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Sexual selection and environmental change:what do we know and what comes next?

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Current Zoology 2021年第3期67卷 293-298页

作者： natalie Pilakouta Murielle Aluimd School of Biological Sciences University of AberdeenAberdeen AB243FXUK Department of Ecology and Genetics Animal EcologyEvolutionary Biology Centre(EBC)Uppsala UniversityNorbyvagen 18D 75236 UppsalaSweden

Anthropogenic environmental change is the most significant threat to biodiversity in the 21st *** populations are experiencing rapid changes in their biotic and abiotic environment,which impose novel selection pressures on organisms and increase the risk of population *** is thus a pressing need to understand what affects the capacity of populations to respond and adapt to environmental *** behavioral traits are very labile,they provide a means of rapidly responding to environmental change(Sih et al.2011;Tuomainen and Candolin 2011).

关键词： al. selection threat

Role of serotonin in modulating the development and function of adult-born neurons in the olfactory bulb

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Neural Regeneration Research 2022年第6期17卷 1253-1254页

作者： natalie Fomin-Thunemann Olga Garaschuk Department of Biomedical Engineering Boston UniversityBostonMAUSA Institute of Physiology Department NeurophysiologyEberhard Karls University of TübingenTübingenGermany

The neuromodulatory transmitter serotonin(5-hydroxytryptamine,5-HT)is synthesized by neurons located in the brainstem,which project more or less densely to the entire central nervous system(Charnay and Leger,2010).Serotonin regulates a variety of physiological functions,including food intake,reward,reproduction,sleep-wake cycle,memory,cognition,emotion,and mood(Charnay and Leger,2010).

关键词： serotonin intake modulator

Integrative genomic and transcriptomic profiling of pulmonary sarcomatoid carcinoma identifies molecular subtypes associated with distinct immune features and clinical outcomes

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Cancer Innovation 2024年第3期3卷 81-94页

作者： Sahil Seth Runzhe Chen Yang Liu Junya Fujimoto Lingzhi Hong Alexandre Reuben Susan Varghese Carmen Behrens Tina McDowell Luisa Solis Soto Cara Haymaker Annikka Weissferdt Neda Kalhor Jia Wu Xiuning Le natalie I Vokes Chao Cheng John V.Heymach Don L.Gibbons P.Andrew Futreal Ignacio IWistuba Humam Kadara Jianhua Zhang Cesar Moran Jianjun Zhang Department of Genomic Medicine The University of Texas MD Anderson Cancer CenterHoustonTexasUSA TRACTION The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Graduate School of Biomedical Sciences The University of Texas MD Anderson and the University of Texas Health Science CenterHoustonTexasUSA Department of Thoracic/Head and Neck Medical Oncology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Translational Molecular Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Pathology The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Imaging Physics The University of Texas MD Anderson Cancer CenterHoustonTexasUSA Department of Medicine Baylor College of MedicineHoustonTexasUSA

Background:Pulmonary sarcomatoid carcinoma(PSC)is a rare and aggressive subtype of non-small cell lung cancer(NSCLC),characterized by the presence of epithelial and sarcoma-like *** molecular and immune landscape of PSC has not been well ***:Multiomics profiling of 21 pairs of PSCs with matched normal lung tissues was performed through targeted high-depth DNA panel,whole-exome,and RNA *** describe molecular and immune features that define subgroups of PSC with disparate genomic and immunogenic features as well as distinct clinical ***:In total,27 canonical cancer gene mutations were identified,with TP53 the most frequently mutated gene,followed by ***,most TP53 and KRAS mutations were earlier genomic events mapped to the trunks of the tumors,suggesting branching evolution in most PSC *** identified two distinct molecular subtypes of PSC,driven primarily by immune infiltration and *** Immune High(IM-H)subtype was associated with superior survival,highlighting the impact of immune infiltration on the biological and clinical features of localized ***:We provided detailed insight into the mutational landscape of PSC and identified two molecular subtypes associated with ***-H tumors were associated with favorable recurrence-free survival and overall survival,highlighting the importance of tumor immune infiltration in the biological and clinical features of PSCs.

关键词： genomic immune pulmonary sarcomatoid carcinoma survival

新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. Sanders Nicholas Williams Tim H. H. Coorens Jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson natalie birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari Peter J. Campbell Foad J. Rouhani & Huw Naylor Sarah J. Aitken & Matthew Hoare Sarah J. Aitken & Susan E. Davies Sarah J. Aitken Ming Yang Efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NEAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDEB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

Responses to threat in a freshwater invader： longitudinal data reveal personality, habituation, and robustness to changing water temperatures in the ＂killer shrimp＂ Dikerogammarus villosus （Crustacea： Amphipoda）

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Current Zoology 2016年第1期62卷 45-51页

作者： Mark BRIFFA natalie JONES Calum MACNEIL Marine Biology and Ecology Research Centre School of Marine Science & Engineering Plymouth University Plymouth PL4 8AA UK Department of Environment Food and Agriculture The Isle of Man GovernmentSt Johns IM4 3AS Isle of Man

Freshwater biodiversity and ecosystem integrity are under threat from biological invasions. The ＂killer shrimp＂ Dikerogammarus villosus is a highly predatory amphipod that has spread readily across Central Europe and recently the UK and its arrival has been associated with the significant loss of resident species. Despite this, studies of its behavioral ecology are sparse, even though its be- havior may contribute to its invasion success. For the first time, we investigated antipredator ＂fleeing＂ behavior in D. villosus and how this changed with water temperature. Three key patterns emerged from our analysis. First, within a particular temperature condition there are moderate but consistent among-individual differences in behavior. These are driven by a combination of mean level among-individual differences and within-individual relative consistency in behavior, and pro- vide the key marker for animal personalities. Second, the fleeing responses were not influenced by temperature and third, regardless of temperature, all individuals appeared to habituate to a repeated nondangerous stimulus, indicating a capacity for individual learning. We suggest that the antipreda- tor behavior of D. villosus contributes to its rapid spread and that consistent among-individual differ- ences in behavior may promote biological invasions across heterogeneous conditions. Robustness to changing water temperatures may also be potentially advantageous, particularly in an era of glo- bal climate change, where average temperatures could be elevated and less predictable.

关键词： invasions Dikerogammarus villosus animal personalities habituation temperature.

No evidence of contagious yawning in the red-footed tortoise Geochelone carbonaria

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Current Zoology 2011年第4期57卷 477-484页

作者： Anna WILKINSON natalie SEBANZ Isabella MANDL Ludwig HUBER Department of Cognitive Biology University of Vienna Althanstrasse 14 Vienna 1090 Austria Department of Biological Sciences University of Lincoln Lincoln LN2 2LG UK Donders Institute for Brain Cognition and Behavior Centre for Cognition Radboud University Nijmegen P.O. Box 9104 6500 HE Nijmegen The Netherlands

Three hypotheses have attempted to explain the phenomenon of contagious yawning. It has been hypothesized that it is a fixed action pattern for which the releasing stimulus is the observation of another yawn, that it is the result of non-conscious mimicry emerging through close links between perception and action or that it is the result of empathy, involving the ability to engage in mental state attribution. This set of experiments sought to distinguish between these hypotheses by examining contagious yawning in a species that is unlikely to show nonconscious mimicry and empathy but does respond to social stimuli： the red-footed tortoise Geochelone carbonaria. A demonstrator tortoise was conditioned to yawn when presented with a red square-shaped stimulus. Observer tortoises were exposed to three conditions： observation of conditioned yawn, non demonstration control, and stimulus only control. We measured the number of yawns for each observer animal in each condition. There was no difference between conditions. Experiment 2 therefore increased the number of conditioned yawns presented. Again, there was no significant difference between conditions. It seemed plausible that the tortoises did not view the conditioned yawn as a real yawn and therefore a final experiment was run using video recorded stimuli. The observer tortoises were presented with three conditions： real yawn, conditioned yawns and empty background. Again there was no significant difference between conditions. We therefore conclude that the red-footed tortoise does not yawn in response to observing a conspecific yawn. This suggests that contagious yawning is not the result of a fixed action pattern but may involve more complex social processes [Current Zoology 57 （4）： 477-484, 2011].

关键词： Reptile Contagious yawn Empathy Nonconscious mimicry Fixed action pattern

可持续未来:不让任何一个人掉队——跨越政治、经济和美学的界限,在国际建筑师协会世界建筑师大会上团结起来

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世界建筑 2024年第1期 4-7页

作者：娜塔莉·莫辛孙斯坦(译) 国际建筑师协会世界建筑师大会丹麦皇家建筑艺术学院建筑与技术研究所不详

当全球建筑师社群于2029年齐聚北京时,将迎来国际建筑师协会(Union International des Architectes,简称UIA)第30届世界建筑师大会。这一旅程始于1948年在瑞士洛桑召开的创始大会(图1),横跨了各大洲,并于2023年在丹麦哥本哈根以“可持... 详细信息

当全球建筑师社群于2029年齐聚北京时,将迎来国际建筑师协会(Union International des Architectes,简称UIA)第30届世界建筑师大会。这一旅程始于1948年在瑞士洛桑召开的创始大会(图1),横跨了各大洲,并于2023年在丹麦哥本哈根以“可持续未来——不让任何一个人掉队”为主题拉开帷幕(图2)。这一全球交流之旅的初衷源于许多人在二战后对和平以及跨越国界的合作的深切需求。对于丹麦建筑师而言,二战结束的那一刻是充满压力的,但同时也是为社会和更美好的未来做贡献的时刻。

关键词：国际建筑师协会世界建筑师大会丹麦哥本哈根瑞士洛桑建筑师

A case of gas gangrene in an immunosuppressed Crohn's patient

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World Journal of Gastroenterology 2011年第33期17卷 3856-3858页

作者： natalie Kiel Vincent Ho Andrew Pascoe Department of Gastroenterology Princess Alexandra HospitalBrisbane4102 QueenslandAustralia

Clostridium septicum(***)gas gangrene is well documented in the literature,typically in the setting of trauma or *** this paper,we report a unique case of spontaneous clostridial myonecrosis in a patient with Crohn's disease and sulfasalazineinduced *** patient presented with left thigh pain,vomiting and *** tests demonstrated a profound neutropenia,and magnetic resonance imaging of the thigh confirmed extensive *** patient underwent emergency hip disarticulation,followed by *** was cultured from the *** completion of antibiotic therapy,the patient developed myonecrosis of the right pectoral muscle necessitating further debridement,and remains on lifelong prophylactic antibiotic therapy.

关键词： Crohn's disease Inflammatory bowel disease Sulfasalazine Neutropenia Clostridium septicum

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战后西德现代设计与救赎的矛盾

国际社会科学杂志（中文版） 2024年第2期41卷 128-142,7,11,12页

作者：娜塔莉·肖尔茨张弛(译) 董耀威(译) 阿姆斯特丹大学历史系不详

历史研究强调,现代设计后来成功地被塑造成一种文化产品,将西德从纳粹的过去中拯救出来。然而,如果人们通过关注各种出版物中的沉默、遗漏和差异来承认第二次世界大战后话语中的否认结构,那么1945年之前和之后现代设计的政治意义之间的... 详细信息

历史研究强调,现代设计后来成功地被塑造成一种文化产品,将西德从纳粹的过去中拯救出来。然而,如果人们通过关注各种出版物中的沉默、遗漏和差异来承认第二次世界大战后话语中的否认结构,那么1945年之前和之后现代设计的政治意义之间的这种救赎性对立就显得不那么明确了。这样的分析揭示了现代设计作为“永恒”的编码以及它在“马歇尔计划”背景下的推广,是如何模糊任何关于日常美学的基本概念与德国人民的种族观念交织在一起的历史理解。

关键词：道德范畴包豪斯启蒙思想启蒙运动