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Implementation of a virtual multicenter gastrointestinal tumor board to reduce cancer disparities in Argentina

World Journal of Clinical Oncology 2022年第6期13卷 423-428页

作者： Federico Esteso natalia soledad tissera Juan Manuel O'Connor Romina Luca Eduardo Huertas Fernando Sánchez Loria Ivana Pedraza Alejandro Pairola Fernando Brancato Lisandro Paganini Mariana Kucharczyk Mora Amat Maria Teresa Pombo Mariana Galli Luisina Bruno Luis Caro Andrés Rodriguez Diego Enrico Federico Waisberg Matías Chacón Department of Gastrointestinal Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Surgery Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Pathology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Radiation Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Gastroenterology Instituto Alexander FlemingBuenos Aires 1426Argentina Department of Medical Oncology Instituto Alexander FlemingBuenos Aires 1426Argentina

Given the increasing complexity of cancer care,multidisciplinary tumor boards have become essential in daily clinical oncology *** Project Extension for Community Healthcare Outcomes(ECHO)initiative developed an innovative telementoring model using a"hub and spoke"design consisting of a team of experts(hub)that offers a full service to multiple participants(the spokes)during regularly scheduled sessions discussing patients'clinical *** Alexander Fleming Cancer Institute in Buenos Aires was the first hub in Latin America to implement Project ECHO for gastrointestinal *** our 3-year experience,80 patients from 37 centers were evaluated within Project ECHO and a range of three to five cases were discussed in each *** our perspective,the impact of this novel approach was a remarkable strategy to reduce care disparities by equalizing access to high-quality medical knowledge in a multidisciplinary environment for medical ***,it was shown to have a cost-effective impact directly on the patients and the local health system,since relevant costs were saved after unnecessary treatments,studies and travel expenses were avoided.

关键词： Tumor board Virtual Gastrointestinal Cancer disparities Oncology Extension for Community Healthcare Outcomes project

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Esterase Activities and Biochemical Properties of Lactic Acid Bacteria Isolated from Goat＇s Milk Cheese in Argentina

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Journal of Agricultural Science and Technology(B) 2014年第9期4卷 752-760页

作者： natalia Veronica Taboada Maria soledad Lopez Alzogaray Maria Claudia Abeijon Mukdsi Roxana Beatriz Medina Departamento de Ciencias de los Alimentos Faeultad de Agronomia y Agroindustrias Universidad Nacional de Santiago delEstero Av. Belgrano 1912 (S) Santiago del Estero CP 4200 Argentina Centro de Refereneia Para Lactobacilos (CERELA-CONICET) Chacabuco 145 Tucum(m CP 4000 Argentina Faeultad de Ciencias de la Salud Universidad del Norte Santo de Aquino 9 de Julio 165 Tueumdn CP 4000 Argentina Facultad de Agronomia y Zootecnia Universidad Nacional de Tucumdn Av. Roca 1900 Tucumdn CP 4000 Argentina

Twenty-two lactic acid bacteria (LAB) strains isolated from Argentinean goat dairy products were evaluated for its biochemical properties and esterase activities relevant to flavor development. Streptococcus thermophilus (UNSE314), Lactobacillus (L.) delbrueckii subsp. bulgaricus (UNSE309), L. rhamnosus (UNSE308), L. plantarum (UNSE287, UNSE316, UNSE317) and Pediococcus pentosaceus (UNSE315) strains presented high acidifying activity. All strains tested metabolized citrate and produced diacetyl-acetoin in goat milk. Based on these results, 10 strains with the best performance in diverse technological properties were selected to determine esterolytic activity. In all evaluated strains, esterase specific activity (ESA) was detected on α-naphthyl (α-NA) acetate and β-naphthyl (β-NA) acetate, propionate, caprylate and α-NA butyrate. No activity was detected on β-NA laurate. The highest values were detected when using α-NA instead of β-NA derivatives as substrate. In Pediococcus strains, wide variability in ESA were observed, which were species- and strain-specific. These results allow us to select strains with biochemical properties and esterase activities to design starter and adjunct cultures that contribute to flavor development during cheese ripening, thus preserving the typical organoleptic characteristics of Argentinean goat cheeses.

关键词：酯酶活性生化特性阿根廷乳酸菌奶酪羊奶工艺性能嗜热链球菌

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