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Ultrafast control of fractional orbital angular momentum of microlaser emissions

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Light(Science & Applications) 2020年第1期9卷 286-294页

作者： Zhifeng Zhang Haoqi Zhao Danilo Gomes Pires Xingdu Qiao Zihe Gao Josep *** Stefano Longhi natalia M.Litchinitser Liang Feng Department of Electrical and Systems Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Computer Engineering Duke UniversityDurhamNC 27708USA Department of Materials Science and Engineering University of PennsylvaniaPhiladelphiaPA 19104USA Department of Electrical and Computer Engineering Northeastern UniversityBostonMA 02115USA Dipartimento di Fisica Politecnico di Milano and Istituto di Fotonica e Nanotecnologie del Consiglio Nazionale delle RicerchePiazza L.da Vinci 32I-20133 MilanoItaly Instituto de Fisica Interdisciplinar y Sistemas Complejos IFISC(CSIC-UIB) Palma de MallorcaSpain

On-chip integrated laser sources of structured light carrying fractional orbital angular momentum(FOAM)are highly desirable for the forefront development of optical communication and quantum information-processing *** integrated vortex beam generators have been previously demonstrated in different optical settings,ultrafast control and sweep of FOAM light with low-power control,suitable for high-speed optical communication and computing,remains *** we demonstrate fast control of the FOAM from a vortex semiconductor microlaser based on fast transient mixing of integer laser vorticities induced by a control pulse.A continuous FOAM sweep between charge 0 and charge+2 is demonstrated in a 100 ps time window,with the ultimate speed limit being established by the carrier recombination time in the gain *** results provide a new route to generating vortex microlasers carrying FOAM that are switchable at GHz frequencies by an ultrafast control pulse.

关键词： momentum fractional vortex

Hydration status,body composition,and anxiety status in aeronautical military personnel from Spain:a crosss-ectional study

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Military Medical Research 2022年第2期9卷 184-192页

作者： Alejandra Carretero-Krug nataliaúbeda Carlos Velasco Juan Medina-Font Trinidad Trujillo Laguna Gregorio Varela-Moreiras Ana Montero Departamento Ciencias Farmacéuticas y de la Salud Facultad de FarmaciaUniversidad San Pablo-CEUCEU UniversitiesUrbanización Montepríncipe28660 Boadilla del MonteSpain Centro de Instrucción de Medicina Aeroespacial Ejército del Aire28850 Torrejón de ArdozMadridSpain

Background: An adequate hydration status is critical to ensure efficiency during mental and physical *** goal was to assess the hydration status of a Spanish group of aeronautical military men and to determine the association of hydration status with body composition and ***: A total of 188 men were evaluated through a validated hydration questionnaire, anthropometric and biochemical parameters, and an anxiety questionnaire. Based on these methods, the criteria of hydration were ***: Of the total sample, 81% met the hydration criteria(urine color = well hydrated, water balance ≥0 ml, and total water intake/weight ≥35 ml/kg), and 19% did not meet the hydration criteria(urine color = not sufficiently hydrated or dehydrated, water balance ydration criteria had lower urine pH, negative water balance, and lower water intake. The latter also had higher anxiety status(score=4 vs. 3, P=0.026), weight [(84.7±10.5) kg vs.(80.5±10.2) kg], body mass index [(26.3±3.1) kg/m;vs.(25.2±2.8) kg/m;], body fat [(22.3±5.6)% vs.(18.3±6.5)%], urine specific gravity, and urine color. Using a logistic binary regression model, hydration status was related significantly with the percentage of body fat(P=0.004), but no relation was found with age, comorbidities, or medications. Furthermore, total water intake/weight was positively correlated with percentage of body water(r=0.357, P=0.000) and negatively with body fat(kg)(r=–0.427, P=0.000), percentage of body fat(r=–0.405, P=0.000), and waist/hip ratio(r=–0.223, P=0.002). Based on a linear regression model, total water intake/weight was related significantly with percentage of body fat(P=0.001) and percentage of body water content(P=0.035). No relation was found, however, with waist/hip ratio, age, comorbidities, or ***: These findings all suggest a relationship between hydration status and body composition but

关键词： Hydration status Military aeronautical personnel Body composition Anxiety status Water intake

Study and ICH validation of a reverse-phase liquid chromatographic method for the quantification of the intact monoclonal antibody cetuximab

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Journal of Pharmaceutical Analysis 2016年第2期6卷 117-124页

作者： Antonio Martinez-Ortega Agustin Herrera Antonio Salmeron-Garcia Jose Cabeza Luis Cuadros-Rodriguez natalia Navas Department of Analytical Chemistry University of Granada Faculty of Science Campus Fuentenueva s/n E-18071 Granada Spain UGC intercentro Interniveles Farmacia Granada San Cecilio Hospital Biomedical Research Institute ibs. GRANADA. Hospitales Universitarios de Granada University of Granada E-18012 Granada Spain Department of Analytical Chemistry Science Faculty Biomedical Research Institute ibis. GRANADA University of Granada Campus Fuentenuevo s/n E-18071 Granada Spain

Cetuximab （CTX） is a potent chimeric mouse/human monoclonal antibody （mAb） approved worldwide for treatment of metastatic colorectal cancer. Among the various biological and physical analyses per- formed for full study on this biopharmaceutic, the determination of the concentration preparations throughout manufacturing and subsequent handling in hospital is particularly relevant. In the present work, the study and validation of a method for quantifying intact CTX by reverse-phase high-perfor- mance liquid chromatography with diode array detection （（RP）HPLC/DAD） is presented. With that end, we checked the performance of a chromatographic method for quantifying CTX and conducted a study to validate the method as stability-indicating in accordance with the International Conference on Harmo- nization guidelines （ICH） for biotechnological drugs; therefore, we evaluated linearity, accuracy, preci- sion, detection and quantification limits, robustness and system suitability. The specificity of the method and the robustness of the mAb formulation against external stress factors were estimated by compre- hensive chromatographic analysis by subjecting CTX to several informative stress conditions. As de- monstrated, the method is rapid, accurate, and reproducible for CTX quantification. It was also suc- cessfully used to quantify CTX in a long-term stability study performed under hospital conditions.

关键词： Reverse-phase high performance liquidchromatography Diode detector Stress study Biopharmaceuticals Cetuximab

Diagnostic performance of serum interleukin-6 in pediatric acute appendicitis:a systematic review

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World Journal of Pediatrics 2022年第2期18卷 91-99页

作者： Javier Arredondo Montero Carlos Bardaji Pascual Monica Bronte Anaut natalia Lopez-Andres Giuseppa Antona Nerea Martin-Calvo Pediatric Surgery Department Complejo Hospitalario de NavarraCalle Irunlarrea 331008 PamplonaNavarraSpain Pathology Department Complejo Hospitalario de NavarraPamplonaSpain Cardiovascular Translational Research Navarrabiomed(Miguel Servet Foundation)Complejo Hospitalario de Navarra(CHN)Universidad Publica de Navarra(UPNA)IdiSNAPamplonaSpain Department of Preventive Medicine and Public Health Instituto de Investigacion Sanitaria de Navarra(IdiSNA).University of Navarra.PamplonaSpain CIBER Fisiopatologia de la Obesidad y Nutricion(CIBERobn) Health Institute CarlosⅢMadridSpain

Background Despite the radiological and analytical advances of the last decades,there is still a significant rate of diagnostic error in pediatric acute *** recent years,multiple biomarkers have emerged as potential diagnostic *** study aimed to examine the diagnostic performance of serum interleukin-6 in pediatric acute *** We conducted a systematic review of the literature that involved an extensive search in the main databases of medical bibliography(Medline,PubMed,Web of Science and SciELO).Two independent reviewers selected the relevant articles based on the previously defined inclusion and exclusion *** quality of the selected article was rated using the QUADAS2 *** extraction was performed by two independent *** The research in the medical bibliography databases resulted in 68 *** removed 26 *** the remaining 42 articles,we excluded 33 following the inclusion and exclusion *** the final 9 studies included in this review,8 provided measured serum interleukin-6 values,and all of them reported significant differences between groups,but inconsistent results regarding sensitivity and *** The diagnostic performance of interleukine-6 alone for the diagnosis of acute appendicitis in children is *** sensitivity and specificity of interleukine-6 for the diagnosis of non-complicated acute appendicitis in the pediatric population are moderate but increased in complicated *** seems to be a direct relationship between serum level of interleukin-6 and the hours of evolution of abdominal pain in children with acute *** increasingly widespread use of non-operative management of acute appendicitis warrants further exploration of the classificatory potential of this marker between complicated and uncomplicated *** consider that this may be an avenue of research to explore in the future.

关键词： Acute appendicitis Children Interleukin-6 Pediatric Sensitivity Specificity Systematic review

The significance of U-Pb zircon ages in zoned plutons:the case of the Flamenco pluton, Coastal Range batholith, northern Chile

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Geoscience Frontiers 2019年第3期10卷 1073-1099页

作者： natalia Rodríguez Juan Díaz-Alvarado Carlos Fernández Paulina Fuentes Christoph Breitkreuz Colombo Celso Gaeta Tassinari Departamento de Geología Universidad de Atacama Departamento de Ciencias de la Tierra Universidad de Huelva Institut für Geologie TU Bergakademie Freiberg High Resolution Geochronological Laboratory University of S?o Paulo

Compositionally zoned plutons, both layered and concentrically arranged, provide granitic exposures where the mechanisms and timing of the magmatic emplacement processes can be studied. The importance of in-situ geochemical differentiation and the magma replenishment rates are revealed by geochemistry and field relations, together with the increasingly accurate U-Pb geochronology, which has promoted the knowledge about the pluton incremental assembly *** Flamenco pluton, located in the Coastal Range of northern Chile, is part of the Upper Triassic to Early Cretaceous Andean intrusives formed in the western active margin of South America, and present a normal zoned structure with mafic magmatic facies(mostly gabbros and Qtz-diorites) close to the contacts with the host metasediments, and tonalites, granodiorites and granites in the inner areas. A combined study of the field relations, geochemistry and zircon geochronology of the magmatic facies was applied to determine the emplacement sequence of the Flamenco pluton, revealing three distinguishable domains separated by metasedimentary septa. The SW area is constituted by mostly homogeneous leucocratic granodiorites that yielded an age of 213 Ma as the best estimation for their emplacement age. Distinctive geochemical characteristics, such as the absence of an Eu anomaly, the depletion in HREE, or the highest Sr, Sr/y and Ce/yb values among the granodioritic facies of the pluton,involve lower T and/or higher P conditions at the magmatic source according to experimental *** conditions were established during an early stage of the Andean magmatic arc building that is firstly defined here as Upper Triassic. The NW and E domains of the pluton were sequentially emplaced between 194 Ma and 186 Ma and both the field relations and the detailed geochronological results suggest that the mafic facies intruded latter in the emplacement sequence. To the NW, Qtz-dioritic and gabbroic externally emplaced pulses ga

关键词： Zircon U-Pb geochronology Zoned plutons Andean magmatic arc Sequential emplacement Individual and statistical zircon ages

Petrography and tectonic provenance of the Permian Tunas Formation:Implications on the paleotectonic setting during the ClaromecóForeland Basin evolution,southwestern Gondwana margin,Argentina

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Journal of Palaeogeography 2022年第3期11卷 427-447页

作者： María Belén Febbo Renata N.Tomezzoli Nora N.Cesaretti Giselle Choque natalia B.Fortunatti Guadalupe Arzadún Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Argentina Dpto.de Geología Universidad Nacional del SurAvenida Alem 1253B8000ICPBahía BlancaArgentina Centro de Geología Aplicada y Medio Ambiente(CGAMA CIC–UNS)Dpto.de GeologíaUniversidad Nacional del SurBahía BlancaArgentina Laboratorio de Paleomagnetismo“Daniel A.Valencio” Instituto de Geociencias BásicasAplicadas y Ambientales de Buenos Aires(IGEBA)Departamento de Ciencias GeológicasFacultad de Ciencias Exactas y Naturales(FCEyN)Universidad de Buenos Aires(UBA)Pabellón II(1428)CABAArgentina Laboratorio de Termocronología(La.Te Andes–CONICET) Las Moreras 310A4401XBAVaquerosSaltaArgentina

The Claromec o Basin is located at the south-western sector of the Buenos Aires province,*** basin is considered a foreland basin closely related to the evolution of the southwestern Gondwana *** contribution focuses on the provenance analysis of the Tunas Formation(Permian,Pillahuinc o Group),which represents the last filling stage for the Claromec o Foreland *** and tectonic provenance analyses were performed in sandstones recovered from subsurface(PANG 0001 and PANG0003 exploration wells)and outcrops located close to the basin center(Gonzales Chaves locality).In the subsurface,the analyzed succession is composed of medium-to fine-grained sandstones interbedded with tuffs,mudrocks,carbonaceous mudrocks and coal *** outcrops,the succession is dominated by mediumto fine-grained sandstones interbedded with *** composition patterns are distributed into the recycled orogen and transitionally recycled to mixed *** analyses,in addition to provenance and sedimentological studies,confirm that sedimentary material was derived from a mixed source,which largely comes from the Sierras Australes fold and thrust belt,located towards the W-SW,where the sedimentary succession is interbedded with volcanic *** Tunas Formation shows clear differences in its modal composition,paleocurrent direction and paleoenvironmental conditions with respect to the underlying units of the Pillahuinc o Group(Sauce Grande,Piedra Azul and Bonete formations).Source areas changed from cratonic to mixed fold belt/arc-derived material,suggesting variations in the Claromec o Basin configuration during the Late *** in the paleotectonic scenario during the deposition of the Tunas Formation have been interpreted as a consequence of a compressive post-collisional deformation event,the product of adjustment,accommodation and translation of terrains towards the equator during the Permian-Triassic to form Pangea.

关键词： Provenance area Petrography Tunas Formation ClaromecóForeland Basin Southwestern Gondwana margin Permian Upper Paleozoic

Involvement of Met receptor pathway in aggressive behavior of colorectal cancer cells induced by parathyroid hormone-related peptide

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World Journal of Gastroenterology 2022年第26期28卷 3177-3200页

作者： María Belén Novoa Díaz Pedro Carriere Graciela Gigola Ariel Osvaldo Zwenger natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Centro de Estudios Clínicos SAGA CEC SAGASantiago de Chile 8320000Chile

BACKGROUND Parathyroid hormone-related peptide(PTHrP)plays a key role in the development and progression of many *** found that in colorectal cancer(CRC)HCT116 cells,the binding of PTHrP to its receptor PTHR type 1(PTHR1)activates events associated with an aggressive *** HCT116 cell xenografts,PTHrP modulates the expression of molecular markers linked to tumor *** evidence suggests that the Met receptor is involved in the development and evolution of *** on these data,we hypothesized that the signaling pathway trigged by PTHrP could be involved in the transactivation of Met and consequently in the aggressive behavior of CRC *** To elucidate the relationship among PTHR1,PTHrP,and Met in CRC *** For in vitro assays,HCT116 and Caco-2 cells derived from human CRC were incubated in the absence or presence of PTHrP(1-34)(10-8 M).Where indicated,cells were pre-incubated with specific kinase inhibitors or dimethylsulfoxide,the vehicle of the *** protein levels were evaluated by Western blot ***-time polymerase chain reaction(RT-qPCR)was carried out to determine the changes in gene *** healing assay and morpho logical monitoring were performed to evaluate cell migration and changes related to the epithelialmesenchymal transition(EMT),*** number of viable HCT116 cells was counted by trypan blue dye exclusion test to evaluate the effects of irinotecan(CPT-11),oxaliplatin(OXA),or doxorubicin(DOXO)with or without *** in vivo tests,HCT116 cell xenografts on 6-wk-old male N:NIH(S)_nu mice received daily intratumoral injections of PTHrP(40μg/kg)in 100μL phosphate-buffered saline(PBS)or the vehicle(PBS)as a control during 20 *** slaughter was carried out and the tumors were removed,weighed,and fixed in a 4%formaldehyde solution for subsequent treatment by *** evaluate the expression of molecular markers in human tumor samples,we studied 23 specimens ob

关键词： PTHrP MET receptor tyrosine kinase Parathyroid hormone receptor type 1 Colorectal cancer Drug resistance

Involvement of parathyroid hormone-related peptide in the aggressive phenotype of colorectal cancer cells

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World Journal of Gastroenterology 2021年第41期27卷 7025-7040页

作者： María Belén Novoa Díaz Pedro Matías Carriere María Julia Martín natalia Calvo Claudia Gentili Departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina Departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Buenos AiresArgentina

Colorectal cancer(CRC)remains one of the leading causes of mortality from malignant diseases *** general terms,CRC presents high heterogeneity due to the influence of different genetic and environmental factors;also,the neoplastic cells are strongly influenced by the extracellular matrix and several surrounding cells,known together as the tumor microenvironment(TME).Bidirectional communication takes place between the tumor and the TME through the release of autocrine and paracrine *** hormone-related peptide(PTHrP)is a cytokine secreted by a wide variety of tissues and is able to regulate several cellular functions both in physiological as well as in pathological *** exerts its effects as a paracrine/autocrine factor,although its mode of action is mainly *** has been shown that this peptide is expressed by several tumors and that the tumor secretion of PTHrP is responsible for the malignant humoral *** years ago,when our research group started studying PTHrP effects in the experimental models derived from intestinal tumors,the literature available at the time addressing the effects of PTHrP on colorectal tumors was limited,and no articles had been published regarding to the paracrine action of PTHrP in CRC *** on this and on our previous findings regarding the role of PTH in CRC cells,our purpose in recent years has been to explore the role of PTHrP in *** analyzed the behavior of CRC cells treated with exogenous PTHrP,focalizing in the study of the following events:Survival,cell cycle progression and proliferation,migration,chemoresistance,tumor-associated angiogenesis,epithelial to mesenchymal transition program and other events also associated with invasion,such us the induction of cancer stem cells *** work summarizes the major findings obtained by our investigation group using in vitro and in vivo CRC models that evidence the participation of PTHrP in the acquisition of an aggressiv

关键词： Parathyroid hormone-related protein Colorectal cancer Tumor biomarkers Neoplastic processes Drug resistance Tumor microenvironment

Phenotypic and genotypic background underlying variations in fatty acid composition and sensory parameters in European bovine breeds

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Journal of Animal Science and Biotechnology 2014年第2期5卷 154-162页

作者： natalia Sevane Hubert Levéziel Geoffrey R Nute Carlos Sanudo Alessio Valentini John Williams Susana Dunner the GeMQual Consortium Departamento de Producción Animal Facultad de Veterinaria Universidad Complutense de Madrid Madrid Spain INRA UMR 1061 F-87000 LimogesFrance Umversité de Limoges UMR 1061 F-87000 Limoges France Division of Farm Animal Science University of Bristol Bristol BS40 5DU UK Departimento de Producción Animal y Ciencia de los Alimentos Universidad de Zaragoza 50013 Zaragoza Spain Dipartimento di Produzioni Animali Universitá della Tuscia via De Lellis 01100 Viterbo italy Parco Tecnologico Padano Via Einstein Polo Universitario 26900 Lodi Italy

Background： Consuming moderate amounts of lean red meat as part of a balanced diet valuably contributes to intakes of essential nutrients, in this study, we merged phenotypic and genotypic information to characterize the variation in lipid profile and sensory parameters and to represent the diversity among 15 cattle populations. Correlations between fat content, organoleptic characteristics and lipid profiles were also investigated. Methods： A sample of 436 largely unrelated purebred bulls belonging to 15 breeds and reared under comparable management conditions was analyzed. Phenotypic data -including fatness score, fat percentage, individual fatty acids （FA） profiles and sensory panel tests- and genotypic information from 11 polymorphisms was used. Results： The correlation coefficients between muscle total lipid measurements and absolute vs. relative amounts of polyunsaturated FA （PUFA） were in opposite directions. Increasing carcass fat leads to an increasing amount of FAs in triglycerides, but at the same time the relative amount of PUFAs is decreasing, which is in concordance with the negative correlation obtained here between the percentage of PUFA and fat measurements, as well as the weaker correlation between total phospholipids and total lipid muscle content compared with neutral lipids. Concerning organoleptic characteristics, a negative correlation between fiavour scores and the percentage of total PUFA, particularly to n-6 fraction, was found. The correlation between juiciness and texture is higher than with flavour scores. The distribution of SNPs plotted by principal components analysis （PCA） mainly reflects their known trait associations, although influenced by their specific breed allele frequencies. Conclusions： The results presented here help to understand the phenotypic and genotypic background underlying variations in FA composition and sensory parameters between breeds. The wide range of traits and breeds studied, along with the genotypic informa

关键词： Bos taurus Beef Fatty acids Omega-3 Genotype assisted selection