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Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy

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Neural Regeneration Research 2022年第10期17卷 2172-2178页

作者： Wei Zheng So natalie Shi Qi wong Hong Chang Tan Molly Tzu Yu Lin Isabelle Xin Yu Lee Jodhbir S.Mehta Yu-Chi Liu Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Singapore Eye Research Institute SingaporeSingapore Department of Endocrinology Singapore General HospitalSingaporeSingapore Department of Cornea and External Eye Disease Singapore National Eye CentreSingaporeSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore

Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus,affecting nerves in all parts of the body including corneal nerves and peripheral nervous system,leading to diabetic corneal neuropathy and diabetic peripheral neuropathy,*** peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies,clinical scoring,and skin ***,these diagnostic methods have limited sensitivity in detecting small-fiber disease,hence they do not accurately reflect the status of diabetic *** recently,analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral *** this review,we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy,elaborating on the foundational aspects of each:pathogenesis,clinical presentation,evaluation,and *** will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy,particularly early diabetic peripheral neuropathy;the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy;and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy.

关键词： corneal nerve quantification corneal nerves diabetic cornea diabetic corneal neuropathy diabetic microvascular complications diabetic peripheral neuropathy in vivo confocal microscopy neurotrophic keratopathy ocular surface

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债务滚雪球全球写字楼市场越来越脆弱

商业周刊（中文版） 2023年第15期 52-55页

作者： natalie wong John Gittelsohn Jack Sidders Shawna Kwan 汪泽(译) 不详

在纽约和伦敦,光鲜亮丽的写字楼的业主们正摆脱债务,而不是白白地拿钱去填坑。旧金山市中心最大购物广场的业主已经放弃了这处物业。香港地区一幢新摩天大楼则只租出去一个季度。

关键词：写字楼市场购物广场光鲜亮丽摩天大楼债务滚雪球物业业主

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圣诞老人的疫情应对方案

商业周刊（中文版） 2020年第24期 12-13页

作者： Carolina Gonzalez natalie wong 杜然(译) 不详

新冠病毒颠覆了生活的方方面面,极大地改变了人们的工作、学习方式,甚至崇拜方式。现在,它准备对现代生存的另一大支柱——圣诞老人下手了。具有标志意义的连锁百货店梅西百货(Macy’s)位于曼哈顿34街的旗舰店,是有史以来最著名的圣诞... 详细信息

新冠病毒颠覆了生活的方方面面,极大地改变了人们的工作、学习方式,甚至崇拜方式。现在,它准备对现代生存的另一大支柱——圣诞老人下手了。具有标志意义的连锁百货店梅西百货(Macy’s)位于曼哈顿34街的旗舰店,是有史以来最著名的圣诞老人电影的拍摄地。该公司宣布,由于新冠肺炎疫情大流行的缘故,这位快活的老精灵今年不会来店里了。虽然美国许多购物中心的圣诞老人还会坚持在岗,但美食广场附近传统的假北极背景会呈现出不同以往的外观,届时许多圣诞老人将在网上清点他们可爱又顽皮的礼品清单。

关键词：应对方案购物中心圣诞老人标志意义旗舰店拍摄地曼哈顿

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谁会在新冠疫情期间买购物中心?

商业周刊（中文版） 2020年第9期 16-17页

作者： Noah Buhayar natalie wong 孟洁冰(译) 不详

早在新型冠状病毒流行前,沃尔玛(Walmart)和西尔斯(Sears)就关掉了位于洛杉机南区的鲍德温山克伦肖广场(Baldwin Hills Crenshaw Plaza)的门店。最近几周,这个购物中心的电影院和其他许多零售商也因为居家令而关门。有些商家可能很难重... 详细信息

早在新型冠状病毒流行前,沃尔玛(Walmart)和西尔斯(Sears)就关掉了位于洛杉机南区的鲍德温山克伦肖广场(Baldwin Hills Crenshaw Plaza)的门店。最近几周,这个购物中心的电影院和其他许多零售商也因为居家令而关门。有些商家可能很难重新开业。

关键词：西尔斯洛杉机沃尔玛购物中心鲍德温零售商门店电影院

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留学?移民?去加拿大吧

商业周刊（中文版） 2019年第5期 33-34页

作者： natalie wong Theophilos Argitis natalie Obiko Pearson Erik Hertzberg Sandrine Rastello 竹西(译) 不详

在加尔各答长大的艾莎·乔克哈尼(Ayesha Chokhani)并不喜欢寒冷的天气。然而,当她攻读硕士学位时,这位29岁的学生选择了多伦多大学,那里的冬季气温远低于冰点。

关键词：加拿大留学移民多伦多大学加尔各答硕士学位学生选择

A review of strategies to overcome immune resistance in the treatment of advanced prostate cancer

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Cancer Drug Resistance 2023年第3期6卷 656-673页

作者： Kenneth Sooi Robert Walsh Nesaretnam Kumarakulasinghe Alvin wong natalie Ngoi Department of Haematology-Oncology National University Cancer InstituteSingapore 119228Singapore

Immunotherapy has become integral in cancer therapeutics over the past two decades and is now part of standard-of-care treatment in multiple cancer types. While various biomarkers and pathway alterations such as dMMR, CDK12, and AR-V7 have been identified in advanced prostate cancer to predict immunotherapy responsiveness, the vast majority of prostate cancer remain intrinsically immune-resistant, as evidenced by low response rates to anti-PD(L)1 monotherapy. Since regulatory approval of the vaccine therapy sipuleucel-T in the biomarker-unselected population, there has not been much success with immunotherapy treatment in advanced prostate cancer. Researchers have looked at various strategies to overcome immune resistance, including the identification of more biomarkers and the combination of immunotherapy with existing effective prostate cancer treatments. On the horizon, novel drugs using bispecific T-cell engager (BiTE) and chimeric antigen receptors (CAR) technology are being explored and have shown promising early efficacy in this disease. Here we discuss the features of the tumour microenvironment that predispose to immune resistance and rational strategies to enhance antitumour responsiveness in advanced prostate cancer.

关键词： Prostate cancer immunotherapy immune checkpoint inhibitor immune resistance tumour microenvironment

Inner blood-retina barrier involvement in dry age-related macular degeneration(AMD) pathology

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Neural Regeneration Research 2020年第9期15卷 1656-1657页

作者： natalie Hudson Mark Cahill Matthew Campbell Neurovascular Genetics Unit Smurfit Institute of GeneticsTrinity College DublinDublinIreland Royal Victoria Eye and Ear Hospital Adelaide RoadDublin 2Ireland

Age-relatedmaculardegeneration(AMD)isaprogressiveneurodegenerative disease with a global prevalence of 8.7%in people over the age of 45. It is one of the leading causes of central retinal blindness in the industrialized world leading to loss of an individual’s ability to read, drive and see fine details, such as recognition of faces. By 2040, it is estimated that 288 million individuals worldwide will be diagnosed with AMD due to improved life expectancy(wong et al., 2014).

关键词： AMD individual degeneration