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Hepatitis C virus and ethanol alter antigen presentation in liver cells

World Journal of Gastroenterology 2009年第10期15卷 1201-1208页

作者： natalia A Osna Department of Internal Medicine University of Nebraska Medical Center Liver Study Unit R151 VA Medical Center 4101 Woolworth Ave Omaha NE 68105 United States

Alcoholic patients have a high incidence of hepatitis C virus （HCV） infection. Alcohol consumption enhances the severity of the HCV disease course and worsens the outcome of chronic hepatitis C. The accumulation of virally infected cells in the liver is related to the HCV- induced inability of the immune system to recognize infected cells and to develop the immune responses. This review covers the effects of HCV proteins and ethanol on major histocompatibility complex （MHC） class Ⅰ- and class Ⅱ-restricted antigen presentation. Here, we discuss the liver which functions as an immune privilege organ; factors, which affect cleavage and loading of antigenic peptides onto MHC class I and class ~I in hepatocytes and dendritic cells, and the modulating effects of ethanol and HCV on antigen presentation by liver cells. Altered antigen presentation in the liver limits the ability ＇of the immune system to clear HCV and infected cells and contributes to disease progression. HCV by itself affects dendritic cell function, switching their cytokine profile to the suppressive phenotype of interleukin-10 （IL-10） and transforming growth factor beta （TGFβ） predominance, preventing cell maturation and allostimulation capacity. The synergistic action of ethanol with HCV results in the suppression of MHC class Ⅱ-restricted antigen presentation. In addition, ethanol metabolism and HCV proteins reduce proteasome function and interferon signaling, thereby suppressing the generation of peptides for MHC class I -restricted antigen presentation. Collectively, ethanol exposure further impairs antigen presentation in HCV-infected liver cells, which may provide a partial explanation for exacerbations and the poor outcome of HCV infection in alcoholics.

关键词： Alcohol Antigen presentation HepatitisC Virus Interferon alpha and gamma Liver Majorhistocompatibility complex (MHC) class Ⅰ MHC class Ⅱ

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The comparison of design airflow rates with dynamic and steady-state displacement models in varied dynamic conditions

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Building Simulation 2021年第4期14卷 1201-1219页

作者： natalia Lastovets risto Kosonen Juha Jokisalo Department of Mechanical Engineering Aalto UniversityEspooFinland College of Urban Construction Nanjing Tech UniversityNanjingChina

A temperature-based method is usually applied in displacement ventilation (DV) design when overheating is the primary indoor climate concern. Different steady-state models have been developed and implemented to calculate airflow rate in rooms with DV. However, in practical applications, the performance of DV depends on potentially dynamic parameters, such as strength, type and location of heat gains and changing heat gain schedule. In addition, thermal mass affects dynamically changing room air temperature. The selected steady-state and dynamic models were validated with the experimental results of a lecture room and an orchestra rehearsal room. Among the presented models, dynamic DV model demonstrated a capability to take into account the combination of dynamic parameters in typical applications of DV. The design airflow rate is calculated for the case studies of dynamic DV design in the modelled lecture room in both dynamic and steady-state conditions. In dynamic conditions of heavy construction in 2–4 hours occupancy periods, the actual airflow rate required could be 50% lower than the airflow rate calculated with the steady-state models. The difference between steady-state and dynamic multi-nodal model is most significant with heavyweight construction and short occupancy period (17%–28%). In cases with light construction, the dynamic DV model provides roughly the same airflow rates for four-hour occupancy period than the Mund’s model calculates. The dynamic model can significantly decrease the design airflow rate of DV, which can result in a reduction of investment costs and electrical consumption of fans.

关键词： displacement ventilation design airflow rate temperature gradient dynamic model simplified building energy models

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Distribution and diversity of microbial communities in meromictic soda Lake Doroninskoe(Transbaikalia,russia) during winter

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Chinese Journal of Oceanology and Limnology 2015年第6期33卷 1378-1390页

作者： Evgeniya MATYUGINA natalia BELKOVA Institute of Natural resources Ecology and CryologySiberian Branch of the Russian Academy of Sciences Limnological Institute Siberian Branch of the Russian Academy of Sciences Irkutsk State University

Meromictic soda and saline lakes are unique ecosystems characterized by the stability of physical,chemical and biological parameters,and they are distributed all over the *** located in regions with average annual negative air temperature are of particular interest because of the presence of two periods with intensive and dynamic processes:the so-called biological summer and the long ice season with the biological *** Lake Doroninskoe is located in Eastern Transbaikalia(51°14′N,112°14′E) in the permafrost zone in an extreme continental climate,and is covered by ice for seven months per *** structure and diversity of the microbial communities throughout the water column of the lake was studied by 16 S r rNA gene amplicon *** species with specific functions were found to dominate at different *** flexible bacteria with a capacity to switch between anoxygenic photosynthesis and aerobic chemotrophic metabolism dominate in soda Lake Doroninskoe.

关键词： bacterial diversity soda lake meromixis Lake Doroninskoe 16S rrNA genes high-throughput amplicon sequencing

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The brain compensatory mechanisms and Alzheimer's disease progression:a new protective strategy

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Neural regeneration research 2015年第5期10卷 696-697页

作者： natalia Bobkova Vasily Vorobyov Institute of Cell Biophysics Russian Academy of Sciences

Compensatory/adaptive mechanisms in the brain are hy- pothesized to be involved in its protection from the Alz- heimer＇s disease （AD） progression. These mechanisms are activated by malfunctioning of various brain systems： anti- oxidant, neurotrophic, neurotransmitter, immune, and oth- ers. Detailed analysis of compensatory^adaptive capabilities of these systems might be a start point for further discovery and development of perspective approaches for early diag- nostics and treatment of AD and associated neurodegenera- tive disorders.

关键词： The brain compensatory mechanisms and Alzheimer’s disease progression AD

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Diffuse matter and cosmogony of stellar systems in researches by ***

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research in Astronomy and Astrophysics 2018年第8期18卷 89-96页

作者： natalia Ivanovna Bondar Crimean Astrophysical Observatory rAS Nauchny298409Russia

The main topic of long-term researches by G.A. Shajn is the nature of diffuse matter, its dis- tribution in the Galaxy and extragalactic systems, interaction with the interstellar medium and hot stars, and the formation of emission and reflection nebulae and stars. Based on the analysis of experimental data, mainly photographic observations of nebulae in the Milky Way and extragalactic systems, he made conclusions and suggested well-founded hypotheses on a wide range of considered problems, including those related to cosmogony. The structure of nebulae, and their masses and sizes give reasons behind the conclusion that most of them are formed not in the process of ejection of matter from the stars, but rather they are objects which are born and evolve, and quite often are comprised of giant conglomerates of gas, dust and stars. The distribution of OB-type stars and nebulae in spiral branches points to their genetic relation and the fundamental role of the interstellar medium as the source of their formation. The structural features of nebulae are determined by the action of magnetohydrodynamic forces. Magnetic fields in a galaxy control the motion of diffuse gas-dust matter and ensure the maintenance of its spiral structure. These ideas continue being developed in modern directions of astrophysics.

关键词： galaxy interstellar matter diffuse nebulae cosmogony

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TrP channels in prostate cancer： the good, the bad and the ugly？

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Asian Journal of Andrology 2011年第5期13卷 673-676页

作者： Dimitra Gkika natalia Prevarskaya llnserm U1003 Equipe labellisee par la Ligue Nationale contre le cancer Villeneuve d＇Ascq France Universite des Sciences et Technologies de Lille （USTL） Villeneuve d＇Ascq France

During the last decade, transient receptor potential （TrP） channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and migration. Initial studies showed that expression profile of some TrP channels, notably TrP melastatin 8 （TrPM8）, TrP vanilloid 6 （TrPV6）,TrP canonical （TrPC6） and TrPV2, is changing during the development and the progression of prostate cancer towards the hormone-refractory stages. The link between the change in expression levels and the functional role of these channels in prostate cancer is step by step being elucidated. These recent advances are here described and discussed.

关键词： ion channel lysophospholipids migration neuroendocrine prostate cancer PSA transient receptor potential (TrP)channels TrP channels TrPM8 TrPV6 TrPV2

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On the Local Solvability and Stability for the Inverse Spectral Problem of the Generalized Dirichlet–regge Problem

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Acta Mathematica Sinica,English Series 2022年第7期38卷 1229-1240页

作者： Xiao Chuan XU natalia Pavlovna BONDArENKO School of Mathematics and Statistics Nanjing University of Information Science and TechnologyNanjing 210044P.R.China Department of Applied Mathematics and Physics Samara National Research UniversityMoskovskoye Shosse 34Samara 443086Russia Department of Mechanics and Mathematics Saratov State UniversityAstrakhanskaya 83Saratov 410012Russia

For the generalized Dirichlet–regge problem with complex coefficients,we prove the local solvability and stability for the inverse spectral problem,which indicates an improved result of the previous work([Journal of ... 详细信息

关键词： Dirichlet-regge problem inverse spectral problem local solvability stability reconstruction algorithm

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Two-way communication: Volatile emission and uptake occur through the same barriers

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Molecular Plant 2023年第1期16卷 1-3页

作者： Joshua r.Widhalm Meng-Ling Shih John A.Morgan natalia Dudareva Department of Horticulture and Landscape Architecture Purdue UniversityWest LafayetteIN 47907USA Center for Plant Biology Purdue UniversityWest LafayetteIN 47907USA avidson School of Chemical Engineering Purdue UniversityWest LafayetteIN 47907USA Department of Biochemistry Purdue UniversityWest LafayetteIN 47907USA

Volatile organic compounds(VOCs)are released from aboveground organs into the atmosphere and/or from roots into the soil,allowing plants to communicate and interact with their environment,including with each ***-plant communication via VOCs includes intra-and inter-species signaling as well as within-plant *** some recipient tissues,for example,VOC perception encompasses storing the modified VOC for direct defense against herbivores(Sugimoto et al.,2014)or increasing tolerance to abiotic stresses(Zhao et al.,2020).In addition,or alternatively,perceived VOCs may initiate signaling cascades that prime plant defenses(Brosset and Blande,2022).In all cases,plant VOCs are first released into the environment before being taken up and perceived by the same or neighboring *** significant progress has been made over the last several years to elucidate how VOCs are released from plant cells,these studies have also revealed new questions about how communicated VOCs are imported across cellular *** reviews(Loreto and D’Auria,2022;Wang and Erb,2022)and a special issue(Vlot and rosenkranz,2022)have proposed mechanisms for VOC perception and *** this Opinion piece,we shed light on the gaps in knowledge about VOC import and offer perspectives for future research aiming at understanding the molecular mechanisms underlying VOC-mediated communication in plants.

关键词： communicate soil barriers

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Gasification of lignite from Polish coal mine to hydrogen-rich gas

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International Journal of Coal Science & Technology 2022年第6期9卷 151-160页

作者： Adam Smolinski Slawomir Wochna natalia Howaniec Central Mining Institute Plac Gwarkow 140-166 KatowicePoland PGE Górnictwo i Energetyka Konwencjonalna S.A. Oddz.Kopalnia Wegla Brunatnego TurówGórników Turowa 159-916 BogatyniaPoland Department of Energy Saving and Air Protection Central Mining InstitutePlac Gwarkow 140-166 KatowicePoland

The efforts of the world research activities involved in clean coal technologies development focus to a considerable extent on integrated hydrogen and power generation technologies based on coal *** an alternative to combustion pro-cesses,gasification offers increased efficiency,lower negative environmental impact as well as wider application range of the main product—synthesis gas—in power generation and chemical *** order to select the most optimal lignite for the purpose of gasification,it is necessary to determine coal reactivity,the key parameter characterizing how fast the fuel reacts with the gasifying medium and controlling its process ability in thermochemical conversion to energy and/or energy *** paper presents the experimental results of oxygen/steam gasification of lignite coal char in a fixed bed reactor under atmospheric pressure and at the temperature of 700,800 and 900℃;the samples come from an open pit lignite mine in the southwest of *** effectiveness of the gasification process was tested in terms of the total gas and hydrogen yields,gas composition,carbon conversion rate and chars reactivity.

关键词： Coal gasification Hydrogen Syngas Clean coal technologies

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On the Number of Polynomials with Small Discriminants in the Euclidean and p-adic Metrics

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Acta Mathematica Sinica,English Series 2012年第3期28卷 469-476页

作者： Jin YUAN natalia BUDArINA Detta DICKINSON Department of Mathematics Northwest University Department of Mathematics Logic HouseMaynooth

In this article it is proved that there exist a large number of polynomials which have small discriminant in terms of the Euclidean and p-adic metrics simultaneously. The measure of the set of points which satisfy cer... 详细信息

关键词： Diophantine approximation discriminant polynomial inequalities

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