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Does delaying surgery following induction chemotherapy compromise survival in patients with mesothelioma?

Journal of Cancer Metastasis and Treatment 2023年第1期9卷 459-470页

作者： Lye-Yeng Wong Ioana Baiu Matthew Leipzig Ashley Titan Douglas Z.Liou natalie lui Mark Berry Joseph B.Shrager Leah Backhus Department of Cardiothoracic Surgery Division of Thoracic SurgeryStanford Hospital and ClinicsStanfordCA 94304USA Department of Surgery Division of General SurgeryStanford Hospital and ClinicsStanfordCA 94304USA VA Palo Alto Health Care System Department of SurgeryPalo AltoCA 94304USA

Objective:The ideal time interval between induction chemotherapy and surgery and the impact on cancer mortality in patients with mesothelioma remains ***:We queried the National Cancer Database(2004-2017)for patients with favorable prognostic factors considered for *** surgery was performed within 3 months following the start of induction chemotherapy,while delayed surgery was defined as surgery performed later than 3 *** compared both groups to those who did not have an operation despite being surgical candidates,as well as to those who were treated with surgery *** mortality was assessed using Cox proportional hazard models adjusting for ***:A total of 4,294 patients were included,with the majority of patients undergoing induction chemotherapy followed by no surgery(3,370,78%).The proportion of patients undergoing both immediate and delayed surgery increased over the last decade,but delayed surgery continued to be more *** were no significant differences in baseline characteristics between the immediate and delayed surgery *** comorbidity scores were significantly associated with an increased risk of death on multivariable analysis,but the timing of surgery was *** held true with a sensitivity analysis using 6 months as the definition of delayed ***:This study shows that delaying surgery following induction chemotherapy does not compromise overall survival in patients with mesothelioma.

关键词： Malignant pleural mesothelioma mesothelioma surgery mesothelioma treatment

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