检索结果-南通市图书馆

Chronological age when health care transition skills are mastered in adolescents/young adults with inflammatory bowel disease

引用

World Journal of Gastroenterology 2017年第18期23卷 3349-3355页

作者： natalie Stollon Yi Zhong Maria Ferris Suneet Bhansali Brian Pitts eniko Rak Maureen Kelly Sandra Kim Miranda AL van Tilburg School of Social Work University of Washington Department of economics University of North Carolina Department of Pediatrics University of North CarolinaSchool of Medicine Department of Pediatrics NYU School of Medicine Department of Allied Health Sciences University of North CarolinaSchool of Medicine Department of Pediatrics Children's Hospital of Pittsburgh Department of Clinical Research Campbell UniversityCollege of Pharmacy and Health Sciences Department of Gastroenterology and Hepatology the University of North CarolinaSchool of Medicine

To describe the longitudinal course of acquisition of healthcare transition skills among adolescents and young adults with inflammatory bowel *** recruited adolescents and young adults (AYA) with inflammatory bowel diseases (IBD), from the pediatric IBD clinic at the University of North Carolina. Participants completed the TRxANSITION Scale™ at least once during the study period (2006-2015). We used the electronic medical record to extract participants’ clinical and demographic data. We used ordinary least square regressions with robust standard error clustered at patient level to explore the variations in the levels and growths of healthcare transition *** sample (n = 144) ranged in age from 14-22 years. Age was significantly and positively associated with both the level and growth of TRxANSITION Scale™ scores (P ealthcare transition (HCT) skills were acquired between ages 12 and 14 years, but others were not mastered until after age 18, including self-management *** is one of the first studies to describe the longitudinal course of HCT skill acquisition among AYA with IBD, providing benchmarks for evaluating transition interventions.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Pediatrics Healthcare transition

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diabetic corneal neuropathy as a surrogate marker for diabetic peripheral neuropathy

引用

Neural Regeneration Research 2022年第10期17卷 2172-2178页

作者： Wei Zheng So natalie Shi Qi Wong Hong Chang Tan Molly Tzu Yu Lin Isabelle Xin Yu Lee Jodhbir S.Mehta Yu-Chi Liu Yong Loo Lin School of Medicine National University of SingaporeSingaporeSingapore Singapore eye Research Institute SingaporeSingapore Department of endocrinology Singapore General HospitalSingaporeSingapore Department of Cornea and external eye Disease Singapore National Eye CentreSingaporeSingapore Ophthalmology and Visual Sciences Academic Clinical Program Duke-NUS Medical SchoolSingaporeSingapore

Diabetic neuropathy is a prevalent microvascular complication of diabetes mellitus,affecting nerves in all parts of the body including corneal nerves and peripheral nervous system,leading to diabetic corneal neuropathy and diabetic peripheral neuropathy,*** peripheral neuropathy is diagnosed in clinical practice using electrophysiological nerve conduction studies,clinical scoring,and skin ***,these diagnostic methods have limited sensitivity in detecting small-fiber disease,hence they do not accurately reflect the status of diabetic *** recently,analysis of alterations in the corneal nerves has emerged as a promising surrogate marker for diabetic peripheral *** this review,we will discuss the relationship between diabetic corneal neuropathy and diabetic peripheral neuropathy,elaborating on the foundational aspects of each:pathogenesis,clinical presentation,evaluation,and *** will further discuss the relevance of diabetic corneal neuropathy in detecting the presence of diabetic peripheral neuropathy,particularly early diabetic peripheral neuropathy;the correlation between the severity of diabetic corneal neuropathy and that of diabetic peripheral neuropathy;and the role of diabetic corneal neuropathy in the stratification of complications of diabetic peripheral neuropathy.

关键词： corneal nerve quantification corneal nerves diabetic cornea diabetic corneal neuropathy diabetic microvascular complications diabetic peripheral neuropathy in vivo confocal microscopy neurotrophic keratopathy ocular surface

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of sorghum mutants with improved in vitro protein digestibility by CRISPR/Cas9 editing of kafirin genes

引用

作物学报:英文版 2023年第5期11卷 1411-1418页

作者： Lev A.elkonin Grigoriy A.Gerashchenkov natalie V.Borisenko Odyssey A.Kenzhegulov Saule Kh.Sarsenova Natalya A.Rozhnova Valery M.Panin Federal Centre of Agriculture Research of South-east Region Saratov 410010Russia Institute of Biochemistry and Genetics-Subdivision of the Ufa Federal Research Centre of the Russian Academy of Sciences Ufa 450054Russia

Sorghum(Sorghum bicolor(L.) Moench) is a major world crop that is a reliable source of fodder and food grain in arid regions. However, unlike other cereals, sorghum grain has low nutritional value, owing mainly to the resistance of its storage proteins(kafirins) to protease digestion. Changing the composition of kafirins or their primary structure may address this problem. To induce mutations in kafirin-encoding genes that were expected to disturb their accumulation in endosperm cells, we used a genome-editing approach. By Agrobacterium-mediated genetic transformation of immature embryos of cv. Avans, we obtained 14 transgenic plants with genetic constructs for site-directed mutagenesis of the k1C5 and g KAF1 genes encoding 22 k Da a-and 28 kDa γ-kafirins, respectively. Sequencing of 5 regenerants obtained by using k1C5-addressing vector revealed two plants with mutations. T_1 progeny of these mutants had higher in vitro digestibility of endosperm proteins(86%–92%), in comparison with the donor Avans(63%–67%). The kernels of these plants had a thick vitreous endosperm. A mutant with increased in vitro protein digestibility and vitreous endosperm, carrying a mutation in the target sequence, was also obtained by use of the gKAF1-addressing vector. Thus, using genome editing technology, we have obtained mutants with improved kafirin digestibility that can be used in sorghum breeding.

关键词： Sorghum CRISPR/Cas Kafirins In vitro protein digestibility Vitreous endosperm

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Production and characterization of bioaerosols for model validation in spacecraft environment

引用

Journal of environmental Sciences 2018年第7期30卷 227-238页

作者： Anniina Salmela eero Kokkonen Ilpo Kulmala Anna-Maria Veijalainen Rob van Houdt natalie Leys Audrey Berthier Ilyin Viacheslav Sergey Kharin Julia Morozova Alexander Tikhomirov Pertti Pasanen Department of environmental and Biological Sciences University of Eastern Finland PO Box 1627 FI-70211 Kuopio Finland VTT Ltd PO Box 1300 FI-33100 Tampere Finland Microbiology Unit Belgian Nuclear Research Centre B-2400 Mol Belgium Institut de Medecine et de Physiologie Spatiales BP 74404 F-31405 Toulouse Cedex France Institute of Bio-Medical Problems 76-A Khorosheu Skoye shosse RU-123007 Moscow Russia Institute of Biophysics SB RAS Akademgorodok Krasnoyarsk RU-660036 Russia

This study aimed to evaluate the suitability of two bioaerosol generation systems（dry and wet generation） for the aerosolization of microorganisms isolated from the International Space Station, and to calibrate the produced bioaerosols to fulfill the requirements of computational fluid dynamics model（CFD） validation. Concentration, stability, size distribution, agglomeration of generated bioaerosol and deposition of bioaerosols were analyzed. In addition, the dispersion of non-viable particles in the air was *** proved that wet generation from microbial suspensions could be used for the production of well-calibrated and stabile bioaerosols for model validation. For the simulation of the natural release of fungal spores, a dry generation method should be used. This study showed that the used CFD model simulated the spread of non-viable particles fairly well. The mathematical deposition model by Lai and Nazaroff could be used to estimate the deposition velocities of bioaerosols on surfaces, although it somewhat underestimated the measured deposition velocities.

关键词： Bioaerosol Modeling CFD Spacecraft Fungi Bacteria

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

两个文化的故事：中国与美国的钢琴教育发展

两个文化的故事：中国与美国的钢琴教育发展

引用

作者： natalie Burton 苏州大学

学位级别：硕士

尽管钢琴教育最早起源于欧洲,但它融和了世界各国的音乐文化,以至于今天我们很难去辨别它其中蕴含的历史和文化差异。本文通过对比美国和中国最古老的两所音乐学院的历史,奥伯林音乐学院(创立于1865年)和上海音乐学院(创立于1927年),来...

尽管钢琴教育最早起源于欧洲,但它融和了世界各国的音乐文化,以至于今天我们很难去辨别它其中蕴含的历史和文化差异。本文通过对比美国和中国最古老的两所音乐学院的历史,奥伯林音乐学院(创立于1865年)和上海音乐学院(创立于1927年),来探索美国与中国的钢琴教育发展。当时两国政权和社会环境的更迭也影响并塑造了各自的钢琴教育体制。中国的钢琴教育以上海音乐学院为例,主要受政府自上而下变化风格的影响,而美国的钢琴教育以奥伯林音乐学院为例,则主要受基督教社团自下而上变化风格的影响。本文探究了政权和社会团体对两个国家的钢琴教育的影响,包括发展历程的时间维度、资金来源、管理决策、教育理念、钢琴专业课程、还有钢琴教育的外来文化和本土文化。本文也会探索这些方面怎么影响到个国家现代的钢琴教育。本文文献的主要来源为The Music of Oberlin and Some who Made It(1968),《中国钢琴文化之形成与发展》(1996)和《中国近代音乐家的摇篮——上海音乐学院简况》(1982)。

关键词：

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Posttreatment Lyme disease syndrome and myalgic encephalomyelitis/chronic fatigue syndrome:A systematic review and comparison of pathogenesis

引用

慢性疾病与转化医学:英文版 2023年第3期9卷 183-190页

作者： natalie A.Bai Christie S.Richardson Department of Psychiatry Rowan‐Virtua School of Osteopathic MedicineMount LaurelNew JerseyUSA

Lyme disease is the most common vector-borne illness in the United States and has been causing significant morbidity since its discovery in *** is well-documented that about 10%of patients properly treated with antibiotics never fully recover,but instead go on to develop a chronic illness dubbed,posttreatment Lyme disease syndrome(PTLDS)characterized by severe fatigue,cognitive slowing,chronic pain,and sleep *** review includes 18 studies that detail the symptoms of patients with PTLDS and uses qualitative analysis to compare them to myalgic encephalitis/chronic fatigue syndrome(Me/CFS),a strikingly similar *** the majority of the PTLDS studies,at least four of the six major symptoms of Me/CFS were also noted,including substantial impairment in activity level and fatigue for more than 6 months,post-exertional malaise,and unrefreshing *** one of the included PTLDS articles,26 of the 29 Me/CFS symptoms were *** study adds to the expanding literature on the post-active phase of infection syndromes,which suggests that chronic illnesses such as PTLDS and Me/CFS have similar pathogenesis despite different infectious origins.

关键词： chronic fatigue syndrome Lyme disease myalgic encephalitis posttreatment Lyme disease syndrome systematic review

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

“No dear”it's the line of entry...

引用

世界高尔夫 2007年第12期 66-74页

作者： Graham Kuhn natalie Nieolaou 姚臣

碧波、清风、美酒,迷人的规则专家Deci- maria和Kamila这一刻化身为"水精灵"。列位看官,别只顾欣赏宝贝而忽略了规则哦……

关键词：高尔夫俱乐部珠宝饰物规则宝贝美兰手套白色钻石人造高球

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Canadian Team Sets World Record in Solar Car

引用

当代外语研究 2000年第9期 3-4页

作者： natalie James 占必乏

提示:上海的汽油价格已经连续提价五次。在如此背景下读到此文,倍感亲切。笔者遐想:当取之不尽,用之不竭的太阳能真正为人类造福时,回顾今日使用汽油的情景,是否会如我们现在回想当年人们以竹简成书那样原始和落后?我们感谢加拿大的几... 详细信息

提示:上海的汽油价格已经连续提价五次。在如此背景下读到此文,倍感亲切。笔者遐想:当取之不尽,用之不竭的太阳能真正为人类造福时,回顾今日使用汽油的情景,是否会如我们现在回想当年人们以竹简成书那样原始和落后?我们感谢加拿大的几名学生给太阳能的实际运用又带来了新的曙光和希望。以太阳能驱车。多云之日,如何是好?本文的回答是: excess energy is stored in a battery pack,which powers the car on cloudydays.本文用得最好的一个词是下句中的guzzle: In contrast,the minivan(小型货车)transporting team members and theirequipment guzzled(本义:狂饮)＄405 worth of gasoline.

关键词：小型货车太阳能 World Canadian Team Sets World Record in Solar Car

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sodium glucose co-transporter 2 inhibition reduces succinate levels in diabetic mice

引用

World Journal of Gastroenterology 2020年第23期26卷 3225-3235页

作者： Lakshini Y Herat natalie C Ward Aaron L Magno elizabeth P Rakoczy Marcio G Kiuchi Markus P Schlaich Vance B Matthews School of Biomedical Sciences Dobney Hypertension CentreRoyal Perth Hospital UnitUniversity of Western AustraliaPerth 6000Australia Faculty of Health and Medical Sciences University of Western AustraliaCrawley 6009Australia Faculty of Health Sciences School of Public HealthCurtin UniversityBentley 6102Australia Research Centre Royal Perth HospitalPerth 6000Australia Department of Molecular Ophthalmology University of Western AustraliaCrawley 6009Australia Dobney Hypertension Centre School of MedicineRoyal Perth Hospital UnitUniversity of Western AustraliaPerth 6000Australia Department of Cardiology and Department of Nephrology Royal Perth HospitalPerth 6000Australia

BACKGROUND Type 1 diabetes(T1D) is associated with major chronic microvascular complications which contribute significantly to diabetes associated *** protein primarily responsible for glucose reabsorption in the kidney is sodium glucose co-transporter 2(SGLT2). Presently, SGLT2 inhibitors are widely used in diabetic patients to improve blood glucose levels and prevent cardiovascular and renal complications. Given the broad therapeutic application of SGLT2 inhibitors, we hypothesised that SGLT2 inhibition may exert its protective effects via alterations of the gut microbiome and tested this in a type 1 diabetic mouse model of diabetic *** To determine whether the treatment with two independent SGLT2 inhibitors affects gut health in a type 1 diabetic mouse *** The SGLT2 inhibitors empagliflozin or dapagliflozin(25 mg/kg/d) or vehicle dimethylsulfoxide(DMSO) were administered to C57 BL/6 J, Akita, Kimba and Akimba mice at 10 wk of age for 8 wk via their drinking water. Serum samples were collected and the concentration of succinate and the short chain fatty acid(SCFA) butyric acid was measured using gas chromatography-mass spectrometry. enzyme-linked immunosorbent assay(eLISA) was performed to determine the concentration of insulin and leptin. Furthermore, the norepinephrine content in kidney tissue was determined using eLISA. Pancreatic tissue was collected and stained with haematoxylin and eosin and analysed using brightfield *** Due to the presence of the Akita allele, both Akita and Akimba mice showed a reduction in insulin production compared to C57 BL/6 J and Kimba ***, Akita mice also showed the presence of apoptotic bodies within the pancreatic islets. The acinar cells of Akita and Akimba mice showed swelling which is indicative of acute injury or pancreatitis. After 8 wk of SGLT2 inhibition with dapagliflozin, the intermediate metabolite of gut metabolism known as succinate was significantly reduced

关键词： Sodium glucose co-transporter inhibitors Sodium glucose co-transporter 2 Diabetes Diabetic retinopathy Mouse Gut microbiota empagliflozin Dapagliflozin Succinate Akimba

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

外商直接投资对中国和印尼经济的影响

外商直接投资对中国和印尼经济的影响

引用

作者： Jane natalie 中国海洋大学

学位级别：硕士

本研究以观察FDI对经济增长的影响以及其他控制变量,如教育,通货膨胀和劳动力对经济增长的影响。使用的外商直接投资是外国每一个国家资金流入的最直接体手段,利用观察世界银行各个时间段的指标数据,从1990年至2013年的研究来看,看到的... 详细信息

本研究以观察FDI对经济增长的影响以及其他控制变量,如教育,通货膨胀和劳动力对经济增长的影响。使用的外商直接投资是外国每一个国家资金流入的最直接体手段,利用观察世界银行各个时间段的指标数据,从1990年至2013年的研究来看,看到的结果最有希望的是两个国家;印尼和中国。该假说是使用普通最小二乘单一线性回归来检验,与古典假设检验。有24年的观察,两个国家(中国和印度尼西亚)。这项研究的结果表明,有外国直接投资对经济增长的影响对于中国和印尼是不同的。有外商直接投资对印尼的经济增长是一个显著和积极的关系,但外国直接投资和中国经济增长之间没有显著关系。

关键词：外商直接投资(FDI) 经济影响经济增长

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：