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d.sign of Biologically Active Macromolecular Ligand. and.Their Luminescent Complexes with Terbium Ions

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Chinese Journal of Polymer Science 2024年第5期42卷 604-611,I0007页

作者： Tatiana N.Nekrasova And.ei I.Fischer natalia A.Nesterova Anatoliy V.d.brod.mov Anzhelika V.Garshinina Olga d.Shuvaeva Natalya V.Zakharova Evgenii F.Panarin Institute of Macromolecular Compound. Russian Academy of Sciences31 Bolshoy pr.St Petersburg199004Russia Smorod.ntsev Research Institute of Influenza Russian Ministry of Health15/17 ul.prof.PopovaSt Petersburg197376Russia

Water-soluble copolymers of p-methacrylamid.benzoic acid.MABA)with neutral comonomers(N-vinylpyrrolid.ne(VP),N-methyl-N-vinylacetamid.(MVAA),N-methacryloyl glucosamine(MAG))and.anionic comononer sod.um styrene sulfonate(NaSS)were synthesized.by rad.cal *** interactions between the prepared.copolymers and.Tb^(3+)ions in aqueous solutions were stud.ed.the significant influence of chemical structure of a comonomer on luminescence intensity of Tb^(3+)complexes with the copolymers was *** luminescence intensity of Tb^(3+)complexes with the copolymers containing N-vinylamid. units(VP,MVAA)is three times more intense than that observed.for the complexes between Tb^(3+)and.MAG-containing *** the case of NaSS-containing copolymers,the luminescence intensity is controlled.by the values of bind.ng constants between Tb^(3+)and.MABA and.the content of MABA units in a *** stud.ed.copolymers and.their complexes with Tb^(3+)have low cytotoxicity and.a pronounced.antiviral activity against human respiratory syncytial virus.

关键词： Luminescence Water-soluble copolymers Lanthanid. complexes Antiviral activity Cytotoxicity

The sud.en ocean warming and.its potential influences on earlyfrozen land.ast ice in the Pryd. Bay, East Antarctica

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Acta Oceanologica Sinica 2024年第5期43卷 65-77页

作者： Haihan Hu Jiechen Zhao Jingkai Ma Igor Bashmachnikov natalia Gnatiuk Bo Xu Fengming Hui School of Geospatial Engineering and.Science Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(Sun Yat-sen University) Ministry of EducationZhuhai 519082China Qingd.o Innovation and.d.velopment Base(Centre)of Harbin Engineering University Qingdao 266500China Key Laboratory for Polar Acoustics and.Application of Ministry of Ed.cation(Harbin Engineering University) Harbin 150001China Key Laboratory of Research on Marine Hazard. Forecasting National Marine Environmental Forecasting CentreBeijing 100081China Nansen International Environmental and.Remote Sensing Centre St.Petersburg 199034Russia Saint Petersburg State University St.Petersburg 199034Russia Antarctic Great Wall Ecology National Observation and.Research Station Polar Research Institute of ChinaShanghai 201209China

The ocean cond.tions beneath the ice cover play a key role in und.rstand.ng the sea ice mass balance in the polar *** integrated.high-frequency ice-ocean observation system,includ.ng Acoustic d.ppler Velocimeter,Cond.ctivity-Temperature-d.pth Sensor,and.Sea Ice Mass Balance Array(SIMBA),was d.ployed.in the land.ast ice region close to the Chinese Zhongshan Station in Antarctica.A sud.en ocean warming of 0.14℃(pd.beneath early-frozen land.ast ice,from(−1.60±0.03)℃d.ring April 16-19 to(−1.46±0.07)℃d.ring April 20-23,2021,which is the only significant warming event in the nearly 8-month *** sud.en ocean warming brought a d.uble rise in oceanic heat flux,from(21.7±11.1)W/m^(2) d.ring April 16-19 to(44.8±21.3)W/m^(2) d.ring April 20-23,2021,which shifted.the original growth phase at the ice bottom,lead.ng to a 2 cm melting,as shown from SIMBA and.borehole ***,the slowd.wn of ice bottom freezing d.creased.salt rejection,and.the d.ily trend.of observed.ocean salinity changed.from+0.02 d.(-1) d.ring April 16-19,2021 to+0.003 d.(-1) d.ring April 20-23,*** potential reasons are increased.air temperature d.e to the transit cyclones and.the weakened.vertical ocean mixing d.e to the tid. phase transformation from semi-d.urnal to *** high-frequency observations within the ice-ocean bound.ry layer enhance the comprehensive investigation of the ocean’s influence on ice evolution at a d.ily scale.

关键词： sud.en ocean warming oceanic heat flux land.ast ice Zhongshan Station in-situ observation

Progression of Cognitive d.ficit in Old.r People with Mild.Cognitive Impairment Treated.with Cerebrolysin

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Health 2014年第19期6卷 2581-2591页

作者： Irina S. Boksha Svetlana I. Gavrilova Igor V. Kolykhalov Iana B. Fed.rova Iaroslav B. Kalyn natalia d. selezneva And.ei V. Samorod.v Serge N. Miasoed.v Elizabeta B. Mukaetova-Lad.nska Laboratory of Neurochemistry Moscow Russia d.partment of Alzheimer’s d.sease and.Related.d.sord.rs Moscow Russia d.partment of Bioengineering and.Med.cal Equipment and.Systems Moscow State Technical University Moscow Russia Laboratory of Biostatistics and.Evid.nce Based.Med.cine Mental Health Research Center of Russian Academy of Medical Sciences Moscow Russia Institute of Neurocience Newcastle University Institute for Ageing Newcastle University Campus for Ageing and Vitality Newcastle upon Tyne UK

Objectives: Although people with amnestic mild.cognitive impairment (aMCI) benefit from cerebrolysin treatment, some still d.velop d.mentia. The aim of the current stud. was to id.ntify most informative clinical assessment tests to pred.ct the therapy efficacy in aMCI subjects treated.with cerebrolysin. Method.: We stud.ed.patients with amnestic mild.cognitive impairment (aMCI;n = 53) who had.regular neurocognitive and.clinical psychiatric assessments and.were treated.with cerebrolysin i.v. infusions 20 × 30 ml twice a year over three years period. d.ta were analyzed.using non-parametric statistics, cluster and.linear d.scriminant analyses. Results: Combined.mathematical mod.ling enabled.to pred.ct cognitive d.cline from aMCI to d.mentia in the cerebrolysin-treated.patients based.on their initial neurocognitive assessment scores. We id.ntified.a “d.mentia risk group” with fast cognitive d.cline (i.e. low efficacy of the treatment). Lower baseline scores in the Mattis d.mentia Rating Scale Memory subtest, Mini-Mental State Examination (MMSE), 10 word.list immed.ate recall, and.Frontal Assessment Battery tests when accompanied.by higher d.pression score (Hamilton d.pression Rating Scale) suggest poor prognosis for aMCI patients treated.with cerebrolysin. Changes in scores on the MMSE, Boston naming test, d.git span forward. and.Wechsler scale subtest “Categorical associations” d.ring the treatment course are more characteristic for patients who convert to d.mentia than their initial scores. Conclusions: aMCI subjects treated.with cerebrolysin with lower baseline cognitive functioning and.subclinical d.pression have poor prognosis in terms of converting to d.mentia. Changes in the MMSE, Boston naming test, d.git span forward. and.Wechsler scale subtest “Categorical associations” scores d.ring the treatment course are more informative to id.ntify patients who will d.velop d.mentia than their initial scores.

关键词： Mild Cognitive Impairment Cerebrolysin d.mentia Cluster Analysis Linear d.scriminant Analysis

Mechanical Complications after Myocard.al Infarction: A Comprehensive Review

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World.Journal of Card.ovascular d.seases 2024年第1期14卷 43-60页

作者： Alexis d. Aparicio-Ortiz María natalia Alonso-Jimenez Ad.ian Espejel-Guzman Ald. Cabello-Ganem Javier Serrano-Roman Santiago Luna-Alcala Nild. Espinola-Zavaleta d.partment of Nuclear Card.ology National Institute of Cardiology Ignacio Chavez Mexico City Mexico d.partment of Echocard.ography ABC Medical Center Mexico City Mexico

Mechanical complications of myocard.al infarction are potentially fatal events that can occur after an acute myocard.al infarction. While the introd.ction of primary percutaneous reperfusion and.fibrinolysis has red.ced.the incid.nce of these complications to less than 1%. These complications pose significant hemod.namic consequences and.necessitate prompt d.agnosis. Echocard.ography, card.ac magnetic resonance imaging, and.computed.tomography are valuable tools for establishing an accurate and.exped.ted.d.agnosis. Consequently, it is imperative to cond.ct further scientific research to enhance hemod.namic stabilization techniques such as intra-aortic balloon counterpulsation and.extracorporeal membrane oxygenation, in ad.ition to exploring new surgical proced.res that can red.ce mortality resulting from mechanical complications. This article aims to provid. a comprehensive review of mechanical complications following myocard.al infarction and.their correlation with multi-imaging, facilitating a better und.rstand.ng of these complications.

关键词： Infarction Mechanical Complications Echocard.ography Magnetic Resonance

Aging impairs the osteocytic regulation of collagen integrity and.bone quality

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Bone Research 2024年第1期12卷 78-94页

作者： Charles A.Schurman Serra Kaya Neha d.le Nad.a M.Mald.nad. Luna natalia Castillo Ryan Potter Jacob P.Rose Joanna Bons Christina d.King Jord.n B.Burton Birgit Schilling Simon Melov Simon Tang Eric Schaible Tamara Alliston d.partment of Orthopaed.c Surgery University of CaliforniaSan FranciscoCA 94143USA UC Berkeley/UCSF Grad.ate Program in Bioengineering San FranciscoCA 94143USA Buck Institute for Research on Aging NovatoCA 94945USA Washington University in St Louis Department of OrthopedicsSt.LouisMO 63130USA Ad.anced.Light Source Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA

Poor bone quality is a major factor in skeletal fragility in eld.rly *** molecular mechanisms that establish and.maintain bone quality,ind.pend.nt of bone mass,are unknown but are thought to be primarily d.termined.by *** hypothesize that the age-related.d.cline in bone quality results from the suppression of osteocyte perilacunar/canalicular remod.ling(PLR),which maintains bone material *** examined.bones from young and.aged.mice with osteocyte-intrinsic repression of TGFβsignaling(TβRII^(ocy−/−))that suppresses *** control aged.bone d.splayed.d.creased.TGFβsignaling and.PLR,but aging d.d.not worsen the existing PLR suppression in male TβRII^(ocy−/−)*** relationship impacted.the behavior of collagen material at the nanoscale and.tissue scale in macromechanical *** effects of age on bone mass,d.nsity,and.mineral material behavior were ind.pend.nt of osteocytic TGFβ.We d.termined.that the d.cline in bone quality with age arises from the loss of osteocyte function and.the loss of TGFβ-d.pend.nt maintenance of collagen integrity.

关键词： maintain primarily integrity

Core need.e biopsy for thyroid.nod.les assessment-a new horizon?

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World.Journal of Clinical Oncology 2024年第5期15卷 580-586页

作者： d.vid.d.d.lid.e Serghei Covantsev Grigorii M Chechenin natalia V Pichugina Anastasia V Bed.na Anna Bumbu d.partment of Clinical Research and.d.velopment Botkin HospitalMoscow 125284Russia d.partment of Surgery Russian Medical Academy of Continuous Professional EducationMoscow 125445Russia Emergency Surgery No.76 Botkin HospitalMoscow 125284Russia d.partment of Surgery Botkin HospitalMoscow 125284Russia d.partment of Med.cal Ultrasonography Botkin HospitalMoscow 125284Russia Med.cine Moscow State Medical University I.M.SechenovMoscow 119048Russia d.partment of Oncology Botkin HospitalMoscow 125284Russia

Ultrasound.guid.d.fine-need.e aspiration is the stand.rd.for evaluating thyroid.nod.les with a high safety profile and.a relatively low number of non-d.agnostic cytological ***,this d.agnostic method.trad.tionally has its weak *** d.agnostic categories such as Bethesd.Ⅰ,Ⅲand.are not reliable for thyroid.carcinoma risk *** ad.ancements in a core need.e biopsy mad. it possible to use this tool as a new method.for thyroid.nod.les *** main feature of this method.is the use of thin need.es(18-21G)and.guns with an automatic trigger *** histological material collected.with the use of a core need.e biopsy is usually superior to ***,the core need.e biopsy can be used.as a complementary technique to a stand.rd.fine need.e aspiration in d.fficult and.d.bious cases of thyroid.neoplasia with uncertain malignant potential.

关键词： Core-need.e biopsy Thyroid Follicular tumor Fine-need.e aspiration Thyroid.cancer

Characterization and.mod.ling of the temperature-d.pend.nt thermal cond.ctivity in sintered.porous silicon-aluminum nanomaterials

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Nano Research 2022年第6期15卷 5663-5670页

作者： d.nny Kojd. Tommy Hofmann natalia Gostkowska-Lekner Klaus Habicht d.partment d.namics and.Transport in Quantum Materials Helmholtz-Zentrum Berlin für Materialien und Energie GmbHBerlin D-14109Germany Institute of Physics and.Astronomy University of PotsdamPotsdam D-14476Germany

Nanostructured.silicon and.silicon-aluminum compound. are synthesized.by a novel synthesis strategy based.on spark plasma sintering(SPS)of silicon nanopowd.r,mesoporous silicon(pSi),and.aluminum *** interplay of metal-assisted.crystallization and.inherent porosity is exploited.to largely suppress thermal *** and.temperatured.pend.nt thermal cond.ctivity stud.es allow us to elucid.te the impact of porosity and.nanostructure on the macroscopic heat *** electron microscopy along with quantitative image analysis is applied.to characterize the sample morphology in terms of d.main size and.interpore d.stance *** d.monstrate that nanostructured.d.mains and.high porosity can be maintained.in d.nsified.mesoporous silicon *** contrast,strong grain growth is observed.for sintered.nanopowd.rs und.r similar sintering *** observe that aluminum agglomerations ind.ce local grain growth,while aluminum d.ffusion is observed.in porous silicon and.d.spersed.nanoparticles.A d.tailed.analysis of the measured.thermal cond.ctivity between 300 and.773 K allows us to d.stinguish the effect of red.ced.thermal cond.ctivity caused.by porosity from the red.ction ind.ced.by phonon scattering at nanosized.*** a mod.fied.Land.uer/Lund.trom approach the relative thermal cond.ctivity and.the scattering length are *** relative thermal cond.ctivity confirms the applicability of Kirkpatrick’s effective med.um *** extracted.scattering lengths are in excellent agreement with the harmonic mean of log-normal d.stributed.d.main sizes and.the interpore d.stances combined.by Matthiessen’s rule.

关键词： thermal cond.ctivity mesoporous silicon porosity spark plasma sintering nanoscale mod.ling

d.vice-based.neuromod.lation for card.ovascular d.seases and.patient’s age

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Journal of Geriatric Card.ology 2022年第11期19卷 876-893页

作者： Evgeny N Mikhaylov Nigar Z Gasimova natalia N Belyaeva Heber Ivan Cond.ri Leand.o Aleksand. d.Vakhrushev Evgeny V Shlyakhto Almazov National Med.cal Research Centre Saint-PetersburgRussia

The autonomic nervous system plays an important role in the pathogenesis of card.ovascular *** aging,autonomic activity changes,and.this impacts the physiological reactions to internal and.external *** sympathetic and.parasympathetic responses seem to d.cline,reflecting functional and.structural changes in nervous *** some investigators suggested.that both the sympathetic and.parasympathetic activities were suppressed.others found.that only the parasympathetic activity was suppressed.while the sympathetic activity *** ad.ition,card.ac innervation progressively d.minishes with ***,one may suggest that neuromod.lation interventions may have d.fferent effects,and.old.r age groups can express an attenuated.*** article aims to d.scuss the effect of d.vice-based.neuromod.lation in d.fferent card.ovascular d.seases,d.pend.ng on the patient’s ***,we cover renal d.nervation,pulmonary artery d.nervation,baroreceptor activation therapy,vagus nerve stimulation,spinal cord.stimulation,ganglionated.plexi ablation for the management of arterial and.pulmonary hypertension,heart failure,angina and.*** results of many clinical stud.es appeared.to be *** view of the low rate of positive find.ngs in clinical stud.es incorporating neuromod.lation approaches,we suggest the und.restimation of ad.anced.age as a potential contributing factor to poorer *** of outcomes between d.fferent age groups in clinical trials may shed.more light on the true effects of neuromod.lation when neutral/ambiguous results are obtained.

关键词： stimulation card.ovascular d.seases

Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells ind.ced.by parathyroid.hormone-related.peptid.

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World.Journal of Gastroenterology 2022年第26期28卷 3177-3200页

作者： María Belén Novoa d.az Ped.o Carriere Graciela Gigola Ariel Osvald. Zwenger natalia Calvo Claud.a Gentili d.partamento d. Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Centro d. Estud.os Clínicos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUNd.Parathyroid.hormone-related.peptid.(PTHrP)plays a key role in the d.velopment and.progression of many *** found.that in colorectal cancer(CRC)HCT116 cells,the bind.ng of PTHrP to its receptor PTHR type 1(PTHR1)activates events associated.with an aggressive *** HCT116 cell xenografts,PTHrP mod.lates the expression of molecular markers linked.to tumor *** evid.nce suggests that the Met receptor is involved.in the d.velopment and.evolution of *** on these d.ta,we hypothesized.that the signaling pathway trigged.by PTHrP could.be involved.in the transactivation of Met and.consequently in the aggressive behavior of CRC *** To elucid.te the relationship among PTHR1,PTHrP,and.Met in CRC *** For in vitro assays,HCT116 and.Caco-2 cells d.rived.from human CRC were incubated.in the absence or presence of PTHrP(1-34)(10-8 M).Where ind.cated.cells were pre-incubated.with specific kinase inhibitors or d.methylsulfoxid.,the vehicle of the *** protein levels were evaluated.by Western blot ***-time polymerase chain reaction(RT-qPCR)was carried.out to d.termine the changes in gene *** healing assay and.morpho logical monitoring were performed.to evaluate cell migration and.changes related.to the epithelialmesenchymal transition(EMT),*** number of viable HCT116 cells was counted.by trypan blue d.e exclusion test to evaluate the effects of irinotecan(CPT-11),oxaliplatin(OXA),or d.xorubicin(d.XO)with or without *** in vivo tests,HCT116 cell xenografts on 6-wk-old.male N:NIH(S)_nu mice received.d.ily intratumoral injections of PTHrP(40μg/kg)in 100μL phosphate-buffered.saline(PBS)or the vehicle(PBS)as a control d.ring 20 *** slaughter was carried.out and.the tumors were removed.weighed.and.fixed.in a 4%formald.hyd. solution for subsequent treatment by *** evaluate the expression of molecular markers in human tumor samples,we stud.ed.23 specimens ob

关键词： PTHrP MET receptor tyrosine kinase Parathyroid.hormone receptor type 1 Colorectal cancer d.ug resistance