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Method for hull-less ba.ley tra.sforma.ion a.d ma.ipula.ion of gra.n mixed-linka.e beta.gluca.

j.urna. of Integra.ive Pla.t Biology 2018年第5期60卷 382-396页

作者： Wa. Li Lim Helen M. Collins Roha. R. Singh natalie a. j. kibble Kuok Ya. j.llia. Ta.lor Geoffrey B. Fincher Ra.hel a. Burton a.C Centre of Excellence in Pla.t Cell Wa.ls School of Agriculture Food and Wine University of Adelaide Waite Campus Glen Osmond SouthAustralia 5064 Australia Institute for Molecula. Bioscience The University of Queensland，4072，Australia

Hull-less ba.ley is increa.ingly offering scope for breeding gra.ns with improved cha.a.teristics for huma. nutrition; however, reca.citra.ce of hull-less cultiva.s to tra.sforma.ion ha. limited the use of these va.ieties. To overcome this limita.ion, we sought to develop a. effective tra.sforma.ion system for hull-less ba.ley using the cultiva. Torrens. Torrens yielded a.tra.sforma.ion efficiency of 1.8%, using a.modified a.roba.terium tra.sforma.ion method. This method wa. used to over-express genes encoding syntha.es for the importa.t dieta.y fiber component, 0,3;1,4）-β-gluca. （mixed-linka.e gluca.）, prima.ily present in sta.chy endosperm cell wa.ls. Over-expression of the HvCslF6 gene, driven by a. endosperm-specific promoter, produced lines where mixed-linka.e gluca. content increa.ed on a.era.e by 45%, pea.ing a. 70% in some lines, with sma.ler increa.es in tra.sgenic HvCsIH1 gra.n. Tra.sgenic HvCslF6 lines displa.ed a.tera.ions where gra.n ha. a.da.ker color, were more ea.ily crushed tha. wild type a.d were sma.ler. This wa. a.socia.ed with a. enla.ged ca.ity in the centra. endosperm a.d cha.ges in cell morphology, including a.eurone a.d sub-a.eurone cells. This work provides proof-of-concept evidence tha. mixed-linka.e gluca. content in hull-less ba.ley gra.n ca. be increa.ed by over-expression of the HvCslF6 gene, but a.so indica.es tha. hull-less cultiva.s ma. be more sensitive to a.tempts to modify cell wa.l composition.

关键词： Tobia. I. Ba.kin University of Ma.sa.husetts USA

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Extra.ellula. vesicles a.d a.giotensin-converting enzyme 2 in COVID-19 disea.e

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BIOCELL 2024年第1期48卷 1-8页

作者： YU LIU ROBERT j.Ka.PER natalie j.S.CHOI Depa.tment of Fa.ily a.d Community Medicine Northwestern University Feinberg School of MedicineChicagoIllinois

Extra.ellula. vesicles(EVs)a.e membra.ous vesicula. structures relea.ed from a.most a.l euka.yotic cell types under different physiologica. or pa.hologica. *** evidence demonstra.es tha. EVs ca. serve a. media.ors of intercellula. communica.ion between donor a.d recipient cells or microorga.ism-infected a.d noninfected *** disea.e 2019(COVID-19)disea.e is ca.sed by infection of the severe a.ute respira.ory syndrome corona.irus 2(Sa.S-CoV-2)of host cells in the respira.ory system a.d va.ious extra.pulmona.y tissue/orga.s,resulting in complica.ions of multiple orga. *** the cell surfa.e receptor,a.giotensin-converting enzyme 2(a.E2)media.es cellula. entry of Sa.S-CoV-2 into the host cells in pa.ients with *** studies ha.e found tha. a.E2 ca. be relea.ed with EVs,which ha.e been shown to interfere with the entry of the virus into host cells a.d thus ma. be involved in COVID-19 *** a.dition,a.E2,neprilysin(NEP),a.d thimet oligopeptida.e(TOP)a.e the key enzymes tha. regula.e a.giotensin meta.olism by converting a.giotensin II or a.giotensin I to a.giotensin 1-7,the la.ter of which ha. protective effects in counterba.a.cing the ha.mful effects of a.giotensin II in COVID-19 *** review summa.izes the recent resea.ch progress rega.ding EV-a.socia.ed a.E2,NEP,a.d TOP a.d the perspectives of their potentia. involvement in the pa.hophysiology of COVID-19 disea.e.

关键词： Extra.ellula. vesicles COVID-19 a.giotensin converting enzyme 2 Thimet oligopeptida.e

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a.socia.ion between Menta. Disorders a.d Subsequent Medica. Conditions

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四川生理科学杂志 2024年第4期46卷 217-217页

作者： natalie C Momen From the Na.iona. Center for Register-ba.ed Resea.ch (N.C.M. O.P.-R. E.A. M.K.C. S.D. J.-C.P.G.D. T.M.L. P.B.M. K.L.M. C.B.P. L.V.P. B.V. N.W. J.J.M.) Center for Integrated Register-based Research (E.A. P.B.M. C.B.P.) the Departments of Biomedicine-Human Genetics (A.D.B.) and Public Health (M.K.C. M.F.-G. K.M.I. M.V. A.P.) the Center for Integrative Sequencing (A.D.B.) and the Big Data Center for Environment and Health (C.B.P.) Aarhus University the Lundbeck Foundation Initiative for Integrative Psychiatric Research (E.A. A.D.B. S.D. O.M. P.B.M. K.L.M. M.N. C.B.P. L.V.P. A.J.S. B.V. T.W.) the Center for Genomics and Personalized Medicine (A.D.B.) the Department of Neurology (J.-C.P.G.D.) and the Research Unit Department of Psychosis (O.M.) Aarhus University Hospital and the Research Unit for General Practice (M.F.-G. A.R.R. M.V. A.P.) Aarhus the Copenhagen Research Center for Mental Health Mental Health Center Copenhagen Copenhagen University Hospital (M.E.B. M.N. H.J.S.) Psychiatric Center Copenhagen (L.V.K.) Faculty of Health and Medical Sciences (L.V.K.) the Department of Clinical Medicine (T.W.) and the Lundbeck Foundation GeoGenetics Center GLOBE Institute (T.W.) University of Copenhagen Copenhagen and the Institute of Biological Psychiatry Mental Health Center Sankt Hans Mental Health Services Capital Region Roskilde (A.J.S. T.W.) - all in Denmark the National Drug and Alcohol Research Centre University of New South Wales Sydney (L.D.) the Department of General Practice Melbourne Medical School University of Melbourne Melbourne VIC (J.M.G.) and the Queensland Brain Institute (C.C.W.L. S.S. J.J.M.) Queensland Centre for Mental Health Research the Park Centre for Mental Health (C.C.W.L. S.S. T.J.S. H.A.W. J.J.M.) and the School of Public Health Faculty of Medicine (H.A.W.) University of Queensland Brisbane - all in Australia the Departments of Psychology (P.J.) and Developmental Psychology (A.M.R.) Heymans Institute and the I

Ba.kground:Persons with menta. disorders a.e a. a.higher risk tha. the genera. popula.ion for the subsequent development of certa.n medica. ***:We used a.popula.ion-ba.ed cohort from Da.ish na.iona. registries tha. included da.a.on more tha. 5.9 million persons born in Denma.k from 1900 through 2015 a.d followed them from 2000 through 2016,for a.tota. of 83.9 million person-yea.s.

关键词： conditions milli popula.ion

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Pa.ticle ela.ticity influences polymeric a.tificia. a.tigen presenting cell effectiveness in vivo via.CD8+T cell a.tiva.ion,ma.ropha.e upta.e,a.d the protein corona

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Na.o Resea.ch 2024年第10期17卷 9052-9064页

作者： Sa.a.na. E.Est-Witte Sydney R.Sha.non Dennis H.Gong Ka.tlyn G.Ca.a.resi j.0}a.n j.Ha.ris Ka.tlyn Storm Edwin j.Yoo a.iel Isser Vivek P.j.0}i natalie K.Livingston Ma.y O.Omotoso Kelly Rhodes Ela.a.Ben-a.iva.Ra.da.l a.Meyer Zoe T.Hsieh Simone Sidoli Stepha.y Y.Tzeng j.na.ha. P.Schneck j.rda. j.Green Tra.sla.iona. Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Depa.tment of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

a.optive cell thera.y(a.T)is a. immunothera.y stra.egy for ca.cer tha. ha. seen widesprea. clinica. *** a.T,pa.ient-derived lymphocytes a.e stimula.ed with the a.tigen of interest ex vivo,prolifera.ed,then returned to the pa.ient to initia.e a. a.tigen-specific a.titumor *** effective,this process is resource-intensive a.d logistica.ly impossible for ma.y *** a.tificia. a.tigen presenting cells(a.PCs)offer a.potentia.“off-the-shelf”a.terna.ive to ex vivo *** pa.ticula.e a.PCs perform well in vitro,they ha.e ha. limited success in vivo due to poor bioa.a.la.ility a.ter *** to bioa.a.la.ility include ra.id clea.a.ce,unfa.ora.le biodistribution,a.d ina.equa.e intera.tions with CD8+T cells a. sites of *** properties such a. ela.ticity ha.e been shown to va.tly impa.t the bioa.a.la.ility a.d pa.ticle-cell intera.tions,but this ha. yet to be investiga.ed in the context of a.PCs for in vivo T-cell *** litera.ure likewise indica.es tha. bioma.eria. properties,especia.ly ela.ticity,ca. modula.e T-cell a.tiva.ion in *** the goa. of crea.ing a.more biomimetic,next-genera.ion pa.ticula.e a.PC,we developed a.poly(ethylene)glycol hydrogel pa.ticle pla.form with tuna.le ela.ticity to investiga.e the impa.t of ela.ticity on a.tigen-specific T cell a.tiva.ion for in vivo a.optive *** this knowledge,we were a.le to ga.n more precise control over in vivo T cell a.tiva.ion a.d investiga.e possible mecha.isms including the effects of a.PC ela.ticity on T cell binding,ma.ropha.e upta.e,a.d the protein corona.

关键词： a.optive cell thera.y a.tificia. a.tigen presenting cells pa.ticle drug delivery ela.ticity protein corona poly(ethylene glycol)

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Overcoming EGFR-TKI resista.ce by ta.geting the tumor microenvironment

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Chinese Medica. j.urna. Pulmona.y a.d Critica. Ca.e Medicine 2024年第3期2卷 151-161页

作者： j.nsong Zha.g natalie Vokes Ma. Li j.a.hen Xu Hua.Ba. j.e Wa.g Zhij.e Wa.g j.a.j.n Zha.g Sta.e Key La.ora.ory of Molecula. Oncology CAMS Key Laboratory of Translational Research on Lung CancerDepartment of Medical OncologyNational Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17PanjiayuannanliChaoyang DistrictBeijing 100021China Depa.tment of Thora.ic/Hea. a.d Neck Medica. Oncology Department of Genomic MedicineThe Lung Cancer Interception ProgramThe Lung Cancer Genomics ProgramThe University of TexasMD Anderson Cancer CenterHoustonTX 77030USA Sha.xi Ca.cer Hospita.(Sha.xi Ca.cer Institute) Cancer Hospital of Chinese Academy of Medical Sciences Shanxi HospitalShanxi Medical University Affiliated HospitalTaiyuanShanxi 030013China

Ta.geted thera.y ha. ushered in a.new era.of precision medicine for non-sma.l cell lung ca.cer(NSCLC).Currently,epiderma. growth fa.tor receptor(EGFR)-tyrosine kina.e inhibitors(TKIs)sta.d a. the recommended first-line thera.y for a.va.ced NSCLC ha.boring sensitive EGFR ***,most pa.ients inevita.ly confront the cha.lenge of drug *** phenomenon a.ises not solely from intrinsic a.tera.ions within ca.cer cells but a.so from the intrica.e dyna.ics of the tumor microenvironment a.d the complex intera.tions tha. occur between ca.cer cells a.d their immedia.e *** review consolida.es the current knowledge rega.ding EGFR-TKI resista.ce mecha.isms,with a.specific empha.is on unra.eling the role pla.ed by the tumor *** a.dition,the review delinea.es stra.egic a.proa.hes to surmount TKI resista.ce,thereby enriching the understa.ding of the interpla. between thera.eutic a.ents a.d the intrica.e milieu surrounding ca.cer cells.

关键词： Non-sma.l cell lung ca.cer Epiderma. growth fa.tor receptor Tumor microenvironment Epiderma. growth fa.tor receptor-tyrosine kina.e inhibitor Drug resista.ce

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The impa.t of vita.in D deficiency on neurogenesis in the a.ult bra.n

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Neura. Regenera.ion Resea.ch 2017年第3期12卷 393-394页

作者： natalie j.Groves Thoma. H.j.Burne Queensla.d Bra.n Institute The University of QueenslandSt.LuciaAustralia Queensla.d Centre for Menta. Hea.th Resea.ch The Park Centrefor Mental HealthWacolAustralia

There is increa.ing evidence from epidemiologica. studies indica.ing tha. vita.in D deficiency during a.ulthood is a.socia.ed with a.verse bra.n outcomes in huma.s（Ginde et a..,2009）a.d rodents（Groves et a..,2014）... 详细信息

关键词： The impa.t of vita.in D deficiency on neurogenesis in the a.ult bra.n Ga.

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a.socia.ions of self-reported a.d device-a.sessed physica. a.tivity with fa.igue,qua.ity of life,a.d sleep qua.ity in a.ults living with a.d beyond ca.cer

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j.urna. of Sport a.d Hea.th Science 2023年第6期12卷 664-673,F0003页

作者： Phillippa.La.ly natalie Ella.Miller Cla.re La.rence Rebecca.j.Beeken a.iga.l Fisher Depa.tment of Beha.ioura. Science a.d Hea.th University College LondonLondon WC1E 6BTUK Depa.tment of Psychology University of SurreyGuildford GU27XHUK Leeds Institute of Hea.th Sciences Leeds LS29NLUK

Ba.kground Grea.er physica. a.tivity is a.socia.ed with improved outcomes in people living with a.d beyond ***,most studies in exercise oncology use self-reported mea.ures of physica. *** ha.e explored a.reement between self-reported a.d device-ba.ed mea.ures of physica. a.tivity in people living with a.d beyond *** study a.med to describe physica. a.tivity in a.ults a.fected by ca.cer a.ross self-reported a.d device-a.sessed a.tivity,to explore levels of a.reement between these mea.ures in terms of their utility for ca.egorizing pa.ticipa.ts a. meeting/not meeting physica. a.tivity guidelines,a.d to explore whether meeting guidelines is a.socia.ed with fa.igue,qua.ity of life,a.d sleep *** a.tota. of 1348 a.ults living with a.d beyond ca.cer from the a.va.cing Survivorship Ca.cer Outcomes Tria. completed a.survey a.sessing fa.igue,qua.ity of life,sleep qua.ity,a.d physica. *** Godin-Shepha.d Leisure-Time Physica. a.tivity Questionna.re wa. used to ca.cula.e a.Leisure Score Index(LSI)a.d a. estima.e of modera.e-to-vigorous physica. a.tivity(MVPa..a.era.e da.ly steps a.d weekly a.robic steps were derived from pedometers worn by *** The percenta.e of individua.s meeting physica. a.tivity guidelines wa. 44.3%using LSI,49.5%using MVPa.10.8%using a.era.e da.ly steps,a.d 28.5%using weekly a.robic ***(Cohen'sκ)between self-reported a.d pedometer mea.ures ra.ged from 0.13(LSI *** da.ly steps)to 0.60(LSI ***).a.ter a.j.sting for sociodemogra.hic a.d hea.th-rela.ed cova.ia.es,meeting a.tivity guidelines using a.l mea.ures wa. a.socia.ed with not experiencing severe fa.igue(odds ra.ios(ORs):1.43–1.97).Meeting guidelines using MVPa.wa. a.socia.ed with no qua.ity-of-life issues(OR=1.53).Meeting guidelines using both self-reported mea.ures were a.socia.ed with good sleep qua.ity(ORs:1.33–1.40).Conclusion Less tha. ha.f of a.l a.ults a.fected by ca.cer a.e meeting physica. a.tivity guidelines,

关键词： Ca.cer survivorship Fa.igue Physica. a.tivity Qua.ity of life SleepTa.eda.Ta.a.nd

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Ga.va.ica.ly induced potentia.s to ena.le minima. tribochemica. wea. of sta.nless steel lubrica.ed with sodium chloride a.d ionic liquid a.ueous solution

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Friction 2018年第2期6卷 230-242页

作者： Tobia. a.a.N Felix Ga.TI natalie OBERLE a.drea. Ka.LER j.rgen RüHE Fra.nhofer Institute for Mecha.ics of Ma.eria.s IWM Institute for Ma.romolecula. Chemistry University of Freiburg IMTEK-Depa.tment of Microsystems Engineering University of Freiburg

The effect of ga.va.ica.ly induced potentia.s on the friction a.d wea. beha.ior of a.1 RK91 sta.nless steel rega.ding to tribocorrosion wa. investiga.ed using a. oscilla.ing ba.l-on-disk tribometer equipped with a. electrochemica. cell. The a.m of this investiga.ion is to develop a.wa.er-ba.ed lubrica.t. Therefore 1 mola. sodium chloride(Na.l) a.d 1% 1-ethyl-3-methylimida.olium chloride [C_2 mim][Cl] wa.er solutions were used. Tribologica. performa.ce a. two ga.va.ica.ly induced potentia.s wa. compa.ed with the non-pola.ized sta.e: ca.hodic potentia.-coupling with pure a.uminum- a.d a.odic potentia.-coupling with pure copper. Frictiona. a.d electrochemica. response wa. recorded during the tests. In a.dition, wea. morphology a.d chemica. composition of the steel were a.a.yzed using sca.ning electron microscopy(SEM) a.d X-ra. photoelectron spectroscopy(XPS), respectively. The ga.va.ica.ly induced ca.hodic pola.iza.ion of the sta.nless steel surfa.e results in electrochemica. corrosion protection a.d the forma.ion of a.tribola.er. Ca.ions from the electrolyte(sodium Na.+ a.d 1-ethyl- 3-methylimida.olium [C_2 mim]^+) intera.t a.d a.here on the surfa.e. These chemica. intera.tions lea. to considera.ly reduced wea. using 1 Na. l(86%) a.d 1% 1-ethyl-3-methylimida.olium chloride [C_2 mim][Cl](74%) compa.ed to the nonpola.ized system. In a.dition, mecha.ica. a.d corrosive pa.t of wea. wa. identified using this electrochemica. technique. Therefore this method describes a.promising method to develop wa.er-ba.ed lubrica.ts for technica. a.plica.ions.

关键词： sliding wea. tribochemistry potentia. controlled friction a.d wea. ga.va.ic coupling ionic liquids tribola.er forma.ion

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Enduring a.tera.ions in hippoca.pa. a.trocytesyna.tic proximity following a.olescent a.cohol exposure: reversa. by ga.a.entin

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Neura. Regenera.ion Resea.ch 2020年第8期15卷 1496-1501页

作者： Ka.i L.Hea.ey Sa.dra.kibble Sierra.Hodges Ka.hryn j.Reissner a.ze Testen Tiffa.y a.Wills Sha.n K.a.heson Benj.0}in M.Siemsen j.hn a.McFa.din Micha.l D.Scofield H.Scott Swa.tzwelder Depa.tment of Psychia.ry a.d Beha.iora. Sciences Duke University Medical CenterDurhamNCUSA Depa.tment of Psychology a.d Neuroscience University of North CarolinaChapel HillNCUSA Depa.tment of Cell Biology a.d a.a.omy LSU School of MedicineNew OrleansLAUSA Depa.tment of a.esthesia.a.d Periopera.ive Medicine Medical University of South CarolinaCharlestonSCUSA

a.olescent a.cohol a.use is a.substa.tive public hea.th problem tha. ha. been the subj.ct of intensive study in recent *** reports of a.wide ra.ge of effects of a.olescent intermittent etha.ol(a.E)exposure on bra.n a.d beha.ior,little is known a.out the mecha.isms tha. ma. underlie those effects,a.d even less a.out trea.ments tha. might reverse *** studies from our la.ora.ory ha.e indica.ed tha. a.E produced enduring cha.ges in a.trocyte function a.d syna.tic a.tivity in the hippoca.pa. forma.ion,suggesting the possibility of a. a.tera.ion in a.trocyte-neurona. connectivity a.d *** utilized a.trocyte-specific,membra.e restricted vira. la.eling pa.red with immunohistochemistry to perform confoca. single cell a.trocyte ima.ing,three-dimensiona. reconstruction,a.d qua.tifica.ion of a.trocyte morphology in hippoca.pa. a.ea.Ca. from a.ult ra.s a.ter ***,we a.sessed the coloca.iza.ion of a.trocyte pla.ma.membra.e la.eling with immunorea.tivity for a.Pa.(α-a.ino-3-hydroxy-5-methyl-4-isoxa.olepropionic a.id)gluta.a.e receptor 1,a. a.Pa.receptor subunit a.d esta.lished neurona. ma.ker of excita.ory syna.ses,a. a.metric of a.trocyte-syna.se *** significa.tly reduced the coloca.iza.ion of the a.trocyte pla.ma.membra.e with syna.tic ma.ker puncta.in *** is striking in tha. it suggests not only a. a.tera.ion of the physica. a.socia.ion of a.trocytes with syna.ses by a.E,but one tha. la.ts into a.ulthood-well a.ter the termina.ion of a.cohol *** even more nota.le,the a.E-induced reduction of a.trocyte-syna.se intera.tion wa. reversed by sub-chronic trea.ment with the clinica.ly used a.ent,ga.a.entin(Neurontin),in *** suggests tha. a.medica.ion in common clinica. use ma. ha.e the potentia. to reverse some of the enduring effects of a.olescent a.cohol exposure on bra.n *** a.ima. experiments conducted were a.proved by the Duke University Institutiona. a.ima. Ca.e a.d Use Committee(Protocol

关键词： a.olescent a.cohol a.trocyte a.trocyte morphology a.trocyte-neurona. coloca.iza.ion Ca. ga.a.entin Glua. hippoca.pus tripa.tite syna.se

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Ubiquitin homeosta.is disruption, a.common ca.se of proteosta.is colla.se in a.yotrophic la.era. sclerosis?

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Neura. Regenera.ion Resea.ch 2022年第10期17卷 2218-2220页

作者： Christen G.Chisholm j.remy S.Lum natalie E.Fa.ra.ell j.stin j.Yerbury Illa.a.ra.Hea.th a.d Medica. Resea.ch Institute/Molecula. Horizons a.d School of Chemistry a.d Molecula. Bioscience Science Medicine and Health FacultyUniversity of WollongongNorthfields AveWollongongNSWAustralia

a.yotrophic la.era. sclerosis(a.S)is a.socia.ed with proteosta.is colla.se:a.S is a. unrelenting neurodegenera.ive disea.e tha. is cha.a.terized by the loss of motor neurons in the bra.n a.d spina. cord,resulting in the progressive a.rophy,a.d eventua. pa.a.ysis,of skeleta. *** due to respira.ory fa.lure usua.ly occurs within 2-5 yea.s from symptom *** 90%of a.S ca.es a.e of unknown etiology a.d a.e termed spora.ic a.S(sa.S).The rema.ning 10%of a.S ca.es present with a.fa.ily history(fa.ilia. a.S;fa.S)a.d a.e a.socia.ed with genetic muta.ions in a.ra.ge of over 20 functiona.ly heterogeneous *** of disea.e origin,the pa.hologica. ha.lma.k of a.S is the a.cumula.ion of ubiquityla.ed protein inclusions in motor neurons a.d surrounding glia. *** presence of these inclusions,compromised la.gely of misfolded a.d a.grega.ed proteins,implies a.colla.se in *** refers to the ma.ntena.ce of the proteome in a.sta.e of ba.a.ce or equilibrium so tha. a.cell ca. perform its proper function.

关键词： sta.is homeosta.is colla.se

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