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Non-Communicable Chronic Diseases and Structural Indicators in an Epidemiological Transition Country

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Open Journal of Epidemiology 2020年第1期10卷 32-42页

作者： natalia romero-sandoval S. Ramiro Canelos Héctor Javier Sánchez-Pérez Ricardo romero Fernando Cornejo Miguel Martín-Mateo Escuela de Medicina Facultad de Ciencias Médicas de la Salud y de la Vida Universidad Internacional del Ecuador Quito Ecuador Grups de Reserca d’Amèrica i àfrica Llatines-GRAAL Cerdanyola del Vallés España Facultad de Ciencias Administrativas Universidad Internacional del Ecuador Quito Ecuador El Colegio de la Frontera Sur-ECOSUR San Cristóbal de Las Casas Chiapas México Instituto Geográfico Militar Seniergues E4-676 y Gral. Telmo Paz y Miño Quito Ecuador Facultad de Medicina Universidad Tecnológica Equinoccial Bourgeois Quito Ecuador Unidad de Bioestadística Facultad de Medicina Universidad Autónoma de Barcelona Cerdanyola del Vallés Barcelona Spain

Objective: To determine associations between standardized prevalence ratios of Metabolic Syndrome (MS), High Blood Pressure (HBP), and Obesity (O) with structural factors in ecuadorian population aged 20 to 59. Methods: An ecological study was conducted through data from the Ecuador’s National Health and Nutrition Survey 2013-2014, and National Census. Standardized prevalence ratio (SPR) variability was analyzed with Poisson multiple regression models (adjusted Relative Risk). Results: The SPR variability for the three diseases was associated with non-affiliation to social security, and inversely related to lower urbanization. HBP and O were associated with functional illiteracy and higher rates of primary care physicians/1000 inhabitants. HBP and MS were related to poor housing. Conclusions: Policies of non-communicable chronic diseases control in ecological transition countries need to take structural variations into account.

关键词： Chronic Illness Social Inequality Statistical Analysis Policy Process Ecuador

Quito Municipal Schools—Cohort Study: Self-Perception of Body Image and Factors Related with It

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Open Journal of Epidemiology 2014年第3期4卷 122-128页

作者： natalia romero-sandoval Oscar Flores Carmen Egas Gabriela Villamar Zuleica Larrea Manuel Cruz Laura Icaza Miguel Martín Postgrado de Medicina Familiar y Comunitaria Facultad de Ciencias Médicas Universidad Central del Ecuador Quito Ecuador Unidad Metropolitana de Salud Centro Municipio del Distrito Metropolitano de Quito Quito Ecuador Universidad Internacional del Ecuador Facultad de Ciencias Médicas de la Salud y la Vida Escuela de Medicina Quito Ecuador

Self-perception of body image is one factor to be considered when planning and performing preventive initiatives and interventions in childhood and adolescence. The aim of this study was to analyse self-perception of body image in relation to body-mass index, physical inactivity, not eating breakfast, dieting, smoking and alcohol consumption or toxic habits. Materials and Methods: using data from the “Quito municipal schools” cohort study 6964 students aged from 9 to 17 years were described using a multivariate log linear model of the multidimensional table generated by the variables. A logistic regression model was then fitted to assess associations via OR. Results: 8.2% perceived themselves as overweight. Of those subjects overweight according to their BMI, 21.8% perceived themselves as such, while among those not overweight according to BMI, 96.8% considered themselves as slim or of normal weight. Among students who were dieting, 15.1% perceived themselves as overweight. Among those pupils who perceived themselves has having excess weight, the most common reasons for dieting were: lose weight (56.8%), be healthier (22.6%), and maintain current weight (8.4%). Self-perception of excess weight interacts with excess weight (ORadjusted 8.42;CI95% 6.92-10.25), no breakfast (ORadjusted 2.83;CI95% 2.13-3.77), diet (ORadjusted 2.38;CI95% 1.95-2.89), and with all the variables except toxic habits (ORadjusted 1.01;CI95% 0.78 a 1.29). Conclusion: Interventions to prevent obesity in childhood and adolescence ought to take account of specific determinants within the personal, behavioural and socio-environmental factors, such as the promotion of a positive body image.

关键词： Body Image Self-Perception Overweight and Obesity School Children Ecuador

“Quito municipal schools” cohort study: Baseline results

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Open Journal of Epidemiology 2012年第3期2卷 70-74页

作者： natalia romero-sandoval Virginia Ruiz Juan Quizanga Ricardo Recalde Efrén Anchali Jaime Falconí Oscar Flores Miguel Martín Instituto Superior de Postgrado Facultad de Ciencias Médicas Universidad Central del Ecuador Quito Ecuador Grupos de Investigación de América y Africa Latinas (GRAAL) Barcelona Espana and Quito Ecuador Consultora de UNICEF Quito Ecuador Municipio del Distrito Metropolitano de Quito Quito Ecuador Unidad de Bioestadística Facultad de Medicina Universidad Autónoma de Barcelona Cerdanyola del Vallès Spain

The lack of population-level data on growth and development of children and adolescents in Ecuador, and the existence of previous data suggesting an alarming increase in the numbers of children presenting overweight or obesity justifies the present cohort study which includes all pupils of municipal schools of Quito aged 9 to 17 years. Follow-up will continue for a minimum of 7 years. This will allow determining the evolution of prevalence of these phenomena and their trends as well as other indices, both physiological and family-related customs, in order to plan appropriate preventive interventions. The present cross-sectional study includes 21 municipal schools, grouped into four health zones, each of which depends on a health centre, also municipal, and which are responsible for the health of pupils in these schools. Of the 6964 pupils studied, 18.7% suffer overweight and 7.9% obesity: 19.3% and 9.7% respectively in boys, compared to 18.2% and 5.4% in girls. The study also assesses family characteristics, degree of sedentarism and nutritional habits: 62.3% declared living in a nuclear family, and 60.5% declared their families to be in the “adolescent” life-cycle stage;91.9% of pupils were sedentary while 5.4% (CI95% 4.87 - 5.94) reported not eating breakfast every day.

关键词： Overweight and Obesity Equatorian School Children Sedentarism Type of Family

Proteostasis failure:at the intersection between aging and Alzheimer's disease

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Neural Regeneration Research 2025年第11期20卷 3221-3222页

作者： natalia Poblete Claudio Hetz Center for Geroscience Brain Health and MetabolismSantiagoChile Biomedical Neuroscience Institute Faculty of MedicineUniversity of ChileSantiagoChile Program of Cellular and Molecular Biology Institute of Biomedical SciencesFaculty of MedicineUniversity of ChileSantiagoChile Buck Institute for Research on Aging NovatoCAUSA

Lifestyle and demographics of the world's population are causing serious health problems impacting the brain,increasing the incidence of Alzheimer's disease(AD)and other types of *** we have gained important insights into the pathogenic mechanisms of AD,only palliative care is available to *** is characterized by the abnormal deposition of protein aggregates in the brain formed by amyloid β and hyper-phosphorylated,Tau in addition to neuroinflammation.

关键词： Alzheimer amyloid stasis

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： natalia Kulesskaya Kira M.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Influence of in vitro capacitation time on structural and functional human sperm parameters

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Asian Journal of Andrology 2020年第5期22卷 447-453页

作者： Paula Saez-Espinosa natalia Huerta-Retamal Laura Robles-Gomez Manuel Aviles Jon Aizpurua Irene Velasco Alejandro romero Maria Jose Gomez-Torres Department of Biotechnology Faculty of ScienceUniversity of AlicanteAlicante 03080Spain FISABI0-University Hospital of San Juan de Alicante Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Departm ent of Cell Biology and Histology Faculty of MedicineUniversity of Murcia and IMIB-ArrixacaMurcia 30100Spain IVF Spain Reproductive MedicineAlicante 03540Spain University Hospital of San Juan de Alicante Service of Gynecology and ObstetricsSan Juan de Alicante 03550Spain Human Fertility Cathedra University of AlicanteAlicante 03080Spain.

A cascade of dramatic physiological events is linked to the sperm acrosome reaction and binding to the oocyte's zona pellucida during human sperm ***,structural and functional sperm changes during capacitation currently remain poorly ***,we performed a multibiomarker approach based on the utilization of sperm concentration,motility,viability,morphology,acrosome reaction,tyrosine phosphorylation,DNA fragmentation,and lectin-binding sites to analyze the impact caused by swim-up selection times(uncapacitated,1 h capacitated,and 4 h capacitated)on sperm function and structure in normozoospermic *** found that a 4 h swim-up capacitation increased sperm quality,because a large number of cells with normal morphology and lower DNA fragmentation rates were ***,the long-term capacitation induced a higher percentage of cells with tyrosine phosphorylation of the principal piece as well as a redistribution of lectin-binding ***,the multivariate biomarkers analyzed showed a less variable distribution on spermatozoa recovered after 4 h capacitation than that with the shorter capacitation *** findings stress the importance of capacitation time as a relevant factor in sperm quality with potential biological reproductive implications both for basic research and in assisted reproduction techniques.

关键词： acrosome reaction capacitation DNA fragmentation glycocalyx lectin-binding sites membrane integrity protein phosphorylation sperm selection

Design and Construction of Adjustable Mini-standing for Children from 4 to 9 Years Old with Diplegic, Triplegic or Hemiplegic Cerebral Palsy

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Journal of Mechanics Engineering and Automation 2021年第4期11卷 97-104页

作者： natalia Lineth Baquero-Salas Luis Mario Mateus-sandoval Structural Integrity Group Department of Mechanical EngineeringUniversidad de Los AndesColombia

The present paper sought to redesign,technify and adjust to different sizes of a mini-standing to improve the physical therapy of children from 4 to 9 years old with mild cerebral palsy or in medical conditions that moderately affect their lower *** orthopedic attachment provides support to the calf of the patient,resembling its body to a cantilevered *** allows the patient to improve their posture and safety and prevent bone *** achieve this attachment,simplified design techniques were complemented with Autodesk Inventor finite elements,also additive manufacturing in Polylactic Acid polymer PLA was used for structural parts like the calf support;Likewise,Computerized Numerical Control(CNC)was carried out on Nylon 6/6,a material used due to hygiene and lubrication between parts.A functional and safe prototype is obtained that meets the required age range,whose limitations are children of 120 cm or 30 *** were determined in the design requirements and verified with own replicable tests,as well with ASTM(American Society of Testing Materials)standards.

关键词： Orthopedic attachment cerebral palsy additive manufacturing physiotherapy adjustability.

The comparison of design airflow rates with dynamic and steady-state displacement models in varied dynamic conditions

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Building Simulation 2021年第4期14卷 1201-1219页

作者： natalia Lastovets Risto Kosonen Juha Jokisalo Department of Mechanical Engineering Aalto UniversityEspooFinland College of Urban Construction Nanjing Tech UniversityNanjingChina

A temperature-based method is usually applied in displacement ventilation (DV) design when overheating is the primary indoor climate concern. Different steady-state models have been developed and implemented to calculate airflow rate in rooms with DV. However, in practical applications, the performance of DV depends on potentially dynamic parameters, such as strength, type and location of heat gains and changing heat gain schedule. In addition, thermal mass affects dynamically changing room air temperature. The selected steady-state and dynamic models were validated with the experimental results of a lecture room and an orchestra rehearsal room. Among the presented models, dynamic DV model demonstrated a capability to take into account the combination of dynamic parameters in typical applications of DV. The design airflow rate is calculated for the case studies of dynamic DV design in the modelled lecture room in both dynamic and steady-state conditions. In dynamic conditions of heavy construction in 2–4 hours occupancy periods, the actual airflow rate required could be 50% lower than the airflow rate calculated with the steady-state models. The difference between steady-state and dynamic multi-nodal model is most significant with heavyweight construction and short occupancy period (17%–28%). In cases with light construction, the dynamic DV model provides roughly the same airflow rates for four-hour occupancy period than the Mund’s model calculates. The dynamic model can significantly decrease the design airflow rate of DV, which can result in a reduction of investment costs and electrical consumption of fans.

关键词： displacement ventilation design airflow rate temperature gradient dynamic model simplified building energy models

Revisiting non-linear Thomson scattering with metamaterials

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National Science Review 2024年第1期11卷 71-72页

作者： natalia M.Litchinitser Department of Electrical and Computer Engineering Duke University

Non-linear optics is a branch of optics that studies the intriguing and sometimes unexpected ways in which light and matter interact at high intensities, when the polarization density does not respond linearly to the electric field of the light. The pursuit of the perfect non-linear optical material has been ongoing ever since the pioneering experiment on second harmonic generation carried out by Franken in 1961 [1]. Indeed,

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