检索结果-南通市图书馆

Performance effects of feed-borne Fusarium mycotoxins on broiler chickens: Influences of timing and duration of exposure

引用

Animal Nutrition 2019年第1期5卷 32-40页

作者： Anhao Wang natacha s.hogan Department of Animal and Poultry science College of Agriculture and Bioresources University of Saskatchewan Toxicology Centre University of Saskatchewan

In commercial practice, broiler chickens may be exposed to Fusarium mycotoxins either during specific growth stages or throughout the entire production cycle. A 34-day feeding trial was conducted to identify sensitive periods for mycotoxin effects during the growth cycle of broiler chickens. A total of 420 newly-hatched Ross 308 male broilers were randomly assigned to 60 cages with 7 birds/cage. sources of clean wheat(sarium-contaminated wheat(11.4 mg/kg DON)were used to formulate the starter diets(0.41 and 6.62 mg/kg DON) provided from 1 to 21 d of age and the grower diets(0.54 and 7.90 mg/kg DON) provided from 22 to 34 d. Control and DON diets were provided to broilers according to treatments(control, DON 1 to 14 d, DON 15 to 21 d, DON 22 to 34 d and DON 1 to 34 d). Birds were monitored daily for morbidity or mortality. Broiler growth performance(body weight, average daily gain, average daily feed intake and feed to gain ratio) was measured *** of duodenum, jejunum and ileum were collected at 21 and 34 d and morphometric parameters(villus height, crypt depth, villus width, muscularis thickness and villi:crypt ratio) were measured. Birds fed the DON starter diet during the first 14 d did not exhibit any changes in growth performance;however, growth performance was suppressed in birds fed DON-contaminated diets during the grower period(22 to 34 d). At 34 d, birds that received the DON grower diet(DON 22 to 34 d and DON 1 to 34 d)were lighter(1,433 vs. 1,695 g) than birds fed the control diet. Feed to gain ratio was higher in birds fed the DON grower diet from 22 to 28 d(1.77 vs. 1.56) and 28 to 34 d(2.24 vs. 1.85) compared with corresponding controls. These results suggest that providing older broiler chicks(22 to 34 d) feed contaminated with Fusarium mycotoxins(specifically DON) may result in production losses. Histopathological analysis of the ileum region revealed that birds provided the DON diets throughout the

关键词： Deoxynivalenol Chicken sensitive period Feed contamination Intestine

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The sweatshop Workers of Nicaragua： subjectivity, Labor, and Domination

引用

Fudan Journal of the Humanities and social sciences 2017年第4期10卷 509-522页

作者： natacha Borgeaud-Garciandfa CONICET/FLACsO Buenos Aires Argentina

This essay is based on an approach that addresses the relationship between work-related domination and the subjects who are submitted to it. This reflection arises from research undertaken in Nicaragua, among workers from the international textile factories known as maquiladoras （or maquilas）. Men, but mostly young women, work and live here under particularly difficult conditions. The constraints of work and domination invade the recesses of their existence, and their power is such that it seems to annul any proper subjectivity. Although it may seem easy to locate the effects of work-related domination in the very intimacy of the subjects＇ lives, it also appears as if part of themselves remains unsubdued. Dominated subjectivities can only rebel for failing to do it would be to condemn their beings to inexistence. What sense can be given to this gap in domination？ Does it preserve the domination by preserving the subjects from the invasion in their own beings by this very domination？ Is it only a resource of the submission？ Those are, between domination and subjectivity, some of the aroused interrogations.

关键词： Labor Domination subjectivity sweatshop workers Nicaragua

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Alzheimer’s disease:a tale of two diseases?

引用

Neural Regeneration Research 2021年第10期16卷 1958-1964页

作者： Eleonora Nardini Ryan hogan Anthony Flamier Gilbert Bernier Whitehead Institute for Biomedical Research CambridgeMAUSA stem Cell and Developmental Biology Laboratory Hôpital Maisonneuve-RosemontMontrealQCCanada Department of Neurosciences University of MontrealMontrealQCCanada

sporadic late-onset Alzheimer’s disease(sLOAD)and familial early-onset Alzheimer’s disease(FEOAD)associated with dominant mutations in APP,PsEN1 and PsEN2,are thought to represent a spectrum of the same disorder based on near identical behavioral and histopathological ***,FEOAD transgenic mouse models have been used in past decades as a surrogate to study sLOAD pathogenic mechanisms and as the gold standard to validate drugs used in clinical ***,such research has yielded little output in terms of therapeutics targeting the disease’s development and *** this short review,we interrogate the widely accepted view of one,dimorphic disease through the prism of the Bmi1+/–mouse model and the distinct chromatin signatures observed between sLOAD and FEOAD brains.

关键词： aging Alzheimer’s disease BMI1 epigenetics familial late-onset sporadic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The Matthew Effect in Running:An Analysis of Elite Endurance Athletes Over 23 Years

引用

Journal of science in sport and Exercise 2023年第3期5卷 236-243页

作者： Mabliny Thuany Beat Knechtle Kevin Kipchumba Lee Hill Thayse natacha Gomes Centre of Research EducationInnovation and Intervention in Sport(CIFI2D)Faculty of SportUniversity of Porto4200-450 PortoPortugal Medbase street Gallen Am Vadianplatz Vadianstrasse 269001 Street GallenGallenSwitzerland Kenyatta University NairobiKenya Division of Gastroenterology&Nutrition Department of PediatricsMcMaster UniversityHamiltonCanada Department of Physical Education Federal University of Sergipe(UFS)São CristóvãoSergipe 49100-000Brazil

Purpose The purpose of this study was to investigate the frequency of countries represented in the TOP20 long-distance elite runners ranking during 1997-2020,taking into account the countries’Human Development Index(HDI),and to verify if the Matthew effect can be observed regarding countries’representativeness in the raking alongside the *** The sample comprised 1852 professional runner athletes,ranked in the senior World TOP20 half-marathon(403 female and 487 male)and marathon(480 female and 482 male)races,between the years *** about the countries’HDI was included,and categorized as“low HDI”,“medium HDI”,“high HDI”,and“very-high HDI”.Athletes were categorized according to their ranking positions(1st-3rd;4th-10th;>10th),and the number of athletes per country/year was summed and categorized as“total number of athletes 1997-2000”;“total number of athletes 2001-2010”;and“total number of athletes 2011-2020”.The Chi-square test and spearman correlation were used to verify potential associations and relationships between *** Most of the athletes were from countries with medium HDI,followed by low HDI and very-high ***-square test results showed significant differences among females(χ^(2)=15.52;P=0.017)and males(χ^(2)=9.03;P=0.014),in half-marathon and marathon,*** significant association was verified between HDI and the total number of athletes,but the association was found for the number of athletes alongside the years(1997-2000 to 2001-2010:r=0.60;Psion Most of the athletes were from countries with medium HDI,followed by those with low HDI and very-high *** Matthew effect was observed,but a generalization of the results should not be done.

关键词： Endurance High-elite athletes Human development index

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Relationship Between Training Volume and BMI in the Expression of Running Performance in Runners: A Mediation Model

引用

Journal of science in sport and Exercise 2023年第2期5卷 142-148页

作者： Mabliny Thuany Lee Hill JoséRamón Alvero‑Cruz Beat Knechtle Thayse natacha Gomes CIFI²D Faculty of SportUniversity of PortoPortoPortugal Division of Gastroenterology and Nutrition Department of PediatricsMcMaster UniversityHamiltonON L8N 3Z5Canada Dpto de Fisiología Humana HistologíaAnatomia Patológica y Educación Física y DeportivaUniversidad de MálagaMálagaSpain Medbase st.Gallen Am Vadianplatz Vadianstrasse 269001 St.GallenSwitzerland Department of Physical Education Federal University of SergipeSão CristóvãoSEBrazil

Purpose The relationships between anthropometric and training variables with running performance were previously ***,it is possible that through the moderating role of anthropometric variables,the magnitude of the relationship between training and performance may be *** purpose of this study was to estimate the mediation role of body mass index(BMI)in the relationship between training volume and running performance among non-professional runners,taking into account sex and age *** The sample comprised 1151 non-professional road runners(61.8%male),aged 18–72 *** about sex,age,body mass(kg),body height(cm),running pace,motivation for running,training volume and frequency were obtained through an online *** into account athletes’age,they were split into two age categories:“until 34 years”(adult runners)and“≥35 years”(master athletes).A mediation analysis was computed in Macro Process(sPss 26),considering sex and age *** was the mediating variable,while training volume/week was used as independ-ent variable,and running pace was considered as dependent *** For both sexes and age categories,a significant association between training volume on running pace was observed[male adult:β=-0.67;95%CI(-1.04 to-0.53);male master:β=-0.241;95%CI(-0.44 to-0.26);female adult:-0.83;95%CI(-1.25 to-0.41);female master:-0.76;95%CI(-1.09 to-0.44)],as well the association between training volume and BMI;and running BMI and running *** for female adult runners,a mediation effect of BMI was *** The present study showed that BMI mediated the association between training volume and running pace in non-professional runners of different sexes and age *** the other hand,a small influence of training volume on the expression of BMI was found.

关键词： Body mass index Running Mediation model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Generalized Hopf Bifurcation in a Delay Model of Neutrophil Cells Model

引用

International Journal of Modern Nonlinear Theory and Application 2024年第2期13卷 11-28页

作者： suqi Ma s. J. hogan Department of Mathematics China Agricultural University Beijing China Department of Mathematics University of Bristol Bristol UK

The DDE-Biftool software is applied to solve the dynamical stability and bifurcation problem of the neutrophil cells model. Based on Hopf point finding with the stability property of the equilibrium solution loss, the continuation of the bifurcating periodical solution starting from Hopf point is exploited. The generalized Hopf point is tracked by seeking for the critical value of free parameter of the switching phenomena of the open loop, which describes the lineup of bifurcating periodical solutions from Hopf point. The normal form near the generalized Hopf point is computed by Lyapunov-schimdt reduction scheme combined with the center manifold analytical technique. The near dynamics is classified by geometrically different topological phase portraits.

关键词： Generalized Hopf Bifurcation DDE-Biftool software Norm Form

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-additive manufacturing of multilevel strengthened aluminum matrix composites

引用

International Journal of Extreme Manufacturing 2023年第1期5卷 254-264页

作者： Chenwei shao Haoyang Li Yankun Zhu Peng Li Haoyang Yu Zhefeng Zhang Herbert Gleiter AndréMcDonald James.hogan Department of Mechanical Engineering University of AlbertaEdmonton T6G 1H9Canada shi-Changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016People’s Republic of China school of Materials science and Engineering University of Science and Technology of ChinaHefei 230026People’s Republic of China nanoFAB Fabrication and Characterization Centre University of AlbertaEdmonton T6G 1H9Canada Institute of Nanotechnology Karlsruhe Institute of TechnologyHermann-von-Helmholtz-Platz 1Eggenstein-Leopoldshafen 76344Germany

Nanostructured materials are being actively developed,while it remains an open question how to rapidly scale them up to bulk engineering materials for broad industrial *** study propose an industrial approach to rapidly fabricate high-strength large-size nanostructured metal matrix composites and attempts to investigate and optimize the deposition process and strengthening ***,advanced nanocrystalline aluminum matrix composites(nanoAMCs)were assembled for the first time by a novel nano-additive manufacturing method that was guided by numerical simulations(*** in-flight particle model and the porefree deposition model).The present nanoAMC with a mean grain sizess eight times higher than the bulk aluminum and shows the highest hardness among all Al–Al2O3 composites reported to date in the literature,which are the outcome of controlling multiscale strengthening mechanisms from tailoring solution atoms,dislocations,grain boundaries,precipitates,and externally introduced reinforcing *** present high-throughput strategy and method can be extended to design and architect advanced coatings or bulk materials in a highly efficient(synthesizing a nanostructured bulk with dimensions of 50×20×4 mm^(3) in 9 min)and highly flexible(regulating the gradient microstructures in bulk)way,which is conducive to industrial production and application.

关键词： high-throughput fabrication bulk nanoAMC low-temperature additive manufacturing multi-level strengthening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

sOPHIE: Generative Neural Networks separate Common and specific Transcriptional Responses

引用

Genomics, Proteomics & Bioinformatics 2022年第5期20卷 912-927页

作者： Alexandra J.Lee Dallas L.Mould Jake Crawford Dongbo Hu Rani K.Powers Georgia Doing James C.Costello Deborah A.hogan Casey s.Greene Genomics and Computational Biology Graduate Program University of PennsylvaniaPhiladelphiaPA 19104USA Department of Microbiology and Immunology Geisel School of Medicine at DartmouthHanoverNH 03755USA Department of systems Pharmacology and Translational Therapeutics University of PennsylvaniaPhiladelphiaPA 19104USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115USA Department of Pharmacology University of Colorado School of MedicineDenverCO 80045USA Center for Health AI University of Colorado School of MedicineDenverCO 80045USA Department of Biochemistry and Molecular Genetics University of Colorado School of MedicineDenverCO 80045USA

Genome-wide transcriptome profiling identifies genes that are prone to differential expression(DE)across contexts,as well as genes with changes specific to the experimental *** genes that are specifically changed in a context of interest from common differentially expressed genes(DEGs)allows more efficient prediction of which genes are specific to a given biological process under ***,common DEGs or pathways can only be identified through the laborious manual curation of experiments,an inordinately time-consuming *** we pioneer an approach,specific cOntext Pattern Highlighting In Expression data(sOPHIE),for distinguishing between common and specific transcriptional patterns using a generative neural network to create a background set of experiments from which a null distribution of gene and pathway changes can be *** apply sOPHIE to diverse datasets including those from human,human cancer,and bacterial pathogen Pseudomonas *** identifies common DEGs in concordance with previously described,manually and systematically determined common *** molecular validation indicates that sOPHIE detects highly specific but low-magnitude biologically relevant transcriptional ***’s measure of specificity can complement log2 fold change values generated from traditional DE *** example,by filtering the set of DEGs,one can identify genes that are specifically relevant to the experimental condition of ***,these results can inform future research *** scripts used in these analyses are available at https://***/greenelab/*** can access https://***/greenelab/sophie to run sOPHIE on their own data.

关键词： Neural network Transcriptomics software Differential expression analysis Machine learning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Arbovirus and seizures

引用

Acta Epileptologica 2020年第1期2卷 151-157页

作者： Mingrui Zheng shichuo Li R.Edward hogan Meihua Yang West China school of Basic Medicine and Forensic Medicine Sichuan UniversityChengdu 610041China. China Association Against Epilepsy(CAAE) BeijingChina. Department of Neurology Washington UniversitySt.LouisMO 63110-1093USA. Epilepsy Centre Department of NeurosurgeryXinqiao HospitalArmy Military Medical UniversityChongqing 400037China.

The high prevalence and spread of arthropod-borne viruses(arboviruses)make them an important cause of viral encephalitis in *** epidemic viral encephalitides have an etiology associated with *** various arboviruses,the Japanese encephalitis virus,West Nile virus,Zika virus,Dengue virus and Chikungunya virus can induce *** of the genus Flavivirus are usually transmitted by mosquitoes and other host *** vector-borne pathogens can cause epidemic viral *** may not be the major manifestation in these viral encephalitides,but may predict a poor *** this article,we discuss the relationships between these viruses and seizures from perspectives of clinical characteristics,pathogenesis,prognosis and treatments of each.

关键词： seizures Japanese encephalitis West Nile virus Zika virus Dengue virus Chikungunya virus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

WHAT's CRAIC'IN?FEILE sHANGHAI IRELAND WEEK

引用

城市漫步（上海版、英文） 2014年第3期 84-85页

作者： LAUREN hogan 不详

March is tur ning out to be a jam-packed month,an d fora full week the Irish are taking over-which doesn't even in elude the few days following needed to nurse you back from your plight of Irish Yoga?

关键词： elude nurse packed

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：