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Delayed allogeneic skin graft rejection in CD26-deficient mice

Cellular & Molecular Immunology 2019年第6期16卷 557-567页

作者： Xiangli Zhao Kai Zhang Peter Daniel natali.Wisbrun Hendrik fuchs Hua fan Institut fur Laboratoriumsmedizin Klinische Chemie und PathobiochemieCVKCharite-Universitatsmedizin BerlinBerlinGermany College of food Science and Technology Shanghai Ocean UniversityShanghaiPR China Max-Delbrück-Center for Molecular Medicine BerlinGermany Leibniz-Institut für Molekulare Pharmakologie im forschungsverbund Berlin e.V. BerlinGermany

Organ transplantation is an effective therapeutic tool for treating many terminal ***,one of the biggest challenges of transplantation is determining how to achieve the long-term survival of the allogeneic or xenogeneic transplant by,for example,preventing transplant *** the current study,CD26 gene-knockout mice were used to investigate the potential role of CD26/dipeptidyl peptidase-4(DPPIV)in allogeneic skin graft rejection by tail-skin *** with wild-type(CD26^(+/+))counterparts,CD26^(-/-)mice showed reduced necrosis of grafts and delayed graft rejection after skin *** of serum IgG,including its subclasses IgG1 and IgG2a,were significantly reduced in CD26^(-/-)mice during graft ***,after allogeneic skin transplantation,the secretion levels of the cytokines IfN-γ,IL-2,IL-6,IL-4,and IL-13 were significantly reduced,whereas the level of the cytokine IL-10 was increased in the serum of CD26^(-/-)mice compared with that in the serum of CD26^(+/+)***,the concentration of IL-17 in serum and the percentage of cells secreting IL-17 in mouse peripheral blood lymphocytes(MPBLs)were both significantly lower,while the percentage of regulatory T cells(Tregs)was significantly higher in MPBLs of CD26^(-/-)mice than in those of CD26^(+/+)***,a lower percentage of CD8^(+)T cells in MPBLs and fewer infiltrated macrophages and T cells in graft tissues of CD26^(-/-)mice were detected during graft *** results indicate that CD26 is involved in allogeneic skin graft rejection and provides another hint that CD26 deficiency leads to less rejection due to lower activation and proliferation of host immune cells.

关键词： Allogeneic graft rejection CD26/DPPIV Cytokine IgG T lymphocytes

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Effect of sowing and oversowing on species abundance in mountain pastures of central Italy

Effect of sowing and oversowing on species abundance in moun...

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ⅩⅪ International Grassland Congress and the Ⅷ International Rangeland Congress

作者： A.Pardini f.natali University of florence-Piazzale Cascine 18-50144 firenze （I）

＜正＞Introduction Large parts of Central Italy are mountainous and marginal due to climate constraints,shallow soils,steeped slopes and distance from main *** productivity is low nonetheless of the agronomic advances,and farmers increase their incomes by offering tourist ***-tourism is favoured by conservation of biodiversity（Uncini Manganelli et al., 2002）.Under this point of view,farmers seek low input techniques for pasture management that sustain the productivity and at the same time conserve plant diversity（Pardini,2002）.A trial was done to control what is the effect of sowing and oversowing on productivity and abundance of pasture *** research has been fund by ARSIA of the Regional Government of Tuscany.

关键词： agro-tourism biodiversity

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Is the ballan wrasse (Labrus bergylta) two species? Genetic analysis reveals within-species divergence associated with plain and spotted morphotype frequencies

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Integrative Zoology 2016年第2期11卷 162-172页

作者： María QUINTELA Elin Annie DANIELSEN Lua LOPEZ Rodolfo BARREIRO Terje svÅSAND Halvor KNUTSEN Anne Berit SKIfTEsvIK Kevin A.GLOVER Institute of Marine Research BergenNorway Grupo de investigación BIOCOST University of A CoruñaSpain Centre for Ecological and Evolutionary Synthesis Department of BiologyUniversity of OsloOsloNorway University of Agder KristiansandNorway Austevoll Research Station StorebøNorway

The ballan wrasse(Labrus bergylta)is a marine fish belonging to the family Labridae characterized by 2 main morphotypes that occur in sympatry:spotty and *** studies have revealed differences in their life-history traits,such as growth and maturation;however,the genetic relationship between forms is presently *** 20 recently developed microsatellite markers,we conducted a genetic analysis of 41 and 48 spotty and plain ballan wrasse collected in Galicia(northwest Spain).The 2 morphotypes displayed highly significant genetic differences to each other(f_(ST)=0.018,Pf genetic differentiation(f_(ST)=0.025,Pfrequency of spotty and plain morphotypes was significantly different(χ^(2)=9.46,P=0.002).It is concluded that there is significant genetic heterogeneity within this species,which appears to be highly associated with the spotty and plain forms,but not completely explained by *** the previously demonstrated biological differences between morphotypes,and the present genetic analyses,we speculate about the convenience of a taxonomic re-evaluation of this species.

关键词： ballan wrasse color morphotypes Labrus bergylta microsatellites speciation

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Analysis of the Interface between Primary and Secondary Metabolism in Catharanthus roseus Cell Cultures Using ^13C-Stable Isotope feeding and Coupled Mass Spectrometry

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Molecular Plant 2013年第2期6卷 581-584页

作者： Carla Antonio natali.R. Mustafa Sonia Osorio Takayuki Tohge Patrick Giavalbco Lothar Willmitzer Heiko Rischer Kirsi-Marj Oksman-Caldentey Robert Verpoorte Alisdair R. fernie Central Metabolism Group Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 1 D-14476 Potsdam-Golm Germany Natural Products Laboratory Institute of Biology Leiden University Einsteinweg 55 2300 RA Leiden The Netherlands Present address: Departamento de Biologia Molecular y Bioquimica Universidad de M.~laga 29071 M=~laga Spain Genes and Small Molecules Group Max Planck Institute of MolecularPlant Physiology Am Muehlenberg 1 D-14476 Potsdam-Golm Germany VTT Technical Research Centre of finland PO Box 1000 F1-02044 VTT (Espoo) Finland

Dear Editor, The tropical plant Madagascar periwinkle Catharanthus roseus （L.） *** is a rich source of plant-derived medicinal ter-penoid indole alkaloids （TIAs）, including the anti-hypertensive ajmalicine, the sedative compound serpentine, and the anti-cancer drugs vinblastine and vincristine. However, the latter two compounds are produced in C. roseus plants only in very low amounts. Elicitors such as hormones （e.g. jasmonates or salicylic acid） activate plant natural defense responses, includ-ing increased secondary metabolite production （EI-Sayed and Verpoorte, 2007; Lackman et al.. 2011）.

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蜂胶对成纤维细胞、单核巨噬细胞系基质金属蛋白酶MMP-9表达的抑制作用

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解放军医学杂志 2006年第6期31卷 545-547页

作者：贾军宏 Min Danqing Lisa Luo DK Yue sv McLennan 解放军总医院第一附属医院内分泌科北京100037 悉尼大学医学院附属皇家阿尔弗雷德王子医院内分泌科

目的探讨蜂胶对糖尿病伤口愈合的作用及其机制。方法采用荧光电泳法,检测不同葡萄糖浓度(5、25mmol/L)和不同蜂胶浓度(10、50、100、200μg/ml)处理的体外培养的人成纤维细胞及单核巨噬细胞系的基质金属蛋白酶MMP9蛋白的表达。结果高浓... 详细信息

目的探讨蜂胶对糖尿病伤口愈合的作用及其机制。方法采用荧光电泳法,检测不同葡萄糖浓度(5、25mmol/L)和不同蜂胶浓度(10、50、100、200μg/ml)处理的体外培养的人成纤维细胞及单核巨噬细胞系的基质金属蛋白酶MMP9蛋白的表达。结果高浓度葡萄糖(25mmol/L)状态下,MMP9表达增加,但与低浓度(5mmol/L)比较,差异无统计学意义。蜂胶可显著降低MMP9的表达,并呈剂量依赖性(P<0.05)。结论高糖能增加单核巨噬细胞系及成纤维细胞MMP9的表达,可能会影响糖尿病患者伤口的愈合。蜂胶可抑制这些细胞MMP9的表达,有益于细胞基质的积聚,从而有益于糖尿病患者伤口的愈合。

关键词：蜂胶明胶酶B4糖尿病伤口愈合

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Responses of the Adult Rat Glucose Metabolism to Early Life feeding, Caloric Restriction and Refeeding

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Journal of Pharmacy and Pharmacology 2018年第4期6卷 370-379页

作者： Nayra T. D. Branquinho Monica S. M. Loiola Leticia D. Crepaldi Lais A. Yamada Silvia C. S. f. Azevedo Camila Bataglini Marcia N. Brito Vilma A. f. de Godoi Maria Montserrat D. Pedrosa Maria Raquel M. natali Program of Graduate Studies in Cell and Molecular Biology State University of Maringa Maringa 87020-900 Brazil Program of Graduate Studies in Physiological Sciences State University of Maringa Maringa 87020-900 Brazil Department of Physiological Sciences State University of Maringa Maringa 87020-900 Brazil Department of Morphological Sciences State University of Maringa Maringa 87020-900 Brazil

Early life overfeeding in the rat can be experimentally induced by reducing litter size. This investigation assessed the consequences of this manipulation on glucose metabolism in vivo and in isolated hepatocytes in 150-day old rats. Additionally, after body growth, the effects of caloric restriction and refeeding were tested. Adult rats from control （G9） and reduced litters （G3L） did not differ in body and fat weights, glucose tolerance or insulin resistance （insulin-induced hypoglycemia）, or hepatocyte glucose release under basal or gluconeogenic conditions. Caloric restriction （G3R） reduced body and fat weights, decreased glucose decay after insulin injection and decreased hepatocyte gluconeogenic glucose release. Refeeding after caloric restriction reversed these parameters to those of the freely-fed groups （G9 and G3L）. Taken together, these results suggest that the liver glucose metabolism is not programmed by lactational overfeeding, but rather is responsive to the current nutritional condition of the animal.

关键词： Glucose homeostasis metabolic programming reduced litter caloric restriction refeeding.

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Modeling of Dark Solitons for Nonlinear Longitudinal Wave Equation in a Magneto-Electro-Elastic Circular Rod

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Sound & Vibration 2021年第3期55卷 241-251页

作者： Hulya Durur Asıf Yokuş Doğan Kaya Hijaz Ahmad Department of Computer Engineering Faculty of EngineeringArdahan UniversityArdahanTurkey Department of Mathematics Faculty of ScienceFirat UniversityElazigTurkey Department of Mathematics Istanbul Commerce UniversityIstanbulTurkey Department of Basic Sciences University of Engineering and TechnologyPeshawarPakistan

In this paper,sub equation and (1=G’)-expansion methods are proposed to construct exact solutions of a nonlinear longitudinal wave equation(LWE)in a magneto-electro-elastic circular *** proposed methods have been used to construct hyperbolic,rational,dark soliton and trigonometric solutions of the LWE in the magnetoelectro-elastic circular *** values are given to the parameters in the solutions obtained.3D,2D and contour graphs are presented with the help of a computer package *** attained by symbolic calculations revealed that these methods are effective,reliable and simple mathematical tool for finding solutions of nonlinear evolution equations arising in physics and nonlinear dynamics.

关键词： (1/G’)-expansion method sub equation method exact solution traveling wave solution nonlinear evolution equations

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Glutamine or Glutamine dipeptide Supplementation Improves Gluconeogenesis and Liver Glycogenosis in Type 1 diabetic Rats

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Journal of Pharmacy and Pharmacology 2019年第7期7卷 398-407页

作者： Silvia Carla S.f.Azevedo Carlos Vinicius D.da Rosa Ana Luiza M.Wunderlich Laís A.Yamada Isabela R.Mariano Camila Bataglini Nayra T.D.Branquinho Scarlett R.Raposo Roberto B.Bazotte Edmara A.Baroni Maria Raquel M.natali.Maria Montserrat D.Pedrosa Vilma A.f.de Godoi Program of Graduate Studies in Cell and Molecular Biology State University of MaringáMaringá87020-900Brazil Program of Graduate Studies in Physiological Sciences State University of MaringáMaringá87020-900Brazil Undergraduation in Biological Sciences University Center of MaringáMaringá87050-390Brazil Department of Pharmacology and Therapeutics State University of MaringáMaringá87020-900Brazil Department of Physiological Sciences State University of MaringáMaringá87020-900Brazil Department of Morphological Sciences State University of MaringáMaringá87020-900Brazil

The effects of the supplementation with L-glutamine(GLN)or L-alanyl-L-glutamine(GDP)on the progression of the systemic and hepatic metabolic status of rats having untreated type 1 diabetes mellitus(T1DM)were *** Wistar diabetic rats(streptozotocin,60 mg/kg)were allotted to four groups supplemented by gavage for thirty days as follows:control and diabetic receiving saline;diabetic receiving GLN(248 mg/kg);and diabetic receiving GDP(400 mg/kg).Body weight,plasmatic parameters and kidney function were *** hepatocytes were used to assess gluconeogenic *** and kidney were used for morphological analyses.T1DM decreased the number and increased the area of the hepatocytes,possibly because of the observed enlargement of glycogen *** weight,glomerular area and proteinuria increased,and glomerular filtration rate decreased,in non-supplemented T1DM *** area and proteinuria were reversed by both *** T1DM hepatocytes released less glucose,which could have been diverted to glycogen synthesis and secondary glycogenosis observed in T1DM;this was partially reversed by the *** results point to a possible beneficial effect of glutamine on the metabolic and hepatic impairments of T1DM.

关键词： Type 1 diabetes mellitus L-glutamine glutamine dipeptide gluconeogenesis glycogenosis

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父母2型糖尿病病史,转录因子7类似物2变异体和低胰岛素分泌与高血压发生相关

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中华高血压杂志 2013年第9期21卷 899-899页

作者： Bonnet f Roussel R natali.A Cauchi S Petrie J Laville M Yengo L froguel P Lange C Lantieri O Marre M Balkau B ferrannini E 刘莉叶鹏

胰岛素分泌和高血压发生之间的关系尚未明确。研究人员假设，父母糖尿病史和转录因子7类似物2（transcription factor 7-like2，TCf7L2）rs7903146基因多态性与高血压发生相关。同时研究人员对另一个独立的队列进行分析，评估低胰岛素... 详细信息

胰岛素分泌和高血压发生之间的关系尚未明确。研究人员假设，父母糖尿病史和转录因子7类似物2（transcription factor 7-like2，TCf7L2）rs7903146基因多态性与高血压发生相关。同时研究人员对另一个独立的队列进行分析，评估低胰岛素分泌与高血压发生的关系。

关键词：胰岛素分泌转录因子糖尿病史高血压类似物 2型糖尿病变异体研究人员

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CHAMP卫星主磁场长期变化和长期加速度的分布特征

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地球物理学报 2009年第8期52卷 1976-1984页

作者：康国发高国明白春华狄传之云南大学地球物理系昆明650091 中国科学院地质与地球物理研究所北京100029

本文利用CHAMP卫星磁测资料建立的新一代地磁场模型POMME-4.2S,分析了全球和中国地区地磁长期变化■ 7个分量以及长期加速度、■、■ 3个分量的分布特征,比较了POMME-4.2S长期变化模型与中国长期变模型CGRf-sv的磁异常分布差异.主要... 详细信息

本文利用CHAMP卫星磁测资料建立的新一代地磁场模型POMME-4.2S,分析了全球和中国地区地磁长期变化■ 7个分量以及长期加速度、■、■ 3个分量的分布特征,比较了POMME-4.2S长期变化模型与中国长期变模型CGRf-sv的磁异常分布差异.主要结果表明,地磁长期变化磁四极子起主要贡献,长期加速度变化磁八极子贡献最大.2004.0年全球长期变化的减小要比增加大得多,地磁场总体在减弱.长期加速度在中低纬度地区变化较大,高纬度地区变化小.■和■分量磁异常沿经度方向正、负交错形成几个大片区,分量主要正负磁异常成对分布于赤道两侧.长期加速度、■、■ 3个分量的磁异常分布存在明显的关系:在■异常焦点的南北两边出现的异常焦点,东西两边出现■的异常焦点.中国地区的长期变化和长期加速度变化量小,分布相对均匀.

关键词：主磁场长期变化长期加速度空间分布

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