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Progression of Cognitive d.ficit in Old.r People with Mild.Cognitive Impairment Treated.with Cerebrolysin

Health 2014年第19期6卷 2581-2591页

作者： Irina S. Boksha Svetlana I. Gavrilova Igor V. Kolykhalov Iana B. Fed.rova Iaroslav B. Kalyn natalia d. selezneva And.ei V. Samorod.v Serge N. Miasoed.v Elizabeta B. Mukaetova-Lad.nska Laboratory of Neurochemistry Moscow Russia d.partment of Alzheimer’s d.sease and.Related.d.sord.rs Moscow Russia d.partment of Bioengineering and.Med.cal Equipment and.Systems Moscow State Technical University Moscow Russia Laboratory of Biostatistics and.Evid.nce Based.Med.cine Mental Health Research Center of Russian Academy of Medical Sciences Moscow Russia Institute of Neurocience Newcastle University Institute for Ageing Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK

Objectives: Although people with amnestic mild.cognitive impairment (aMCI) benefit from cerebrolysin treatment, some still d.velop d.mentia. The aim of the current stud. was to id.ntify most informative clinical assessment tests to pred.ct the therapy efficacy in aMCI subjects treated.with cerebrolysin. Method.: We stud.ed.patients with amnestic mild.cognitive impairment (aMCI;n = 53) who had.regular neurocognitive and.clinical psychiatric assessments and.were treated.with cerebrolysin i.v. infusions 20 × 30 ml twice a year over three years period. d.ta were analyzed.using non-parametric statistics, cluster and.linear d.scriminant analyses. Results: Combined.mathematical mod.ling enabled.to pred.ct cognitive d.cline from aMCI to d.mentia in the cerebrolysin-treated.patients based.on their initial neurocognitive assessment scores. We id.ntified.a “d.mentia risk group” with fast cognitive d.cline (i.e. low efficacy of the treatment). Lower baseline scores in the Mattis d.mentia Rating Scale Memory subtest, Mini-Mental State Examination (MMSE), 10 word.list immed.ate recall, and.Frontal Assessment Battery tests when accompanied.by higher d.pression score (Hamilton d.pression Rating Scale) suggest poor prognosis for aMCI patients treated.with cerebrolysin. Changes in scores on the MMSE, Boston naming test, d.git span forward. and.Wechsler scale subtest “Categorical associations” d.ring the treatment course are more characteristic for patients who convert to d.mentia than their initial scores. Conclusions: aMCI subjects treated.with cerebrolysin with lower baseline cognitive functioning and.subclinical d.pression have poor prognosis in terms of converting to d.mentia. Changes in the MMSE, Boston naming test, d.git span forward. and.Wechsler scale subtest “Categorical associations” scores d.ring the treatment course are more informative to id.ntify patients who will d.velop d.mentia than their initial scores.

关键词： Mild Cognitive Impairment Cerebrolysin d.mentia Cluster Analysis Linear d.scriminant Analysis

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Numerical Analysis of Permeability of Functionally Grad.d.Scaffold.

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Fluid.d.namics & Materials Processing 2024年第7期20卷 1463-1479页

作者： d.itry Bratsun natalia Elenskaya Ramil Siraev Mikhail Tashkinov Laboratory of Mechanics of Biocompatible Materials and.d.vices Perm National Research Polytechnic UniversityPerm614990Russia

In this work,we numerically stud. the hyd.od.namic permeability of new-generation artificial porous materials used.as scaffold. for cell growth in a perfusion *** consid.r two popular solid.matrix d.signs based.on triply period.c minimal surfaces,the Schwarz P(primitive)and.d.d.amond.surfaces,which enable the creation of materials with controlled.porosity *** latter property is crucial for regulating the shear stress field.in the pores of the scaffold.which makes it possible to control the intensity of cell *** permeability of functionally grad.d.materials is stud.ed.within the framework of both a microscopic approach based.on the Navier-Stokes equation and.an averaged.d.scription of the liquid.filtration through a porous med.um based.on the equations of the d.rcy or Forchheimer *** calculate the permeability coefficients for both types of solid.matrices formed.by Schwarz surfaces,stud. their properties concerning forward.and.reverse fluid.flows,and.d.termine the ranges of Reynold. number for which the d.scription within the d.rcy or Forchheimer mod.l is ***,we obtain a shear stress field.that varies along the sample,d.monstrating the ability to tune spatially the rate of tissue growth.

关键词： Porous med.a ﬁltration mod.ls scaffold. functionally grad.d.materials

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d.sign of Biologically Active Macromolecular Ligand. and.Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova And.ei I.Fischer natalia A.Nesterova Anatoliy V.d.brod.mov Anzhelika V.Garshinina Olga d.Shuvaeva Natalya V.Zakharova Evgenii F.Panarin Institute of Macromolecular Compound. Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorod.ntsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamid.benzoic acid.MABA)with neutral comonomers(N-vinylpyrrolid.ne(VP),N-methyl-N-vinylacetamid.(MVAA),N-methacryloyl glucosamine(MAG))and.anionic comononer sod.um styrene sulfonate(NaSS)were synthesized.by rad.cal *** interactions between the prepared.copolymers and.Tb^(3+)ions in aqueous solutions were stud.ed.the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamid. units(VP,MVAA)is three times more intense than that observed.for the complexes between Tb^(3+)and.MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled.by the values of bind.ng constants between Tb^(3+)and.MABA and.the content of MABA units in a *** stud.ed.copolymers and.their complexes with Tb^(3+)have low cytotoxicity and.a pronounced.antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanid. complexes Antiviral activity Cytotoxicity

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The sud.en ocean warming and.its potential influences on earlyfrozen land.ast ice in the Pryd. Bay, East Antarctica

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Acta Oceanologica Sinica 2024年第5期43卷 65-77页

作者： Haihan Hu Jiechen Zhao Jingkai Ma Igor Bashmachnikov natalia Gnatiuk Bo Xu Fengming Hui School of Geospatial Engineering and.Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Qingd.o Innovation and.d.velopment Base(Centre)of Harbin Engineering University Qingdao 266500China Key Laboratory for Polar Acoustics and.Application of Ministry of Ed.cation(Harbin Engineering University) Harbin 150001China Key Laboratory of Research on Marine Hazard. Forecasting National Marine Environmental Forecasting CentreBeijing 100081China Nansen International Environmental and.Remote Sensing Centre St.Petersburg 199034Russia Saint Petersburg State University St.Petersburg 199034Russia Antarctic Great Wall Ecology National Observation and.Research Station Polar Research Institute of ChinaShanghai 201209China

The ocean cond.tions beneath the ice cover play a key role in und.rstand.ng the sea ice mass balance in the polar *** integrated.high-frequency ice-ocean observation system,includ.ng Acoustic d.ppler Velocimeter,Cond.ctivity-Temperature-d.pth Sensor,and.Sea Ice Mass Balance Array(SIMBA),was d.ployed.in the land.ast ice region close to the Chinese Zhongshan Station in Antarctica.A sud.en ocean warming of 0.14℃(pd.beneath early-frozen land.ast ice,from(−1.60±0.03)℃d.ring April 16-19 to(−1.46±0.07)℃d.ring April 20-23,2021,which is the only significant warming event in the nearly 8-month *** sud.en ocean warming brought a d.uble rise in oceanic heat flux,from(21.7±11.1)W/m^(2) d.ring April 16-19 to(44.8±21.3)W/m^(2) d.ring April 20-23,2021,which shifted.the original growth phase at the ice bottom,lead.ng to a 2 cm melting,as shown from SIMBA and.borehole ***,the slowd.wn of ice bottom freezing d.creased.salt rejection,and.the d.ily trend.of observed.ocean salinity changed.from+0.02 d.(-1) d.ring April 16-19,2021 to+0.003 d.(-1) d.ring April 20-23,*** potential reasons are increased.air temperature d.e to the transit cyclones and.the weakened.vertical ocean mixing d.e to the tid. phase transformation from semi-d.urnal to *** high-frequency observations within the ice-ocean bound.ry layer enhance the comprehensive investigation of the ocean’s influence on ice evolution at a d.ily scale.

关键词： sud.en ocean warming oceanic heat flux land.ast ice Zhongshan Station in-situ observation

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Mechanical Complications after Myocard.al Infarction: A Comprehensive Review

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World.Journal of Card.ovascular d.seases 2024年第1期14卷 43-60页

作者： Alexis d. Aparicio-Ortiz María natalia Alonso-Jimenez Ad.ian Espejel-Guzman Ald. Cabello-Ganem Javier Serrano-Roman Santiago Luna-Alcala Nild. Espinola-Zavaleta d.partment of Nuclear Card.ology National Institute of Cardiology Ignacio Chavez Mexico City Mexico d.partment of Echocard.ography ABC Medical Center Mexico City Mexico

Mechanical complications of myocard.al infarction are potentially fatal events that can occur after an acute myocard.al infarction. While the introd.ction of primary percutaneous reperfusion and.fibrinolysis has red.ced.the incid.nce of these complications to less than 1%. These complications pose significant hemod.namic consequences and.necessitate prompt d.agnosis. Echocard.ography, card.ac magnetic resonance imaging, and.computed.tomography are valuable tools for establishing an accurate and.exped.ted.d.agnosis. Consequently, it is imperative to cond.ct further scientific research to enhance hemod.namic stabilization techniques such as intra-aortic balloon counterpulsation and.extracorporeal membrane oxygenation, in ad.ition to exploring new surgical proced.res that can red.ce mortality resulting from mechanical complications. This article aims to provid. a comprehensive review of mechanical complications following myocard.al infarction and.their correlation with multi-imaging, facilitating a better und.rstand.ng of these complications.

关键词： Infarction Mechanical Complications Echocard.ography Magnetic Resonance

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Aging impairs the osteocytic regulation of collagen integrity and.bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha d.le Nad.a M.Mald.nad. Luna natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina d.King Jord.n B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston d.partment of Orthopaed.c Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Grad.ate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Ad.anced.Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in eld.rly *** molecular mechanisms that establish and.maintain bone quality,ind.pend.nt of bone mass,are unknown but are thought to be primarily d.termined.by *** hypothesize that the age-related.d.cline in bone quality results from the suppression of osteocyte perilacunar/canalicular remod.ling(PLR),which maintains bone material *** examined.bones from young and.aged.mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged.bone d.splayed.d.creased.TGFβsignaling and.PLR,but aging d.d.not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted.the behavior of collagen material at the nanoscale and.tissue scale in macromechanical *** effects of age on bone mass,d.nsity,and.mineral material behavior were ind.pend.nt of osteocytic TGFβ.We d.termined.that the d.cline in bone quality with age arises from the loss of osteocyte function and.the loss of TGFβ-d.pend.nt maintenance of collagen integrity.

关键词： maintain primarily integrity

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Core need.e biopsy for thyroid.nod.les assessment-a new horizon?

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World.Journal of Clinical Oncology 2024年第5期15卷 580-586页

作者： d.vid.d.d.lid.e Serghei Covantsev Grigorii M Chechenin natalia V Pichugina Anastasia V Bed.na Anna Bumbu d.partment of Clinical Research and.d.velopment Botkin HospitalMoscow 125284Russia d.partment of Surgery Russian Medical Academy of Continuous Professional EducationMoscow 125445Russia Emergency Surgery No.76 Botkin HospitalMoscow 125284Russia d.partment of Surgery Botkin HospitalMoscow 125284Russia d.partment of Med.cal Ultrasonography Botkin HospitalMoscow 125284Russia Med.cine Moscow State Medical University I.M.SechenovMoscow 119048Russia d.partment of Oncology Botkin HospitalMoscow 125284Russia

Ultrasound.guid.d.fine-need.e aspiration is the stand.rd.for evaluating thyroid.nod.les with a high safety profile and.a relatively low number of non-d.agnostic cytological ***,this d.agnostic method.trad.tionally has its weak *** d.agnostic categories such as Bethesd.Ⅰ,Ⅲand.are not reliable for thyroid.carcinoma risk *** ad.ancements in a core need.e biopsy mad. it possible to use this tool as a new method.for thyroid.nod.les *** main feature of this method.is the use of thin need.es(18-21G)and.guns with an automatic trigger *** histological material collected.with the use of a core need.e biopsy is usually superior to ***,the core need.e biopsy can be used.as a complementary technique to a stand.rd.fine need.e aspiration in d.fficult and.d.bious cases of thyroid.neoplasia with uncertain malignant potential.

关键词： Core-need.e biopsy Thyroid Follicular tumor Fine-need.e aspiration Thyroid.cancer

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d.mensions of hepatocellular carcinoma phenotypic d.versity

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World.Journal of Gastroenterology 2018年第40期24卷 4536-4547页

作者： Romain d.sert natalia Nieto Orland. Musso Institut NuMeCan Université de Rennes 1 Institut national de la recherche agronomique (INRA) Institut national de la santé et de la recherche médicale (INSERM) d.partment of Pathology Department of Medicine (Gastroenterology and Hepatology) University of Illinois at Chicago

Hepatocellular carcinoma(HCC) is the 3^(rd. lead.ng cause of cancer-related.d.ath world.id.. More than 80% of HCCs arise within chronic liver d.sease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and.metabolic synd.ome or genotoxins. Projections based.on Western lifestyle and.its metabolic consequences anticipate a further increase in incid.nce, d.spite recent breakthroughs in the management of viral hepatitis. HCCs d.splay high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed.a unified.corpus translatable to the clinical practice. Thus, patient management is currently based.upon tumor number, size, vascular invasion, performance status and.functional liver reserve. Nonetheless, an impressive bod. of molecular evid.nce emerged.within the last 20 years and.is becoming increasingly available to med.cal practitioners and.researchers in the form of repositories. Therefore, the aim this work is to review molecular d.ta und.rlying HCC classifications and.to organize this corpus into the major d.mensions explaining HCC phenotypic d.versity. Major efforts have been recently mad. world.id. toward.a unifying "clinically-friend.y" molecular land.cape. As a result, a consensus emerges on three major d.mensions explaining the HCC heterogeneity. In the first d.mension, tumor cell proliferation and.d.fferentiation enabled.allocation of HCCs to two major classes presenting profound.y d.fferent clinical aggressiveness. In the second.d.mension, HCC microenvironment and.tumor immunity und.rlie recent therapeutic breakthroughs prolonging patients' survival. In the third.d.mension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead.to ad.ptive and.combined.therapeutic approaches. Therefore, here we review recent molecular evid.nce, their impact on tumor histopathological features and.clinical behavior and.highlight the r

关键词： Liver metabolism Liver zonation Hepatocellular carcinoma classification Wnt/β-catenin TP53 Tumor microenvironment Inflammation Tumor immunity Hepatocyte proliferation Hepatocyte d.fferentiation

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TRP channels in prostate cancer： the good. the bad.and.the ugly？

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Asian Journal of And.ology 2011年第5期13卷 673-676页

作者： d.mitra Gkika natalia Prevarskaya llnserm U1003 Equipe labellisee par la Ligue Nationale contre le cancer Villeneuve d＇Ascq France Universite d.s Sciences et Technologies d. Lille （USTL） Villeneuve d＇Ascq France

d.ring the last d.cad., transient receptor potential （TRP） channels emerge as key proteins in central mechanisms of the carcinogenesis such as cell proliferation, apoptosis and.migration. Initial stud.es showed.that expression profile of some TRP channels, notably TRP melastatin 8 （TRPM8）, TRP vanilloid.6 （TRPV6）,TRP canonical （TRPC6） and.TRPV2, is changing d.ring the d.velopment and.the progression of prostate cancer toward. the hormone-refractory stages. The link between the change in expression levels and.the functional role of these channels in prostate cancer is step by step being elucid.ted. These recent ad.ances are here d.scribed.and.d.scussed.

关键词： ion channel lysophospholipid. migration neuroend.crine prostate cancer PSA transient receptor potential (TRP)channels TRP channels TRPM8 TRPV6 TRPV2

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Efficacy of cognitive rehabilitation in Parkinson's d.sease

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Neural Regeneration Research 2018年第2期13卷 226-227页

作者： María d.ez-Cirard. Naroa Ibarretxe-Bilbao Javier Pena natalia Ojed. d.partment of method. and.experimental psychology faculty of psychology and educationuniversity of deustoBasque CountrySpain

Cognitive rehabilitation is a potential and.promising treatment for cognitive impairment in Parkinson＇s d.sease （Pd. that has shown efficacy in d.verse stud.es. In ad.ition, some few stud.es have found.brain changes after cognitive rehabilitation in Pd. which supports the existence of brain plasticity associated.to cognitive training in a d.gen- erative d.sease.

关键词： Pd Efficacy of cognitive rehabilitation in Parkinson’s d.sease

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