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Physical-Chemical Aggressiveness of Solutions of Medicines as a Factor in the Rheology of the Blood inside Veins and Catheters

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Journal of Chemistry and Chemical Engineering 2014年第1期8卷 61-65页

作者： Aleksandr Urakov natalia urakova Anton Kasatkin Leisan Chernova Department of the Deformed Solid Body Institute of Mechanics of the Ural Branch of the RAS Izhevsk 426067 Russia Department of General and Clinical Pharmacology Izhevsk State Medical Academy Izhevsk 426034 Russia

In experiments in vitro and observations in the clinic in vivo studied the state of the lumen of subcutaneous veins and blood rheology of patients after their interaction with vascular catheters and solutions of medicines based on the values of temperature, volume, concentration, osmotic activity and pH. It is shown that heparin injection in blood not prevent, but solution of 4% sodium bicarbonate injection prevents blood clotting, blood clots and blockage blood clots of veins and of catheters. It is shown that the heating to a temperature of +42 °С with the solution of 4% sodium bicarbonate provides softening action on old dry blood clots in 1 min, and their subsequent irrigation with a warm solution of 4% sodium bicarbonate and 3% hydrogen peroxide provides complete destruction and discoloration of the remaining spots of blood during 2 s. Proposed new medicines and hygiene products for the protection of the veins and installed in them vascular catheters from blockage of blood clots, and for removing blood stains from clothes and body surface patients.

关键词：血液流变学导管静脉物理化学碳酸氢钠注射液过氧化氢溶液攻击性因子

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Possibility of Dissolution and Removal of Thick Pus due to the Physical-Chemical Characteristics of the Medicines

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材料科学与工程（中英文B版） 2013年第11期3卷 714-720页

作者： Aleksandr Urakov natalia urakova Leisan Chemova Department General and Clinical Pharmacology Izhevsk State Medical Academy Izhevsk 426034 Russia Department of Thermal Deformation Processes Institute of Mechanics of the Ural branch of RAS Izhevsk 426067 Russia

This paper presented the dynamics of the rheological properties of dense pus after mixing it with solutions plasma substitutes and antiseptics with respect to physical and chemical factors of the local interaction. It was studied the effect of the following factors gravity, specific gravity, temperature, turbulence, strength, internal pressure, carbonation, pH, osmotic activity, the total concentration of ingredients, the surface activity and the amount of medication. It was found that rheology of liquid, viscous and dense biological tissues may improve medicines having the following physicochemical characteristics hypertermia, high alkaline, high turbulence and high saturation by gas. Found that the leaders of improving rheology medicines and biological tissues are sodium bicarbonate, hydrogen peroxide and carbon dioxide, introduced in medecines similar carbonated beverages. The data allowed to develop a new hygienic medicines designed to liquefy thick purulent masses in patients with pleural empyema, peritonitis, rhinitis, sinusitis, conjunctivitis, tearful stones, osteomyelitis and sulfur tubes. New sanitary preparations are heated to 39-42 °C aqueous solutions 0.5%-10% sodium bicarbonate, 0.5%-3% peroxide of hydrogen and carbon dioxide, which is entered into the solution at a pressure of 0.2 ATM.

关键词：物理化学特性药物溶解湍流强度内部压力生物组织碳酸氢钠二氧化碳

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