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Inflammation/bioenerg.tics-associated neurodeg.nerative patholog.es and concomitant diseases:a role of mitochondria targ.ted catalase and xanthophylls

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Neural Reg.neration Research 2021年第2期16卷 223-233页

作者： Mikhail A.Filippov Olg. g.Tatarnikova natalia V.Pozdnyakova Vasily V.Vorobyov Sistema-BioTech LLCMoscowRussia Institute of Cell Biophysics Russian Academy of SciencesPushchinoRussia

Various inflammatory stimuli are able to modify or even"re-prog.am"the mitochondrial metabolism that results in g.neration of reactive oxyg.n *** noncommunicable chronic diseases such as atherosclerosis and other cardiovascular patholog.es,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nervous *** processes associated with chronic inflammation are frequently g.ouped into"vicious circles"which are able to stimulate each other constantly amplifying.the patholog.cal *** circles are evidently observed in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated ***,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's *** is supposedly associated with some common g.netic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also develop ***,in the transg.nic mice expressing.the recombinant mitochondria targ.ted catalase,that removes hydrog.n peroxide from mitochondria,demonstrates the sig.ificant patholog. amelioration and health *** addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to targ.t the reactive oxyg.n species at cellular or mitochondrial membranes,have been demonstrated in both animal and human *** propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodeg.nerative disorders and other noncommunicable diseases associated with chronic inflammation in ***,some prospective drug. based on mitochondria targ.ted catalase or xanthophylls could be used as an effective treatment of these patholog.es,especially at early stag.s of their development.

关键词： alg.e xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targ.ted catalase noncommunicable chronic diseases stress

Ore-placer shows of platinum g.oup elements in the areal of North-Asian Superplume derivations(South-East Russia)

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g.obal g.olog. 2011年第4期14卷 209-220页

作者： Vadim g.Khomich Natalya g.boriskina Far East g.olog.cal Institute of FEB of RAS Vladivostok 690022Russia

The sources of larg. and unique platinum-metal placers were the zonal alkali-ultrabasic massifs be- coming.active in the Cretaceous time that g.avitated to the periphery of the areal of the North-Asian Superplume （NAS） influence. Orig.n of the conditions favorable for the formation of the placer platinum presence in the re- g.on is g.verned by the plume ore-g.nerating.mag.atism of several g.nerations （ in Proterozoie and Phanerozo- ic）. Ultramafite-mafite mag.atism was responsible for the orig.n of the stratified zonal massifs subjected in the Late Paleozoic and Mesozoic to the action of g.anitog.ne derivations of the NAS. The latter provided the devel- opment of the ore-forming.mag.ag.ne-fluid-metasomatic processes and favorable conditions for the platinum g.oup elements concentration.

关键词： platinum-bearing.ore-placer South-East Russia

Liver reg.neration is associated with lipid reorg.nization in membranes of the endoplasmic reticulum

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Frontiers in Biolog. 2016年第5期11卷 396-403页

作者： Anatoly I. Bozhkov natalia g. Menzyanova Vadim V. Davydov natalia I. Kurg.zova Vadim I. Sidorov Anastasia S. Vasilieva Research Institute of Biolog. of V.N. Karazin Kharkov National University sq. Svobody 4 61022 Kharkov Ukraine Institute of Fundamental Biolog. and Biotechnolog. of Siberian Federal University pr. Svobodny 79 660041 Krasnoyarsk Russia Ryazan State Medical University named after academician I.P.. Pavlov Visokovoltnaya 9 390026 Ryazan Russia

BACKg.OUND： In recent years, an adaptive endoplasmic reticulum （ER） stress response has been actively investig.ted. The ER membrane, isolated from the intact and reg.nerating.liver, may be an appropriate model for investig.ting.the association between structural and functional characteristics of ER in vivo and their corresponding.behavioral characteristics in vitro. The rate of lipid synthesis and that of intracellular lipid exchang. between the ER and cytosol were investig.ted in the intact and reg.nerating.liver （13 h after partial hepatectomy）. Particularly, membrane characteristics, surface potential, and g.ucose 6- phosphatase （g.Pase） activity were investig.ted, along.with the deg.adation rate of g.Pase in vitro, which was estimated by the loss of g.Pase activity, formation of lipid peroxides, and size of excreted membrane vesicles. METHODS： The rate of lipid synthesis was determined by measuring.the intensity of radioactive precursor （C^14-sodium acetate） in different fractions of lipids （phospholipids, non-esterified fatty acids, and triacylg.ycerides） after 30 min exposure. The rate of lipid metabolism was assessed by measuring.the quantity oflipids with radioactive labels emerg.ng.in the cytosol of hepatocytes （CPM）. Viscosity and surface potential were determined by fluorescent probes. RESULTS： It was observed that after 13 h of partial hepatectomy, the rate of lipid synthesis in the ER of hepatocytes in the reg.nerating.liver was 3 times lower than that in ER ofhepatocytes in the intact liver, wherein the rate of incorporation of newly synthesized lipids in cytosol was several times hig.er in the reg.nerating.liver. Increase in the rate of exchang. of neutral lipids in cells of the reg.nerating.liver was accompanied by lipid reconstruction in the ER, chang.ng.the structural and functional characteristics of the membrane. Such membrane rebuilding.also contributed to the rate of deg.adation of the ER in vitro, which that must be taken into account during.d

关键词： reg.neration neutral lipids microsomes in vitro

Novel Approaches of Using.of Spirulina Platensis in Natural Rubber Based Composites

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Journal of Renewable Materials 2018年第7期6卷 680-687页

作者： Ewa g.owińska Janusz Datta Paulina Parcheta and natalia Kaźmierczak Department of Polymers Technolog. Gdańsk University of TechnologyNarutowicza Street 11/1280-233 GdańskPoland

The aim of this work was to investig.te the influence of Spirulina (Spirulina platensis) as a natural filler on thecuring.characterization, morpholog. and mechanical, thermomechanical and thermal properties of naturalrubber (NR) based composites. Spirulina was introduced into NR mixture in amount of 0 phr, 10 phr and 30 *** vulcanization process was carried out at the determined process condition by using.hydraulic press atoptimum vulcanization time (t90). It was noticed that Spirulina affected on the reduction of t90, and scorch time(t2) of the NR mixtures. Obtained vulcanizates were subjected to the number of tests e.g. scanning.electronmicroscopy analysis, mechanical dynamical analysis, tensile test, hardness, and thermog.avimetry. g.nerally, itwas found that Spirulina added in amount of 10 phr NR positively influenced on tensile streng.h (TSb), storag.modulus and hardness of obtained composites.

关键词： Spirulina alg.e natural rubber composites DMA

Deep-seated g.odynamics and position of Platinum-bearing.basite-ultrabasite massifs of southeast Russia

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g.obal g.olog. 2012年第3期15卷 204-209页

作者： Khomich V.g. boriskina N.g. Far East g.olog.cal Institute of FEB of Russian Academy of Sciences

In the southeast part of the North-Asian craton, several ring.basite-uhrabasite plutons have been rec- og.ized, with which the commercial placers of platinoids associate. Analysis of the known g.odynamic models of the reg.on formation and materials of seismic tomog.aphy showed that the subduction processes, that actively manifested themselves in the Asia-Pacific converg.nce zone in Mesozoic, were responsible for initiation of the stag.ated oceanic slab. Its NE and SW boundaries appear to coincide with the transform faults. Projection of the transform fault, bordering.the above mentioned slab in the NEN, coincides with the Konder-Feklistovsky metal- log.nic belt disting.ished earlier and its Aldan （Inag.insky） member. Hig.er platinum content of ring.massifs of the belt is controlled by the influence of the lower mantle derivatives on the ascending.upper mantle plumes.

关键词： southeast Russia mantle plumes Platinum-bearing.ring.massifs

Asymmetry in Value Relevance of Environmental Performance （EP） Information： Conting.ncy Effects of Size and Industry

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Journal of Modern Accounting.and Auditing 2013年第6期9卷 777-789页

作者： natalia Semenova Lars g. Hassel Abo Akademi University Turku Finland Umea University Umea Sweden

Contemporary research documents a positive but weak price premium from environmental performance （EP）. The specific circumstances of pricing.EP of larg. and small companies and in polluting.and clean industries have not, however, been investig.ted. This study predicts that financial markets price EP beyond financial fundamentals differently, depending.on company size and the environmental risk of the industry and provides evidence relying.on a set of the Sweden Stock Market 300 （SIX 300） companies listed on the Stockholm Stock Exchang. （OMX Stockholm）. Applying.a value relevance model, the averag. results are in line with previous finding. that EP adds value beyond the book value of equity and earning.. The asymmetry in EP is, however, driven by company size and the environmental risk of the industry. This study sug.ests that larg. companies in low-risk industries obtain strong.price premiums from being.environmental industry leaders. In contrast, small companies and also companies in hig.-risk industries do not necessarily accrue the same market benefits.

关键词： environmental performance (EP) market premium industry risk size moderated reg.ession analysis (MRA)

The present and the future in the diag.osis and manag.ment of celiac disease

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g.stroenterolog. Report 2015年第1期3卷 3-11页

作者： natalia E.Castillo Thimmaiah g.Theethira Daniel A.Leffler Division of g.stroenterolog. Beth Israel Deaconess Medical CenterBostonMAUSA

Celiac disease is an autoimmune enteropathy caused by g.uten in g.netically predisposed *** celiac disease,adaptive and innate immune activation results in intestinal damag. and a wide rang. of clinical *** the past,celiac disease was thoug.t to result in sig.s and symptoms solely related to the g.strointestinal ***,more than half of the adult population presents with extra-intestinal manifestations that can also be expected to improve on a g.uten-free *** this reason,it is recommended that physicians have a low threshold of suspicion for celiac *** knowledg. of the immune pathog.nesis of this autoimmune disease has served as a catalyst for the development of novel diag.ostic tools and *** the years,hig.ly sensitive and speciﬁc serolog.cal assays,in addition to g.netic markers,have been found to targ.t speciﬁc steps in the cascade pathway of celiac *** the advent of the g.uten challeng. has enabled experts to desig. diag.ostic alg.rithms and monitor clinical responses in clinical *** g.uten challeng. has provided substantial beneﬁt in the advance of novel therapeutics as an adjuvant treatment to the g.uten free ***,a strict g.uten-free diet is hig.ly burdensome to patients and can be limited in its efﬁ*** therapies-including.g.uten modiﬁcation,modulation of intestinal permeability and immune response--could be central to the future treatment of celiac disease.

关键词： celiac disease g.uten-free diet autoimmune diseases

Challeng. of liver disease in systemic lupus erythematosus:Clues for diag.osis and hints for pathog.nesis

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World Journal of Hepatolog. 2014年第6期6卷 394-409页

作者： Ferno Bessone natalia Poles Marcelo g.Roma g.stroenterolog. and Hepatolog. Department University of Rosario School of Medicine Institute of Experimental Physiolog. (CONI-CET-UNR) Faculty of Biochemical and Pharmaceutical SciencesUniversity of Rosario

Systemic lupus erythematosus(SLE) encompass a broad spectrum of liver diseases. We propose here to classify them as follows:(1) immunolog.cal comorbilities(overlap syndromes);(2) non-immunolog.cal comorbilities associated to SLE; and(3) a putative liver damag. induced by SLE itself, referred to as "lupus hepatitis". In the first g.oup, liver injury can be ascribed to overlapping.hepatopathies trig.ered by autoimmune mechanisms other than SLE occurring.with hig.er incidence in the context of lupus(e.g., autoimmune hepatitis, primary biliary cirrhosis). The second g.oup includes non-autoimmune liver diseases, such as esteatosis, hepatitis C, hypercoag.lation state-related liver lesions, hyperplasic parenchymal and vascular lesions, porphyria cutanea tarda, and drug.induced hepatotoxicity. Finally, the data in the literature to support the existence of a hepatic disease produced by SLE itself, or the occurrence of a SLE-associated prone condition that increases susceptibility to acquire other liver diseases, is critically discussed. The patholog.cal mechanisms underlying.each of these liver disorders are also reviewed. Despite the hig. heterog.neity in the literature reg.rding.the prevalence of SLE-associated liver diseases and, in most cases, lack of histopatholog.cal evidence or clinical studies larg. enoug. to support their existence, it is becoming.increasing.y apparent that liver is an important targ.t of SLE. Consequently, biochemical liver tests should be routinely carried out in SLE patients to discard liver disorders, particularly in those patients chronically exposed to potentially hepatotoxic drug.. Diag.osing.liver disease in SLE patients is always challeng.ng. and the systematization of the current information carried out in this review is expected to be of help both to attain a better understanding.of pathog.nesis and to build an appropriate work-up for diag.osis.

关键词： Systemic lupus erythematosus Lupus hepatitis Esteatosis Reg.nerative nodular hyperplasia Hepatitis C Autoimmune hepatitis Hepatotoxicity Nonsteroidal anti-inflammatory drug. Methotrexate

Diffuse matter and cosmog.ny of stellar systems in researches by ***

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Research in Astronomy and Astrophysics 2018年第8期18卷 89-96页

作者： natalia Ivanovna Bondar Crimean Astrophysical Observatory RAS Nauchny298409Russia

The main topic of long.term researches by g.A. Shajn is the nature of diffuse matter, its dis- tribution in the g.laxy and extrag.lactic systems, interaction with the interstellar medium and hot stars, and the formation of emission and reflection nebulae and stars. Based on the analysis of experimental data, mainly photog.aphic observations of nebulae in the Milky Way and extrag.lactic systems, he made conclusions and sug.ested well-founded hypotheses on a wide rang. of considered problems, including.those related to cosmog.ny. The structure of nebulae, and their masses and sizes g.ve reasons behind the conclusion that most of them are formed not in the process of ejection of matter from the stars, but rather they are objects which are born and evolve, and quite often are comprised of g.ant cong.omerates of g.s, dust and stars. The distribution of OB-type stars and nebulae in spiral branches points to their g.netic relation and the fundamental role of the interstellar medium as the source of their formation. The structural features of nebulae are determined by the action of mag.etohydrodynamic forces. Mag.etic fields in a g.laxy control the motion of diffuse g.s-dust matter and ensure the maintenance of its spiral structure. These ideas continue being.developed in modern directions of astrophysics.

关键词： g.laxy interstellar matter diffuse nebulae cosmog.ny