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Neural Regeneration Research 2024年第11期19卷 2339-2340页

作者： Valerie M.K.Verge nataliya Tokarska Justin M.Naniong Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Multiple sclerosis(MS)is a debilitating inflammatory disease of the central nervous system characterized by immune-mediated segmental demyelination and variable degrees of axonal and neuronal degeneration that contribute to disability.Inducing efficient and effective repair programs following demyelination is a major goal and challenge in MS.Conventional MS therapies focus largely on modulating the immune aspects of the disease contributing to lesions.While this alleviates some symptoms and mitigates damage,it does not tackle the fundamental challenge of effective remyelination,which few MS patients experience,especially in the progressive phase of the disease.

关键词： sclerosis degeneration damage

Age and geochemical evolution of granite magmatism in Olkhon region from Caledonian syncollisional ore-free granite to the rare metal granite and pegmatite of Middle Paleozoic intraplate setting

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China Geology 2024年第1期7卷 63-79页

作者： Viktor Antipin Valentina Makrygina Larisa Kushch nataliya Sheptyakova Vinogradov Institute of Geochemistry SB RAS664033 IrkutskRussia

The detailed description of two granite complexes in the Olkhon subterrane is given.The Early Paleozoic Sharanur complex was formed by granitization of gneisses of the Olkhon series.It includes migmatites,granite-gneisses,granites and pegmatites of normal alkalinity;they belong to the type of syncollisional granites.The Middle Paleozoic Aya granite complex includes mother Aya massif of amazonite-bearing granites and several types of rare-metal pegmatites.They have elevated alkalinity,low of Ba,Sr,and high LILE and HFSE elements contents.The Aya pegmatites lie in northwest cracks of stretching and associated with the rise of the territory under the influence of the North Asian plume.These cracks and pegmatites mark the beginning of a new intraplate geodynamic setting.Two geochemical types are distinguished among the pegmatites of this complex.These are amazonite pegmatites of Li-F type with Ta mineralization and complex type pegmatite with Be-Rb-Nb-Ta and Li-F mineralization(the Ilixin vein).The Tashkiney pegmatite vein is similar to Ilixin,but lies in the gneisses of the Olkhon series.It shows high concentrations of Be,Nb,Ta,as well as W,Sn,but lacks Li and F,due to a greater depth and higher temperature of the melt crystallization of this pegmatite.

关键词： Pegmatite Geochemistry Submantle plume Magmatism Caledonian collision Middle Paleozoic intraplate setting Be-Rb-Nb-Ta-Li-F mineralization Olkhon region Russia

The effects of slight atmospheric pressure fluctuations on the occurrence of emergency transport due to suicidal injuries

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Health 2010年第5期2卷 448-453页

作者： Lyudmyla Aleksandrovna didyk Yuriy Pavlovich Gorgo Joris Jan Josef Dirckx Irina Aleksandrovna Semenova nataliya petrovna didyk Dmytro Sergeevich Gorlov 不详

The objective of this study was to test the hypothesis that a relation exists between slight atmospheric pressure fluctuations (APF) in the far infrasound frequency range and daily number of emergency transport events due to suicidal injuries (EESU). The regression models to compare groups were used to assess the relation of EESU to the mean daily amplitude of APF (APF-A) and to the ratio of APF amplitude averaged over the daytime to the APF amplitude averaged over the nighttime (Rdn). To eliminate the confounding effects of basic meteorological parameters and annual trend in EESU, the non- parametric smoothing method was used in a stepwise manner. The low APF-A (95% CI = 1.06- 1.16 Pa) compared to their common middle levels and the high (95% CI = 3.18-3.64 Pa), as well the low Rdn (СI = 0.83-0.92) and very high Rdn (CI = 3.05-3.77) compared to their more closed to common regular values (СI = 1.69-1.90) turned out to be more beneficial factors promoting the decrease in the incidence of EESU. We suppose that more attention needs to be paid to the meteorotropic effects of APF on certain kinds of psychopathology resulting in suicidal behaviour, and further investigations in different geograph- ical and climatic conditions, especially in those with more intense atmospheric perturbations, are necessary.

关键词： Atmospheric Pressure Fluctuations Suicidal Injuries Emergency Events

Porous Shish-Kebab Structure Prepared from Oriented UHMWPE Films by Processing in Supercritical CO_(2)

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Chinese Journal of Polymer Science 2024年第1期42卷 97-104,I0009页

作者： Sergey A.Lermontov Aleksey V.Maksimkin nataliya A.Sipyagina Tarek Dayyoub Alena N.Malkova Evgeniy A.Kolesnikov Elena A.Straumal Inna O.Gozhikova Saidkhodzha G.Nematulloev Dmitry V.Telyshev Institute of Physiologically Active Compounds of the Russian Academy of Sciences Chernogolovka 142432Russia Institute for Bionic Technologies and Engineering I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 19991Russia National University of Science and Technology"MISIS"Moscow 119049 Russia Institute of Biomedical Systems National Research University of Electronic TechnologyZelenogradMoscow 124498Russia

For the first time, a highly crystalline porous shish-kebab structure with a high degree of crystallinity was obtained by using a combination of two methods for the formation of porous polymeric materials. A treatment procedure using supercritical carbon dioxide(sc CO_(2))was carried out for oriented ultrahigh molecular weight polyethylene(UHMWPE) films, which provided special conditions for the crystallization of dissolved UHMWPE macromolecules on the surface of oriented UHMWPE crystals. The prepared porous materials were investigated by scanning electron microscopy(SEM) and differential scanning calorimetry(DSC). The particularity of the obtained porous shish-kebab is the absence of the amorphous phase between lamellar crystals(kebabs). The obtained pores had an oval shape, and they were oriented in the orientation direction of the UHMWPE macromolecules. The pore size ranged from 0.05 μm to 4 μm. Controlling the conditions for the crystallization of the UHMWPE macromolecules using supercritical CO_(2) gives the possibility to control the size of both lamellar disks and pores formed.

关键词： UHMWPE Supercritical CO_(2) Porous shish-kebab structure

最狭长山脉造就最狭长国度散落在智利与秘鲁的异度空间之谜

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环球人文地理 2024年第5期 38-49页

作者：丸子 Mark.C 胡子捷森郭卓然徐霄宇惺辰 MitchellFrye Nicole videobuzzing nataliya atosan Leckerstudio

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪...

在安第斯山脉的中部，谜团伴随着文明散落在狭长的海岸线，似乎永远找不到答案……安第斯山脉从南到北分为三大部分，北安第斯包括厄瓜多尔、哥伦比亚和委内瑞拉；中安第斯包括智利和秘鲁科迪勒拉；南安第斯包括火地岛和巴塔哥尼亚科迪勒拉。其中最引人关注的是中安第斯，这里仿佛是被神明选中的圣地，狭长的智利拥有世界上最孤独的岛屿；神秘的秘鲁掌握着印加帝国古老的文明。

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An Ensemble Methods for Medical Insurance Costs Prediction Task

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Computers, Materials & Continua 2022年第2期70卷 3969-3984页

作者： nataliya Shakhovska Nataliia Melnykova Valentyna Chopiyak Michal Gregus ml Department of Artificial Intelligence Lviv Polytechnic National UniversityLviv79013Ukraine Department of Clinical Immunology and Allergology Danylo Halytsky Lviv National Medical UniversityLviv79010Ukraine Faculty of Management Comenius UniversityBratislava81499Slovakia

The paper reports three new ensembles of supervised learning predictors for managing medical insurance costs.The open dataset is used for data analysis methods development.The usage of artificial intelligence in the management of financial risks will facilitate economic wear time and money and protect patients’health.Machine learning is associated withmany expectations,but its quality is determined by choosing a good algorithm and the proper steps to plan,develop,and implement the model.The paper aims to develop three new ensembles for individual insurance costs prediction to provide high prediction accuracy.Pierson coefficient and Boruta algorithm are used for feature selection.The boosting,stacking,and bagging ensembles are built.A comparison with existing machine learning algorithms is given.Boosting modes based on regression tree and stochastic gradient descent is built.Bagged CART and Random Forest algorithms are proposed.The boosting and stacking ensembles shown better accuracy than bagging.The tuning parameters for boosting do not allow to decrease the RMSE too.So,bagging shows its weakness in generalizing the prediction.The stacking is developed using K Nearest Neighbors(KNN),Support Vector Machine(SVM),Regression Tree,Linear Regression,Stochastic Gradient Boosting.The random forest(RF)algorithm is used to combine the predictions.One hundred trees are built forRF.RootMean Square Error(RMSE)has lifted the to 3173.213 in comparison with other predictors.The quality of the developed ensemble for RootMean Squared Error metric is 1.47 better than for the best weak predictor(SVR).

关键词： Healthcare medical insurance prediction task machine learning ensemble data analysis

PNN-SVM Approach of Ti-Based Powder’s Properties Evaluation for Biomedical Implants Production

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Computers, Materials & Continua 2022年第6期71卷 5933-5947页

作者： Ivan Izonin Roman Tkachenko Michal Gregus Zoia Duriagina nataliya Shakhovska Lviv Polytechnic National University Lviv79013Ukraine Comenius University in Bratislava Bratislava82005Slovak Republic The John Paul II Catholic University of Lublin Lublin20-708Poland

The advent of additive technologies has provided a significant breakthrough in the production of medical implants.It has reduced costs,increased productivity and accuracy of the implant manufacturing process.However,there are problems associated with assessing defects in the microstructure,mechanical and technological properties of alloys,both during their production by powder metallurgy and in the process of 3D printing.Thus traditional research methods of alloys properties demand considerable human,material,and time resources.At the same time,artificial intelligence tools create opportunities for intelligent evaluation of the conformity for the microstructure,phase composition,and properties of titanium powder’s alloys.It provides new possibilities for the efficient production of biocompatible implants for various functional purposes.However,the accuracy of the methods and models used should be as high as possible.In this paper we designed a hybrid PNN-SVM(Probabilistic Neural Network-Support Vector Machine)high-precision approach for the intelligent evaluation of alloy properties for additive manufacturing of biomedical implants.We have proposed a new approach for extending the dimensionality of input data space by the outputs of the summation layer of the modified PNN topology.Subsequent classification based on the expanded dataset is performed using SVM.We conducted experimental modeling of the proposed approach using a data set on the properties of titanium alloys Ti-6Al-4V and Ti-Al-V-Zr.We have demonstrated a significant increase in the accuracy of the PNN-SVM scheme compared to the single classifiers that form it and other machine learning methods.

关键词： PNN SVM hybrid systems classification accuracy medical implants additive manufacturing 3D printing titanium alloys

Brief electrical nerve stimulation enhances intrinsic repair capacity of the focally demyelinated central nervous system

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Neural Regeneration Research 2022年第5期17卷 1042-1050页

作者： Lydia Ayanwuyi nataliya Tokarska Nikki A.McLean Jayne M.Johnston Valerie M.K.Verge Department of Anatomy Physiology and PharmacologyUniversity of SaskatchewanSaskatoonSKCanada Cameco MS Neuroscience Research Center University of SaskatchewanSaskatoonSKCanada

Our lab has shown that brief electrical nerve stimulation(ES)has a dramatic impact on remyelination of lysophosphatidyl choline(LPC)-induced focally demyelinated rat peripheral nerves,while also inducing an axon-protective phenotype and shifting macrophages from a predominantly pro-inflammatory toward a pro-repair phenotype.Whether this same potential exists in the central nervous system is not known.Thus,for proof of principle studies,the peripheral nerve demyelination and ES model was adapted to the central nervous system,whereby a unilateral focal LPC-induced demyelination of the dorsal column at the lumbar enlargement where the sciatic nerve afferents enter was created,so that subsequent ipsilateral sciatic nerve ES results in increased neural activity in the demyelinated axons.Data reveal a robust focal demyelination at 7 days post-LPC injection.Delivery of 1-hour ES at 7 days post-LPC polarizes macrophages/microglia toward a pro-repair phenotype when examined at 14 days post-LPC;results in smaller LPC-associated regions of inflammation compared to non-stimulated controls;results in significantly more cells of the oligodendroglial lineage in the demyelinated region;elevates myelin basic protein levels;and shifts the paranodal protein Caspr along demyelinated axons to a more restricted distribution,consistent with reformation of the paranodes of the nodes of Ranvier.ES also significantly enhanced levels of phosphorylated neurofilaments detected in the zones of demyelination,which has been shown to confer axon protection.Collectively these findings support that strategies that increase neural activity,such as brief electrical stimulation,can be beneficial for promoting intrinsic repair following focal demyelinating insults in demyelinating diseases such as multiple sclerosis.All animal procedures performed were approved by the University of Saskatchewan's Animal Research Ethics Board(protocol#20090087;last approval date:November 5,2020).

关键词： axon protection demyelination immune response lysophosphatidyl choline macrophage microglia multiple sclerosis myelin nervous system repair neural activity polarization

The effect of two COVID-19 lockdowns on physical activity of school-age children

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Sports Medicine and Health Science 2022年第2期4卷 119-126页

作者： Olena Yelizarova Tetiana Stankevych Alla Parats Nadiya Polka Oksana Lynchak nataliya Diuba Svitlana Hozak State Institution“O.M.Marzieiev Institute for Public Health” National Academy of Medical Sciences of UkraineKyivUkraine Brovary School N9 Kyiv OblastUkraine

The introduction of strict quarantine restrictions in many countries initiated a direction in science to study the behavioral characteristics of children and adolescents during the social isolation at the population level.We present our observations during the two lockdowns in Ukraine.The objective of this study was to determine:a)the level of light(LPA)and moderate-to-vigorous(MVPA)physical activity among school-age children,and b)the impact of the external and internal factors on their physical activity during the lockdown.Global Physical Activity Questionnaire(GPAQ)as part of our questionnaire Q-RAPH was used.Parents of 1091 children 6–18 years old(54%boys)filled Q-RAPH at two measurement points in 2020 and 2021.After performing ANCOVA and logistic regression,we found a significant decrease in MVPA by 12.7%in 2021 compared to 2020(p<0.001)while LPA was about 1.5 h a day during both periods.The proportion of children who reach the recommended levels of MVPA also decreased by 13.7%in 2021(p<0.001).Factors negatively affecting the achievement of 60 min a day of MVPA were female gender,chronic diseases,overweight/obesity,non-participation in organized sports,and a decrease in the average air temperature.This study evidences the insufficient level of preventive measures and requires an intensification of health education among the Ukrainian population.When developing preventive measures,special attention should be paid to groups vulnerable to MVPA reduction as children who have chronic diseases and/or overweight/obesity as well as non-participation in sports.

关键词： Children Adolescents School-age Physical activity Lockdown COVID-19

Late recurrence of localized pure seminoma in prostate gland:A case report

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World Journal of Clinical Oncology 2022年第1期13卷 62-70页

作者： Abinav Baweja nataliya Mar Arash Rezazadeh Kalebasty Hematology/Oncology UCI Medical CenterUniversity of CaliforniaOrangeCA 92868United States

BACKGROUND Late relapses of early-stage germ cell tumors are rare.Most patients(-85%)with stage I seminoma are cured by radical orchiectomy.The detection of late relapse is challenging given the relative rarity of this phenomenon,and the fact that patients who have completed surveillance are usually not undergoing regular oncologic workup nor imaging.While many treatment options do exist for a patient with late relapse of seminoma,surgery is typically the mainstay as these tumors are generally thought to be more chemo-resistant.CASE SUMMARY In this article,we describe the management of a patient with an early-stage pure seminoma who was subsequently identified to have a recurrence two decades later.We provide a review of the literature not only focused on clinical factors and biology,but also the management of late recurrences specifically in pure seminoma and in prostate gland.CONCLUSION There is a paucity of data and treatment recommendations for this clinical entity,and a multidisciplinary approach emphasizing subspecialty expert consultation and patient education is imperative.

关键词： Late recurrence of pure seminoma Pure seminoma Seminoma Primary prostatic seminoma Germ cell tumor relapse Treatment of relapsed seminoma Biology of pure seminoma Seminoma tumor markers Case report