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Atrial fibrillation among Russian men and women aged 55 years and older:prevalence,mortality,and associations with biomarkers in a population-based study

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Journal of Geriatric Cardiology 2020年第2期17卷 74-84页

作者： Maria A.Shkolnikova Dmitri A.Jdanov Rukizhat A.Ildarova natalia v.Shcherbakova Ekaterina B.Polyakova Evgeny N.Mikhaylov Svetlana A.Shalnova vladimir M.Shkolnikov veltischev Research and Clinical Institute for Pediatrics of the Pirogov Russian National Research Medical University MoscowRussian Federation Laboratory of Demographic Data Max Planck Institute for Demographic ResearchRostockGermany International Laboratory for Population and Health Research University Higher School of EconomicsMoscowRussian Federation Arrhythmia Department and Neuromodulation Laboratory Almazov National Medical Research CentreSaint-PetersburgRussian Federation National Research Center for Preventive Medicine MoscowRussian Federation

Objective To examine the prevalence of atrial fibrillation(AF),its impacts on cardiovascular disease(CvD)and all-cause mortality,and the associations between AF and inflammatory and serum biomarkers in a population-based sample of *** The study is a secondary analysis of data from the Stress,Aging and Health in Russia(SAHR)survey that includes information on 1800 individuals with an average age of 68.5 years at baseline,and on their subsequent mortality during 7.4 years on *** is detected by 12-lead electrocardiogram(ECG)and 24-hour Holter *** statistical analysis includes proportional hazard and logistic regression *** Of the 1732 participants with relevant Holter data,AF was detected in 100(74 by ECG and Holter,26 by Holter only).The prevalence of AF was 5.8%for men and 7.4%for *** fully adjusted model showed strongly elevated hazard of CvD and all-cause mortality in men and women with long non-self-limiting AF(LAF).LAF was found to be negatively associated with elevated total and lowdensity lipoprotein cholesterol and to be positively associated with elevated markers of inflammation in *** The study assessed for the first time the prevalence and the risks of death related to AF among older *** was shown to be a strong and independent predictor of CvD and all-cause *** is unlikely to contribute to the large excess male mortality in *** finding that one-quarter of AF cases were detected only by Holter monitoring demonstrates the usefulness of diagnostics with prolonged ECG registration.

关键词： Aging Atrial fibrillation Gender differences Holter monitoring Mortality Prevalence

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The characteristic pattern of multiple colored layers in coastal stratified lakes in the process of separation from the White Sea

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Journal of Oceanology and Limnology 2018年第6期36卷 1962-1977页

作者： Elena D.KRASNOvA Dmitry N.MATORIN Tatiana A.BELEvICH Ludmila E.EFIMOvA Anastasiia v.KHARCHEvA natalia M.KOKRYATSKAYA Galina N.LOSYUK Daria A.TODORENKO Dmitry A.vORONOv Svetlana v.PATSAEvA Biological Faculty of Lomonosov Moscow State University Leninskye Gory 1bld.12Moscow 119234Russia Faculty of Geography Lomonosov Moscow State University GSP-1 Leninskye Gory1Moscow 119991Russia Faculty of Physics Lomonosov Moscow State UniversityLeninskye Gory1Moscow 119991Russia N.Laverov Federal Center for Integrated Arctic Research Russian Academy of SciencesSevernoj Dviny Emb.23Arkhangelsk 163000Russia A.A.Kharkevich Institute for Information Transmission Problems Russian Academy of SciencesBolshoy Karetny Per.19bld.1Moscow 127051Russia A.N.Belozersky Institute of Physico-Chemical Biology Lomonosov Moscow State UniversityLeninskye Gory1Bld.40Moscow 119991Russia

An unusual feature of the saline stratified lakes that were formed due to ongoing postglacial uplift on the White Sea coast is the presence of several differently colored thin layers in the zone with sharp gradients. Colored layers in five lakes at various stages of separation from the sea were investigated using optical microscopy, spectrophotometry, spectrofluorimetry, and photobiology. The upper greenish colored layer located in the aerobic strata of all lakes near the compensation depth of 1% light penetration contains green algae. In the chemocline, another layer, brightly green, red or pink, is dominated by mixotrophic flagellates. Despite the very low light intensities and the presence of H 2 S, active photosynthesis by these algae appears to be occurring, as indicated by high values of the maximum quantum yield of primary photochemistry, electron transport activity, photosynthetic activity of photosystem II, the fraction of active centers, and low values of heat dissipation. In the reduced zone of the chemocline, a dense green or brown suspension of anoxygenic phototrophs(green sulfur bacteria) is located.

关键词： algal blooms coastal lakes chemocline fluorescence kinetics Arctic White Sea

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Russian Collaborative Development of Reproduction Technologies for the Sustainable Management of Amphibian Biodiversity

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Asian Herpetological Research 2023年第1期14卷 103-115页

作者： victor K.UTESHEv Edith N.GAKHOvA Ludmila I.KRAMAROvA natalia v.SHISHOvA Svetlana A.KAUROvA Elena A.KIDOvA Artem A.KIDOv Robert K.BROWNE Institute of Cell Biophysics Russian Academy of SciencesPushchinoMoscow 142290Russia Institute of Theoretical and Experimental Biophysics Russian Academy of SciencesPushchinoMoscow 142290Russia Russian State Agrarian University-K.A.Timiryazev Agricultural Academy Moscow 127550Russia Sustainability America La Isla RoadCorozal DistrictBelize

Reproduction technologies(RTs)can provide for the reliable reproduction of amphibians,as well as perpetuation of species genetic variation with the use of *** 1982,in anticipation of the biodiversity conservation crisis,major Russian institutions collaborated in a dynamic program to develop and implement RTs for the sustainable management of amphibian *** initial primary focus was the captive breeding of threatened Russian endemic anuran and caudate species,using RTs that varied from environmental manipulation to the use of exogenous gonadotropic hormones to stimulate *** species were mostly from Palearctic or cool mountain regions,but also included a wide range of species from warm *** early achievements included the successful cryopreservation of anuran spermatozoa and anuran diploid pluripotent cell nuclei,in order to store both the matrilineal and patrilineal genomes in biobanks,with their subsequent development to the blastula stage after implantation into enucleated *** the turn of the 21st Century,in support of the priorities of the Amphibian Conservation Action Plan(2007),we developed RTs for the refrigerated storage of testicular or urinary spermatozoa for days to weeks at 4℃,the cryopreservation of urinary spermatozoa using anovel cryoprotectant,the in vitro fertilisation of hormonally induced oocytes either fresh or after refrigerated ex situ or in situ storage,and the artificial insemination of salamanders with fresh *** this article,we describe previously unpublished techniques and techniques from obscure Russian sources.

关键词： artificial fertilisation assisted reproductive technologies(ART) cryopreservation gonadotropic hormones oocytes spermatozoa storage urinary spermatozoa

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Seasonal Distribution of Manganese in the Soil-Water-Plant in the Zone of Burshtyn Thermal Power Station

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Journal of Physical Science and Application 2014年第5期4卷 317-322页

作者： Ivan v. Mazepa natalia v. Dovganich Maria A. Mazepa vasyl Stefanyk Precarpathian National University lvano-Frankivsk 76025 Ukraine

This study deals with the impact of Burshtyn thermal power station on the amount of manganese in soil, water and celandine tissue. The research of manganese amount and form in the system： water-plant is of great importance due to active influence of thermal power station on the chemical structure of the polluted area. The changes in the amount and form of manganese in soil, water and plant are interrelated and depend on the season, the distance from the polluter and morph-functional plant structure, the cleaning system possibilities of the industrial enterprise and some meteorological factors.

关键词： Soil water celandine gross and changeable manganese amount Burshtyn thermal power station.

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A historical literature review of coronary microvascular obstruction and intra-myocardial hemorrhage as functional/structural phenomena

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The Journal of Biomedical Research 2023年第4期37卷 268-289页

作者： Leonid N.Maslov natalia v.Naryzhnaya Sergey v.Popov Alexandr v.Mukhomedzyanov Ivan A.Derkachev Boris K.Kurbatov Andrey v.Krylatov Feng Fu Jianming Pei vyacheslav v.Ryabov Evgenii v.vyshlov Svetlana v.Gusakova Alla A.Boshchenko Akpay Sarybaev Laboratory of Experimental Cardiology Cardiology Research InstituteTomsk National Research Medical Center of the Russian Academy of SciencesTomskTomsk Region 634012Russia Department of Physiology and Pathophysiology National Key Discipline of Cell BiologySchool of Basic Medicinethe Fourth Military Medical UniversityXi'anShaanxi 710032China Siberian State Medical University TomskTomsk Region 634050Russia National Center of Cardiology and Internal Medicine Bishkek 720040Kyrgyzstan.

The analysis of experimental data demonstrates that platelets and neutrophils are involved in the no-reflow phenomenon,also known as microvascular obstruction(MvO).However,studies performed in the isolated perfused hearts subjected to ischemia/reperfusion(I/R)do not suggest the involvement of microembolization and microthrombi in this *** intracoronary administration of alteplase has been found to have no effect on the occurrence of MvO in patients with acute myocardial ***,the major events preceding the appearance of MvO in coronary arteries are independent of microthrombi,platelets,and *** cells appear to be the target where ischemia can disrupt the endothelium-dependent vasodilation of coronary ***,reperfusion triggers more pronounced damage,possibly mediated by *** and intra-myocardial hemorrhage contribute to the adverse post-infarction myocardial ***,pharmacological agents used to treat MvO should prevent endothelial injury and induce relaxation of smooth *** conditioning protocols have been shown to prevent MvO,with L-type Ca2+channel blockers appearing the most effective in treating MvO.

关键词： heart ischemia reperfusion microvascular obstruction intra-myocardial hemorrhage

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Liver blood supply after a modified Appleby procedure in classical and aberrant arterial anatomy

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World Journal of Gastrointestinal Surgery 2013年第3期5卷 51-61页

作者： vyacheslav I Egorov Roman v Petrov Michail v Lozhkin Olga A Maynovskaya natalia S Starostina natalia R Chernaya Ekaterina M Filippova Ostroumov 14~(th) City Hospital Department of Surgical Oncology Sechenov First State Medical University Department of General Surgery Russian National Research Medical University Department of Abdominal Surgery Herzen Institute of Oncology Department of Pathology Herzen Institute of Oncology Department of Radiological Herzen Institute of Oncology Department of Interventional Radiology Sklifosovsky Emergency Institute Department of Pathology VishnevskyInstitute of Surgery

Reported here are two cases of a modified Appleby operation for borderline resectable ductal adenocarcinoma of the pancreatic body, in one of which a R0 distal resection was attended to by excision, not only of the celiac axis, but also of the common and left hepatic arteries in the presence of arterial anatomic variation Michels, type Ⅷb. The possibility and avenues of the maintenance of the blood supply to the left hepatic lobe after surgical aggression of this kind are demonstrated employing computed tomography (CT) and 3-D CT angiography. Furthermore, both cases highlight all important worrisome aspects of pancreatic cancer resectability prediction.

关键词： Cancer Pancreas Management Pancreatectomy Distal pancreatectomy vascular invasion Computed tomography Blood supply

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The Effect of Ultra Low Concentrations of Some Biologically Active Substances on the Aerobic Respiration

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CellBio 2016年第1期5卷 1-13页

作者： Sergii v. Girin Iryna v. Savinova Iryna v. Antonenko natalia v. Naumenko Cascade-Medical Reference Laboratory UBI Glevakha Ukraine

For today it is known, that primary and secondary disorders of the aerobic respiration, which are based on mitochondrial deficiency, lead to a wide spectrum of clinical manifestations and diseases. Therefore, the question about effective correction of various types of energy exchange disorders remains topical. Thus, the aim of our work was the study effect of the complex of biologically active substances (BAS) in ultra low concentrations on the activity of key enzymes of aerobic energy metabolism succinate dehydrogenase (EC 1.***.99.1) (SQR) and mitochondrial glycerol-3-phosphate dehydrogenase (EC 1.***.99.5) (GPD2). The human lymphocytes assays were tested in vitro (22 donors). In negative control lymphocytes, cell culture normal saline solution was added. Normal saline solution with NaN3 was added in positive control lymphocytes cell culture. Experimental cell culture contained NaN3 and BAS. Our investigations had been revealed increase SQR activity in the experimental cell culture as compared with positive control culture throughout the time of experiment (measurements were carried out at 4, 24, 48, 72 h of incubation). The SQR activity of experimental cell culture and negative control lymphocytes cell culture was equal up to 24 h of experiment. It showed neutralization of NaN3 inhibitory effect (during 24 h) due to BAS influence. Activity of base glycerophosphate shunt ferment GPD2 of experimental lymphocyte cell culture was not different from GPD2 index in the negative control, but was lower than GPD2 activity in the positive control. It also indicated neutralization NaN3 inhibitory effect due to BAS influence. So we had found that extremely low concentrations of selected BAS with their complex impact on human lymphocytes in vitro could effectively neutralize the inhibitory effect of NaN3 on processes of aerobic energy metabolism link.

关键词： Energy Metabolism Ultralow Concentrations Succinate Dehydrogenase Glycerol-3-Phosphate Dehydrogenase

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Hepatotoxicity Induced by High Dose of Methylprednisolone Therapy in a Patient with Multiple Sclerosis: A Case Report and Brief Review of Literature

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Open Journal of Gastroenterology 2016年第5期6卷 146-150页

作者： Mohamed A. H. Kadle natalia v. Mazurchik Center for the Study of the Liver Peoples Friendship University of Russia Moscow Russia

Toxic hepatitis due to drugs is an important and frequent drug adverse reaction in clinical practice. Here, we report a case of high dose methylprednisolone-induced acute hepatitis in a 51-year-old woman that suffers from multiple sclerosis while steroids are usually safe drugs with regards to liver injury and even they are the treatment choice of autoimmune hepatitis, but the literatures about corticosteroids showed are not entirely safe to liver injury and they have occasionally linked to hepatotoxicity. Although recent reports have demonstrated that prednisolone may cause hepatitis. This case report includes a brief review of the relevant literature on corticosteroids-induced hepatitis that is presented.

关键词： Toxic Hepatitis Methylprednisolone Multiple Sclerosis

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Evolutionary history of mountain voles of the subgenus Aschizomys (Cricetidae, Rodentia), inferred from mitochondrial and nuclear markers

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Integrative Zoology 2020年第3期15卷 187-201页

作者： Semen Yu.BODROv vera K.vASILJEvA Innokentiy M.OKHLOPKOv Nikolai v.MAMAYEv Evgeniy S.ZAKHAROv Alexey Yu OLEINIKOv Evgeniy A.GENELT-YANOvSKIY natalia I.ABRAMSON Zoological Institute Russian Academy of SciencesSaint PetersburgRussia Institute for Biological Problems of Cryolithozone YakutskSakha Republic(Yakutia)Russia Institute of Water and Ecological Problems KhabarovskRussia Saint-Petersburg Scientific Center RAS Saint PetersburgRussia

In this study,we present an assessment of the evolutionary history and phylogenetic relationships of Asian mountain voles of the subgenus Aschizomys,genus Alticola,based on extensive sampling and phylogenetic analyses of data from mitochondrial and nuclear *** species of this subgenus are widespread in the mountain areas of north-eastern ***,both their distribution and taxonomic borders remained questionable for more than 100 *** study showed discordance in the phylogenetic patterns between nuclear and mtDNA *** found that mtDNA in *** is paraphyletic relative to ***,but nuclear markers demonstrated reciprocal *** to species distribution modeling,ranges of *** and *** experienced a secondary contact during the Last Glacial Maximum(approximately 22 kyr BP),and thus a hybridization event seems plausible during that *** tree analyses recovered a sister group relationship between the two species of the Aschizomys subgenus,with an estimated divergence date of around 0.8 *** results provided good support for currently recognized subspecies within both *** and *** based on mitochondrial and nuclear datasets.A new,yet undescribed form,supposedly of a subspecific status within ***,was found in the Bureinskiy Range in the Khabarovsk *** finding expands the current species distribution range further to the southeast.

关键词： Asian mountain voles Aschizomys phylogeny taxonomy species tree species distribution modeling

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Production of Camphene by Isomerization Reaction on Sulfated ZrO_2

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Chinese Journal of Chemical Engineering 2000年第1期8卷 64-67页

作者： Nora Alejandra Comelli Omar Masini Alfredo Lzaro Carrascull Esther natalia Ponzi Marta Isabel Ponzi INTEQUI(CONICET-UNSL) Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaINTEQUI(CONICET-UNSL)Facultad de Ingenieriay Ciencias Economico Sociales25 de Mayo 384V.Mercedes (SL)ArgentinaCINDECA(CONICET-UNLP)Calle 47 N°2571900 La PlataArgentina

The kinetics of camphene production in liquid phase from α-pinene was experimentally determined in an isothermal batch reactor. To this end, a sulfated ZrO2 catalyst was used and the reaction studied in the temperature range of 370-403 K. By analyzing the experimental data, second reaction order for α-pinene was found. A kinetic model is presented which includes term for the catalyst load used. The specific rate constant at 393K was 2.19×10^-3 mol·L^-1·min^-1, the activation energy being 93kJ·mo1·^-1. Both values are within the range of literature results.

关键词：生产工艺莰烯异构化反应硫酸盐催化剂 ZrO2 反应动力学 α-蒎烯

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