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Resolving the Mortierellaceae phylogeny through synthesis of multi-gene phylogenetics and phylogenomics

Fungal Diversity 2020年第5期104卷 267-289页

作者： natalie vandepol Julian Liber Alessandro Desirò Hyunsoo Na Megan Kennedy Kerrie Barry Igor V.Grigoriev Andrew N.Miller Kerry O’Donnell Jason E.Stajich Gregory Bonito Department of Microbiology and Molecular Genetics Michigan State UniversityEast LansingMI 48824USA Department of Plant Biology Michigan State UniversityEast LansingMI 48824USA Department of Plant Soil and Microbial Sciences Michigan State UniversityEast LansingMI 48824USA Joint Genome Institute BerkeleyCA 94720USA Illinois Natural History Survey University of Illinois Urbana-ChampaignChampaignIL 61820USA United States Department of Agriculture Agricultural Research ServicePeoriaIL 61604USA Department of Microbiology and Plant Pathology&Institute for Integrative Genome Biology University of California-RiversideRiversideCA 92521USA

Early efforts to classify Mortierellaceae were based on macro-and micromorphology,but sequencing and phylogenetic studies with ribosomal DNA(rDNA)markers have demonstrated conflicting taxonomic groupings and polyphyletic *** some taxonomic confusion in the family has been clarified,rDNA data alone is unable to resolve higher level phylogenetic relationships within *** this study,we applied two parallel approaches to resolve the Mortierel-laceae phylogeny:low coverage genome(LCG)sequencing and high-throughput,multiplexed targeted amplicon sequenc-ing to generate sequence data for multi-gene *** then combined our datasets to provide a well-supported genome-based phylogeny having broad sampling depth from the amplicon *** the Mortierellaceae phylogeny into monophyletic genera resulted in 13 genera,7 of which are newly ***-coverage genome sequencing proved to be a relatively cost-effective means of generating a high-confidence *** multi-gene phylogenetics approach enabled much greater sampling depth and breadth than the LCG approach,but has limitations *** present this work to resolve some of the taxonomic confusion and provide a genus-level framework to empower future studies on Mortierellaceae diversity and evolution.

关键词： Mortierellaceae Phylogenomics Molecular systematics Taxonomy Multi-locus sequence typing

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CO2 activation on bimetallic CuNi nanoparticles

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Progress in Natural Science:Materials International 2016年第5期26卷 487-492页

作者： natalie Austin Brandon Butina Giannis Mpourmpakis Department of Chemical Engineering University of Pittsburgh

Density functional theory calculations have been performed to investigate the structural, electronic, and CO2adsorption properties of 55-atom bimetallic Cu Ni nanoparticles（NPs） in core-shell and decorated architectures,as well as of their monometallic counterparts. Our results revealed that with respect to the monometallic Cu55and Ni55parents, the formation of decorated Cu12Ni43and core-shell Cu42Ni13are energetically favorable. We found that CO2chemisorbs on monometallic Ni55, core-shell Cu13Ni42, and decorated Cu12Ni43and Cu43Ni12,whereas, it physisorbs on monometallic Cu55and core-shell Cu42Ni13. The presence of surface Ni on the NPs is key in strongly adsorbing and activating the CO2molecule（linear to bent transition and elongation of C=O bonds）. This activation occurs through a charge transfer from the NPs to the CO2molecule, where the local metal d-orbital density localization on surface Ni plays a pivotal role. This work identifies insightful structureproperty relationships for CO2activation and highlights the importance of keeping a balance between NP stability and CO2adsorption behavior in designing catalytic bimetallic NPs that activate CO2.

关键词： Density functional theory Alloys CO2adsorption Catalysis Stability

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Sexual selection and environmental change:what do we know and what comes next?

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Current Zoology 2021年第3期67卷 293-298页

作者： natalie Pilakouta Murielle Aluimd School of Biological Sciences University of AberdeenAberdeen AB243FXUK Department of Ecology and Genetics Animal EcologyEvolutionary Biology Centre(EBC)Uppsala UniversityNorbyvagen 18D 75236 UppsalaSweden

Anthropogenic environmental change is the most significant threat to biodiversity in the 21st *** populations are experiencing rapid changes in their biotic and abiotic environment,which impose novel selection pressures on organisms and increase the risk of population *** is thus a pressing need to understand what affects the capacity of populations to respond and adapt to environmental *** behavioral traits are very labile,they provide a means of rapidly responding to environmental change(Sih et al.2011;Tuomainen and Candolin 2011).

关键词： al. selection threat

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Role of serotonin in modulating the development and function of adult-born neurons in the olfactory bulb

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Neural Regeneration Research 2022年第6期17卷 1253-1254页

作者： natalie Fomin-Thunemann Olga Garaschuk Department of Biomedical Engineering Boston UniversityBostonMAUSA Institute of Physiology Department NeurophysiologyEberhard Karls University of TübingenTübingenGermany

The neuromodulatory transmitter serotonin(5-hydroxytryptamine,5-HT)is synthesized by neurons located in the brainstem,which project more or less densely to the entire central nervous system(Charnay and Leger,2010).Serotonin regulates a variety of physiological functions,including food intake,reward,reproduction,sleep-wake cycle,memory,cognition,emotion,and mood(Charnay and Leger,2010).

关键词： serotonin intake modulator

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No evidence of contagious yawning in the red-footed tortoise Geochelone carbonaria

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Current Zoology 2011年第4期57卷 477-484页

作者： Anna WILKINSON natalie SEBANZ Isabella MANDL Ludwig HUBER Department of Cognitive Biology University of Vienna Althanstrasse 14 Vienna 1090 Austria Department of Biological Sciences University of Lincoln Lincoln LN2 2LG UK Donders Institute for Brain Cognition and Behavior Centre for Cognition Radboud University Nijmegen P.O. Box 9104 6500 HE Nijmegen The Netherlands

Three hypotheses have attempted to explain the phenomenon of contagious yawning. It has been hypothesized that it is a fixed action pattern for which the releasing stimulus is the observation of another yawn, that it is the result of non-conscious mimicry emerging through close links between perception and action or that it is the result of empathy, involving the ability to engage in mental state attribution. This set of experiments sought to distinguish between these hypotheses by examining contagious yawning in a species that is unlikely to show nonconscious mimicry and empathy but does respond to social stimuli： the red-footed tortoise Geochelone carbonaria. A demonstrator tortoise was conditioned to yawn when presented with a red square-shaped stimulus. Observer tortoises were exposed to three conditions： observation of conditioned yawn, non demonstration control, and stimulus only control. We measured the number of yawns for each observer animal in each condition. There was no difference between conditions. Experiment 2 therefore increased the number of conditioned yawns presented. Again, there was no significant difference between conditions. It seemed plausible that the tortoises did not view the conditioned yawn as a real yawn and therefore a final experiment was run using video recorded stimuli. The observer tortoises were presented with three conditions： real yawn, conditioned yawns and empty background. Again there was no significant difference between conditions. We therefore conclude that the red-footed tortoise does not yawn in response to observing a conspecific yawn. This suggests that contagious yawning is not the result of a fixed action pattern but may involve more complex social processes [Current Zoology 57 （4）： 477-484, 2011].

关键词： Reptile Contagious yawn Empathy Nonconscious mimicry Fixed action pattern

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Health anxiety and work loss in patients diagnosed with serrated polyposis syndrome:A cross sectional study

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World Journal of Clinical Oncology 2025年第2期16卷 52-62页

作者： Angus Thompson natalie R Dierick Louise Heiniger Stuart N Kostalas School of Clinical Medicine University of New South WalesPort Macquarie 2444New South WalesAustralia Department of Gastroenterology Port Macquarie GastroenterologyPort Macquarie 2444New South WalesAustralia

BACKGROUND Serrated polyposis syndrome(SPS)is a polyposis condition with neoplastic potential,but its psychological impact is not well *** To assess health anxiety prevalence in a regional Australian cohort of SPS patients and explore factors influencing it,including workforce impacts of regular *** This cross-sectional study screened patients aged 18-65 undergoing colonoscopy in a regional gastroenterology practice between January 2015 and June *** SPS patients were invited to *** included the Short Health Anxiety Inventory,employment status,and previous demographic and medical *** Health anxiety was found in 21.57%of SPS patients,with anxious patients being significantly more concerned about surveillance(OR=7.70).Patients lost an average of 11.04 work hours per *** Health anxiety in SPS patients aligns with rates in other gastroenterology *** it may improve management,though further research is needed to better understand prevalence and care improvements.

关键词： Serrated polyposis syndrome Health anxiety Colorectal cancer Surveillance

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Therapeutic response in children with ADHD: role of observers and settings

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World Journal of Pediatrics 2020年第3期16卷 314-321页

作者： Venkat Bhat Sarojini MSengupta natalie Grizenko Ridha Joober Douglas Mental Health University Institute FBC Building6875 Boul.LaSalleVerdunQC H4H 1R3Canada Department of Psychiatry University of TorontoTorontoCanada Department of Psychiatry McGill UniversityMontrealCanada Department of Neurology and Neurosurgery McGill UniversityMontrealCanada Department of Human Genetics McGill UniversityMontrealCanada

Background This study aims at characterizing the extent of correlation of treatment response (TR) obtained in various observation settings (home,school,clinic) by different observers (parents,teachers,clinicians).Methods Children with attention deficit hyperactivity disorder (ADHD) underwent a 2-week double-blind,randomized,cross-over clinical trial with methylphenidate and placebo,and various measures were obtained during the 2 *** of TR were examined using Pearson's correlation *** The study included 526 children (420 male,106 female) with *** between different observers shows a variable correlation between parents and *** correlation is seen between parents/teacher evaluation of TR and laboratory-based measures (Continuous Performance Task;Restricted Academic Situation Scale).Conclusion The results firmly support the need to synthesize information from many sources in evaluating TR in ADHD.

关键词： ADHD Methylphenidate Parents Teachers Treatment response

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Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders

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Genomics, Proteomics & Bioinformatics 2016年第3期14卷 155-165页

作者： natalie Kaminsky Ofer Bihari Sivan Kanner Ari Barzilai Department of Neurobiology George S.WiseFaculty of Life SciencesTel Aviv University Sagol School of Neuroscience Tel Aviv University

The DNA damage response（DDR） is a complex biological system activated by different types of DNA *** in certain components of the DDR machinery can lead to genomic instability disorders that culminate in tissue degeneration,premature aging,and various types of ***,malfunctioning DDR plays a role in the etiology of late onset brain degenerative disorders such as Parkinson＇s,Alzheimer＇s,and Huntington＇s *** many years,brain degenerative disorders were thought to result from aberrant neural *** we discuss the evidence that supports our novel hypothesis that brain degenerative diseases involve dysfunction of glial cells（astrocytes,microglia,and oligodendrocytes）.Impairment in the functionality of glial cells results in pathological neuro-glial interactions that,in turn,generate a ‘‘hostile＂ environment that impairs the functionality of neuronal *** events can lead to systematic neural demise on a scale that appears to be proportional to the severity of the neurological deficit.

关键词： DNA damage response Genomic instability Brain degenerative diseases Glial cells Astrocytes Microglia

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Inner blood-retina barrier involvement in dry age-related macular degeneration(AMD) pathology

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Neural Regeneration Research 2020年第9期15卷 1656-1657页

作者： natalie Hudson Mark Cahill Matthew Campbell Neurovascular Genetics Unit Smurfit Institute of GeneticsTrinity College DublinDublinIreland Royal Victoria Eye and Ear Hospital Adelaide RoadDublin 2Ireland

Age-relatedmaculardegeneration(AMD)isaprogressiveneurodegenerative disease with a global prevalence of 8.7%in people over the age of 45. It is one of the leading causes of central retinal blindness in the industrialized world leading to loss of an individual’s ability to read, drive and see fine details, such as recognition of faces. By 2040, it is estimated that 288 million individuals worldwide will be diagnosed with AMD due to improved life expectancy(Wong et al., 2014).

关键词： AMD individual degeneration

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Intersection of autophagy with pathways of antigen presentation

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Protein & Cell 2012年第12期3卷 911-920页

作者： natalie L.Patterson Justine D.Mintern Department of Biochemistry and Molecular Biology The University of MelbourneParkvilleVictoria 3010Australia

Traditionally,macroautophagy(autophagy)is viewed as a pathway of cell *** ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of ***,autophagy can also directly intersect with,and impact,other major pathways of cellular ***,we will review the contribution of autophagy to pathways of antigen *** autophagy machinery acts to modulate both MHCⅠ and MHCⅡ antigen *** such autophagy is an important participant in pathways that elicit host cell immunity and the elimination of infectious pathogens.

关键词： autophagy antigen presentation antigen presenting cells dendritic cells MHCⅠ MHCⅡ

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