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How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician

World Journal of Gastroenterology 2021年第11期27卷 1022-1042页

作者： Júlio Maria Fonseca Chebli natália sousa freitas queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra Division of Gastroenterology Department of MedicineInflammatory Bowel Disease CenterFederal University of Juiz de ForaJuiz de Fora 36036-900MGBrazil Department of Gastroenterology University of São Paulo School of MedicineSão Paulo 05403-000SPBrazil Department of Clinical Medicine Fluminense Federal UniversityRio de Janeiro 24210-200RJBrazil Department of Surgery and Anatomy Ribeirão Preto Medical SchoolUniversity of São PauloRibeirão Preto 14048-900SPBrazil

Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly *** particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with *** patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of *** this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic.

关键词： Inflammatory bowel disease SARS-CoV-2 COVID-19 Crohn disease Colitis ulcerative Biological therapy

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Risk stratification and geographical mapping of Brazilian inflammatory bowel disease patients during the COVID-19 outbreak:Results from a nationwide survey

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World Journal of Gastroenterology 2021年第12期27卷 1226-1239页

作者： natália sousa freitas queiroz Fábio Vieira Teixeira Marina Pamponet Motta Liliana Andrade Chebli Adriano Akira Ferreira Hino Camilla de Almeida Martins Abel Botelho Quaresma Alexandre Augusto de Paula da Silva Adérson Omar Mourão Cintra Damião Rogerio Saad-Hossne Paulo Gustavo Kotze Department of Gastroenterology University of São Paulo School of MedicineSão Paulo 05403-000SPBrazil IBD Unit Gastroenterology DepartmentGastrosaúde ClinicMarilia 17509190SPBrazil School of Medicine Federal University of BahiaSalvador 40020-025BHBrazil IBD Outpatient Clinics Universidade Federal de Juiz de ForaJuiz de Fora 36010-010MGBrazil Health Sciences Postgraduate Program Pontifícia Universidade Católica do Paraná(PUCPR)Curitiba 80440-220PRBrazil Departamento de Ciências da Saúde Universidade do Oeste de Santa Catarina(UNOESC)Joaçaba 89600-000SCBrazil Botucatu Medical School Paulista State University(UNESP)Botucatu 18600-050SPBrazil IBD Outpatient Clinics Pontificia Universidade Católica do Paraná(PUCPR)Curitiba 80440-220PRBrazil

BACKGROUND Coronavirus disease 2019(COVID-19)pandemic is still evolving globally,and Brazil is currently one of the most affected *** is still debated whether patients with inflammatory bowel disease(IBD)are at a higher risk for developing COVID-19 or its *** To assess geographical distribution of IBD patients at the highest risk and correlate these data with COVID-19 mortality rates in *** The Brazilian IBD Study Group(Grupo de Estudos da Doença Inflamatória Intestinal do Brasil)developed a web-based survey adapted from the British Society of Gastroenterology *** included categories were demographic data and inquiries related to risk factors for complications from *** were categorized as highest,moderate or lowest individual *** Spearman correlation test was used to identify any association between highest risk and mortality rates for each state of the *** A total of 3568 patients(65.3%females)were *** participants were from the southeastern and southern regions of Brazil,and 84.1%were using immunomodulators and/or *** patients(55.1%)were at moderate risk,23.4%were at highest risk and 21.5%were at lowest risk of COVID-19 *** association between the proportion of IBD patients at highest risk for COVID-19 complications and higher mortality rates was identified in different Brazilian states(r=0.146,P=0.467).CONCLUSION This study indicates a distinct geographical distribution of IBD patients at highest risk for COVID-19 complications in different states of the country,which may reflect contrasting socioeconomic,educational and healthcare *** association between high risk of IBD and COVID-related mortality rates was identified.

关键词： Crohn’s disease Colitis,Ulcerative COVID-19 Inflammatory bowel disease Brazil

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Use of Initial Modified RECIST Tumor Response Evaluation Criteria for Predicting Survival in Patients with Hepatocellular Carcinoma Undergoing Transarterial Chemoembolization with Drug-Eluting Beads

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Journal of Cancer Therapy 2015年第13期6卷 1115-1123页

作者： natália sousa freitas queiroz Luciana Kikuchi Regis Otaviano Franca Bezerra Regiane S. S. M. Alencar Aline Lopes Chagas Cláudia Megumi Tani Márcio Augusto Diniz Aline Cristine Barbosa Santos Airton Mota Moreira Manoel de Souza Rocha Luiz Augusto Carneiro D’Albuquerque Francisco César Carnevale Flair José Carrilho Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Gastroenterology University of Sao Paulo School of Medicine Sao Paulo Brazil Sao Paulo Clínicas Liver Cancer Group Instituto do Cancer do Estado de Sao Paulo Hospital das Clínicas Department of Radiology University of Sao Paulo School of Medicine Sao Paulo Brazil

Introduction: Transarterial chemoembolization (TACE) reduces tumor growth and increases survival in patients with hepatocellular carcinoma (HCC). Drug-eluting beads (DEB) deliver slow-release chemotherapy and reduce systemic toxicity during TACE. This study correlated initial tumor response according to modified RECIST (mRECIST) criteria and 1-year survival in patients with HCC treated with TACE-DEB, and identified predictors of tumor response. Methods: Fifty-two patients with HCC received TACE-DEB loaded with doxorubicin 75 mg during a 6-month period. Tumor response was evaluated 1 month after the procedure according to mRECIST criteria. Results: Most patients were cirrhotic and etiology of liver disease was hepatitis C in 26/52 (50%). Similar numbers of patients had Barcelona Clinic Liver Cancer (BCLC) A and BCLC B disease. Most patients had one nodule (66%). Complete response (CR) was achieved in 12/52 (23%), partial response in 19/52 (37%), stable disease in 4/52 (8%) and progressive disease in 17/52 (32%). Largest HCC ≤58 mm and BCLC stage A were associated with CR. The 1-year survival was 74%, with survival rates of 95% and 56% in the BCLC A and B groups, respectively. Variables reflecting tumor extension were associated with better survival. CR according to mRECIST criteria was a predictor of better 1-year survival (100% vs. 64%, P < 0.05). Conclusion: BCLC A and CR according to mRECIST criteria predict improved 1-year survival in patients with HCC treated with TACE-DEB. Further studies are needed to evaluate other predictors of survival and to determine if tumor response predicts long-term survival.

关键词： Hepatocellular Carcinoma mRECIST Criteria Transarterial Chemoembolization Overall Survival Drug-Eluting Beads

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Analysis of the Performance of Optical Code-Division Multiple-Access System(OCDMA),Operating with Gold Codes under Nonlinear Effects

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Journal of Electromagnetic Analysis and Applications 2013年第2期5卷 49-57页

作者： Glendo de freitas Guimaraes Agliberto Melo Bastos Alisson da Conceicao Ferreira Alex Sander Barros queiroz Jose Wally Mendonca Menezes Jose Rubens Rodrigues de sousa Antonio Sergio Bezerra Sombra Laboratorio de Telecomunicacoes e Ciencia e Engenharia dos Materiais(LOCEM) Departamento de FisicaUniversidade Federal do Ceara(UFC)FortalezaBrazil Laboratorio Especializado em Sistema de Telecomunicacoes e Ensino(LESTE) Departamento de TelematicaInstituto Federal do Ceara(IFCE)Campus FortalezaFortalezaBrazil Grupo de Fisica Aplicada e Docencia(GFAD) Instituto Federal do Ceara(IFCE)Campus SobralSobralBrazil Departamento de Engenharia de Teleinformatica(DETI) Centro de TecnologiaUniversidade Federal do Ceara(UFC)FortalezaBrazil Departamento de Engenharia de Energias Universidade da Integracao Internacional da Lusofonia Afro-Brasileira(UNILAB)RedencaoBrazil

A numerical simulation study of the performance of encoding and decoding of short optical pulse in OCDMA (Optical Code Division Multiple Access) systems under non-linear optical effects is presented. The performance of encoding and decoding short pulses is obtained through use of device FBG (fiber Bragg grating) where the codes are inserted through discrete jumps in the optical phase (±π). The multiuser interference is also the object of the present study, where a figure of merit (interference figure) is used to quantify the interference in multiuser auto and cross correlation. We evaluate the dependence of the multiuser interference for the coupling constant of FBG. Finally, the interference inserted in the autocorrelation due to nonlinear effects generated in the nonlinear switching of the coded pulse in a dual core nonlinear directional coupler is examined, where temporal broadening of pulses decoded is observed.

关键词： Fiber Bragg Grating Gold Code OCDMA All-Optical Digital Processing of Signals

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Transpiration and growth responses by Eucalyptus species to progressive soil drying

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Journal of Forestry Research 2022年第5期33卷 1529-1543页

作者： Marcel Carvalho Abreu Alvaro Augusto Vieira Soares Cleverson Henrique de freitas Fabrina Bolzan Martins Department of Environment Science Forest InstituteFederal Rural University of Rio de JaneiroSeropédicaRio de Janeiro 23890-000Brazil Institute of Agricultural Sciences Federal University of UberlândiaMonte CarmeloMinas Gerais 38405-302Brazil “Luiz de queiroz”College of Agriculture University of São PauloPiracicabaSão Paulo 13418-900Brazil natural Resources Institute Federal University of ItajubáItajubáMinas Gerais 37500-903Brazil

The regulation of plant transpiration is a key factor affecting transpiration efficiency, growth and adaptation of Eucalyptus species to limited water availability in tropical and subtropical environments. However, few studies have related this trait to the performance of Eucalyptus seedlings and none have investigated the influence of vapor pressure deficit (VPD) on transpiration rates and growth. In this study, the transpiration and growth responses of seedlings of Eucalyptus urophylla (S.T. Blake) and Eucalyptus cloeziana (F. Muell.) to progressive soil water deficits were evaluated under semi-controlled conditions using the fraction of transpirable soil water (FTSW) method. In addition, the influence of VPD on seedling transpiration, development and growth was also investigated. The FTSW threshold ranged from 0.40 to 0.99 for the transpiration rate and from 0.32 to 0.97 for the development and growth variables. Little or no changes in the FTSW threshold were detected in response to changes in atmospheric VPD. Both Eucalyptus species presented a conservation strategy under drought stress. In addition, water-conserving mechanisms during the seedling phase were related to rapid stomatal closure, reduced leaf area, and number of leaves.

关键词： Soil water deficit Fraction of transpirable soil water Transpiration Seedling growth Vapor pressure deficit

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Nurse Leaders’ Challenges Fighting the COVID-19 Pandemic: A Qualitative Study

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Open Journal of Nursing 2021年第5期11卷 267-280页

作者： Juliana S. freitas Ana L. queiroz Isabelle M. Bortotti Cláudia R. Laselva Eliseth R. Leão Hospital Israelita Albert Einstein S&#227 o Paulo Brazil

Nursing leaders play a pivotal role in managing the COVID-19 pandemic. Aiming to describe the challenges of nursing leaders and the solutions implemented to face the coronavirus pandemic in a Brazilian hospital we developed this qualitative study. Six tactical nursing leaders were recruited by convenience and responded via audio recordings to two open-ended questions: 1) What challenges have you experienced and what solutions have you implemented related to physical, human, and technological resources during the COVID-19 pandemic? and 2) What challenges have you experienced and what solutions have you implemented in relation to patient and staff safety during the COVID-19 pandemic? All audio files were transcribed, anonymized, and analyzed using inductive content analysis. We identified two main categories of challenges: the first, concerning the changes and challenges in the face of an unknown disease;the second category, consisting of an evaluation of the experiences lived by the nursing leaders. Numerous solutions were implemented in response to the challenging scenario. The technical competence and systemic view of nursing leaders were vital to face the challenges and develop solutions to ensure the quality of care provided and the safety of the workforce, patients, and families.

关键词： COVID-19 Emerging Infectious Disease Leadership Nursing Healthcare

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Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus

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World Journal of Hepatology 2020年第4期12卷 137-148页

作者： Cliviany Borges da Silva Diego Alves Vieira Luisa freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva Sciences Applied to Adult Health Care Post-Graduate Programme Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Outpatient Clinic of Viral Hepatitis Instituto Alfa de GastroenterologiaFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Medical undergraduate student Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Laboratory of Research in Bacteriology Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Department of Internal Medicine Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Division of Endocrinology Department of Internal MedicineFaculdade de MedicinaUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil Epidemiology of Infectious and Parasitic Diseases Laboratory Department of ParasitologyInstitute of Biological SciencesUniversidade Federal de Minas GeraisBelo Horizonte 30130100Minas GeraisBrazil

BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes *** the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune *** serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C *** To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same *** between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC *** Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively *** 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes ***,biochemical,histological and radiological methods were used for the diagnosis of the liver ***-6 polymorphism was evaluated by Taqman SNP genotyping *** data were analysed by logistic regression *** Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,*** frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C *** identification of potential inflammatory mediato

关键词： Chronic Hepatitis C Type 2 diabetes mellitus Interleukin 6-174G/Cgenepromoter single nucleotide polymorphism Blood hypertension Healthy control subjects

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A soil quality index for subtropical sandy soils under different Eucalyptus harvest residue managements

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Journal of Forestry Research 2023年第1期34卷 243-255页

作者： Jackson freitas Brilhante de Sao José Maurício Roberto Cherubin Luciano Kayser Vargas Bruno Brito Lisboa Josiléia Acordi Zanatta Elias Frank Araújo Cimélio Bayer Department of Agricultural Research and Diagnosis Agriculture SecretariatLivestock and Rural Development of Rio Grande do Sul.570Goncalves Dias St.Porto AlegreRio Grande do SulBrazil Department of Soil Science “Luiz de Queiroz”College of Agriculture/University of Sao PauloPadua Dias Ave 11PiracicabaSao PauloBrazil Embrapa Floretas Estrada da Ribeirakm 111ColomboParanáBrazil CMPC Celulose RiograndenseSao Geraldo St.GuaíbaRio Grande do Sul 1680Brazil Department of Soil Science Federal University of Rio Grande do SulPorto AlegreBrazil

Eucalyptus harvest residues are attractive energy production resources for the forestry ***,their removal can have adverse impacts on soil quality and forest productivity,especially in sandy *** this study,we assessed the effects of Eucalyptus harvest residue managements with variable intensity on forest productivity and on physical,chemical,and biological indicators of the soil *** experiment was conducted in a Quartzipsamment(33 g kg-1clay)planted with Eucalyptus saligna in Barra do Ribeiro in southern *** the Eucalyptus was planted,residues from the previous rotation were subjected to five different management treatments:(1)FRM,in which all forest residues(bark,branches,leaves,and litter)were allowed to remain on the soil and only trunk wood was removed;(2)FRMB,in which was identical to FRM except that bark was also removed;(3)FRMBr,in which only trunk wood and branches were removed;(4)FRR,which involved removing all types of residues(bark,branches,leaves,and litter);and,(5)FRRs,in which all forest residues from the previous rotation were removed,and leaves and branches from the new plantation were prevented from falling onto the soil surface using a shade *** years after planting,soil samples were collected at four different depths(0-2.5,2.5-5,5-10,and 10-20 cm)to determine 17 soil chemical,physical,and biological *** results were combined into a soil quality index(SQI)using the principal component analysis *** SQI reduced by 30%,in the 0-20 cm layer,due to removal of harvest residues from the previous rotation,and collection of litter before it falls on the *** main drivers of SQI reduction were the principal components associated with soil organic matter and biological ***,the SQI was positively linearly related to tree height at P<0.01 and to tree diameter at breast height at P=*** adverse impact on soil quality and forest productivity in our study indicates that removal

关键词： Forest residues Soil health Soil organic carbon Microbial biomass Soil conservation

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Selection of Bacillus thuringiensis strains in citrus and their pathogenicity to Diaphorina citri (Hemiptera: Liviidae) nymphs

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Insect Science 2020年第3期27卷 519-530页

作者： Silvia de Oliveira Dorta Juliana Balbinotte Rose Monnerat Joao Roberto Spotti Lopes Tatiane da Cunha Odimar Zanuzo Zanardi Marcelo Pedreira de Miranda Marcos Antonio Machado Juliana de freitas-Astua Programs de Pos-Graduagao em Microbiologia Agricola Escola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Laboratorio de Biotecnologia Centro de Citricultura Sylvio MoreiraInstituto Agronomico de CampinasCordeiropolisSPBrazil Laboratorio de Insetos Vetores de Fitopatdgenos Departamento de Entomologia e AcarologiaEscola Superior de Agricultura Luiz de QueirozUniversidade de Sao PauloPiracicabaSPBrazil Embrapa Recursos Geneticos e Biotecnologia BrasiliaDFBrazil Fundo de Defesa da Citricultura(Fundecitrus) AraraquaraSPBrazil Embrapa Mandioca e Fruticultura Cruz das AlmasBABrazil Laboratdrio de Bioquimica Fitopatoldgica Instituto BioldgicoSao PauloSPBrazil

Bacillus thuringiensis(Bt)toxins are effective in controlling insect pests either through the spraying of products or when expressed in transgenic *** discovery of endophytic Bt strains opened new perspectives for studies aimed at the control of sap‐sucking insects,such as the Asian citrus psyllid Diaphorina citri Kuwayama(Hemiptera:Liviidae),a vector of“Candidatus Liberibacter spp.,”associated with citrus huanglongbing(HLB).In this study,translocation of endophytic Bt strains in citrus seedlings inoculated with Bt suspension delivered by soil‐drench,and their systemic pathogenicity to *** nymphs were *** pathogenicity of three wild‐type Bt strains against *** third‐instar nymphs was *** the 10 recombinant strains tested(each of them harboring a single cry or cyt gene),3 can be highlighted,causing 42%–77%and 66%–90%nymphal mortality at 2 and 5 d after inoculation,*** isolation of Bt cells from young citrus shoots and dead nymphs,and PCR performed with specific primers,confirmed the involvement of the Bt strains in the psyllid *** is the first report showing the translocation of Bt strains from citrus seedling roots to shoots and their potential to control *** nymphs that fed on these soil‐drench inoculated *** Bt strains that caused the highest mortality rates have the potential to be used as bioinsecticides to control *** and the identified genes can be used for the production of transgenic Bt citrus.

关键词： Asian citrus psyllid Citrus sinensis Cry toxins endophytic Bt huanglongbing young shoots

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Human Seroreactivity to Secreted Molecules of Corynebacterium pseudotuberculosis

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Advances in Microbiology 2022年第3期12卷 150-158页

作者： Ramon Mendes dos Santos Silvânia Maria Andrade Cerqueira Caio Lopez Borge Andrade Gabriel Saldanha Müller Vitória Costa de Menezes Santos Hévlyn Ribeiro de Araújo Samanta queiroz Rogério Reis Conceição Luiz Gustavo freitas Oliveira Marcos Borges Ribeiro Silvana Marchioro Lilia Ferreira de Moura-Costa Fúlvia Soares Campos de sousa Maria da Conceição Aquino de Sá José Tadeu Raynal Rocha Filho Soraya Castro Trindade Eduardo Martins Netto Roberto Meyer Songelí Menezes Freire Laboratory of Immunology and Molecular Biology of the Health Sciences Institute of the Federal University of Bahia Bahia Brazil Specialized Hospital Otávio Mangabeira Bahia Brazil Microbiology of the Federal University of Bahia Bahia Brazil Laboratory of Infectology of the University Hospital Complex Professor Edgard Santos Salvador Bahia Brazil

Corynebacterium pseudotuberculosis is an infectious agent that occurs in small ruminants causing caseous lymphadenitis, and more rarely in humans causing lymphadenitis and pneumonia. The breeding small ruminants have great economic importance in Brazil. Rural farm workers and veterinary students who acquired this disease suffered from weakening symptoms for weeks, and the identification of the etiological agent was time-consuming and complex. Due to the low prevalence of case records, there is probably no available commercial diagnostic kit for C. pseudotuberculosis infection in humans. This study aimed to describe human seroreactivity to secreted antigens from C. pseudotuberculosis. Reactivity of serum from farm workers (n = 14), individuals who work with the bacillus at laboratory (n = 8) or individuals without contact (n = 25) was tested with secreted proteins from PAT10 strain of C. pseudotuberculosis by Western blotting. Samples of all (100%) farm workers showed reactivity to 31 kDa, 71 kDa and 164 kDa proteins, while laboratory workers showed 87.5%, 62.5 % and 37.5%, and no-contact 20%, 0% and 16%, respectively. All sera recognized the 275 kDa protein. Our data suggest that C. pseudotuberculosis secreted proteins are antigenic in humans and the recognition profiles allowed the identification of individuals with and without prior contact with this bacillus. This is the first paper which describes human reactivity to C. pseudotuberculosis in serum samples of workers in Brazil.

关键词： Human Immunoreactivity Antigenicity Corynebacterium pseudotuberculosis Secreted Proteins Western Blot

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