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Use of Initial Modified RECIST Tumor Response Evaluation Criteria for Predicting Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization with Drug-Eluting Beads

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Journal of Cancer Therapy 2015年第13期6卷 1115-1123页

作者： nat.lia Sousa Freitas Queiroz Luciana Kikuchi Regis Otaviano Franca Bezerra Regiane S. S. M. Alencar Aline Lopes Chagas Cláudia Megumi Tani Márcio Augusto Diniz Aline Cristine Barbosa Santos Airton Mota Moreira Manoel de Souza Rocha Luiz Augusto Carneiro D’Albuquerque Francisco César Carnevale Flair José Carrilho Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Gastroenterology University of Sao Paulo School of Medicine Sao Paulo Brazil Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Radiology University of Sao Paulo School of Medicine Sao Paulo Brazil

Introduction: Transarterial chemoembolization (TACE) reduces tumor growth and increases survival in patients with hepatocellular carcinoma (HCC). Drug-eluting beads (DEB) deliver slow-release chemotherapy and reduce systemic toxicity during TACE. This study correlated initial tumor response according to modified RECIST (mRECIST) criteria and 1-year survival in patients with HCC treated with TACE-DEB, and identified predictors of tumor response. Methods: Fifty-two patients with HCC received TACE-DEB loaded with doxorubicin 75 mg during a 6-month period. Tumor response was evaluated 1 month after the procedure according to mRECIST criteria. Results: Most patients were cirrhotic and etiology of liver disease was hepatitis C in 26/52 (50%). Similar numbers of patients had Barcelona Clinic Liver Cancer (BCLC) A and BCLC B disease. Most patients had one nodule (66%). Complete response (CR) was achieved in 12/52 (23%), partial response in 19/52 (37%), stable disease in 4/52 (8%) and progressive disease in 17/52 (32%). Largest HCC ≤58 mm and BCLC stage A were associated with CR. The 1-year survival was 74%, with survival rates of 95% and 56% in the BCLC A and B groups, respectively. Variables reflecting tumor extension were associated with better survival. CR according to mRECIST criteria was a predictor of better 1-year survival (100% vs. 64%, P < 0.05). Conclusion: BCLC A and CR according to mRECIST criteria predict improved 1-year survival in patients with HCC treated with TACE-DEB. Further studies are needed to evaluate other predictors of survival and to determine if tumor response predicts long-term survival.

关键词： Hepatocellular Carcinoma mRECIST Criteria Transarterial Chemoembolization Overall Survival Drug-Eluting Beads

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Arboviruses and Sexually Transmitted Infections in the Bioceanic Route: Health Indicators in a Municipality

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Advances in Infectious Diseases 2021年第4期11卷 344-356页

作者： Paloma Almeida Kowalski João Pedro Arantes da Cunha Erika Kaneta Ferri nat.lia Scigliano Rachel Carvalho Lemos Emily Ruiz Cavalcante Vitor Keisi Medeiros Kataoka Fabiana Moreira Coutinho Elton Hiroyuki Ytamura Moriya Leonardo Marzola Hirata Gabriela Félix Dias Lima Letícia Roque Ribeiro Lucas Matheus Pinto Sávio Carvalho Cobianchi Paulo Otávio Souza Leonel State University of Mato Grosso do Sul (UEMS—UniversidadeEstadual de Mato Grosso do Sul) Campo Grande MS Brazil Federal University of Mato Grosso do Sul (UFMS—Universidade Federal de Mato Grosso do Sul) Campo Grande MS Brazil University for the Development of the State and Region of the Pantanal (UNIDERP—Universidade para o Desenvolvimento do Estado e da Regiã o do Pantanal) Campo Grande MS Brazil

Background: the physical integration of South America through a Bioceanic Corridor has been idealized for a long time by the countries that make up Mercosur. This integration will have impacts on the population residing in the cities where the route will be built. Among them, Porto Murtinho, southern Mato Grosso on the border with Paraguay, stands out, where a bridge will be built over the Paraguay River that will link these two countries. Methods: a retrospective, quantitative and cross-sectional study of a descriptive type of documentary approach that sought to analyze the prevalence of arboviruses, Sexually Transmitted Infections (STIs) and Diseases Related to Inadequate Environmental Sanitation (DRIES) notified and stored in the national System of Notifiable Diseases (SINAN). The sample consisted of new cases of these pathologies in the municipality of Porto Murtinho registered between January 2017 and December 2020. Results: there was an increase of 10% in the total number of diseases within this period. The number of dengue cases increased 36 times;the incidence of Syphilis, HIV and HPV decreased;and, finally, maintenance of cases of Gonorrhea, Leptospirosis, Yellow Fever, Zika, Chikungunya, Hepatitis A and B. Conclusions: actions are needed to prevent the increase of these pathologies together with the construction of the Bioceanic Route, thus avoiding damage population health and increased consumption of government resources.

关键词： Bioceanic Route Epidemiology Public Health Sexually Transmitted Diseases Arboviruses

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Development of a Ready-to-Use PSMA-11 Kit Formulation and Biological Evaluation of Binding Affinity

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Advances in Molecular Imaging 2024年第2期13卷 7-22页

作者： Maria Renata Valente Brandão Freire nat.lia Marchesan Bexiga Marco Antonio Stephano João Ezequiel Oliveira Carlos Roberto Jorge Soares Ana Cláudia Camargo Miranda Anna Carolina de Alcântara Barbosa Marycel Figols de Barboza Laura Fernanda Garcia Luiz Felipe S. Teixeira Maria Helena Marumo Bellini natanael Gomes da Silva Luiza Mascarenhas Balieiro Joel Mendes Elaine Bortoleti de Araújo Centro de Radiofarmcia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Tecnologia Farmacutica Faculdade de Cincias Farmacuticas (USP) Cidade Universitria So Paulo Brasil Centro de Biotecnologia Instituto de Pesquisas Energticas e Nucleares (IPEN) Cidade Universitria So Paulo Brasil Departamento de Medicina Nuclear do Hospital Israelita Albert Einstein So Paulo/SP Brasil

Introduction: 68Ga-PSMA-11 is considered the gold standard in detection of micro and oligometastases in advanced prostate cancer, being used for therapeutic planning, as well as, potentially, for evaluating response to treatment. The development of ready-to-use lyophilized kit of PSMA-11 adds quality and safety to the routine use of this radiopharmaceutical and represents a pharmacotechnical challenge as it must preserve the integrity and specificity of the ligand. Methods: PSMA-11 kit formulation was proposed, considering radiolabeling parameters and the preservation of the peptide during the lyophilization process, using mannitol as an excipient. Critical temperature characterization studies were carried out using DSC equipment and the freeze-drying process was developed. The direct radiolabeling conditions were evaluated and standardized using 68Ge/68Ga generator eluate from two different manufacturers (ITG and Eckert & Ziegler). The radiochemical purity was evaluated by TLC and HPLC. Biological evaluation was carried out with lyophilized PSMA-11 to demonstrate the integrity of the peptide and preservation of biological activity after the lyophilization process. Results: Based on critical temperature characterization studies, the freeze-drying cycle was designed to reach a freezing temperature of around −40˚C and primary drying at 2˚C. Using 20 mg of mannitol, an intact and elegant lyophilized cake was obtained. PSMA-11 lyophilized kit was directly labeled with 68Ga eluate from 68Ge/68Ga GMP generators (ITG and Eckert & Ziegler) resulting in % RP > 95% at pH 4.0 to 4.5. The results obtained from in vitro and in vivo biological competition studies confirmed the preservation of PSMA-11 affinity for the receptor after lyophilization. Conclusion: A lyophilized formulation (Kit) of PSMA-11 was successfully obtained, which preserved the integrity and biological activity of the peptide and guaranteed radiolabeling efficiency.

关键词： 68Ga-PSMA-11 Prostate-Specific Membrane Antigen (PSMA) Ready-to-Use Kit GMP-Grade Generators Metastatic Prostate Cancer PET Imaging

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氮素改变辣椒初级代谢和薄壁组织厚度调控比叶面积研究

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辣椒杂志 2021年第3期19卷 36-48页

作者： Lucas de ávila Silva Rebeca P.Omena-Garcia Jorge A.Condori-Apfata Paulo Mafra de Almeida Costa nat.lia Machado Silva Fábio M.Da Matta Agustin Zsogon Wagner L.Araújo Edgard A.de Toledo Picoli Ronan Sulpice Adriano Nunes-Nesi 沈凌峰吉雪花(译) 不详石河子大学农学院乌鲁木齐832003

比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinens... 详细信息

比叶面积(SLA)是影响植物光截获和光利用效率的关键性状,常常影响植物的生长和产量。SLA是解释不同植物在不同环境下生长差异的一个关键性状。光照和氮素供应都是决定SLA的重要因素。为了更好地了解辐照度和氮素对辣椒(Capsicum chinense)SLA的影响,研究对两个中国辣椒商品种(Biquinho和Habanero)的初级代谢产物和形态特征进行了分析。两种基因型辣椒的SLA随着遮阴而增加,但随氮供应量的增加而下降;在氮素供应由缺乏到充足的范围内Habanero品种的SLA表现稳定。相关分析表明,高氮供应导致SLA降低是因为氨基酸、蛋白质和淀粉含量的调节,从而影响叶片密度。此外,在中度缺氮到充足供氮范围内,两种基因型辣椒的SLA表现出响应差异,Biquinho和Habanero分别在栅栏和海绵状薄壁组织上表现出差异。总之,结果表明,SLA对氮供应的反应是由某些代谢物含量和依赖于基因型的影响叶片厚度及密度的薄壁组织变化平衡调节的。

关键词：辣椒叶片形态和解剖结构组织密度遮阴

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Role of Cognitive Behavioral Therapy in Fibromyalgia: A Systematic Review

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第4期11卷 169-187页

作者： Heloisa Lima Heller Aline Rizzo Borges Luís Otávio Amarante Franco João Pedro De Oliveira Aucelio Marcos Igor Albanaz Vargas Rebeca Naoum Lorga Mirella Bastos Sales nat.lia Vargas Do Nascimento Gabriela Furlan Ribeiro Barbosa Netto Beatriz Carneiro Passos Beatriz Pires Paes Beatriz Toledo Mendes Bruna De Paula Gonçalves Sousa Lyra Ciro Moisés Oliveira Vieira Dos Santos Gustavo Araújo Do Nascimento Santos Maria Luiza Pimentel De Oliveira Matheus Macêdo Da Silva Maurício Silva De Jesus Paulo Ricardo Guimaraes Rocha Storni Tamires Martinelli De Oliveira Ferraz Viviane Cristina Uliana Peterle Ana Paula Monteiro Gomides Reis Centro Universitário de Brasília Brasília Brazil Universidade Católica de Brasília Brasília Brazil Centro Universitário Euro Americano Brasília Brazil

A literature search of articles from 2002-2019 was performed using Medline, Embase, Cochrane, LILACS, IBECS, CRD, and Epistemonikos databases, to analyze the effects of Cognitive-Behavioral Therapy (CBT) in the treatment of fibromyalgia. Twenty-seven articles were selected in which CBT was performed exclusively by specialist physicians, associated or not with conventional pharmacological treatment and/or physical exercise. In most articles, CBT worked with self-knowledge and cognitive restructuring, attempting to reduce pain perception, and it showed a general improvement in daily activities by decreasing patient’s limitations, such as morning stiffness. The literature showed significant correlations of CBT in pain processing over time. When CBT was compared to conventional pharmacological therapy, a certain superiority of CBT could be observed concerning the quality of life, catastrophizing, and acceptance of pain. However, when they were simultaneously applied, this improvement in quality of life was not observed.

关键词： Cognitive Behavioral Therapy Fibromyalgia Pain

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Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang Kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott XChang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu Karl JJobst Chengjun Ge Frederic Coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann Changer Chen Yang Song Concepcion Sanchez-Cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet Cheuk-Fung Law Chenggang Gu Huizhong Shen Yanpeng Gao Chao Qin Hao Li Tong Zhang nat.lia Corcoll Min Liu Daniel SAlessi Hui Li Kristian KBrandt Yolanda Pico Cheng Gu Jianhua Guo Jianqiang Su Philippe Corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin Yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde Cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin Chen Baoshan Xing Wulf Amelung Zongwei Cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias C.Rillig Fengchang Wu Gang Yu James M.Tiedje State Key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Department of Chemistry Hong Kong Baptist UniversityHong KongChina HKBU Institute of Research and Continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China Climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory of Environmental Theoretical Chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA Center for Reservoir and Aquatic Systems Research(CRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of Civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on Chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

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Disentangling spatial,environmental and historical effects on tropical forest tree species turnover

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Journal of Plant Ecology 2021年第4期14卷 717-729页

作者： Alisson Borges Miranda Santos Vinicius Andrade Maia Cleber Rodrigo de Souza nathalle Cristine Alencar Fagundes Fernanda Moreira Gianasi Aurelio de Jesus Rodrigues Pais nat.lia de Aguiar-Campos Gabriela Gomes Pires Diego Teixeira Girardelli Jean Daniel Morel Mariana Caroline Moreira Morelli Felipe de Carvalho Araujo Rubens Manoel dos Santos Department of Forestry Sciences Federal University of LavrasUniversity CampusLavrasBrazil Biological Sciences University of the State of Minas GeraisItuiutaba UnitItuiutabaBrazil Department of Biology Federal University of LavrasUniversity CampusLavrasBrazil Faculty of Environmental Engineering and natural Resources Zambeze UniversityChimoioMozambique

Aims We aimed at disentangling the effects of spatial distance,current and past environmental dissimilarity,and their combinations on tree community taxonomic and phylogenetic turnover by addressing the following questions:(i)Is tree community taxonomic and phylogenetic turnover related to the indirect effects of spatial distance via environmental dissimilarity?(ii)Does tree community taxonomic and phylogenetic turnover respond to paleoclimate(Last Glacial Maximum and Mid-Holocene)?Methods The study was carried out in 14 Atlantic rainforest sites in Brazil(20.4 ha sampled)containing 615 tree species from 83 plant *** obtained plot-level geographic coordinates and soil variables and site-level bioclimatic variables in the current,Mid-Holocene and Last Glacial *** used structural equation models with a distance-based approach to(i)test the direct effects of spatial distance and environmental dissimilarity and(ii)test the indirect effects of spatial distance via environmental dissimilarity on taxonomic(Bray–Curtis distance)and phylogenetic turnover(Comdist and Comdistnt distances).Important Findings Our results suggest a weak indirect effect of spatial distance via environmental dissimilarity on taxonomic and phylogenetic *** community turnover was driven by the direct effects of neutral,niche-based and historical ***,we inferred that the paleoclimate(historical processes)promoted the selection of the clades that gave rise to the current flora,while spatial distances(neutral processes)limited the dispersal range of species from the regional pool and environmental conditions(niche-based processes)locally selected the taxa that are able to persist.

关键词： assembly processes phylogenetic communities environmental filtering neutral communities phylogenetic turnover ecological niche paleoclimate effects

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