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Quality of drinking water and risk to the health of the population of the south Baikal region (Russia)

Emerging Contaminants 2024年第2期10卷 106-114页

作者： viktor S.Rukavishnikov natalia v.efimova Mikhail F.Savchenkov Inna v.Mylnikova Alexander A.Lisovtsov East-Siberian Institute of Medical and Ecological Research 665827AngarskRussia

Providing good quality water in sufficient quantities is a major challenge in the *** purpose of the study is to assess the quality of drinking water and the health risk of various population groups in the southern Baikal region(Siberia,Russia)under changing hydrological *** Baikal is the largest freshwater body of water and is one of the sites protected by *** and *** analysis of centralized and non-centralized water supply was carried out in the south-eastern part of the Irkutsk region,adjacent to Lake *** data used are from the Baikal(regional)Information Center for 2011–2022,and they include the results of monitoring the water quality of the centralized domestic and drinking water supply(CDW)with 140 thousand samples,and non-centralized domestic and drinking water supply(NDW)with 108 thousand *** all samples,17 substances were *** addition,during the flood period,accompanied by additional water disinfection,trihalomethanes were determined in populated areas exposed to negative *** quality of drinking water was assessed in comparison with the maximum permissible concentrations of substances(MPCs)approved by regulatory documents of *** assessment of the characteristics of drinking water consumption by the population of the Baikal region was carried out,based on interview data from sample groups of the *** assessment of the risk to public health,due to chronic oral intake of chemicals,was carried out using the values of the hazard coefficient(HQi),the hazard index(HI),individual carcinogenic risk(ICR),and population carcinogenic risk(PCR).village residents more often use underground water sources(centralized and non-centralized).Residents of cities are provided with water from surface sources(Lake Baikal and the Angara River).Significant concentrations of iron,nitrates,and manganese were found in drinking water used by *** concentrations of iron-2.25 mg/dl,manganese

关键词： Drinking water Noncarcinogenic risk Carcinogenic risk Population South Baikal region

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Proteostasis failure:at the intersection between aging and Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3221-3222页

作者： natalia Poblete Claudio Hetz Center for Geroscience Brain Health and MetabolismSantiagoChile Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile Buck Institute for Research on Aging NovatoCAUSA

Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of *** we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to *** is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.

关键词： Alzheimer amyloid stasis

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： natalia Kulesskaya Kira M.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Assessment of health risk of the baikal region population associated with the wildfire air pollution:Approaches,modelling,digital environment

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Emerging Contaminants 2023年第1期9卷 33-40页

作者： natalia efimova viacheslav Paramonov viktor Rukavishnikov Roman Fedorov Gennadiy Ruzhnikov Andrei Tsyrendorzhiyev East-Siberian Institute of Medical and Ecological Research 3“12a mikrorayon”Angarsk665827Irkutsk oblastRussia Matrosov Institute for System Dynamics and Control Theory of SB RAS 134 Lermontov St.Irkutsk664033Russia Rospotrebnadzor for the Republic of Buryatia 45Kluchevskaya St.Ulan-Ude670013Republic of BuryatiaRussia

The latest forecasts indicate wildfire activity in many parts of the *** smoke contains hazardous air pollutants such as carbon monoxide,nitrogen dioxide,ozone,particulate matter et ***,prediction of this impact and on time medical care are difficult due to the lack of digital decision-making *** aim of this study is to assess population health risks associated with the sub-daily exposure to wildfire smoke produced by massive foci of combustion near the populated areas and at a significant distance from *** consider reflex reactions as a response to a short-term *** maximum value of the 95th percentile from the series of observations at the monitoring point was used to assess the *** the mathematical description of the“concentration-effect”relationship,the model of individual thresholds is *** model describes a dependence as a straight line under the condition that the concentration is expressed in the form of a normalprobabilistic *** frequency of additional cases is determined by studying the number of requests for medical assistance(including calls for ambulance)with complaints of respiratory disorders,lacrimation,*** the territories affected by wildfires *** indicator is calculated per 1000 *** probability of negative biological effects in response to the impact of wildfire smoke is associated mainly with the content of CO and TPM in the conditions of the Baikal *** frequency of additional requests for medical care ranged from 0.137 to 0.933 per 1000 exposed population during the fire period in settlements where risk levels are>*** developed a digital environment that allows us to get information about harmful substances in the outdoor air from different sources and in different formats and data *** digital environment supports implementation of models for assessing hazards to human body organs.

关键词： Air pollution Wildfire Health risk Digital environment

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The characteristic pattern of multiple colored layers in coastal stratified lakes in the process of separation from the White Sea

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Journal of Oceanology and Limnology 2018年第6期36卷 1962-1977页

作者： Elena D.KRASNOvA Dmitry N.MATORIN Tatiana A.BELEvICH Ludmila E.efimova Anastasiia v.KHARCHEvA natalia M.KOKRYATSKAYA Galina N.LOSYUK Daria A.TODORENKO Dmitry A.vORONOv Svetlana v.PATSAEvA Biological Faculty of Lomonosov Moscow State University Leninskye Gory 1bld.12Moscow 119234Russia Faculty of Geography Lomonosov Moscow State University GSP-1 Leninskye Gory1Moscow 119991Russia Faculty of Physics Lomonosov Moscow State UniversityLeninskye Gory1Moscow 119991Russia N.Laverov Federal Center for Integrated Arctic Research Russian Academy of SciencesSevernoj Dviny Emb.23Arkhangelsk 163000Russia A.A.Kharkevich Institute for Information Transmission Problems Russian Academy of SciencesBolshoy Karetny Per.19bld.1Moscow 127051Russia A.N.Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Bld.40Moscow 119991Russia

An unusual feature of the saline stratified lakes that were formed due to ongoing postglacial uplift on the White Sea coast is the presence of several differently colored thin layers in the zone with sharp gradients. Colored layers in five lakes at various stages of separation from the sea were investigated using optical microscopy, spectrophotometry, spectrofluorimetry, and photobiology. The upper greenish colored layer located in the aerobic strata of all lakes near the compensation depth of 1% light penetration contains green algae. In the chemocline, another layer, brightly green, red or pink, is dominated by mixotrophic flagellates. Despite the very low light intensities and the presence of H 2 S, active photosynthesis by these algae appears to be occurring, as indicated by high values of the maximum quantum yield of primary photochemistry, electron transport activity, photosynthetic activity of photosystem II, the fraction of active centers, and low values of heat dissipation. In the reduced zone of the chemocline, a dense green or brown suspension of anoxygenic phototrophs(green sulfur bacteria) is located.

关键词： algal blooms coastal lakes chemocline fluorescence kinetics Arctic White Sea

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Electric field distributions along helium plasma jets

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High voltage 2020年第6期5卷 650-653页

作者： George v.Naidis natalia Yu Babaeva Joint Institute for High Temperatures RAS 125412 MoscowRussia

Results of simulations of streamers propagating along the atmospheric-pressure helium plasma jets ejected from a thin tube into ambient air are presented. The computational model includes the equations governing the helium-air mixture composition along and across the jet, as well as the equations, describing streamer propagation in the mixture, for the electric field and the charged species densities. Streamer velocity and spatial-temporal profiles of plasma parameters are obtained for various values of the helium flow rate. It is shown, in agreement with available experimental data, that the electric field values in the heads of streamers increase nearly linearly with the distance from the tube exit and that the slope of this dependence decreases with the growth of the helium flow rate.

关键词： field mixture ambient

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Dispersion of ventricular repolarization: Temporal and spatial

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World Journal of Cardiology 2020年第9期12卷 437-449页

作者： natalia v Arteyeva Laboratory of Cardiac Physiology Institute of Physiology of Komi Science Centre of the Ural Branch of the Russian Academy of SciencesSyktyvkar 167982Russia

Repolarization heterogeneity(RH)is an intrinsic property of ventricular myocardium and the reason for T-wave formation on electrocardiogram(ECG).Exceeding the physiologically based RH level is associated with appearance of life-threatening ventricular arrhythmias and sudden cardiac *** this regard,an accurate and comprehensive evaluation of the degree of RH parameters is of importance for assessment of heart state and arrhythmic *** review is devoted to comprehensive consideration of RH phenomena in terms of electrophysiological processes underlying RH,cardiac electric field formation during ventricular repolarization,as well as clinical significance of RH and its reflection on ECG *** formation of transmural,apicobasal,left-toright and anterior-posterior gradients of action potential durations and end of repolarization times resulting from the heterogenous distribution of repolarizing ion currents and action potential morphology throughout the heart ventricles,and the different sensitivity of myocardial cells in different ventricular regions to the action of pharmacological agents,temperature,frequency of stimulation,etc.,are being *** review is focused on the fact that RH has different aspects–temporal and spatial,global and local;ECG reflection of various RH aspects and their clinical significance are being *** for comprehensive assessment of ventricular RH using different ECG indices reflecting various RH aspects are presented.

关键词： Temporal Spatial Global and local dispersion of repolarization Action potential duration Tpeak-Tend interval Tpeak-Tend dispersion T-vector Arrhythmogenesis

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Cell signaling mechanisms and metabolic regulation of germination and dormancy in barley seeds

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The Crop Journal 2017年第6期5卷 459-477页

作者： Zhenguo Ma natalia v.Bykova Abir U.Igamberdiev Department of Biology Memorial University of Newfoundland Pacific Forestry Centre Natural Resources Canada Morden Research and Development Centre Agriculture and Agri-Food Canada

During germination of barley(Hordeum vulgare L.) seeds, important morphological and physiological changes take place, including development of organs and tissues and activation of metabolic pathways. Germination and dormancy of seeds are regulated by abscisic acid, gibberellins, reactive oxygen species(ROS), reactive nitrogen species(RNS)and several other factors. Activities of ascorbate-glutathione cycle enzymes, responsible for scavenging ROS, strongly increase. Catalase and superoxide dismutase activities, also scavenging ROS, decrease at the onset of seed germination and then increase. With the increase in aerobic metabolism after radicle protrusion, the activities of the fermentation enzymes lactate and alcohol dehydrogenase decline rapidly. The RNS-scavenging activity of S-nitrosoglutathione reductase decreases in the course of seed germination, in concert with elevation of nitric oxide production and protein nitrosylation. This activity supports the role of RNS in regulating seed germination. Transcription of various genes at different phases of seed germination exhibits phase-specific changes. During imbibition, genes involved in cell wall metabolism are highly expressed; in the middle phase of seed germination before radicle protrusion, genes involved in amino acid synthesis, protein synthesis, and transport and nucleic acid synthesis are upregulated significantly, and after radicle protrusion, genes involved in photosynthetic metabolism are induced. In summary, signal transduction and metabolic regulation of seed germination involve diverse reactions and complex regulation at different levels of metabolic organization.

关键词： Seed germination Reactive oxygen species Reactive nitrogen species Signal transduction Gene expression

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Inflammation/bioenergetics-associated neurodegenerative pathologies and concomitant diseases:a role of mitochondria targeted catalase and xanthophylls

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Neural Regeneration Research 2021年第2期16卷 223-233页

作者： Mikhail A.Filippov Olga G.Tatarnikova natalia v.Pozdnyakova vasily v.vorobyov Sistema-BioTech LLCMoscowRussia Institute of Cell Biophysics Russian Academy of SciencesPushchinoRussia

various inflammatory stimuli are able to modify or even"re-program"the mitochondrial metabolism that results in generation of reactive oxygen *** noncommunicable chronic diseases such as atherosclerosis and other cardiovascular pathologies,type 2 diabetes and metabolic syndrome,these modifications become systemic and are characterized by chronic inflammation and,in particular,"neuroinflammation"in the central nervous *** processes associated with chronic inflammation are frequently grouped into"vicious circles"which are able to stimulate each other constantly amplifying the pathological *** circles are evidently observed in Alzheimer's disease,atherosclerosis,type 2 diabetes,metabolic syndrome and,possibly,other associated ***,chronic inflammation in peripheral tissues is frequently concomitant to Alzheimer's *** is supposedly associated with some common genetic polymorphisms,for example,Apolipoprotein-Eε4 allele carriers with Alzheimer's disease can also develop ***,in the transgenic mice expressing the recombinant mitochondria targeted catalase,that removes hydrogen peroxide from mitochondria,demonstrates the significant pathology amelioration and health *** addition,the beneficial effects of some natural products from the xanthophyll family,astaxanthin and fucoxanthin,which are able to target the reactive oxygen species at cellular or mitochondrial membranes,have been demonstrated in both animal and human *** propose that the normalization of mitochondrial functions could play a key role in the treatment of neurodegenerative disorders and other noncommunicable diseases associated with chronic inflammation in ***,some prospective drugs based on mitochondria targeted catalase or xanthophylls could be used as an effective treatment of these pathologies,especially at early stages of their development.

关键词： algae xanthophylls Alzheimer's disease atherosclerosis depression type 2 diabetes metabolic syndrome mitochondria-targeted catalase noncommunicable chronic diseases stress

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Geochemistry of Thermal Waters of Continental Margin of Far East of Russia

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Acta Geologica Sinica(English Edition) 2016年第1期90卷 276-284页

作者： Ivan v. BRAGIN Georgy A. CHELNOKOv Oleg v. CHUDAEv natalia A. KHARITONOvA Sergey v. vYSOTSKIY Far East Geological Institute Russian Academy of SciencesVladivostok690022 Russia Moscow State University Moscow119991 Russia Far East Federal University Vladivostok690922 Russia

Studied waters belong to warm （T=30-50℃）, alkaline （pH=8.9-9.3）, low mineralized （TDS〈235 mg/l） Na-HCO3 or Na-SO4-HCO3 thermal waters with high content of SiO2 （up to 81 mg/1） and F （up to 3.9 mg/l）, occur on modern volcano-tectonic rejuvenated areas of Eastern Sikhote-Alin orogenic belt. Low 3He concentration as well as N2/O2 and N2/Ar ratios exclude influence of deep mantle fluid. New rare earth element data constrain our understanding of water-rock interaction occurring in the water source region. Meteoric origin of waters is proved by stable isotope values varying from -71%o to -136.1‰ and from -10.8‰ to -18.8%o for δ^2H and δ^18O respectively. REE patterns reflect high pH, resultfing from water-rock interaction and oxidative conditions. Calculations of deep aquifer temperature using Na-K and quartz geothermometers show 116.8-131.1℃ and 82.2-125.8℃ respectively. Presence of deep faults both with abnormal thermal gradient （-45- 50 K/km） define unique geochemical shape of thermal waters of Sikhote-Alin, area, where no present volcanic activity is registered.

关键词： thermal waters water-rock interaction stable water isotopes rare earth elements in thermal waters

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