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International Journal of Sediment Research 2020年第5期35卷 527-539页

作者： Dejan Kr?mar Nenad Grba Marijana Kragulj Isakovski nata?a varga Jelena Spasojevi? Jasmina Agbaba Bozo Du?an Dalmacija University of Novi Sad Faculty of Sciences Department of ChemistryBiochemistry and Environmental Protection

The objective of this current study is to compare related sediment legislation standards and norms to the diversity and influence of anthropogenic and natural(geogenic) sources of pollution in the investigated fluvial relief test site region of the Obedska *** metals(nickel(Ni).zinc(Zn),cadmium(Cd),copper(Cu) and lead(Pb) except chromium(Cr)) and arsenic(As) have higher values than the Upper Continental Crust(UCC) for loess *** sharp leaps in the enrichment factor(r) suggested "indicators of anthropogenic metal pollution" for Cd,Cu(r> 5.0) and Zn,Ni(r> 1.0) for this *** addition,the Chemical Proxy of Alteration(CPA,60-95) from the unique Jadar block terrane and neighbouring representative catchment areas,confirmed moderate to higher intensity of *** Component Analysis/Factor Analysis(PCA/FA) and cluster analysis suggest that Ni,Zn,Cu and Cd are derived from several anthropogenic sources,whereas As is convincingly of geogenic origin,and Pb and Cr exhibit dual *** sum of 16 *** Protection Agency Polycyclic Aromatic Hydrocarbons(EPA PAHs) indicated heterogenic sources,but minor effects to *** results of the current investigation indicated intensive and highly diffuse sources of pollution in this United Nations Educational,Scientific and Cultural Organization [UNESCO's] *** outcomes indicate that Cu should be added to the European Union [EU] watch list of emerging contaminants.

关键词： Priority substances in sediment Contamination criteria Multivariate statistical techniques Heterogeneous sources

Design and initial testing of a maize cob collection system

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 108-114页

作者： Bojan Dolšak Anita Breznik Klemen Kaučič nataša Imenšek Marko Marčec Peter Gselman Jani Humar Mitja Krajnc University of Maribor Faculty of Mechanical EngineeringSmetanova ulica 172000 MariborSlovenia ŽIPO Lenart Ltd. Šetarova 212230 LenartSlovenia KGS Krajnc Ltd Vinička vas 42230 LenartSlovenia Interkorn Ltd. Gančani 949231 BeltinciSlovenia

Maize cobs are valuable plant residues that can be used for many different purposes,including as a renewable energy *** their value,maize cobs are still underutilized,mainly because people are not aware of their potential and harvesting techniques for their collection are still being ***,this research focused on finding the most suitable energy-and time-efficient method for mechanical collection of maize *** the combine harvester with an additional hopper proved to be the most promising solution,as it allows harvesting and storage of maize grain and maize cobs in one pass,while the harvesting time remains almost the same and the maize cobs are of good quality,as they do not fall on the field.A prototype with enlarged openings in the straw walkers,an additional grab container for maize cobs,a transport auger,a transport cleaning fan with built-in knives,a transport tube and some other assemblies was fabricated and used in *** first test results are very encouraging(94.4%-96.0%purity of maize cobs)and the system has been patented as a promising solution,especially in times when the environmental sustainability of the planet and energy independence are becoming increasingly important.

关键词： maize cobs utilization mechanical harvesting combine harvester upgrade

In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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Microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović nataša V.Todorović Aleksandar J.Krmpot Miroslav Živić Svetlana Savić-Šević Steva M.Lević Marina Stanić Dejan Pantelić Brana Jelenković Mihailo D.Rabasović Institute of Physiology and Biochemistry“Ivan Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics Belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia University of Belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for Multidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

Epidemiologic investigation of pediatric distal humerus fractures: An American insurance claims database study

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World Journal of Orthopedics 2024年第1期15卷 52-60页

作者： Kyle Jay Klahs Jake E Dertinger Grant T Mello Kevin Thapa Alexis B Sandler E'Stephan J Jesus Garcia nata Parnes Department of Orthopaedic Surgery Texas Tech University Health Sciences-El PasoEl PasoTX 79905United States Medical School California Health Sciences University College of Osteopathic MedicineClovisCA 93611United States Undergraduate School Binghampton UniversityVestalNY 13902United States Department of Orthopaedic Surgery William Beaumont Army Medical CenterFort BlissTX 79918United States Department of Orthopaedic Surgery Carthage Area HospitalCarthageNY 13619United States

BACKGROUND Distal humerus elbow fractures are one of the most common traumatic fractures seen in pediatric patients and present as three main types:Supracondylar(SC),lateral condyle(LC),and medial epicondyle(ME)*** To evaluate the epidemiology of pediatric distal humerus fractures(SC,LC,and ME)from an American insurance claims *** A retrospective review was performed on patients 17 years and younger with the ICD 9 and 10 codes for SC,LC and ME fractures based on the IBM Truven MarketScan®Commercial and IBM Truven MarketScan Medicare Supplemental *** from 2015 to 2020 were queried for treatments,patient age,sex,length of hospitalization,and *** A total of 1133 SC,154 LC,and 124 ME fractures were *** fractures had the highest percentage of operation at 83%,followed by LC(78%)and ME fractures(41%).Male patients were,on average,older than female patients for both SC and ME *** In the insurance claims databases used,SC fractures were the most reported,followed by LC fractures,and finally ME *** was identified to be a factor for how a pediatric distal humerus fractures,with patients with SC and LC fractures being younger than those with ME *** peak age per injury per sex was similar to reported historic central tendencies,despite reported trends for younger physiologic development.

关键词： Supracondylar humerus fracture Lateral condyle fracture Medial epicondyle fracture Pediatric elbow Truven Epidemiology

Clinical/Behavioral Monitoring of Rodents and Rabbits Undergoing Scientific Experiments

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Open Journal of Veterinary Medicine 2024年第5期14卷 91-109页

作者： Luiz Cesar Cavalcanti Pereira Jhônata Willy Rocha Coelho Hyago da Silva Medeiros Elidio Rita de Cássia dos Passos Ferraz Da Silva João Gabriel Regis Sobral Bárbara Alves de Brito Soledade Leandro Thomaz Vilela Isabele Barbieri Dos Santos Institute of Science and Technology in Biomodels (ICTB) Oswaldo Cruz Foundation (FIOCRUZ) Rio de Janeiro Brazil Laboratory Animal Facility of the Carlos Chagas Pavilion of the Animal Experimentation Center (CEA) Oswaldo Cruz Institute (IOC) Oswaldo Cruz Foundation (FIOCRUZ) Rio de Janeiro Brazil

Background: We currently have international and national guidelines regarding the assessment and monitoring of clinical signs and humane endpoints in animals used in teaching and research, which make the performance of these activities mandatory for any experiment and professional working in this area. Assigning the severity of a research experiment is the result of an analysis of records of observations of the animal’s behavior, and clinical signs. The aim of this study was to describe the importance of carrying out a severity assessment associated with clinical and behavioral monitoring of rodents and rabbits during experimentation to maintain the welfare of these animals undergoing scientific research. Methods: The literature search was carried out using the following terms: “Monitoring”;“Humane endpoints”;“Animal welfare”, “Rodents”;“Rabbits”, and as connectors “and”;“or”, in the following databases: PubMed;LILACS/BIREME and SciELO. Results: A total of 987 articles were identified in the databases, and 20 of these studies were included in this review. Conclusions: Humane endpoint protocols and procedure severity tables are of the utmost importance, both from an ethical point and to refine the results of research conducted on laboratory animals. They should be drawn up jointly by the teams responsible for the project and the maintenance of the animals during the research period, and the data obtained should be published so that the scientific community can have access to it, helping to disseminate these practices, as well as helping to draw up new procedures. Monitoring and evaluating the welfare and clinical condition of animals undergoing scientific research procedures is the responsibility of the professors, researchers, veterinarians, and animal facility coordinators. The Ethics Committee on the Use of Animals must monitor all the activities conducted with the animals, by inspecting the experimental procedures and the physical environment of the laboratory an

关键词： Monitoring Humane Endpoints Animal Welfare Experimental Design Laboratory Animals’ Investigations

Neuroimmune,clinical and treatment challenges in multiple sclerosis-related psychoses

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World Journal of Psychiatry 2023年第4期13卷 161-170页

作者： Katarina Vesic Aleksandar Gavrilovic nataša R Mijailović Milica M Borovcanin Department of Neurology University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Department of Pharmacy University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia Department of Psychiatry University of KragujevacFaculty of Medical SciencesKragujevac 34000SumadijaSerbia

In recent years,epidemiological and genetic studies have shown an association between autoimmune diseases and *** question arises whether patients with schizophrenia are more likely to develop multiple sclerosis(MS)later in *** is well known that the immune system plays an important role in the etiopathogenesis of both *** disturbances may be similar or very different in terms of different types of immune responses,disturbed myelination,and/or immunogenetic predispositions.A psychotic symptom may be a consequence of the MS diagnosis itself or a separate *** this review article,we discussed the timing of onset of psychotic symptoms and MS and whether the use of corticosteroids as therapy for acute relapses in MS is unfairly neglected in patients with psychiatric *** addition,we discussed that the anti-inflammatory potential of antipsychotics could be useful and should be considered,especially in the treatment of psychosis that coexists with *** disorders could precipitate psychotic symptoms,and in this context,autoimmune psychosis must be considered as a persistent symptomatology that requires continuous and specific treatment.

关键词： Multiple sclerosis Psychosis Schizophrenia Corticosteroids Antipsychotics

Biochemical and Physiological Responses of Arabidopsis thaliana Leaves to Moderate Mechanical Stimulation

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Phyton-International Journal of Experimental Botany 2023年第3期92卷 901-920页

作者： Iva Šutevski Klara Krmpotić Sandra Vitko nataša Bauer Eva Fancev Mario Cifrek Željka Vidaković-Cifrek Department of Biology Faculty of ScienceUniversity of ZagrebZagreb10000Croatia Faculty of Electrical Engineering and Computing University of ZagrebZagreb10000Croatia

Mechanical stimulation of plants can be caused by various abiotic and biotic environmental *** from the negative consequences,it can also cause positive changes,such as acclimatization of plants to stress ***,it is necessary to study the physiological and biochemical mechanisms underlying the response of plants to mechanical *** aim was to evaluate the response of model plant Arabidopsis thaliana to a moderate force of 5 N(newton)for 20 s,which could be compared with the pressure caused by animal movement and weather conditions such as heavy *** stimulated leaves were sampled 1 h after exposure and after a recovery period of 20 *** study a possible systemic response,unstimulated leaves of treated plants were collected 20 h after exposure alongside the stimulated leaves from the same *** effect of stimulation was assessed by measuring oxidative stress parameters,antioxidant enzymes activity,total phenolics,and photosynthetic *** leaves showed increased lipid peroxidation 1 h after treatment and increased superoxide dismutase activity and phenolic oxidation rate after a 20-h recovery *** photosynthetic performance after the 20-h recovery period,the effective quantum yield of the photosystem II was lower in the stimulated leaves,whereas photochemical quenching was lower in the unstimulated leaves of the treated *** quenching was lower in the stimulated leaves 1 h after *** study suggested that plants sensed moderate force,but it did not induce pronounced change in metabolism or photosynthetic *** component analysis distinguished three groups–leaves of untreated plants,leaves analysed 1 h after stimulation,while stimulated and unstimulated leaves of treated plants analysed 20 h after treatment formed together the third *** grouping of stimulated and unstimulated leaves of treated plants could indicate signal transducti

关键词： Arabidopsis thaliana mechanical stimulation oxidative stress antioxidant enzymes photosynthetic performance systemic response

Choroidal thickening with serous retinal detachment in BRAF/MEK inhibitor-induced uveitis:A case report

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World Journal of Clinical Cases 2022年第19期10卷 6536-6542页

作者： Peter Kiraly Alenka Lavrič Groznik nataša Vidovič Valentinčič Polona Jaki Mekjavić Mojca Urbančič Janja Ocvirk Tanja Mesti Eye Hospital University Medical Centre LjubljanaGrablovičeva 46SI-1000 LjubljanaSlovenia Oxford Eye Hospital Oxford University Hospitals NHS Foundation TrustOX39DUOxfordUnited Kingdom Department of Medical Oncology Institute of Oncology LjubljanaFaculty of MedicineUniversity of LjubljanaLjubljana 1000Slovenia

BACKGROUND Immune checkpoint inhibitors have revolutionized the treatment of patients with unresectable metastatic malignant *** addition to systemic side effects,several usually mild ocular adverse effects have been *** report a case of rarely reported vision-threatening bilateral panuveitis with serous retinal detachment,thickened choroid,and chorioretinal folds associated with dabrafenib and trametinib targeted therapy for B-Raf proto-oncogene serine/threonine kinase(BRAF)mutant metastatic cutaneous *** SUMMARY A 59-year-old female patient with metastatic melanoma treated with dabrafenib and trametinib presented with blurry vision and central scotoma lasting for 3 d in both *** examination and multimodal imaging revealed inflammatory cells in the anterior chamber,mild vitritis,bullous multiple serous retinal detachments,and chorioretinal folds in both *** with dabrafenib and trametinib was suspended,and the patient was treated with topical and intravenous corticosteroids followed by oral corticosteroid treatment with a tapering *** and a half months after the disease onset,ocular morphological and functional improvement was *** to the metastatic melanoma dissemination,BRAF/mitogen-activated protein kinase inhibitors were reintroduced and some mild ocular adverse effects reappeared,which later subsided after receiving oral *** Patients on combination therapy with dabrafenib and trametinib may rarely develop severe bilateral panuveitis with a good *** studies have to establish potential usefulness of ophthalmological examination for asymptomatic ***,appropriate guidelines for managing panuveitis associated with dabrafenib and trametinib should be established.

关键词： Metastatic melanoma treatment BRAF/MEK inhibitors Dabrafenib and trametinib Ocular adverse effects Bilateral panuveitis Case report

Epidemiology of shoulder dislocations presenting to United States emergency departments:An updated ten-year study

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世界骨科杂志:英文版 2023年第9期14卷 690-697页

作者： Cole M Patrick Josiah Snowden Michael D Eckhoff Clare K Green John P Scanaliato John C Dunn nata Parnes Department of Orthopaedics William Beaumont Army Medical CenterFort BlissTX 79918United States Burnett School of Medicine Texas Christian UniversityFort WorthTX 76129United States School of Medicine and Health Sciences George Washington UniversityWashingtonWA 20052United States Department of Orthopaedic Surgery Carthage Area HospitalCarthageNY 13619United States

BACKGROUND Glenohumeral dislocation is a common injury that may predispose patients to chronic pain and ***,there is a paucity of current data available regarding the epidemiological trends of this *** To provide an updated,comparative assessment of the epidemiology of shoulder dislocations presenting to emergency departments in the United *** also sought to analyze patient demographic risk factors and consumer products associated with dislocation *** Data were obtained from the national electronic injury surveillance system database for glenohumeral dislocations between 2012 and ***,age,sex,and injury characteristics were analyzed using weighted population statistics as well as incidence rates and 95%confidence intervals(CI).RESULTS In total,an estimated 773039 shoulder dislocations(CI:640598-905481)presented to emergency rooms across the United States during the study *** annual incidence rate was 23.96 per 100000 persons and the average patient age at the time of injury was 37.1 *** more male patients sustained dislocations than female patients(537189,69.5%,vs 235834,30.5%,P<0.001).With regard to associated consumer products,sports and recreation equipment were involved in the highest proportion of incidents(44.31%),followed by home structures and construction materials(21.22%),and home furnishings,fixtures,and accessories(21.21%).Regarding product sub-groups,stairs,ramps,landings,floors was cited in the greatest number of cases(131745).CONCLUSION The national annual incidence rate of glenohumeral dislocations throughout the study period was approximately 23.92 per 100000 *** adolescents sustained the highest proportion of dislocations,with a peak incidence in age group 15-20 years,predominantly secondary to participation in sporting and recreational ***,women experienced a relatively consistent incidence of dislocation throughout their *** age 63,the i

关键词： Shoulder dislocation Epidemiology United States Emergency department Glenohumeral dislocation national electronic injury surveillance system

Pentadecapeptide BPC 157 and the central nervous system

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Neural Regeneration Research 2022年第3期17卷 482-487页

作者： Jakša Vukojević Marija Milavić Darko Perović Spomenko Ilić Andrea ZembaČilić natašaĐuran SanjaŠtrbe Zoran Zoričić Igor Filipčić Petrana Brečić Sven Seiverth Predrag Sikirić Department of Pharmacology Medical SchoolUniversity of ZagrebZagrebCroatia Department of Pathology Medical SchoolUniversity of ZagrebZagrebCroatia University Clinical Hospital Center“Zagreb” ZagrebCroatia University Psychiatric Hospital“Vrapče” ZagrebCroatia University Clinical Hospital Center“Sestre Milosrdnice” ZagrebCroatia Psychiatric Hospital“Sveti Ivan” ZagrebCroatia

We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157,three very recent demonstrations that may be essential in the gut-brain and braingut axis operation,and therapy application in the central nervous system disorders,in ***,given in the reperfusion,BPC 157 counteracted bilateral clamping of the common carotid arteries-induced stroke,sustained brain neuronal damages were resolved in rats as well as disturbed memory,locomotion,and *** therapy effect supports particular gene expression in hippocampal tissues that appeared in BPC 157-treated ***,there are L-NG-nitro arginine methyl ester(L-NAME)-and haloperidol-induced catalepsy as well as the rat acute and chronic models of 'positivelike' schizophrenia symptoms,that BPC 157 counteracted,and resolved the complex relationship of the nitric oxide-system with amphetamine and apomorphine(dopamine agents application),MK-801(non-competitive antagonist of the N-methyl-D-aspartate receptor) and chronic methamphetamine administration(to induce sensitivity).Thirdly,after rat spinal cord compression,there were advanced healing and functional recovery(counteracted tail paralysis).Likewise,in BPC 157 therapy,there is specific support for each of these topics:counteracted encephalopathies;alleviated vascular occlusion disturbances(stroke);counteracted dopamine disturbances(dopamine receptors blockade,receptors super sensitivity development,or receptor activation,over-release,nigrostriatal damage,vesicles depletion),and nitric oxide-system disturbances("L-NAME non-responsive,L-arginine responsive," and "L-NAME responsive,L-arginine responsive")(schizophrenia therapy);inflammation reduction,nerve recovery in addition to alleviated hemostasis and vessels function after compression(spinal cord injury therapy).Thus,these disturbances may be all resolved within the same agent's beneficial activity,i.e.,the stable gastric pentadecapeptide BPC 157.

关键词： BPC 157 central nervous system cytoprotection injury nitric oxide system peptide regeneration