients’*** learning is associated withmany expectations,but its quality is determined by choosing a good algorithm and the proper steps to plan,develop,and implement the *** paper aims to develop three new ensembles for individual insurance costs prediction to provide high prediction *** coefficient and Boruta algorithm are used for feature *** boosting,stacking,and bagging ensembles are built.A comparison with existing machine learning algorithms is *** modes based on regression tree and stochastic gradient descent is *** CART and Random Forest algorithms are *** boosting and stacking ensembles shown better accuracy than *** tuning parameters for boosting do not allow to decrease the RMSE ***,bagging shows its weakness in generalizing the *** stacking is developed using K Nearest Neighbors(KNN),Support Vector Machine(SVM),Regression Tree,Linear Regression,Stochastic Gradient *** random forest(RF)algorithm is used to combine the *** hundred trees are built *** Square Error(RMSE)has lifted the to 3173.213 in comparison with other *** quality of the developed ensemble for RootMean Squared Error metric is 1.47 better than for the best weak predictor(SVR).

关键词： Healthcare medical insurance prediction task machine learning ensemble data analysis